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37 results for “thymidine”
Inactive to active transition of human Thymidine Kinase 1 revealed by Molecular Dynamics simulations
<p>The trajectories and input files for the manuscript <em>Inactive to active transition of human Thymidine</em></p> <p><em>Kinase 1 revealed by Molecular Dynamics simulations</em> (<a href="https://doi.org/10.1021/acs.jcim.1c01157">https://doi.org/10.1021/acs.jcim.1c01157</a>) </p> <p>ABSTRACT</p> <p>Despite its importance for the nucleoside (and nucleoside prodrug) metabolism, the structure<br> of the active conformation of human Thymidine Kinase 1 (hTK1) remains elusive. We perform<br> microsecond molecular dynamics simulations of the inactive enzyme form bound to a<br> bisubstrate inhibitor that was shown experimentally to activate another TK1-like kinase,<br> Thermotoga maritima TK (TmTK). Our results are in excellent agreement with the<br> experimental findings for the TmTK closed-to-open state transition. We show that the inhibitor<br> induces an increase of the enzyme radius of gyration due to the expansion on one of the dimer<br> interfaces; the structural changes observed, including the active site pocket volume increase,<br> decrease in monomer-monomer buried surface area and of the number of hydrogen bonds (as<br> compared to the inactive enzyme control simulation), show that the catalytically competent<br> (open) conformation of hTK1 can be assumed in the presence of an activating ligand.</p>
Thymidine uptake rates for estimating bacterial production in lakes, McMurdo Dry Valleys, Antarctica (1993-2023, ongoing)
An important part of the McMurdo Long Term Ecological Research (LTER) is monitoring of spatial and temporal patterns, and processes that control bacterial production in perennial ice-covered lakes. This data set quantifies thymidine (TdR) uptake by bacteria, which can be used to estimate bacterial production.
Collection of UV/Vis spectra acquired while monitoring reaction progress of thymidine phosphorolysis with varying reactant concentrations
<p>This data set accompanies the publication "Dynamic modelling of phosphorolytic cleavage catalyzed by pyrimidine-nucleoside phosphorylase" in MDPI Processes, and is a collection of UV/vis spectra used for monitoring of reaction progress under various experimental conditions.</p> <p>The monitored reaction is thymidine phosphorolysis, catalyzed by an enzyme (EC 2.4.2.2). Phosphate and thymidine concentrations are in the range of 2–80 mM and 0.8–5 mM, respectively, and final enzyme concentration in the range of 12.5–50 µg/mL. The recorded data represents time courses over 24 hours for 48 reaction conditions.</p> <p>This collection also contains the documentation of all work done in the laboratory to achieve this data (provenance in the form of the complete lab journal).</p>
Thymidine Kinase 1 in Risk Assessment for Hereditary Breast /Ovarian Cancer
ClinicalTrials.gov study NCT00855998. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Treatment of TK2 Deficiency With Thymidine and Deoxycytidine
ClinicalTrials.gov study NCT03639701. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Doxecitin and Doxribthymine in Adult Subjects With Thymidine Kinase 2 (TK2) Deficiency
ClinicalTrials.gov study NCT06754098. IPD Sharing: NO. Countries: 1. Publications: 4.
A Trial of Carboxypeptidase-G2 (CPDG2) and Thymidine for the Management of Patients With Methotrexate Toxicity and Renal Dysfunction
ClinicalTrials.gov study NCT00001298. IPD Sharing: Not stated. Countries: 1. Publications: 3.
raw data - In classical Hodgkin lymphoma, the activity of Thymidine kinase-1 is not related to the tumor size.
Open the record for dataset details and reuse information.
A Pilot Study Evaluating 18F-L-Thymidine (FLT) PET Imaging in Children With Gliomas
ClinicalTrials.gov study NCT01117155. IPD Sharing: Not stated. Countries: 0. Publications: 3.
Serial [18F]Thymidine (FLT)PET/CT as a Biomarker of Response in Pemetrexed Therapy for Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT02274038. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Trial of Erythrocyte Encapsulated Thymidine Phosphorylase In Mitochondrial Neurogastrointestinal Encephalomyopathy
ClinicalTrials.gov study NCT03866954. IPD Sharing: UNDECIDED. Countries: 0. Publications: 4.
Metabolic Effects of Non-Thymidine Analogue Anti-HIV Medications
ClinicalTrials.gov study NCT00433992. IPD Sharing: NO. Countries: 1. Publications: 0.
Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression
GEO Series GSE90483. Homo sapiens. 4 samples. Type: Expression profiling by array.
Gene expression profile of human epidermoid carcinoma KB cells that overexpress thymidine phosphorylase
GEO Series GSE31467. Homo sapiens. 2 samples. Type: Expression profiling by array.
Targeting thymidine phosphorylase as a potential therapy for bone loss associated periprosthetic osteolysis
GEO Series GSE171542. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Thymidine Kinase and mtDNA Depletion in Human Cardiomyopathy: Epigentic and Translational Evidence for Energy Starvation
GEO Series GSE43435. Homo sapiens. 40 samples. Type: Expression profiling by array; Methylation profiling by genome tiling array.
Thymidine starvation
GEO Series GSE147758. Escherichia coli. 6 samples. Type: Expression profiling by high throughput sequencing.
RNAseq profiling of dog primary mammary triple-negative breast cancer cells infected or not with a vaccinia virus deleted for the thymidine kinase gene
GEO Series GSE142180. Canis lupus familiaris. 8 samples. Type: Expression profiling by high throughput sequencing.
Phase Ib/II Clinical Study of Pexa-Vec (Vaccinia GM CSF / Thymidine Kinase-Deactivated Virus) Combined With Recombinant Whole Human Anti-PD-L1 Monoclonal Antibody (ZKAB001) in Metastatic Melanoma
ClinicalTrials.gov study NCT04849260. IPD Sharing: NO. Countries: 1. Publications: 0.
Analysis of Changes in Adipose Tissue of Patients With Lipoatrophy HIV Infection Treated With Nucleoside Thymidine, After Switching to Monotherapy With Lopinavir / Ritonavir
ClinicalTrials.gov study NCT01031849. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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