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190
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ShareScore release 0.9.0
Dataset results
190 results for “tumor-associated macrophages”
YY1 enhances HIF-1α stability in tumor-associated macrophages to suppress anti-tumor immunity of prostate cancer
Open the record for dataset details and reuse information.
Novel M2-like tumor-associated macrophage-related biomarkers predict prognosis of Acute myeloid leukemia patients.
<p>The supplementary material for the Novel M2-like tumor-associated macrophage-related biomarkers predict prognosis of Acute myeloid leukemia patients.</p>
ImmunoMRI for Assessment of Tumor-associated Macrophages
ClinicalTrials.gov study NCT07066436. IPD Sharing: NO. Countries: 1. Publications: 5.
Dataset related to article: "Heme catabolism by tumor-associated macrophages controls metastasis formation"
<p>This record contains raw data related to article "Heme catabolism by tumor-associated macrophages controls metastasis formation"</p> <p> </p> <p>Although the pathological significance of tumor-associated macrophage (TAM) heterogeneity is still poorly understood, TAM reprogramming is viewed as a promising anticancer therapy. Here we show that a distinct subset of TAMs (F4/80<sup>hi</sup>CD115<sup>hi</sup>C3aR<sup>hi</sup>CD88<sup>hi</sup>), endowed with high rates of heme catabolism by the stress-responsive enzyme heme oxygenase-1 (HO-1), plays a critical role in shaping a prometastatic tumor microenvironment favoring immunosuppression, angiogenesis and epithelial-to-mesenchymal transition. This population originates from F4/80<sup>+</sup>HO-1<sup>+</sup> bone marrow (BM) precursors, accumulates in the blood of tumor bearers and preferentially localizes at the invasive margin through a mechanism dependent on the activation of Nrf2 and coordinated by the NF-κB1-CSF1R-C3aR axis. Inhibition of F4/80<sup>+</sup>HO-1<sup>+</sup> TAM recruitment or myeloid-specific deletion of HO-1 blocks metastasis formation and improves anticancer immunotherapy. Relative expression of HO-1 in peripheral monocyte subsets, as well as in tumor lesions, discriminates survival among metastatic melanoma patients. Overall, these results identify a distinct cancer-induced HO-1<sup>+</sup> myeloid subgroup as a new antimetastatic target and prognostic blood marker.</p>
The Role of Tumor-associated Macrophages in Colorectal Liver Metastases
ClinicalTrials.gov study NCT03888638. IPD Sharing: NO. Countries: 0. Publications: 1.
Targeting the RNA m6A reader YTHDF2 in tumor-associated macrophages shapes tumor immunity and immunotherapy [scRNA-seq]
GEO Series GSE189193. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Bexmarilimab activates human tumor-associated macrophages to support adaptive immune responses in interferon-poor immune microenvironments
GEO Series GSE222649. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing.
A tumor-associated macrophage-targeted immunocytokine leveraging T and NK cell synergy for potent cancer immunotherapy [scRNA-seq]
GEO Series GSE302715. Mus musculus. 187 samples. Type: Expression profiling by high throughput sequencing.
A tumor-associated macrophage-targeted immunocytokine leveraging T and NK cell synergy for potent cancer immunotherapy
GEO Series GSE303870. Mus musculus; Homo sapiens. 223 samples. Type: Expression profiling by high throughput sequencing; Other.
Profiling of tumor-associated macrophages (TAM) after anti-MerTK treatment
GEO Series GSE119952. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
The loss of RNA N 6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8 + T cell dysfunction and tumor growth
GEO Series GSE155098. Mus musculus; Homo sapiens. 41 samples. Type: Expression profiling by high throughput sequencing; Other.
IL-1b+ tumor-associated macrophages fuel pathogenic inflammation in pancreatic cancer - scRNA-seq of murine PDAC samples
GEO Series GSE217846. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
IL-1b+ tumor-associated macrophages fuel pathogenic inflammation in pancreatic cancer
GEO Series GSE217847. Homo sapiens; Mus musculus. 136 samples. Type: Expression profiling by high throughput sequencing; Other.
Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages [scRNA-seq]
GEO Series GSE228105. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8+ T cell activity
GEO Series GSE243210. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Glutamine antagonist JHU083 reprograms immunosuppressive tumor-associated macrophages to drive tumor immunity in urologic cancers, single-cell RNA-seq
GEO Series GSE229223. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
ZEB2 is a Master Switch Controlling the Tumor-Associated Macrophage Program [in vivo]
GEO Series GSE269191. Mus musculus. 145 samples. Type: Expression profiling by high throughput sequencing.
Murine macrophages: Peritoneal exudate macrophages (PECs) vs tumor-associated macrophages (TAMs)
GEO Series GSE167413. Mus musculus. 9 samples. Type: Expression profiling by array.
The Immune Landscape of Tumor-Associated Macrophage Reprogramming.
GEO Series GSE274402. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Tumor-associated macrophages respond to chemotherapy by detrimental transcriptional reprogramming and suppressing stabilin-1 mediated clearance of EGF
GEO Series GSE224681. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.