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datasets available to search
ShareScore release 0.9.0
Dataset results
36 results for “targeted monitoring”
Monitoring melanoma patients on treatment reveals a distinct macrophage population driving targeted therapy resistance
<p><span>Resistance to targeted therapy remains a major clinical challenge in melanoma patients. To uncover resistance mechanisms, we performed single cell RNA sequencing of fine needle aspirates from resistant and responding tumors from melanoma patients before and during BRAFi/MEKi treatment. Among the genes most differentially expressed between malignant cells from resistant vs. responding tumors was POSTN encoding the secreted factor periostin. POSTN was predicted to predominantly signal to a macrophage population associated with targeted therapy resistance (TTR). Accordingly, tumors from patients with fast disease progression after targeted therapy exhibited high POSTN expression levels as well as high numbers of TTR macrophages, and POSTN was able to polarize macrophages towards a TTR phenotype. In a mouse model in vivo, POSTN expression protected melanoma from targeted therapy, which was associated with a phenotype change of intratumroal macrophages. Finally, polarized TTR macrophages protected melanoma cells from MEKi-induced killing through CD44 receptor expression on melanoma cells. Thus, interfering with the protective activity of TTR macrophages might represent a strategy to overcome resistance to targeted therapy in melanoma.</span></p>
Gout Self-Monitoring Aiming to Reach Target
ClinicalTrials.gov study NCT03274063. IPD Sharing: YES. Countries: 1. Publications: 1.
Brain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART)
ClinicalTrials.gov study NCT03183388. IPD Sharing: NO. Countries: 1. Publications: 1.
Understanding the Immune System's Role in Tree Nut and Peanut Allergies: Key Biomarkers for Diagnosis and Treatment Monitoring and Treatment Targets
ClinicalTrials.gov study NCT06554691. IPD Sharing: NO. Countries: 1. Publications: 13.
Therapeutic Drug Monitoring - Targeting IMproved Effectiveness
ClinicalTrials.gov study NCT05971979. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Noninvasive Hemoglobin Monitoring for Maintaining Hemoglobin Concentration Within the Target Range
ClinicalTrials.gov study NCT03816514. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Non-Invasive Aortic Ambulatory Blood Pressure Monitoring for The Detection of Target Organ Damage in The Chinese Population
ClinicalTrials.gov study NCT03154203. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Detection of Plasmatic Cell-free BRAF and NRAS Mutations : a New Tool for Monitoring Patients with Metastatic Malignant Melanoma Treated with Targeted Therapies or Immunotherapy ( MALT )
ClinicalTrials.gov study NCT03493230. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Granzyme B-targeted PET Imaging Monitoring Tumor Responses to Immunotherapy
ClinicalTrials.gov study NCT06916442. IPD Sharing: NO. Countries: 1. Publications: 1.
Precision Imaging for Early Detection and Targeted Treatment Monitoring in Pancreatic Cancer
ClinicalTrials.gov study NCT06144762. IPD Sharing: NO. Countries: 1. Publications: 18.
Clinical Trial of Telenursing for Monitoring Supportive Care Needs in Patients With Lung Cancer and Melanoma Candidates for the First Prescription of Targeted Therapies
ClinicalTrials.gov study NCT06254196. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Target Therapy With GEMOX in Recectable Gallbladder Carcinoma Patients Monitored by ctDNA
ClinicalTrials.gov study NCT04183712. IPD Sharing: NO. Countries: 1. Publications: 1.
Comparison of Conventional Fluid Management Protocol With Targeted Pleth Variability Index (PVI) Monitoring Protocol During Total Abdominal Hysterectomy and Bilateral Salpingooferectomy Operation
ClinicalTrials.gov study NCT04775576. IPD Sharing: YES. Countries: 1. Publications: 6.
Evaluation of HER2-targeted Therapy for Gastric Cancer and Establishment and Verification of Monitoring System
ClinicalTrials.gov study NCT05165602. IPD Sharing: NO. Countries: 1. Publications: 14.
Local Monitoring of Photosensitizer Transient States Provides Feedback for Enhanced Efficiency and Targeting Selectivity in Photodynamic Therapy.
<p><strong>This folder contains all raw data underlying the results presented in a manuscript, accepted for publication in Scientifc Reports, entitled:</strong></p> <p><strong>Local Monitoring of Photosensitizer Transient States Provides Feedback for Enhanced Efficiency and Targeting Selectivity in Photodynamic Therapy.</strong></p> <p><strong>Authored by:</strong></p> <p>Elin Sandberg <sup>1</sup>, Chinmaya V Srambickal <sup>1</sup>, Joachim Piguet <sup>1</sup>, Haichun Liu <sup>1</sup> and Jerker Widengren <sup>1,</sup>*</p> <p><sup>1</sup> Experimental Biomolecular Physics, Department of Applied Physics, Royal Institute of Technology (KTH), Stockholm, Sweden</p> <p><sup>* </sup>To whom correspondence should be addressed. Email: jwideng@kth.se. Tel: +46-8-7907813</p> <p> </p> <p><strong>The data files are grouped with respect to the figures/tables in the manuscript where the extracted results are presented. </strong></p> <p><strong>ABSTRACT</strong></p> <p>Photodynamic therapy (PDT) fundamentally relies on local generation of PDT precursor states in added photosensitizers (PS), particularly triplet and photo-radical states. Monitoring these states <em>in situ</em> can provide important feedback but is difficult in practice. The states are strongly influenced by local oxygenation, pH and redox conditions, often varying significantly at PDT treatment sites. To overcome this problem, we followed local PDT precursor state populations of PS compounds, via their fluorescence intensity response to systematically varied excitation light modulation. Thereby, we could demonstrate local monitoring of PDT precursor states of methylene blue (MB) and IRdye700DX (IR700), and determined their transitions rates under different oxygenation, pH and redox conditions. By fiber-optics, using one fiber for both excitation and fluorescence detection, the triplet and photo-radical state kinetics of locally applied MB and IR700 could then be monitored in a tissue sample. Finally, potassium iodide and ascorbate were added as possible PDT adjuvants, enhancing intersystem crossing and photoreduction, respectively, and their effects on the PDT precursor states of MB and IR700 could be locally monitored. Taken together, the presented procedure overcomes current methodological limitations and can offer feedback, guiding both excitation and PDT adjuvant application, and thereby more efficient and targeted PDT treatments.</p>
Data from: Screening sticky cards as a simple method for improving efficiency of Diaphorina citri (Hemiptera: Liviidae) monitoring and reducing non-target organisms
Open the record for dataset details and reuse information.
Direct Selection of an Allosteric RNA-Cleaving DNAzyme for a Protein Target: A Specific DNAzyme for Eosinophil Peroxidase to Monitor Airway Eosinopilia
GEO Series GSE217946. synthetic construct. 1 samples. Type: Other.
Monitoring CAR T cell generation with a CD8-targeted lentiviral vector by single cell transcriptomics
GEO Series GSE184895. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Monitoring of melanoma patients on treatment reveals a distinct macrophage population driving targeted therapy resistance
GEO Series GSE262779. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Monitoring melanoma patients on treatment reveals a distinct macrophage population driving targeted therapy resistance
GEO Series GSE229908. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.