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104 results for “tissue growth”
Raw data: Patterned apoptosis has an instructive role for local growth and tissue shape regulation in a fast-growing epithelium
<p>What regulates organ size and shape remains one fundamental mystery of modern biology. Research in this area has primarily focused on deciphering the regulation in time and space of growth and cell division, while the contribution of cell death has been overall neglected. This includes studies of the <i>Drosophila</i> wing, one of the best characterised systems for the study of growth and patterning, undergoing massive growth during larval stage and important morphogenetic remodeling during pupal stage. So far, it has been assumed that cell death was relatively neglectable in this tissue both during larval and pupal stage and as a result the pattern of growth was usually attributed to the distribution of cell division. Here, using systematic mapping and registration combined with quantitative assessment of clone size and disappearance as well as live imaging, we outline a persistent pattern of cell death and clone elimination emerging in the larval wing disc and persisting during pupal wing morphogenesis. Local variation of cell death is associated with local variation of clone size, pointing to an impact of cell death on local growth which is not fully compensated by proliferation. Using morphometric analyses of adult wing shape and genetic perturbations, we provide evidence that patterned death affects locally and globally adult wing shape and size. This study describes a roadmap for precise assessment of the contribution of cell death to tissue shape, and outlines an important instructive role of cell death in modulating quantitatively local growth and morphogenesis of a fast-growing tissue.</p><p>This repository contains the raw data (local projection images, ROI and quantificatiosn) of the Current Biology article "<strong>Patterned apoptosis has an instructive role for local growth and tissue shape regulation in a fast-growing epithelium".</strong></p>
Figure 1. Plant tissue-culture growth chamber Percival. A in Survivorship of soybean aphid biotypes (Hemiptera: Aphididae) on winter hosts, common and glossy buckthorn
Figure 1. Plant tissue-culture growth chamber Percival. A) Soybean plants maintained in a plant growth chamber for 21 days before placed Rhamnus cathartica. B) Leaf of R. cathartica infested with soybean aphid biotype 1. C) Leaf of Frangula alnus with soybean aphid biotype 4.
Raw data for Maier et al. "Seasonal controls on the diet, metabolic activity, tissue reserves and growth of the cold-water coral Lophelia pertusa"
<p>All raw data presented in the article:</p> <p>Maier SR, Bannister RJ, van Oevelen D and Kutti T: Seasonal controls on the diet, metabolic activity, tissue reserves and growth of the cold-water coral <em>Lophelia pertusa</em>. Coral Reefs, <em>in press.</em></p>
No Escape: The Influence of Substrate Sodium on Plant Growth and Tissue Sodium Responses
<p>This dataset contains data from a systematic review carried out to understand substrate sodium's influence on plant growth and sodium accumulation strategies. Accordingly, we carried out a systematic review of plants' responses to variation in substrate sodium concentrations. We compared biomass and tissue-sodium accumulation among 107 cultivars or populations (67 species in 20 plant families), broadly expanding beyond the agricultural and model taxa for which several generalizations previously had been made. We hypothesized a priori response models for each population's growth and sodium accumulation as a function of increasing substrate NaCl and used Bayesian Information Criterion to choose the best model. Additionally, using a phylogenetic signal analysis, we tested for phylogenetic patterning of responses across taxa. The influence of substrate sodium on growth differed across taxa, with most populations experiencing detrimental effects at high concentrations. Irrespective of growth responses, tissue sodium concentrations for most taxa increased as sodium concentration in the substrate increased. We found no strong associations between type of growth response and type of sodium accumulation response across taxa. Although experiments often fail to test plants across a sufficiently broad range of substrate salinities, non-crop species tended toward higher sodium tolerance than domesticated species. Moreover, some phylogenetic conservatism was apparent, in that evolutionary history helped predict the distribution of total-plant growth responses across the phylogeny, but not sodium accumulation responses. Our study reveals that saltier plants in saltier soils prove to be a broadly general pattern for sodium across plant taxa. Regardless of growth responses, sodium accumulation mostly followed an increasing trend as substrate sodium levels increased.</p>
Data from: Assessing the effect of tissue and fire-response traits on plant growth rates post-disturbance in Eastern Australia
<p>Here is the necessary code and data to reproduce results published in 'Assessing the effect of tissue and fire-response traits on plant growth rates post-disturbance in Eastern Australia'.</p>
Supplemental data to "Acute and persistent effects of oral glutamine supplementation on growth, cellular proliferation, and tight junction protein transcript abundance in jejunal tissue of low and normal birthweight pre-weaning piglets"
<p>Supplementary data to "Acute and persistent effects of oral glutamine supplementation on growth, cellular proliferation, and tight junction protein transcript abundance in jejunal tissue of low and normal birthweight pre-weaning piglets"</p>
A higher tissue fraction of parenchyma in secondary xylem supports growth recovery of angiosperm trees after drought
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Metabolomics data from: Dietary caloric input and tumor growth accelerate senescence and modulate liver and adipose tissue crosstalk
