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28 results for “suprachiasmatic nucleus”
Data sets and code for "Suprachiasmatic Nucleus-wide Estimation of Oscillatory Temporal Dynamics" (Yao et al, 2024)
<ul> <li>Data from iDISCO clearing and scanning of three adult mouse suprachaismatic nuclei. Brains are labeled as b1, b2, and b3. Each lobe of the SCN is recorded in a separate csv file. Animals were sacrificed at ZT 19. </li> <li>Data for PER2::LUC recordings of ix adult mouse suprachaismatic nuclei. For each slice there are two files: the time series data (labeled "slice-[orientation]-time-series-#" and the coordinates of the pixels represented (labeled "slice-[orientation]-pixel-coords-#."</li> <li>Code in MATLAB to perform phase extraction, linear modeling, phase estimation, and dynamical simulation.</li> </ul>
Data from: Diurnal variation of brain activity in the human suprachiasmatic nucleus
<p>The suprachiasmatic nucleus (SCN) is the central clock for circadian rhythms. Animal studies have revealed daily rhythms in the neuronal activity in the SCN. However, the circadian activity of the human SCN has remained elusive. In this study, to reveal the diurnal variation of the SCN activity in humans, the SCN was localized, and its activity was investigated using perfusion imaging. We scanned each participant four times a day, every six hours, and higher activity was observed at noon while lower activity was recorded in the early morning. The SCN activity was then measured every thirty minutes for six hours from midnight to dawn and showed a decreasing trend and was comparable with the rodent SCN activity after switching off the lights. These results suggest that the diurnal variation of the human SCN follows the zeitgeber cycles of mammals and is modulated by physical lights rather than the local time.</p>
A phosphate transporter in VIPergic neurons of the suprachiasmatic nucleus gates locomotor activity during the light/dark transition in mice
<p>Raw Data for <strong>An atypical phosphoswitch in specific neurons of the suprachiasmatic nucleus gates locomotor activity at the light/dark transition in mice</strong></p> <ol> <li>Multi-electrode array data from PiT2<sup>+/+</sup> and PiT2<sup>-/-</sup> mice</li> <li>Locomotor activity from PiT2<sup>+/+ </sup>and PiT2<sup>-/-</sup> mice in LD 12:12, DD, LD 4:20, LD 20:4 and DD with light pulses</li> <li>Phosphoproteome data</li> </ol>
Data from: Diurnal variation of brain activity in the human suprachiasmatic nucleus
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Arginine-vasopressin expressing neurons in the murine suprachiasmatic nucleus exhibit a circadian rhythm in network coherence in vivo
<p>The suprachiasmatic nucleus (SCN) is composed of functionally distinct subpopulations of GABAergic neurons which form a neural network responsible for synchronizing most physiological and behavioral circadian rhythms in mammals. To date, little is known regarding which aspects of SCN rhythmicity are generated by individual SCN neurons, and which aspects result from neuronal interaction within a network. Here, we utilize in vivo miniaturized microscopy to measure fluorescent GCaMP-reported calcium dynamics in arginine vasopressin (AVP)-expressing neurons in the intact SCN of awake, behaving mice. We report that SCN AVP neurons exhibit periodic, slow calcium waves which we demonstrate, using in vivo electrical recordings, likely reflect burst firing. Further, we observe substantial heterogeneity of function in that AVP neurons exhibit unstable rhythms and relatively weak rhythmicity at the population level. Network analysis reveals that correlated cellular behavior, or coherence, among neuron pairs also exhibited stochastic rhythms with about 33% of pairs rhythmic at any time. Unlike single-cell variables, coherence exhibited a strong rhythm at the population level with time of maximal coherence among AVP neuronal pairs at CT/ZT 6 and 9, coinciding with the timing of maximal neuronal activity for the SCN as a whole. These results demonstrate robust circadian variation in the coordination between stochastically rhythmic neurons and interactions between AVP neurons in the SCN may be more influential than single-cell activity in the regulation of circadian rhythms. Furthermore, they demonstrate that cells in this circuit, like those in many other circuits<span></span>, exhibit profound heterogenicity of function over time and space.</p>
Arginine-vasopressin expressing neurons in the murine suprachiasmatic nucleus exhibit a circadian rhythm in network coherence in vivo
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Spatiotemporal single-cell analysis of gene expression in the mouse suprachiasmatic nucleus
GEO Series GSE118403. Mus musculus. 82 samples. Type: Expression profiling by high throughput sequencing.
REV-ERB nuclear receptors in the suprachiasmatic nucleus control circadian period and restrict diet-induced obesity
GEO Series GSE152919. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Spatiotemporal single-cell analysis of gene expression in the mouse suprachiasmatic nucleus
GEO Series GSE118404. Mus musculus. 96 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome profiling of light-induced gene expression in the suprachiasmatic nucleus of T7 and T24 cycle-housed mice
GEO Series GSE113875. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Spatiotemporal single-cell analysis of gene expression in the mouse suprachiasmatic nucleus
GEO Series GSE132608. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Circadian rhythms in mouse choroid plexus identified by time-resolved RNAseq require clock in the suprachiasmatic nucleus
GEO Series GSE243858. Mus musculus. 26 samples. Type: Expression profiling by high throughput sequencing.
Spatiotemporal single-cell analysis of gene expression in the mouse suprachiasmatic nucleus
GEO Series GSE117295. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing.
NPAS4 regulates the transcriptional response of suprachiasmatic nucleus neurons to photic input
GEO Series GSE148252. Mus musculus. 52 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Transcriptome profiling of the mouse suprachiasmatic nucleus at single cell resolution
GEO Series GSE167927. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Suprachiasmatic nucleus regulation of brown fat thermogenesis via ADRB3-S100B axis
GEO Series GSE300640. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Zinc finger homeobox-3 (ZFHX3) exerts genome-wide regulation of dailygene expression in the suprachiasmatic nucleus
GEO Series GSE261795. Mus musculus. 65 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Zinc finger homeobox-3 (ZFHX3) exerts genome-wide regulation of dailygene expression in the suprachiasmatic nucleus [ChIP-seq]
GEO Series GSE261430. Mus musculus. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Light-induced Changes in the Suprachiasmatic Nucleus Transcriptome Regulated by the ERK/MAPK Pathway
GEO Series GSE165799. Mus musculus. 36 samples. Type: Expression profiling by array.
Diurnal transcriptome rhythms in mice with genetically ablated clock function in the suprachiasmatic nucleus (SCN)
GEO Series GSE81532. Mus musculus. 24 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.