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15 results for “telomere attrition”
Dataset for: Smoking does not accelerate leukocyte telomere attrition: a meta-analysis of 18 longitudinal cohorts
<p>Summary dataset (.csv file) and R script (.R file) for the manuscript entitled:</p> <p>Smoking does not accelerate leukocyte telomere attrition: a meta-analysis of 18 longitudinal cohorts.</p> <p>The column names are explained at the beginning of the R script.</p> <p> </p>
Data from: Telomere attrition with age in a wild amphibian population
<p>Telomere shortening with age has been documented in many organisms, but few studies have reported telomere length measurements in amphibians, and no information is available for growth after metamorphosis, nor in wild populations. We provide both cross-sectional and longitudinal evidence of net telomere attrition with age in a wild amphibian population of natterjack toads (<em>Epidalea calamita</em>). Based on age-estimation by skeletochronology and qPCR telomere length measurements in the framework of an individual-based monitoring programme, we confirmed telomere attrition in recaptured males. Our results support that toads experience telomere attrition throughout<br> their ontogeny, and that most attrition occurs during the first 1–2 years.We did not find associations between telomere length and inbreeding or body condition. Our results on telomere length dynamics under natural conditions confirm telomere shortening with age in amphibians and provide quantification of wide telomere length variation within and among age-classes in a wild breeding population.</p>
Data for: Dietary nucleotides can prevent glucocorticoid-induced telomere attrition in a fast-growing wild vertebrate
<p><span>T<span>elomeres are chromosome protectors that shorten during eukaryotic cell replication and in stressful conditions. Developing individuals are </span>susceptible <span>to telomere erosion when their growth is fast and resources are limited. This is critical because the rate of telomere attrition in early life is linked to health and life span of adults. The metabolic telomere attrition hypothesis (MeTA) suggests that telomere dynamics can respond to biochemical signals conveying information about the organism's energetic state. Among these signals are glucocorticoids, hormones that promote catabolic processes, potentially impairing costly telomere maintenance, and nucleotides, which activate anabolic pathways through the cellular enzyme target of rapamycin (TOR), thus preventing telomere attrition. During the energetically demanding growth phase, the regulation of telomeres in response to two contrasting signals—one promoting telomere maintenance and the other attrition—provides an ideal experimental setting to test the MeTa. We studied nestlings of a rapidly developing free-living passerine, the great tit (<em>Parus</em> <em>major</em>), that either received glucocorticoids (Cort-chicks), nucleotides (Nuc-chicks), or a combination of both (NucCort-chicks), comparing these with controls (Cnt-chicks). As expected, Cort-chicks showed telomere attrition, while NucCort- and Nuc-chicks did not. NucCort-chicks was the only group showing increased expression of a proxy for TOR activation (the gene telo2), of mitochondrial enzymes linked to ATP production (cytochrome oxidase and ATP-synthase) and a higher efficiency in aerobically producing ATP. NucCort-chicks had also a higher expression of telomere maintenance genes (shelterin protein TERF2 and telomerase TERT) and of enzymatic antioxidant genes (glutathione peroxidase and superoxide dismutase). The findings show </span>that nucleotide availability is crucial for preventing telomere erosion during fast growth in stressful environments. </span></p>
Data from: Telomere attrition with age in a wild amphibian population
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Data for: Dietary nucleotides can prevent glucocorticoid-induced telomere attrition in a fast-growing wild vertebrate
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Data from: Telomere attrition and growth: a life-history framework and case study in common terns
The relationship between growth and age-specific telomere length, as a proxy of somatic state, is increasingly investigated, but observed patterns vary and a predictive framework is lacking. We outline expectations based on the assumption that telomere maintenance is costly and argue that individual heterogeneity in resource acquisition is predicted to lead to positive covariance between growth and telomere length. However, canalization of resource allocation to the trait with a larger effect on fitness, rendering that trait relatively invariant, can cause the absence of covariance. In a case study of common tern (Sterna hirundo) chicks, in which hatching order is the main determinant of variation in resource acquisition within broods, we find that body mass, but not telomere length or attrition, varies with hatching order. Moreover, body mass and growth positively predict survival to fledging, whereas telomere length and attrition do not. Using a novel statistical method to quantify standardized variance in plasticity, we estimate between-individual variation in telomere attrition to be only 12% of that of growth. Consistent with the relative invariance of telomere attrition, we find no correlation between age-specific body mass or growth and telomere attrition. We suggest that common tern chicks prioritize investment in long-term somatic state (as indicated by canalization of telomere maintenance) over immediate survival benefits of growth as part of an efficient brood reduction strategy that benefits the parents. As such, inter-specific variation in the growth-telomere length relationship may be explained by the extent to which parents benefit from rapid mortality of excess offspring.
Data from: Rapid growth accelerates telomere attrition in a transgenic fish
Background: Individuals rarely grow as fast as their physiologies permit despite the fitness advantages of being large. One reason may be that rapid growth is costly, resulting for example in somatic damage. The chromosomal ends, the telomeres, are particularly vulnerable to such damage, and telomere attrition thus influences the rate of ageing. Here, we used a transgenic salmon model with an artificially increased growth rate to test the hypothesis that rapid growth is traded off against the ability to maintain somatic health, assessed as telomere attrition. Results: We found substantial telomere attrition in transgenic fish, while maternal half-sibs growing at a lower, wild-type rate seemed better able to maintain the length of their telomeres during the same time period. Conclusions: Our results are consistent with a trade-off between rapid growth and somatic (telomere) maintenance in growth-manipulated fish. Since telomere erosion reflects cellular ageing, our findings also support theories of ageing postulating that unrepaired somatic damage is associated with senescence.
Flashy male Jamaican anoles (Anolis grahami) show accelerated telomere attrition
<p>Data on Jamaican Anoles dewlap size and colouration, bite force and telomere attrition</p>
The TELO-SCOPE Study: Attenuating Telomere Attrition With Danazol. Is There Scope to Dramatically Improve Health Outcomes for Adults and Children With Pulmonary Fibrosis
ClinicalTrials.gov study NCT04638517. IPD Sharing: YES. Countries: 1. Publications: 1.
Data from: Telomere attrition and growth: a life-history framework and case study in common terns
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Data from: Ultra-long telomeres shorten with age in nestling great tits but are static in adults and mask attrition of short telomeres
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Data from: Rapid growth accelerates telomere attrition in a transgenic fish
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Hematopoiesis under telomeric attrition at the single-cell resolution
GEO Series GSE169709. Homo sapiens; Mus musculus. 42 samples. Type: Expression profiling by high throughput sequencing.
Distinctions between the stasis and telomere attrition senescence barriers in cultured human mammary epithelial cells
GEO Series GSE16058. Homo sapiens. 48 samples. Type: Expression profiling by array.
Hematopoiesis under telomeric attrition at the single-cell resolution [ATAC-seq]
GEO Series GSE171220. Homo sapiens; Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
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