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267 results for “target of selection”
Dataset for paper "Target selection for Near-Earth Asteroids in-orbit sample collection missions"
<p>This dataset can be used to reproduce the results of the paper titled "Target selection for Near-Earth Asteroids in-orbit sample collection missions."</p> <p>The "results" folder contains the data to reproduce the maps and the rankings of the target asteroids.</p> <p>The "trajectories" folder contains the propagation of the sample trajectories used to obtain the grids.</p>
The target of selection matters: an established resistance – development-time negative genetic trade-off is not found when selecting on development time.
<p>Trade-offs are fundamental to evolutionary outcomes and play a central role in eco-evolutionary theory. They are often examined by experimentally selecting on one life-history trait and looking for negative correlations in other traits. For example, populations of the moth Plodia interpunctella selected to resist viral infection show a life-history cost with longer development times. However, we rarely examine whether the detection of such negative genetic correlations depends on the trait on which we select. Here we examine a well-characterised negative genotypic trade-off between development time and resistance to viral infection in the moth Plodia interpunctella and test whether selection on a phenotype known to be a cost of resistance (longer development time) leads to the predicted correlated increase in resistance. If there is tight pleiotropic relationship between genes that determine development time and resistance underpinning this trade-off, we might expect increased resistance when we select on longer development time. However, we show that selecting for longer development time in this system selects for reduced resistance when compared to selection for shorter development time. This shows how phenotypes typically characterised by a trade-off can deviate from that trade-off relationship, and suggests little genetic linkage between the genes governing viral resistance and those that determine response to selection on the key life-history trait. Our results are important for both selection strategies in applied biological systems and for evolutionary modelling of host-parasite interactions.</p>
Data from: Convergent rates of protein evolution identify novel targets of sexual selection in primates
<p>Sexual selection is the differential reproductive success of individuals, resulting from competition for mates, mate choice, or success in fertilization. In primates, this selective pressure often leads to the development of exaggerated traits which play a role in sexual competition and successful reproduction. In order to gain insight into the mechanisms driving the development of sexually selected traits, we used an unbiased genome-wide approach across 21 primate species to correlate individual rates of protein evolution to relative testes size and sexual dimorphism in body size, two anatomical hallmarks of sexual selection in mammals. Among species with presumed high levels of sperm competition, we detected strong conservation of testes-specific proteins responsible for spermatogenesis and ciliary form and function. In contrast, we identified accelerated evolution of female reproductive proteins expressed in the vagina, cervix, and fallopian tubes in these same species. Additionally, we found accelerated protein evolution in lymphoid tissue, indicating that adaptive immune functions may also be influenced by sexual selection. This study demonstrates the distinct complexity of sexual selection in primates revealing contrasting patterns of protein evolution between male and female reproductive tissues.</p>
Associated code and data for "Multi-level computational modeling of anti-cancer dendritic cell vaccination utilized to select molecular targets for therapy optimization (doi: 10.3389/fcell.2021.74635)"
<p>This deposit contains the data, code, and analysis to reproduce the results in the manuscript - Lai X, Keller C, Santos-Rosales G, Schaft N, Dörrie J, Vera J. Multi-level computational modeling of anti-cancer dendritic cell vaccination utilized to select molecular targets for therapy optimization. Frontiers in Cell and Developmental Biolology. 2022; 9:746359; <a href="https://www.researchgate.net/publication/358461035_Multi-Level_Computational_Modeling_of_Anti-Cancer_Dendritic_Cell_Vaccination_Utilized_to_Select_Molecular_Targets_for_Therapy_Optimization">doi:10.3389/fcell.2021.746359</a>.</p> <p>If you have used the code for your research, please cite the original publication. Thank you very much.</p> <p> </p>
BRAIN Journal-The Presence and Activity on Facebook of the Informative Travel Organizations in Romania-Figure 1. Selected Romanian counties in order to strengthen the target group of tourism organizations with informative role
<p>In this regard, we analysed the current state of presence and communication on Facebook for<br> 109 informative tourism entities located in 25 Romanian counties, selected on the basis of tourist<br> traffic indicators for the period between 2007 and 2013. The structure of the 109 organizations<br> analysed is: 43 tourist information centers (39.45%), 44 entities with the name of the association for<br> tourism promotion, ecotourism promotion, mountaineering promotion etc. (40.36%), 18 tourism<br> clubs (16.51%) and 4 tourist information points/offices (3.67%)</p>
Set of Data from "Selective targeting of striatal parvalbumin-expressing interneurons for transgene delivery" https://doi.org/10.1016/j.jneumeth.2021.109105
<p>PV<sup>Cre</sup> (+/+) mice were injected in the right striatum with AAV2/1-hsyn-FLEX-eGFP AAV2/9-CBA-FLEX-eGFP or AAV2/9-hsyn-FLEX-eGFP vectors. Two weeks after, cells were manually counted by a blind observer on 2D maximal intensity projections of confocal images transformed into the tiff format using the Multi-point tool in ImageJ. The GraphPad .pzfx files show the quantitative anaylsis of the proportion of GFP+ cells which were PV+ (specificty) , the proportion of PV+ cells which were GFP+ (efficiency), the proportion of PV+ cells in the injected striatum relative to to the injected striatum of PV<sup>Cre</sup> (+/+) mice (absence of vector toxicity) and the proportion of PV+ cells in the striatum of PV<sup>Cre</sup> (+/+) mice versus wt mice.</p> <p> </p>
The target of selection matters: an established resistance – development-time negative genetic trade-off is not found when selecting on development time.
