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72 results for “tufted cells”
Activation patterns of afferent synapses on layer 5 tufted pyramidal cells in a biologically detailed simulation
<p>The data set is based on a biologically detailed simulation of a circuit of cortical neurons. The circuit was activated by thalamo-cortical inputs every 1 s for 500 ms. We report for a number of exemplary tufted pyramidal cells in layer 5 the pattern activation of their afferent synapses.</p> <p>Specifically, we report for all afferent excitatory synapses the pairwise path distances along the dendrite / soma (note that the soma was simplified to a point for the purpose of calculating path distances, but not during the simulation), and the times of activation of each of these synapses.</p> <p>The simulation is based on the model described in <a href="https://www.biorxiv.org/content/10.1101/2022.08.11.503144v1">this preprint</a>. The model can also be found <a href="https://zenodo.org/record/6906785">here on Zenodo</a>. For more details on the simulation, contact the author.</p> <p>For more details about the format of the data, refer to the included jupyter notebook.</p>
RNA sequencing code associated with Billipp et al. Immunity 2024 - Chat + vs Chat - tuft cells
<p>R code and result for RNA-sequencing analysis comparing <em>Chat(GFP)+ </em>and <em>Chat(GFP)- </em>tuft cells sorted from the small intestine of <em>B6.Chat-GFP</em> mice. Associated with Billipp et al. Immunity 2024 titled "Tuft cell-derived acetylcholine promotes epithelial chloride secretion and intestinal helminth clearance"</p>
RNA sequencing code associated with Billipp et al. Immunity 2024 - Prox vs. distal tuft cells
<p>R code and result for RNA-sequencing analysis comparing tuft cells sorted from the proximal and distal small intestine of mice. Associated with Billipp et al. Immunity 2024 titled "<span>Tuft cell-derived acetylcholine promotes epithelial chloride secretion and intestinal helminth clearance</span>"</p>
Data from: Weak sinusoidal electric fields entrain spontaneous Ca transients in the dendritic tufts of CA1 pyramidal cells in rat hippocampal slice preparations
Neurons might interact via electric fields and this notion has been referred to as ephaptic interaction. It has been shown that various types of ion channels are distributed along the dendrites and are capable of supporting generation of dendritic spikes. We hypothesized that generation of dendritic spikes play important roles in the ephaptic interactions either by amplifying the impact of electric fields or by providing current source to generate electric fields. To test if dendritic activities can be modulated by electric fields, we developed a method to monitor local Ca-transients in the dendrites of a neuronal population in acute rat hippocampal slices by applying spinning-disk confocal microscopy and multi-cell dye loading technique. In a condition in which the dendrites of CA1 pyramidal neurons show spontaneous Ca-transients due to added 50 μM 4-aminopyridine to the bathing medium and adjusted extracellular potassium concentration, we examined the impact of sinusoidal electric fields on the Ca-transients. We have found that spontaneously occurring fast-Ca-transients in the tufts of the apical dendrites of CA1 pyramidal neurons can be blocked by applying 1 μM tetrodotoxin, and that the timing of the transients become entrained to sub-threshold 1-4 Hz electric fields with an intensity as weak as 0.84 mV/mm applied parallel to the somato-dendritic axis of the neurons. The extent of entrainment increases with intensity below 5 mV/mm, but does not increase further over the range of 5-20 mV/mm. These results suggest that population of pyramidal cells might be able to detect electric fields with biologically relevant intensity by modulating the timing of dendritic spikes.
Data from: Weak sinusoidal electric fields entrain spontaneous Ca transients in the dendritic tufts of CA1 pyramidal cells in rat hippocampal slice preparations
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Ikaros is a principal regulator of Aire+ mTEC homeostasis, thymic mimetic cell diversity, and central tolerance [Tuft cell RNA-seq]
GEO Series GSE237988. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer [Single cell RNA-seq]
GEO Series GSE279200. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing; Other.
OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage
GEO Series GSE186614. Homo sapiens; Mus musculus. 79 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Tuft cells act as regenerative stem cells in the human intestine
GEO Series GSE233451. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Regulatory network analysis of Dclk1 gene expression reveals a tuft cell-ILC2 axis that inhibits pancreatic tumor progression [RNA-seq]
GEO Series GSE259357. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer [RNA-seq]
GEO Series GSE115122. Homo sapiens. 26 samples. Type: Expression profiling by high throughput sequencing.
Tuft cell formation reflects epithelial plasticity in pancreatic injury; implications for modeling human pancreatitis
GEO Series GSE143749. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation
GEO Series GSE279898. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Tuft cell-derived acetylcholine promotes epithelial chloride secretion and intestinal helminth clearance
GEO Series GSE262198. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Regulatory network analysis of Dclk1 gene expression reveals a tuft cell-ILC2 axis that inhibits pancreatic tumor progression [scRNA-seq]
GEO Series GSE259356. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
TCF7L1 controls tuft cell differentiation
GEO Series GSE226187. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Tissue specific gene expression of epithelial tuft cells from small intestine and gallbladder in mouse
GEO Series GSE194035. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair
GEO Series GSE197163. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Epithelium intrinsic zinc sensing maintains host-microbiome symbiosis via modulation of Tuft and Paneth cell lineages [rna-seq_mtf_ko_sio_zn]
GEO Series GSE284341. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Selective Regulation of Tuft Cell-Like Small Cell Lung Cancer by Novel Transcriptional Co-activators C11orf53 and COLCA2
GEO Series GSE212912. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.