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72 results for “toxicity assessment”
Predicted and experimental chemical and ecotoxicological properties for the toxic unit based hazard assessment
<p><strong>Description</strong></p> <p>This dataset contains ecotoxicity data of 1585 chemicals of environmental concern (CECs) and chemical identifiers. The ecotoxicity data was retrieved from <a href="https://cfpub.epa.gov/ecotox">US EPA ECOTOX Knowlegdebase</a> in ASCII file format and was aggregated for the ecotoxicity groups algae, crustaceans, and fish based on the ideas of <a href="https://dx.doi.org/10.1002/etc.3460">Busch et al. 2016</a>. The dataset includes the 5-percentile, the mean and the geomean of all retrieved ecotoxicity for each compound. Missing ecotoxicity data was estimated with ECOSAR 1.0 algorithms for green algae, daphnids, and fish using <a href="https://www.ufz.de/index.php?en=34593">ChemProp 6.8</a>. The main purpose of this dataset is the <a href="http://doi.org/10.1016/0043-1354(70)90018-7">toxic unit</a> (TU) based hazard assessment of environmental water samples. Chemical properties were estimated using <a href="https://github.com/kmansouri/OPERA">OPERA 2.7</a>, <a href="https://chemaxon.com/products/instant-jchem">Instant JChem</a>, and ACD Percepta 2015 based on QSAR-ready SMILES derived from OPERA 2.7. All data aggregated from EcoTox Knowledgebase (e.g., raw values, species, etc.) is available in the dataset in the detailed sheets. REcoTox, the processing script written in R is available on <a href="https://github.com/tsufz/REcoTox/releases/latest">GitHub</a>.</p> <p><strong>CAUTION</strong></p> <p>It needs to be emphasized that quantitative-structure activity relationship data is just an estimate, which does not necessarily reflect the real property and behaviour of a modelled compound. The calculated data needs to be reviewed in deep. Especially for non-polar or very polar compounds, the QSAR predictions might fail. If a compound ranks high in the TU ranking, it is required to search for literature or regulative data evidences to underpin the finding to avoid false positive prioritizations.</p> <p><strong>RELEASE NOTE</strong></p> <p>Version 210714_v1 was created with <a href="https://github.com/tsufz/REcoTox/releases/tag/v0.1.0">REcoTox version v0.1.0</a>.</p>
Рис. 2. Ментум Λичинок роΑа Chironomus из озера Кенон Fig. 2. Mentum of the Chironomus genus larvae from Lake Kenon in Toxic pollution assessment of Chita TPP-1 cooling reservoir by applying the method of head capsule morphological deformations in chironomid larvae
Рис. 2. Ментум Λичинок роΑа Chironomus из озера Кенон Fig. 2. Mentum of the Chironomus genus larvae from Lake Kenon
Рис. 1. Схема мониторинговых станций на озере Кенон: 1–1.6 — ТЭЦ; 2–2.1 — КСК; 3 — Нефтебаза; 4 — Центр озера; 5 — КаΑаΛинка Fig. 1. Diagram of monitoring stations on Kenon lake: 1–1.6 — TPP; 2–2.1 — KSK; 3 — Tank farm; 4 — Lake Center; 5 — Kadalinka in Toxic pollution assessment of Chita TPP-1 cooling reservoir by applying the method of head capsule morphological deformations in chironomid larvae
Рис. 1. Схема мониторинговых станций на озере Кенон: 1–1.6 — ТЭЦ; 2–2.1 — КСК; 3 — Нефтебаза; 4 — Центр озера; 5 — КаΑаΛинка Fig. 1. Diagram of monitoring stations on Kenon lake: 1–1.6 — TPP; 2–2.1 — KSK; 3 — Tank farm; 4 — Lake Center; 5 — Kadalinka
Figure 1 in Bio-efficacy of iron and zinc fortified wheat flour along with bio-assessment of its hepatic and renal toxic potential
Figure 1. Microscopic morphology of representative liver tissues under the effect of varied iron and zinc supplementation in fortified wheat flour (100X; magnification). (A) Normal, no tissue changes = 0, (B) cellular swelling in hepatocytes = 1, (C) microvascular changes in hepatocytes = 2, (D) marked cellular swelling and necrosis of hepatocytes = 3.
