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20 results for “sulfonamides”
Supplementary data for "Structural, biochemical, and computational characterization of sulfonamides as bimetallic peptidase inhibitors"
<p>Supplementary data for "Structural, biochemical, and computational characterization of sulfonamides as bimetallic peptidase inhibitors"</p> <p>Coordinates, schemes, NCI density visualization in VMD, and PyMOL sessions for the Figures in the publication are provided.</p>
Investigation the cytotoxicity of newly synthesized quinazo-line–sulfonamide derivatives in human leukemia cell lines and hematopoietic activity in zebrafish embryos.
<p>These videos contain the time lapse imaging of the wild type zebrafish embryos showing the circulation, control (mock 0.5% V/V DMSO) and compound 4a treated embryos at 72 hours post fertilization. The compound 4a specifically blocked the formation of blood and no circulation was seen in these embryos. </p>
Enantioselective Modification of Sulfonamides and SulfonamideContaining Drugs via Carbene Organic Catalysis
<p>This folder /xyz_structures/ contains the geometries (in .xyz format together with the energy, E, in Hartree) </p> <p>accompanying the paper<br> "Carbene Catalyzed Enantioselective Synthesis of Phthalidyl Sulfonamides"</p> <p>Where conformers occur, they are always named from the lowest Gibbs energy to the highest in ascending order from c1 (sometimes omitted), c2, c3, ...</p> <p>This folder has the following structure and they correspond to the raw data in the SI:</p> <p><br> /int_II_confs/ <br> --> conformers from conformational sampling of acyl azolium intermediate II using SMD(DCM)-M06-2X/def2-TZVP//M06-2X/def2-SVP level of theory.</p> <p>/with_Li_ion/ <br> --> structures for the reaction between acyl azolium intermediate II and lithium sulfonamide with explicit Li+ ion participation.</p> <p>/without_Li_ion/ <br> --> structures for the reaction between acyl azolium intermediate II and deprotonated sulfonamide without explicit Li+ ion participation.</p>
16S rRNA gene data for aerobic BTEX-degrading enrichments exposed to sulfonamide polyfluorinated substances in fire-fighting foams and transformation products
<p>Per- and polyfluoroalkyl substances (PFASs) from aqueous film forming foams (AFFFs) can hinder bioremediation of co-contaminants, such as trichloroethene (TCE) and benzene, toluene, ethylbenzene, and xylene (BTEX). Anaerobic dechlorination can require bioaugmentation of <em>Dehalococcoides</em> and for BTEX, oxygen is often sparged to stimulate in-situ aerobic biodegradation. We tested PFAS inhibition to TCE and BTEX bioremediation by exposing an anaerobic TCE-dechlorinating co-culture, an aerobic BTEX-degrading enrichment culture, and an anaerobic toluene-degrading enrichment culture to n-dimethyl perfluorohexane sulfonamido amine (AmPr-FHxSA), perfluorohexane sulfonamide (FHxSA), perfluorohexane sulfonic acid (PFHxS), or non-fluorinated surfactant sodium dodecyl sulfate (SDS). The anaerobic TCE-dechlorinating co-culture was resistant to individual PFASs exposures but was inhibited by >1,000x diluted AFFF. FHxSA and AmPr-FHxSA inhibited the aerobic BTEX-degrading enrichment. The anaerobic toluene-degrading enrichment was not inhibited by AFFF or individual PFASs. Increases in amino acids in the anaerobic TCE-dechlorinating co-culture compared to the control indicated stress response, while the BTEX culture exhibited lower concentrations of all amino acids upon exposure to most surfactants (both fluorinated and non-fluorinated) compared to the control. These data suggest the main mechanisms of microbial toxicity are related to interactions with cell membrane synthesis as well as protein stress signaling.</p>
Raw Data for Article "Metal-Free Introduction of Primary Sulfonamide into Electron Rich Aromatics"
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A Randomized, Comparative Study of Daily Dapsone and Daily Atovaquone for Prophylaxis Against PCP in HIV-Infected Patients Who Are Intolerant of Trimethoprim and/or Sulfonamides
ClinicalTrials.gov study NCT00000802. IPD Sharing: Not stated. Countries: 2. Publications: 1.
16S rRNA gene data for aerobic BTEX-degrading enrichments exposed to sulfonamide polyfluorinated substances in fire-fighting foams and transformation products
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A Study of Pentamidine Plus Dapsone in the Prevention of Pneumocystis Carinii Pneumonia (PCP) in HIV-Infected Patients Who Cannot Take Trimethoprim or Sulfonamides
ClinicalTrials.gov study NCT00001028. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Determination of sulfonamides in milk by capillary electrophoresis with PEG@MoS2 as a dispersive solid-phase extraction sorbent
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The aryl sulfonamide indisulam inhibits acute megakaryoblastic leukemia (AMKL) by altering the alternative splicing of the transcription factor ZMYND8
GEO Series GSE266925. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Selective Degradation of Splicing Factor CAPER-alpha by Anticancer Sulfonamides
GEO Series GSE93829. Homo sapiens. 12 samples. Type: Expression profiling by array.
Anti-cancer effects of 7-oxabicyclo[2.2.1]heptene sulfonamide (OBHSA) derivative 17e on gene expression of breast cancer T47D cells
GEO Series GSE210169. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Chloroquinoxaline Sulfonamide in Treating Patients With Stage IV Colorectal Cancer
ClinicalTrials.gov study NCT00005864. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Chloroquinoxaline Sulfonamide in Treating Patients With Small Cell Lung Cancer
ClinicalTrials.gov study NCT00008372. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Chemical genetics approach identifies ABNORMAL INFLORESCENCE MERISTEM 1 as a putative target of a novel sulfonamide that protects Arabidopsis against photorespiratory stress [RNA-seq]
GEO Series GSE155105. Arabidopsis thaliana. 12 samples. Type: Expression profiling by high throughput sequencing.
Chemical genetics approach identifies ABNORMAL INFLORESCENCE MERISTEM 1 as a putative target of a novel sulfonamide that protects Arabidopsis against photorespiratory stress
GEO Series GSE155026. Arabidopsis thaliana. 6 samples. Type: Expression profiling by array.
Sulfonamide functional head group drives developmental toxicity of short-chain per- and polyfluorolkyl substances
GEO Series GSE186576. Danio rerio. 15 samples. Type: Expression profiling by high throughput sequencing.
RNA Expression Profiling of CD8+ T Cell-Enriched Peripheral Blood Mononuclear Cells from Potentiated Sulfonamide-Treated Patients with a Range of Lymphocyte Cytotoxicity Phenotypes
GEO Series GSE100443. Homo sapiens. 20 samples. Type: Expression profiling by array.
E7820, an Anti-Cancer Sulfonamide, Degrades RBM39 in Patients with Splicing Factor Mutant Myeloid Malignancies: A Phase II Clinical Trial
GEO Series GSE227343. Homo sapiens. 29 samples. Type: Expression profiling by high throughput sequencing.
Effects of fluoro-phenyl-styrene-sulfonamide (FPSS) on transcription factor sigma B regulons in Staphylococcus aureus
GEO Series GSE253363. Staphylococcus aureus RF122. 3 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.