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28 results for “trichostatin A”
Effect of the histone deacetylase inhibitor Trichostatin A on facial development in cichlid fishes
<p>A central question in biology is the molecular origins of phenotypic diversity. While genetic changes are key to the genotype-phenotype relationship, alterations to chromatin structure and the physical packaging of histone proteins may also be important drivers of vertebrate divergence. We investigate the impact of such an epigenetic mechanism, histone acetylation, within a textbook example of an adaptive radiation. Cichlids of Lake Malawi have adapted diverse craniofacial structures, and here we investigate how histone acetylation influences morphological variation in these fishes. Specifically, we assessed the effect of inhibiting histone deacetylation using the drug trichostatin A (TSA) on developing facial structures. We examined this during three critical developmental windows in two cichlid species with alternate adult morphologies. Exposure to TSA during neural crest cell (NCC) migration and as post-migratory NCCs proliferate into the pharyngeal arches resulted in significant changes in lateral and ventral shape in <em>Maylandia</em>, but not in <em>Tropheops</em>. This included an overall shortening of the head, widening of the lower jaw, and steeper craniofacial profile, all of which are paedomorphic morphologies. In contrast, treatment with TSA during early chondrogenesis did not result in significant morphological changes in either species. Together, these data suggest a sensitivity to epigenetic alterations that are both time- and species-dependent. We find that morphologies are due to non-autonomous or potentially indirect effects on NCC development, including in part a global developmental delay. Our research bolsters the understanding that proper histone acetylation is essential for early craniofacial development and identifies a species-specific robustness to developmental change. Overall, this study demonstrates how epigenetic regulation may play an important role in both generating and buffering morphological variation.</p>
Effect of the histone deacetylase inhibitor Trichostatin A on facial development in cichlid fishes
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Tolerability Study of Trichostatin A In Subjects With Relapsed or Refractory Hematologic Malignancies
ClinicalTrials.gov study NCT03838926. IPD Sharing: NO. Countries: 2. Publications: 0.
Schistosomula exposed to HDAC inhibitor (Trichostatin A) [48hrs]
GEO Series GSE83210. Schistosoma mansoni. 6 samples. Type: Expression profiling by array.
Schistosomula exposed to HDAC inhibitor (Trichostatin A) [12hrs]
GEO Series GSE83208. Schistosoma mansoni. 6 samples. Type: Expression profiling by array.
Transcriptome analysis for the effect of Trichostatin A on intrahepatic cholangiocarcinoma cells
GEO Series GSE252094. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Trichostatin A preferentially reverses the upregulation of gene expression levels induced by gain of chromosome 7 in colorectal cancer cell lines
GEO Series GSE100705. Homo sapiens. 26 samples. Type: Expression profiling by array.
Schistosomula exposed to HDAC inhibitor (Trichostatin A) [24hrs]
GEO Series GSE83209. Schistosoma mansoni. 6 samples. Type: Expression profiling by array.
Transcriptome profiling reveals a novel role for Trichostatin A in antagonizing histone chaperone Chz1 mediated telomere anti-silencing.
GEO Series GSE30228. Saccharomyces cerevisiae. 11 samples. Type: Expression profiling by array.
Microarray analysis of human monocytic THP-1 cell treated with 1α,25-dihydroxyvitamin D3 or Trichostatin A and the combination of both
GEO Series GSE36323. Homo sapiens. 18 samples. Type: Expression profiling by array.
Trichostatin A specifically improves the aberrant expression of transcription factor genes in embryos produced by somatic cell nuclear transfer
GEO Series GSE63886. Mus musculus. 39 samples. Type: Expression profiling by array.
Safety, Tolerability and Efficacy of Trichostatin A in Patients With Mild to Severe Onychomycosis
ClinicalTrials.gov study NCT07065773. IPD Sharing: NO. Countries: 1. Publications: 0.
Schistosomula exposed to HDAC inhibitor (Trichostatin A)
GEO Series GSE83211. Schistosoma mansoni. 18 samples. Type: Expression profiling by array.
Expression analysis of trichostatin A-treated Aspergillus fumigatus Af293
GEO Series GSE19682. Aspergillus fumigatus Af293. 4 samples. Type: Expression profiling by array.
Trichostatin A (TSA) inhibition of histone deacetylase in Arabiodopsis thaliana
GEO Series GSE3783. Arabidopsis thaliana. 4 samples. Type: Expression profiling by array.
The activation of inflammatory response genes by LPS is blocked by HDAC inhibitor Trichostatin A (TSA)
GEO Series GSE6352. Mus musculus. 6 samples. Type: Expression profiling by array.
Microarray whole transcriptome profiling of Trichostatin A and Grape Seed Extract in SK-MEL-3 melanoma cells.
GEO Series GSE104265. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Gene expression in MEFs in response to treatment with dipyridyl and trichostatin A
GEO Series GSE3296. Mus musculus. 16 samples. Type: Expression profiling by array.
A Trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling
GEO Series GSE91395. synthetic construct; unidentified; Homo sapiens. 290 samples. Type: Expression profiling by high throughput sequencing.
5-aza-2'-cytidine and trichostatin A effect to gene expression of Epstein-Barr virus-transformed human lymphoblastoid cell lines (LCLs).
GEO Series GSE35359. Homo sapiens. 4 samples. Type: Expression profiling by array.
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