An Assessment of the Ocular Toxicity of Two Major Sources of Environmental Exposure
<p>These data contain information on chemicals released in to the air from burn pits in Iraq (waste disposal areas for US military bases) and the 2023 Ohio train derailment in East Palestine. The goals of the study were to 1) predict the effects of exposure to these chemicals on the ocular surface and 2) to call attention to the relationship between environmental events and long-term damage to the surface of the eye—in particular, dry eye disease, which is a known result of workplace chemical exposures. The study employed in silico methods through the ACD Labs Percepta platform, using data from the European Chemical Inventory and the Registry of Toxic Effects of Chemical Substances to model the chemicals’ probability of ocular irritation. Variables include the names of compounds identified from the burn pits and the train derailment, along with their chemical formulas, simplified molecular input line entry system (abbreviated to SMILES), and probability of causing eye irritation.</p>
FIGURE 1 in Assessment of potentially toxic metals in water, sediment, and the tissues of seven important fish species from neotropical brazilian river
FIGURE 1 | Location of the study area in the Sorocaba River drainage, São Paulo State, Brazil, indicating the Sorocaba river, the fish collection points, in addition to the urban area and areas of contamination.
Figure 3 in Assessment of carbamazepine acute toxicity in the cockle Cerastoderma edule through chemical, physiological and biochemical tools
Figure 3. Effect of carbamazepine on proxydants and cellular damage, H 2 O 2 level 48 h (A), 96 h (B), nitrite level NO 48 h (C), 96 h (D) and malondialdehyde level MDA 48 h (E), 96 h (F). Values are the mean (± SD) of 5 replicates. Significant differences (p ≤ 0.05) among exposure concentrations, for each condition, are presented with different letters (a-b).
Figure 2 in Assessment of carbamazepine acute toxicity in the cockle Cerastoderma edule through chemical, physiological and biochemical tools
Figure 2. Effect of carbamazepine on enzymatic biomarkers, and AChE activity 48 h (A), 96 h (B), Antioxidant enzyme activities, SOD activity 48 h (C), 96h (D), CAT activity 48 h (E), 96 h (F) and GST activity 48 h (G), 96 h (H). Values are the mean (± SD) of 5 replicates. Significant differences (p≤0.05) among exposure concentrations, for each condition, are presented with different letters (a-b).
Figure 1 in Assessment of carbamazepine acute toxicity in the cockle Cerastoderma edule through chemical, physiological and biochemical tools
Figure 1. Clearance rate in Cerastoderma edule exposed to three concentrations of CBZ (5, 10, 20 Μg.L-1) during 2 h. Values are the mean of 3 replicates. Letters (a-b) indicate significant differences (p ≤0.05) between control and exposure conditions.
In-Vivo Assessment of Silver Biomaterial Nano-Toxicity 32 Ppm
ClinicalTrials.gov study NCT01405794. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Assessing Toxicity of Waterpipe Tobacco Smoking
ClinicalTrials.gov study NCT03253653. IPD Sharing: NO. Countries: 1. Publications: 1.
Geriatric Assessment Intervention for Reducing Toxicity in Older Patients With Advanced Cancer
ClinicalTrials.gov study NCT02054741. IPD Sharing: Not stated. Countries: 1. Publications: 11.
In Vivo Assessment of Silver Biomaterial Nano-Toxicity
ClinicalTrials.gov study NCT01243320. IPD Sharing: Not stated. Countries: 1. Publications: 1.
An advancement in developmental and reproductive toxicity (DART) risk assessment: evaluation of a bioactivity and exposure-based NAM toolbox
Open the record for dataset details and reuse information.
A test method for assessing chronic oral toxicity of a pesticide to solitary nesting orchard bees, Osmia spp. (Hymenoptera: Megachilidae)
Open the record for dataset details and reuse information.
Identifying in vitro toxicity testing approaches for (novel) proteins in the context of food and feed risk assessment
<p>Annexes to EFSA external scientific report Identifying <em>in vitro</em> toxicity testing approaches for (novel) proteins in the context of food and feed risk assessment</p>
Cardiovascular Morbidity in Testicular Cancer Survivors: Study of Risk Factors and Assessment of Pharmacogenomic Determinants of Toxicity
ClinicalTrials.gov study NCT00161174. IPD Sharing: Not stated. Countries: 1. Publications: 52.
Development and Validation of a Tool for Patient-reported Assessment of Cancer-related Financial Toxicity in Italy
ClinicalTrials.gov study NCT03473379. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Prospective Study of Stereotactic Body Radiation Therapy for Thymoma Inoma: Therapeutic Effect and Toxicity Assessment
ClinicalTrials.gov study NCT03078699. IPD Sharing: NO. Countries: 1. Publications: 2.
Cardiovascular Toxicity Induced by Antitumoral Drugs: Risk Assessment and Early Diagnosis. CARDIOTOX Registry
ClinicalTrials.gov study NCT02039622. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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International Brain Laboratory public data
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OpenNeuro
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