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No Escape: The Influence of Substrate Sodium on Plant Growth and Tissue Sodium Responses
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Investment in adult reproductive tissues is affected by larval growth conditions but not by evolution under poor larval growth conditions in Drosophila melanogaster
<p><span>In many insects, the larval environment is confined to the egg-laying site, which often leads to crowded larval conditions,</span><span> exposing the developing larvae to poor resource availability and toxic metabolic wastes. Larval crowding imposes two opposing selection pressures. On one hand, due to poor nutritional resources during developmental stages, adults from the crowded larval environment have reduced investment in reproductive tissues. On the other hand, a crowded larval environment acts as a cue for future reproductive competition inducing increased investment in reproductive tissues. Both these selection pressures are likely affected by the level of crowding. The evolutionary consequence of adaptation to larval crowding environment on adult reproductive investment is bound to be a result of the interaction of these two opposing forces. In this study, we used experimentally evolved populations of <i>Drosophila melanogaster </i>adapted to larval crowding to investigate the effect of adaptation to larval crowding on investment in reproductive organs (testes and accessory glands) of males. Our results show that there is a strong effect of larval developmental environment on absolute sizes of testes and accessory glands. However, there was no effect of the developmental environment when testis size was scaled by body size. We also found that flies from crowded cultures had smaller accessory gland sizes relative to body size. Moreover, the sizes of the reproductive organs were not affected by the selection histories of the populations. This study highlights that adaptation to two extremely different developmental environments does not affect the patterns of reproductive investment. We discuss the possibility that differential investment in reproductive tissues could be influenced by the mating dynamics and/or investment in larval survival traits, rather than just the developmental environment of the populations</span><span>.</span></p>
Data from: A multi-tissue view on telomere dynamics and postnatal growth
<p>Trade-offs between growth and self-maintenance are common in nature, such that early-life effects on growth can generate lasting consequences on survival and longevity. Telomeres – putative biomarkers of self-maintenance – may link early growth with these later phenotypic effects, but evidence for growth-telomere trade-offs is mixed. Null or even positive relationships between growth and telomeres may be driven by heterogeneity in resource availability or invariable allocation towards telomere maintenance within a population. We used nestling tree swallows (<i>Tachycineta bicolor</i>) to assess the directionality and timing of relationships between growth and telomere length in several tissues. We focused on two important phases of growth: first, the peak of postnatal growth occurring around 6-days old when nestlings grow by ~33% in a single day, and subsequently, the later phase of growth occurring as body mass plateaus near adult size at 12-days old. We quantified telomere attrition in blood during postnatal growth, as well as telomere length in the blood, brain, adrenals, and liver at 12-days old. Growth was unrelated to telomere length in the liver and telomere dynamics in blood. However, brain telomere length was positively correlated with peak growth, and adrenal telomere length was positively related to later growth, particularly for chicks that had experienced a temporary stressor. These observations suggest that variation in resource availability may mask trade-offs, generating positive correlations between growth and telomere length at the population level. They also provide insights into complex relationships between growth and self-maintenance that can be revealed by looking in multiple tissues.</p>
Supplementary Information - Circulating insulin-like growth factor system adaptations in hibernating brown bears indicate increased tissue IGF availability
<p>Supplementary figures and tables for the manuscript entitled “Circulating insulin-like growth factor system adaptations in hibernating brown bears indicate increased tissue IGF availability”.</p>
Growth Hormone as a Model for Reversible Activation of Adipose Tissue Fibrosis
ClinicalTrials.gov study NCT04998500. IPD Sharing: Not stated. Countries: 1. Publications: 18.
Study to Evaluate Concordance of Detecting EGFR (Epidermal Growth Factor Receptor) Mutation by Circulating Tumour Free DNA Versus Tissues Biopsy in NSCLC (Non-small Cell Lung Cancer).
ClinicalTrials.gov study NCT03562819. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Assessment of Growth Factors Levels Associated with Wound Healing After Soft Tissue Crown Lengthening
ClinicalTrials.gov study NCT06806319. IPD Sharing: NO. Countries: 1. Publications: 2.
Treatment of Gingival Recessions with Connective Tissue or Concentrated Growth Factor Membrane Using Tunnel Technique
ClinicalTrials.gov study NCT04561947. IPD Sharing: NO. Countries: 1. Publications: 1.
Metabolic Signalling in Muscle- and Adipose-tissue Following Insulin Withdrawal and Growth Hormone Injection.
ClinicalTrials.gov study NCT02077348. IPD Sharing: Not stated. Countries: 1. Publications: 15.
The Role of Connective Tissue Growth Factor in the Development of Kidney Disease After Organ Transplantation
ClinicalTrials.gov study NCT00056784. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Growth Hormone During Fasting.Signaltransduktion in Muscle and Adipose Tissue and Changes in Intrahepatic Lipid Content
ClinicalTrials.gov study NCT00476879. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Growth Hormone Supplementation to Adults With Growth Hormone Deficient on Metabolism and Adipose Tissue Molecular Phenotype
ClinicalTrials.gov study NCT01616095. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.