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5 results for “tissue engineered vascular graft”

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zenodo48/100

Histological Dataset for Microvascular Segmentation of Tissue-Engineered Vascular Grafts

Objectives: The pursuit of understanding vascular tissue regeneration within tissue-engineered vascular grafts (TEVGs) is of paramount importance due to the critical role these grafts play in replacing damaged or diseased blood vessels. TEVGs offer a promising alternative to traditional grafts, with the potential to integrate into the host's tissue and support the natural regenerative processes. However, challenges such as thrombosis, inflammation, and the need for grafts that can adapt to the dynamic biological environment remain. By studying the regenerative processes in TEVGs, researchers can gain insights into the mechanisms that underpin successful graft integration and function, which is essential for improving patient outcomes in vascular surgeries. This dataset, with its detailed annotations of histological features, provides a valuable resource for developing and refining machine-learning models that can analyze and predict patterns of vascular tissue regeneration. The ability to accurately segment and quantify microvessels and immune cells in regenerated arteries is a significant step forward in distinguishing between physiological and pathological regeneration, ultimately contributing to the design of more effective and reliable TEVGs for clinical use. Ethical Approval: Experimental strategy of the study is described in detail in <a href="https://www.mdpi.com/2073-4360/14/23/5149" target="_blank" rel="noopener">[1]</a> and <a href="https://www.mdpi.com/1422-0067/24/10/8540" target="_blank" rel="noopener">[2]</a>. The study was conducted according to the guidelines of the Declaration of Helsinki, and was approved by the Local Ethical Committee of the Research Institute for Complex Issues of Cardiovascular Diseases (Kemerovo, Russia, protocol code 2020/06, date of approval: 19 February 2020). Animal experiments were performed in accordance with the European Convention for the Protection of Vertebrate Animals (Strasbourg, 1986) and Directive 2010/63/EU of the European Parliament on the protection of animals used for scientific purposes. For the implantation, we used female Edilbay sheep of 42–45 kg body weight which were received from the Animal Core Facility of the Research Institute for Complex Issues of Cardiovascular Diseases (Kemerovo, Russia) and selected for the surgery by Doppler ultrasonography to identify those having carotid artery diameter of 4.0 ± 0.2 mm. Description: The dataset comprises a collection of Whole Slide Images (WSIs) obtained from biodegradable TEVGs implanted into the carotid arteries of 20 sheep. A total of 104 WSIs were acquired, each measuring an average size of 135,000 x 123,000 pixels. These WSIs were stained using Hematoxylin and Eosin (H&E), a common practice for highlighting the structure of tissue sections, which facilitates the detailed examination of histological features. These WSIs were automatically sliced into 99,831 patches of 3,000 x 3,000 pixels and subsequently filtered, resulting in 1,401 selected patches for manual annotation. Annotation Method: Two pathologists independently selected and meticulously annotated the 1401 patches, identifying nine distinct histological features associated with vascular tissue regeneration. These features include arteriole lumen (AL), arteriole media (AM), arteriole adventitia (AA), venule lumen (VL), venule wall (VW), capillary lumen (CL), capillary wall (CW), immune cells (IC), and nerve trunks (NT). The annotations were performed using binary masks, delineating each feature within the patches. Subsequently, a senior pathologist conducted a triple verification process, reviewing and refining the annotations to ensure accuracy and consistency. The annotations are provided in the form of binary masks, meticulously defined for each feature within the patches. Dataset Split: Given the limited number of subjects studied, comprising 20 sheep, we employed a 5-fold cross-validation technique to split our dataset. This method was chosen because it allows for the efficient use of limited data, ensuring that each observation has the opportunity to be used in both the training and testing sets, thus reducing bias and providing a more accurate estimate of the model's performance. In this approach, each fold involved 16 sheep for training and the remaining 4 for testing (see Table 1 and Figure 3). This partitioning scheme was consistently applied to maintain the integrity of subject groups within each subset and to prevent data leakage. The 5-fold cross-validation is particularly beneficial for our study's objectives as it maximizes the training data available for developing robust machine learning models while also ensuring that the models are tested on unseen data, thereby enhancing the generalizability of our findings. Access to the Study: Further information about this study, including curated source code, dataset details, and trained models, can be accessed through the following repositories: <ul> <li>Source code: <a href="https://github.com/ViacheslavDanilov/histology_segmentation" target="_blank" rel="noopener">https://github.com/ViacheslavDanilov/histology_segmentation</a></li> <li>Dataset: <a href="https://doi.org/10.5281/zenodo.10838384" target="_blank" rel="noopener">https://doi.org/10.5281/zenodo.10838384</a></li> <li>Models: <a href="https://doi.org/10.5281/zenodo.10838431" target="_blank" rel="noopener">https://doi.org/10.5281/zenodo.10838431</a></li> </ul> <div> </div> <div>Table 1. Patch and feature distributions across folds and subsets <table> <tbody> <tr> <td> Fold </td> <td> Subset </td> <td> Patches </td> <td> AL </td> <td> AM </td> <td> AA </td> <td> VL </td> <td> VW </td> <td> CL </td> <td> CW </td> <td> IC </td> <td> NT </td> <td> Total </td> </tr> <tr> <td> 1 </td> <td> Train </td> <td> 1168 </td> <td> 510 </td> <td> 512 </td> <td> 220 </td> <td> 675 </td> <td> 648 </td> <td> 770 </td> <td> 765 </td> <td> 409 </td> <td> 448 </td> <td> 4957 </td> </tr> <tr> <td>1</td> <td> Test </td> <td> 233 </td> <td> 81 </td> <td> 84 </td> <td> 36 </td> <td> 186 </td> <td> 169 </td> <td> 178 </td> <td> 182 </td> <td> 91 </td> <td> 25 </td> <td> 1032 </td> </tr> <tr> <td> 2 </td> <td> Train </td> <td> 1053 </td> <td> 406 </td> <td> 411 </td> <td> 179 </td> <td> 678 </td> <td> 638 </td> <td> 743 </td> <td> 746 </td> <td> 423 </td> <td> 315 </td> <td> 4539 </td> </tr> <tr> <td>2</td> <td> Test </td> <td> 348 </td> <td> 185 </td> <td> 185 </td> <td> 77 </td> <td> 183 </td> <td> 179 </td> <td> 205 </td> <td> 201 </td> <td> 77 </td> <td> 158 </td> <td> 1450 </td> </tr> <tr> <td> 3 </td> <td> Train </td> <td> 1127 </td> <td> 507 </td> <td> 511 </td> <td> 222 </td> <td> 743 </td> <td> 702 </td> <td> 759 </td> <td> 760 </td> <td> 299 </td> <td> 423 </td> <td> 4926 </td> </tr> <tr> <td>3</td> <td> Test </td> <td> 274 </td> <td> 84 </td> <td> 85 </td> <td> 34 </td> <td> 118 </td> <td> 115 </td> <td> 189 </td> <td> 187 </td> <td> 201 </td> <td> 50 </td> <td> 1063 </td> </tr> <tr> <td> 4 </td> <td> Train </td> <td> 1064 </td> <td> 466 </td> <td> 472 </td> <td> 199 </td> <td> 611 </td> <td> 566 </td> <td> 759 </td> <td> 758 </td> <td> 423 </td> <td> 291 </td> <td> 4545 </td> </tr> <tr> <td>4</td> <td> Test </td> <td> 337 </td> <td> 125 </td> <td> 124 </td> <td> 57 </td> <td> 250 </td> <td> 251 </td> <td> 189 </td> <td> 189 </td> <td> 77 </td> <td> 182 </td> <td> 1444 </td> </tr> <tr> <td> 5 </td> <td> Train </td> <td> 1192 </td> <td> 475 </td> <td> 478 </td> <td> 204 </td> <td> 737 </td> <td> 714 </td> <td> 761 </td> <td> 759 </td> <td> 446 </td> <td> 415 </td> <td> 4989 </td> </tr> <tr> <td>5</td> <td> Test </td> <td> 209 </td> <td> 116 </td> <td> 118 </td> <td> 52 </td> <td> 124 </td> <td> 103 </td> <td> 187 </td> <td> 188 </td> <td> 54 </td> <td> 58 </td> <td> 1000 </td> </tr> </tbody> </table> </div>

