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94 results for “trabectedin”
Dataset related to article "Mechanisms of responsiveness to and resistance against trabectedin in murine models of human myxoid liposarcoma"
<p>This record contains data related to article "Mechanisms of responsiveness to and resistance against trabectedin in murine models of human myxoid liposarcoma".</p> <p>Myxoid liposarcoma (MLPS) is a rare soft-tissue sarcoma characterised by the expression of FUS-DDIT3 chimera. Trabectedin has shown significant clinical anti-tumour activity against MLPS. To characterise the molecular mechanism of trabectedin sensitivity and of resistance against it, we integrated genomic and transcriptomic data from treated mice bearing ML017 or ML017/ET, two patient-derived MLPS xenograft models, sensitive to and resistant against trabectedin, respectively. Longitudinal RNA-Seq analysis of ML017 showed that trabectedin acts mainly as a transcriptional regulator: 15 days after the third dose trabectedin modulates the transcription of 4883 genes involved in processes that sustain adipocyte differentiation. No such differences were observed in ML017/ET. Genomic analysis showed that prolonged treatment causes losses in 4p15.2, 4p16.3 and 17q21.3 cytobands leading to acquired-resistance against the drug. The results dissect the complex mechanism of action of trabectedin and provide the basis for novel combinatorial approaches for the treatment of MLPS that could overcome drug-resistance.</p>
Effects of trabectedin in the zebrafish Danio rerio: from cells to larvae
<p>These archives contain the original data set for the research article "Effects of trabectedin in the zebrafish Danio rerio: from cells to larvae"<br> </p> <p><strong>FACS_ZFL_cells_Trabectedin.rar</strong> </p> <p>Contains the original data regarding cells morphology evaluated by flow cytometry (Becton Dickinson FACScan).</p> <p><strong>Original data set_</strong></p> <p>This archive contains the original data tables for the research article "Effects of trabectedin in the zebrafish Danio rerio: from cells to larvae"</p> <p><strong>Original data set_Spreadsheet Trypan Blue test_in vitro</strong></p> <p>Cells viability on ZFL exposed to trabectedin measured by Trypan blue dye exclusion method</p> <p><strong>Original data set_Spreadsheet MTT test_in vitro</strong></p> <p>Cytotoxicity of trabectedin and doxorubicin (positive control) against ZFL cells as analyzed by the MTT assay</p> <p><strong>Original data set_Spreadsheet Survival_in vivo</strong></p> <p>Percentage of zebrafish embryos under trabectedin exposure</p> <p><strong>Original data set_Spreadsheet Abnormalities_in vivo</strong></p> <p>Percentage of abnormalities (somite alteration, pericardial edema, tail malformations, lack of equilibrium) of zebrafish embryos under trabectedin exposure</p> <p><strong>Original data set_Spreadsheet Swimming behavior_in vivo</strong></p> <p>Total distance covered and mean velocity by zebrafish larvae (120 hpf) after exposure to trabectedin</p> <p> </p> <p> </p>
Original dataset of the study entitled Molecular biomarkers of zebrafish exposed to trabectedin
<p><strong>Original data set_Spreadsheet ZFL cells - enzymes activity</strong></p> <p>Activity of the acetylcholinesterase, Glutathione-<em>S</em>-transferase, Catalase, Glutathione reductase, and Lactate dehydrogenase in zebrafish embryos measured by spectrophotometry.</p> <p><strong>Original data set_Spreadsheet </strong><strong>ZF larvae - enzymes activity</strong></p> <p>Activity of the acetylcholinesterase, Glutathione-<em>S</em>-transferase, Catalase, Glutathione reductase, and Lactate dehydrogenase in zebrafish liver (ZFL) cells measured by spectrophotometry.</p> <p><strong>Original data set_Spreadsheet ZF larvae - genotoxicity</strong></p> <p>DNA in tail percentage in zebrafish embryos measured by comet assay.</p> <p><strong>Original data set_Spreadsheet </strong><strong>ZFL cells - Cell cycle</strong></p> <p>Number of cells en each cell cycle phase measured by flow cytometry.</p> <p><strong>Original data set_Spreadsheet </strong><strong>ZFL cells - qPCR</strong></p> <p>Expression of genes associated to cell proliferation and survival in ZFL cells.</p>
Original dataset of the study entitled Effects of trabectedin on the hepatic metabolism of adult zebrafish Danio rerio
<p>Original chromatograms (.qgd files) and normalized peak areas of the annotaded metabolites (.csv file)</p>
Original dataset of the study entitled Effects of trabectedin on the gut bacterial communities structure of the zebrafish Danio rerio
<p><strong>Original data set_Spreadsheet Genus</strong></p> <p>Relative abundance of the bacterial genus found on the gut of adult male zebrafish under trabectedin exposure</p> <p><strong>Original data set_Spreadsheet Family</strong></p> <p>Relative abundance of the bacterial family found on the gut of adult male zebrafish under trabectedin exposure</p> <p><strong>Original data set_Spreadsheet Order</strong></p> <p>Relative abundance of the bacterial order found on the gut of adult male zebrafish under trabectedin exposure</p> <p><strong>Original data set_Spreadsheet Class</strong></p> <p>Relative abundance of the bacterial class found on the gut of adult male zebrafish under trabectedin exposure</p> <p><strong>Original data set_Spreadsheet Phylum</strong></p> <p>Relative abundance of the bacterial phylum found on the gut of adult male zebrafish under trabectedin exposure</p>
An Efficacy and Safety Study for Yondelis (Trabectedin) in Patients With Advanced Relapsed Ovarian Cancer
ClinicalTrials.gov study NCT00113607. IPD Sharing: Not stated. Countries: 20. Publications: 4.
