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12 results for “thyrotoxicosis”
Differential Diagnosis of STA-PSV in Thyrotoxicosis
ClinicalTrials.gov study NCT01227499. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clinical Application of Pulse Rate-monitoring Activity Trackers in Thyrotoxicosis
ClinicalTrials.gov study NCT03009357. IPD Sharing: NO. Countries: 1. Publications: 2.
Randomised Trial of Block and Replace versus dose titration antithyroid drug treatment in children and adolescents with thyrotoxicosis.
<p><strong>This dataset contains the study regimens for the randomised controlled trial. </strong></p> <p><strong>Context</strong></p> <p>First line treatment of thyrotoxicosis in young people is thionamide antithyroid drug (ATD) in a blocking dose with levothyroxine replacement (block and replace, BR) or in a smaller dose tailored to render the patient euthyroid (dose titration, DT). </p> <p><strong>Objective</strong></p> <p>To determine which regimen provides more stable biochemical control. </p> <p><strong>Design and setting</strong></p> <p>A multi-centre phase III, open-label randomised trial comparing BR with DT in patients aged 2 to 16 years with newly diagnosed thyrotoxicosis at 15 UK centres. Patients were randomised shortly after diagnosis and treated for 3 years. The primary outcome was the percentage of serum thyroid stimulating hormone (TSH) levels in the reference range between 6 months and 3 years. Secondary outcomes included the proportion of Free thyroxine (FT4) levels in the reference range, adverse event frequency and 4y outcome (remission/relapse).</p> <p><strong>Results</strong></p> <p>Eighty-two patients were randomised, with details on clinical course in 81 (62 Female); 40 were allocated to BR (41 DT). Three withdrew with one ineligible. The mean percentage of serum TSH within reference range was 60·2% in BR and 63·8% in DT patients; adjusted difference 4·3%, 95% CI (-7·8 to 16·4);p=0.48. Proportions for FT4 were 79·2% in BR and 85·7% in DT patients; adjusted difference 6·8%, (-0·2 to 15·6);p=0·13. Three patients developed neutropenia – all on BR. 6 BR and 10 DT patients were in remission at 4y. </p> <p><strong>Conclusion</strong></p> <p>This trial has shown no evidence to suggest that BR improves biochemical stability. DT, recommended by American Thyroid Association guidelines, remains the preferred approach in this age group. </p>
Data from: Effect of mild thyrotoxicosis on performance and brain activations in a working memory task
Aims: Disturbed levels of thyroid hormones are associated with neuropsychiatric disorders, including memory impairments. The aim of this study was to evaluate effects of mild induced thyrotoxicosis on working memory and its neural correlates. Methods: Twenty-nine healthy, male subjects with normal thyroid state participated in the study. Functional MRI was acquired during a working memory task (n-back task) before and after ingesting 250 μg L-thyroxin per day for a period of eight weeks. In addition, neuropsychological tests were performed. Results: In the hyperthyroid condition the subjects showed slower reaction times, but a higher accuracy in the 0-back version of the memory tasks. Fewer differences between euthyroid and hyperthyroid state were seen for the more difficult conditions of the n-back task. FMRI revealed effects of difficulty in the parahippocampal gyrus, supplementary motor area, prefrontal cortex, anterior cingulate cortex, posterior cerebellum, rolandic operculum and insula (p<0.05, FWE corrected). When comparing euthyroid and hyperthyroid condition in relation to task-induced activation, differences of activation were found in the right prefrontal cortex as well as in the right parahippocampal area. In the psychological assessment, the alerting effect in the Attention Network Task (ANT) and four out of five parameters of the auditory verbal learning test (AVLT) showed an increase from euthyroid to hyperthyroid state. Conclusions: It can be concluded that even a short-term intake of thyroid hormones leads to an activation of brain areas associated with working memory and to an improvement of accuracy of working memory tasks.
Radiofrequency Ablation for Amiodarone-induced Thyrotoxicosis
ClinicalTrials.gov study NCT03720210. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Effect of mild thyrotoxicosis on performance and brain activations in a working memory task
Open the record for dataset details and reuse information.
Transcriptional regulation of hepatic target genes during thyrotoxicosis and recovery
GEO Series GSE68867. Mus musculus. 15 samples. Type: Expression profiling by array.
Trial to Evaluate the Efficacy of a Zinc, Selenium, and L-Tyrosine Supplement in the Prevention of Thyrotoxicosis in Subjects With r25191G/A SEPP1 Polymorphism
ClinicalTrials.gov study NCT06264544. IPD Sharing: NO. Countries: 1. Publications: 0.
Antithyroid Drug Treatment of Thyrotoxicosis in Young People
ClinicalTrials.gov study NCT01436994. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Thyroidectomy for Graves' Disease or Amiodarone-induced Thyrotoxicosis
ClinicalTrials.gov study NCT06963203. IPD Sharing: UNDECIDED. Countries: 5. Publications: 0.
Therapeutic Plasma Exchange in Thyrotoxicosis
ClinicalTrials.gov study NCT04485975. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Dataset related to article "Thyrotoxicosis in patients with COVID-19: the THYRCOV study"
<p>This record contains data related to article "Thyrotoxicosis in patients with COVID-19: the THYRCOV study"</p> <p>Abstract</p> <p><strong>Objective: </strong>This study assessed thyroid function in patients affected by the coronavirus disease-19 (COVID-19), based on the hypothesis that the cytokine storm associated with COVID-19 may influence thyroid function and/or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may directly act on thyroid cells, such as previously demonstrated for SARS-CoV-1 infection.</p> <p><strong>Design and methods: </strong>This single-center study was retrospective and consisted in evaluating thyroid function tests and serum interleukin-6 (IL-6) values in 287 consecutive patients (193 males, median age: 66 years, range: 27-92) hospitalized for COVID-19 in non-intensive care units.</p> <p><strong>Results: </strong>Fifty-eight patients (20.2%) were found with thyrotoxicosis (overt in 31 cases), 15 (5.2%) with hypothyroidism (overt in only 2 cases), and 214 (74.6%) with normal thyroid function. Serum thyrotropin (TSH) values were inversely correlated with age of patients (rho -0.27; P < 0.001) and IL-6 (rho -0.41; P < 0.001). In the multivariate analysis, thyrotoxicosis resulted to be significantly associated with higher IL-6 (odds ratio: 3.25, 95% confidence interval: 1.97-5.36; P < 0.001), whereas the association with age of patients was lost (P = 0.09).</p> <p><strong>Conclusions: </strong>This study provides first evidence that COVID-19 may be associated with high risk of thyrotoxicosis in relationship with systemic immune activation induced by the SARS-CoV-2 infection.</p>
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