Open the record for dataset details and reuse information.
Data from: Convergent rates of protein evolution identify novel targets of sexual selection in primates
Open the record for dataset details and reuse information.
Combining GWAS and FST-based approaches to identify targets of Borrelia-mediated selection in natural rodent hosts
Recent advances in high-throughput sequencing technologies provide opportunities to gain novel insights into the genetic basis of phenotypic trait variation. Yet to date, progress in our understanding of genotype-phenotype associations in non-model organisms in general and natural vertebrate populations in particular has been hampered by small sample sizes typically available for wildlife populations and a resulting lack of statistical power, as well as a limited ability to control for false positive signals. Here we propose to combine a genome-wide association (GWAS) and FST-based approach with population-level replication to partly overcome these limitations. We present a case study in which we used this approach in combination with Genotyping-by-Sequencing (GBS) SNP data to identify genomic regions associated with Borrelia afzelii resistance or susceptibility in the natural rodent host of this Lyme disease-causing spirochete, the bank vole (Myodes glareolus). Using this combined approach we identified four consensus SNPs located in exonic regions of the genes Slc26a4, Tns3, Wscd1 and Espnl, which were significantly associated with the voles' Borrelia infectious status within and across populations. Functional links between host responses to bacterial infections and most of these genes have previously been demonstrated in other rodent systems, making them promising new candidates for the study of evolutionary host responses to Borrelia emergence. Our approach is applicable to other systems and may facilitate the identification of genetic variants underlying disease resistance or susceptibility, as well as other ecologically relevant traits, in wildlife populations.
Compounds with multi-target activities forming target cliffs and selectivity cliffs
<p>On the basis of high-confidence activity data assembled from ChEMBL release 20, compounds active against one or more pairs of targets are provided (in the file 'Compounds_In_Target_Pairs.xlsx') for the K<sub>i</sub> and IC<sub>50</sub> value-based data sets, respectively. Target cliffs formed by selective compounds are listed in the file 'Target_Cliffs.xlsx'. In addition, selectivity cliffs formed by structurally analogous compounds with significantly different selectivity are given in the file 'Selectivity_Cliffs.xlsx'. The content of individual files is detailed in the README file.</p>
Development of a genus-specific antigen capture ELISA for orthopoxviruses. Target selection and optimized screening
<p><strong>Raw data for quantification of anti surface protein antibody binding to vaccinia virus.</strong></p> <p>Method description</p> <p>Immuno-negative staining and electron microscopy were performed as described elsewhere (Laue, 2010). Briefly, purified VACV<sub>NYCBOH</sub> particles were inactivated by incubation in freshly prepared 2% PFA in 0.05 M HEPES (pH 7.2), sonicated and immobilized on sample supports for transmission electron microscopy. Biotinylated pAbs were titrated on BSA coated grids, until detection with 5 nm gold nanoparticle coupled streptavidin (British Biocell, Cardiff, United Kingdom) resulted in the same mean background labelling density of ~10 particles per view field at a, 87,000-fold magnification (anti-A27: 0.7 µg/mL; anti-D8: 2 µg/mL; anti-H3: 0.9 µg/mL; anti-L1: 1.9 µg/mL). Negative staining was performed with either 0.1 or 0.5% uranyl acetate solution. For quantification, only IMV particles of the mulberry form, which were found isolated from other particles, were analyzed. Randomized sampling was done in 22 evenly distributed mesh areas with five viral particles analyzed per area. Imaging was done with a Tecnai 12 BioTwin (FEI Corp.) at 120 kV and a 1k digital CCD camera (Megaview III, Olympus Soft Imaging Solutions).</p>
