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37 results for “trimethylamine”
Data from: Puerarin alleviates atherosclerosis via the inhibition of Prevotella copri and its trimethylamine production
<p><strong>Objective </strong>Puerarin (PU) is a natural compound that exhibits limited oral bioavailability but has shown promise in the treatment of atherosclerosis (AS). However, the precise mechanisms underlying its therapeutic effects remain incompletely understood. This study aimed to investigate the effects of PU and its mechanisms in mitigating AS in both mice and humans.</p> <p><strong>Design </strong>The impact of PU on AS was examined in <em>ApoE</em><sup>-/-</sup> mice fed a high-fat diet (HFD) and in human patients with carotid artery plaque. To explore the causal link between PU-associated gut microbiota and AS, faecal microbiota transplantation (FMT) and mono-colonization of mice with <em>Prevotella copri</em> (<em>P. copri</em>) were employed.</p> <p><strong>Results </strong>PU alleviated AS by modulating the gut microbiota, as evidenced by alterations in gut microbiota composition and the amelioration of AS following FMT from PU-treated mice into <em>ApoE</em><sup>-/-</sup> mice fed HFD. Specifically, PU reduced the abundance of <em>P. copri</em>, which exacerbated AS by producing trimethylamine (TMA). Prolonged mono-colonization of <em>P. copri</em> undermines the beneficial effects of PU on AS. In clinical, the plaque scores of AS patients were positively correlated with the abundance of <em>P. copri</em> and plasma trimethylamine-N-oxide (TMAO) levels. A 1-week oral intervention with PU effectively decreased <em>P. copri</em> levels and reduced TMAO concentrations in patients with carotid artery plaque.</p> <p><strong>Conclusion </strong>PU may provide therapeutic benefits in combating AS by targeting <em>P. copri</em> and its production of TMA.</p>
Choline Source, Gut Microbiota and Trimethylamine-N-oxide Response
ClinicalTrials.gov study NCT04255368. IPD Sharing: NO. Countries: 1. Publications: 3.
Evaluation of Trimethylamine N-oxide (TMAO) Levels in Periodontal Disease
ClinicalTrials.gov study NCT06906510. IPD Sharing: NO. Countries: 1. Publications: 8.
Trimethylamine N-oxide Effects of a Pomegranate Supplement Simultaneously With Carnitine (TESSA)
ClinicalTrials.gov study NCT06518343. IPD Sharing: NO. Countries: 1. Publications: 0.
The Effect of Sevelamer Carbonate on Serum Trimethylamine-n-Oxide (TMAO) Level in Patients With Chronic Kidney Disease (CKD) Stage 3b-4
ClinicalTrials.gov study NCT03596749. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Trimethylamine N-oxide (TMAO) Levels in Periodontal Disease
ClinicalTrials.gov study NCT06580431. IPD Sharing: NO. Countries: 1. Publications: 2.
Trimethylamine-N-oxide Production and Metabolism
ClinicalTrials.gov study NCT02558673. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Plasma Trimethylamine N-oxide Elevation Induced by L-carnitine Supplementation and Insulin Resistance
ClinicalTrials.gov study NCT05251207. IPD Sharing: Not stated. Countries: 1. Publications: 2.
The Effect of Beetroot Juice on Plasma Trimethylamine N-oxide Concentration
ClinicalTrials.gov study NCT05004935. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Facilitated Vegan Diet on Cardiometabolic Endpoints and Trimethylamine N-oxide
ClinicalTrials.gov study NCT05071196. IPD Sharing: NO. Countries: 1. Publications: 6.
Data from: Puerarin alleviates atherosclerosis via the inhibition of Prevotella copri and its trimethylamine production
Open the record for dataset details and reuse information.
Association Between Trimethylamine-N-oxide and Gestational Diabetes Mellitus
ClinicalTrials.gov study NCT03415295. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Red Wine Effects Upon Gut Flora and Plasma Levels of Trimethylamine-N-oxide (TMAO) - WineFlora Study
ClinicalTrials.gov study NCT03232099. IPD Sharing: UNDECIDED. Countries: 0. Publications: 8.
Trimethylamine oxide is a new plant signaling molecule that mediates abiotic stress tolerance
GEO Series GSE144502. Arabidopsis thaliana. 2 samples. Type: Expression profiling by high throughput sequencing.
The Gut Microbe-Derived Metabolite Trimethylamine is a Biomarker of and Therapeutic Target in Alcohol-Associated Liver Disease
GEO Series GSE157681. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional profiling of trimethylamine N-oxide (TMAO) stimulated human aortic endothelial cells (HAECs)
GEO Series GSE216833. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Trimethylamine N-oxide impairs β-cell function and glucose tolerance
GEO Series GSE243083. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
The effect of trimethylamine N-oxide on the metabolism of visceral white adipose tissue in spontaneously hypertensive rat
GEO Series GSE188336. Rattus norvegicus. 18 samples. Type: Expression profiling by high throughput sequencing.
Concentration of Trimethylamine Oxide (TMAO) in Blood Plasma as a Risk Factor for Vascular Cerebral Damage
ClinicalTrials.gov study NCT03903601. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study the Effect of Probiotic Supplementation on Trimethylamine-N-Oxide Plasma Level in Hemodialysis Patients
ClinicalTrials.gov study NCT06421883. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.