A Study of Trabectedin or Dacarbazine for the Treatment of Patients With Advanced Liposarcoma or Leiomyosarcoma
ClinicalTrials.gov study NCT01343277. IPD Sharing: Not stated. Countries: 4. Publications: 5.
A Study Comparing the Combination of Trabectedin (YONDELIS) and DOXIL/CAELYX With DOXIL/CAELYX for the Treatment of Advanced-Relapsed Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
ClinicalTrials.gov study NCT01846611. IPD Sharing: Not stated. Countries: 10. Publications: 3.
Safety and Efficacy Study of Trabectedin for the Treatment of Localized Myxoid / Round Cell Liposarcoma
ClinicalTrials.gov study NCT00579501. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Docetaxel, Trabectedin, and G-CSF or Pegfilgrastim in Treating Patients With Recurrent or Persistent Ovarian Epithelial Cancer, Primary Peritoneal Cavity Cancer, or Fallopian Tube Cancer
ClinicalTrials.gov study NCT00569673. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Trabectedin in Treating Patients With Advanced, Persistent, or Recurrent Leiomyosarcoma of the Uterus
ClinicalTrials.gov study NCT00379145. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Trabectedin for Recurrent Grade II/III Meningioma
ClinicalTrials.gov study NCT02234050. IPD Sharing: Not stated. Countries: 10. Publications: 1.
Trabectedin in Treating Young Patients With Recurrent or Refractory Soft Tissue Sarcoma or Ewing's Family of Tumors
ClinicalTrials.gov study NCT00070109. IPD Sharing: Not stated. Countries: 2. Publications: 1.
An Efficacy and Safety Study of Trabectedin Versus Doxorubicin-Based Chemotherapy in Participants With Translocation-Related Sarcomas (TRS)
ClinicalTrials.gov study NCT00796120. IPD Sharing: Not stated. Countries: 5. Publications: 1.
A Study to Assess the Potential Effects of a Single-Dose Administration of Trabectedin on the QT Intervals of the Electrocardiogram
ClinicalTrials.gov study NCT00786838. IPD Sharing: Not stated. Countries: 7. Publications: 1.
An Efficacy Study of Trabectedin in the Treatment of Participants With Specific Subtypes of Metastatic Breast Cancer
ClinicalTrials.gov study NCT00580112. IPD Sharing: Not stated. Countries: 4. Publications: 1.
Trial on Trabectedin (ET-743) vs Clinician's Choice Chemotherapy in Recurrent Ovarian, Primary Peritoneal or Fallopian Tube Cancers of BRCA Mutated or BRCAness Phenotype Patients
ClinicalTrials.gov study NCT02903004. IPD Sharing: NO. Countries: 1. Publications: 10.
Trabectedin Plus Olaparib in Metastatic or Advanced Sarcomas (TOMAS)
ClinicalTrials.gov study NCT02398058. IPD Sharing: Not stated. Countries: 1. Publications: 2.
ATREUS - Phase II Study on the Activity of Trabectedin in Patients With Malignant Pleural Mesothelioma (MPM)
ClinicalTrials.gov study NCT02194231. IPD Sharing: YES. Countries: 1. Publications: 6.
Study Comparing Efficacy of Doxorubicin With Trabectedin Followed by Trabectedin Versus Doxorubicine in Patients With Leiomyosarcoma
ClinicalTrials.gov study NCT02997358. IPD Sharing: NO. Countries: 1. Publications: 3.
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