Perceptual task induces saccadic adaptation by target selection
<p>Dataset from the following publication:</p> <p>Schütz, A. C. & Souto, D. (2015). Perceptual task induces saccadic adaptation by target selection. <em>Front. Hum. Neurosci., 9</em>(566), 1-14. <a>doi:10.3389/fnhum.2015.00566 <span></span></a><a></a></p>
Off-target integron activity leads to rapid plasmid compensatory evolution in response to antibiotic selection pressure
Integrons are mobile genetic elements that have played an important role in the dissemination of antibiotic resistance. As shown previously (Souque et al, 2021), the integron can generate under stress combinatorial variation in resistance cassette expression by cassette re-shuffling, accelerating the evolution of resistance. However, the flexibility of the integron integrase site recognition motif hints at potential off-target effects of the integrase on the rest of the genome that may have important evolutionary consequences. Here we test this hypothesis by selecting for increased piperacillin resistance populations of <em>P.aeruginosa</em> with a mobile integron containing a hard-to-mobilise beta-lactamase cassette to minimize the potential for adaptive cassette re-shuffling. We found that integron activity can both decrease overall survival rate but also improve the fitness of the surviving populations. Off-target inversions mediated by the integron accelerated plasmid adaptation by disrupting costly conjugative genes otherwise mutated in control populations lacking a functional integrase. Plasmids containing integron-mediated inversions were associated with lower plasmid costs and higher stability than plasmids carrying mutations, albeit at a cost of reduced conjugative ability. These findings highlight the potential for integrons to create structural variation that can drive bacterial evolution, and they provide an interesting example showing how antibiotic pressure can drive the loss of conjugative genes.
ER values of the targeted by-products as a function of their metallogenic family. The bold text highlights the most relevant metal association regarding the selected metallogenic families.
<p>This dataset is table 3 from the article "Predictive assessment of metallogenic signatures using the DataBase Querying (DBQ) method: A European application by Blandine Gourcerol *, Guillaume Bertrand, Laurent Bailly, Pauline Moreau, Isabelle Duhamel-Achin, Maxime Picault, Philippe Négrel</p> <p>DOI : https://doi.org/10.1016/j.gexplo.2022.106966</p>
Chromatin Accessibility Plays a Key Role in Selective Targeting of Hox Proteins
<p>Supplementary data tables for bioRxiv preprint "Chromatin Accessibility Plays a Key Role in Selective Targeting of Hox Proteins "</p> <p>All tables as Tab Delimited Text files</p>
Targeted Surface Manipulation of Cu/Zn/Ag coatings and Ag/Cu particles based on Sacrificial Element Selection by Electrodeposition and Redox replacement
<p>Dataset Targeted Surface Manipulation of Cu/Zn/Ag coatings and Ag/Cu particles based on Sacrificial Element Selection by Electrodeposition and Redox replacement</p>
Plinabulin in Combination With Radiation/Immunotherapy in Patients With Select Advanced Cancers After Progression on PD-1 or PD-L1 Targeted Antibodies
ClinicalTrials.gov study NCT04902040. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Non-Selective Beta-Blockers on Outcomes in Cirrhosis Patients After Hospitalization: A Retrospective Cohort Using Target Trial Design
ClinicalTrials.gov study NCT06977685. IPD Sharing: NO. Countries: 1. Publications: 0.
Pilot Study Using Molecular Profiling to Find Potential Targets & Select Treatments for Pts With Met br ca
ClinicalTrials.gov study NCT01074814. IPD Sharing: NO. Countries: 1. Publications: 1.
Selective Complex Fractionated Atrial Electrograms (CFAE) Targeting for Atrial Fibrillation
ClinicalTrials.gov study NCT00926783. IPD Sharing: Not stated. Countries: 3. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.