opencc-by-4.0Mar 2024View details →

zenodo40/100

Research data supporting "Pericyte seeded dual peptide scaffold with improved endothelialization for vascular graft tissue engineering"

Raw research data supporting the paper: Campagnolo, P. et al., Pericyte seeded dual peptide scaffold with improved endothelialization for vascular graft tissue engineering, 2016, Advanced Healthcare Materials, 5(23), 3046-3055.

opencc-by-4.0Nov 2016View details →

zenodo36/100

Vascular Damage and Repair - Are Small-diameter Vascular Grafts Still the "Holy Grail" of Tissue Engineering?

Open the record for dataset details and reuse information.

opencc-by-4.0May 2024View details →

ClinicalTrials.gov32/100

Two-Year Study of the Safety and Efficacy of the Second-Generation Tissue Engineered Vascular Grafts

ClinicalTrials.gov study NCT04467671. IPD Sharing: YES. Countries: 1. Publications: 6.

controlledIPD-YESFeb 2026View details →

ClinicalTrials.gov24/100

A Pilot Study Investigating the Clinical Use of Tissue Engineered Vascular Grafts in Congenital Heart Surgery

ClinicalTrials.gov study NCT01034007. IPD Sharing: Not stated. Countries: 1. Publications: 0.

restrictedIPD-UNDECIDEDFeb 2026View details →

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International Brain Laboratory public data

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