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142 results for “upper airway”
The Upper-Airway Microbiome as a Biomarker of Asthma Exacerbations despite Inhaled Corticosteroid Treatment
<p>The response to inhaled corticosteroids (ICS) in asthma is affected by the interplay of several factors. Among these, the role of the upper-airway microbiome has been scarcely investigated. We aimed to evaluate the association between the salivary, pharyngeal, and nasal microbiome with asthma exacerbations despite ICS use. Samples from 250 asthma patients from the Genomics and Metagenomics of Asthma Severity (GEMAS) study treated with ICS were analyzed. Controls/cases were defined by the absence/presence of asthma exacerbations in the past six months despite being treated with ICS. The bacterial microbiota was profiled by sequencing the V3-V4 region of the 16S rRNA gene. Differences between groups were assessed by PERMANOVA and regression models adjusted for potential confounders. A false discovery rate (FDR) of 5% was used to correct for multiple comparisons. Classification models of asthma exacerbations despite ICS treatment were built with machine learning approaches based on clinical, genetic, and microbiome data. In nasal and saliva samples, cases had lower bacterial diversity (Richness, Shannon, and Faith indexes) than controls (0.007≤p≤0.037). Asthma exacerbations accounted for 8-9% of the interindividual variation of the salivary and nasal microbiomes (0.003≤p≤0.046). Three, four, and eleven bacterial genera from the salivary, pharyngeal, and nasal microbiomes were differentially abundant between groups (4.09x10<sup>-12</sup>≤FDR≤0.047). Integrating clinical, genetic, and microbiome data showed good discrimination for the development of asthma exacerbations despite ICS use (AUC<sub>training</sub>:0.82 and AUC<sub>validation</sub>:0.77). The diversity and composition of the upper-airway microbiome are associated with asthma exacerbations despite ICS treatment. The salivary microbiome has a potential application as a biomarker of asthma exacerbations despite ICS use.</p> <p>The summary results of the association between bacterial genera and asthma exacerbations despite ICS use are published in this repository. Analyses were conducted using the DESeq2 package adjusting for potential confounders (see more details in the manuscript). The submitted summary tables contains the following columns:</p> <ul> <li>Kingdom: Taxonomic classification at Kingdom level</li> <li>Phylum: Taxonomic classification at Phylum level</li> <li>Class: Taxonomic classification at Class level</li> <li>Order: Taxonomic classification at Order level</li> <li>Family: Taxonomic classification at Family level</li> <li>Genus: Taxonomic classification at Genus level</li> <li>log2FC: log<sub>2</sub>(fold-change). Positive values indicate higher abundance in cases and negative values in controls</li> <li>SE: standard error of log<sub>2</sub>(fold-change)</li> <li>P.Value: p-value of the regression model</li> <li>FDR: adjusted p-value by false discovery rate (Benjamin-Hochberg method)</li> </ul>
Novel by Upper Airway Respiratory Muscle Training to Treat OSA in Chronic SCI
ClinicalTrials.gov study NCT03664765. IPD Sharing: YES. Countries: 1. Publications: 0.
CUCO Database: A voice and speech corpus of patients who underwent upper airway surgery in pre- and post-operative states
<p>The data set comprises 3,800 speech audio files of 3 types of upper respiratory tract surgeries and 1 control set. The dataset has an average of <strong>35.51 +- 5.91</strong> audio recordings per patient. It provides valuable resources to the scientific community to systematically investigate the objective effects of upper respiratory tract surgery on voice and speech. </p> <p>This data set is a complete corpus comprising data from 107 Spanish Castilian speakers. This corpus encompasses voice and speech recordings from both control speakers and patients who underwent upper airway surgical procedures in pre- and post-operative stages. The surgeries in focus include <strong>Tonsillectomy</strong>, <strong>Functional Endoscopic Sinus Surgery</strong>, and <strong>Septoplasty</strong>, all consistently performed by a single surgeon.</p> <p>This corpus has been the basis for different previous studies to evaluate changes in voice and its quality due to surgery. The results do not suggest significant changes in the most relevant acoustic parameters studied for the voice, which is consistent with the initial hypothesis. However, the analysis of speech recordings remains open, with a special focus on the nasalised segments, which are expected to change due to surgical intervention.</p> <p>This data set also opens the way to study the effect of upper airway surgery on the performance of speaker recognition and identification methods, as well as to be used to test anti-spoofing methodologies to make them more robust. </p> <p>Please, if you use this database, cite this open-access paper where the data acquisition is explained and detailed:</p> <p>Hernández-García, E., Guerrero-López, A., Arias-Londoño, J. D., & Godino-Llorente, J. I. (2024). A voice and speech corpus of patients who underwent upper airway surgery in pre-and post-operative states. <em>Scientific Data</em>, <em>11</em>(1), 746.</p>
The upper airway volume effects produced by Hyrax, Hybrid-Hyrax and Keles Keyless expanders: a single-centre randomised controlled trial
<p>Datasets for all analyses in the paper.</p>
Trial on Oral Appliance Design for Improving Upper Airway Function and Sleep Quality
ClinicalTrials.gov study NCT03219034. IPD Sharing: NO. Countries: 1. Publications: 1.
Systematic Laryngoscopic Evaluation of Upper Airways in Ventilated ALS Patients in Portugal and in Norway
ClinicalTrials.gov study NCT03887338. IPD Sharing: NO. Countries: 2. Publications: 5.
Effects of High-flow Oxygen Therapy and Non-invasive Ventilation on Lung Volumes and on Upper Airway
ClinicalTrials.gov study NCT05643911. IPD Sharing: YES. Countries: 1. Publications: 1.
Inhaled Fluticasone Effects on Upper Airway Patency in Obstructive Lung Disease
ClinicalTrials.gov study NCT01554488. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Comparison Between VCV and FCV Through Ultra-thin Tube in Upper Airway Surgery
ClinicalTrials.gov study NCT05033730. IPD Sharing: YES. Countries: 1. Publications: 2.
Incidence of Sleep-disordered Breathing and Upper Airway Collapsibility in Postpartum Patients and Its Intervention
ClinicalTrials.gov study NCT01719224. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effects of General Anesthetics on Upper Airway Collapsibility in Healthy Subjects
ClinicalTrials.gov study NCT01557920. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Effectiveness of Continuous Negative External Pressure in Preventing Upper Airway Impairment During Routine Colonoscopy
ClinicalTrials.gov study NCT01895062. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Pilot Study of the Comparison of the Upper Airway Dynamics of Oronasal vs Nasal Masks With PAP Treatment
ClinicalTrials.gov study NCT01939938. IPD Sharing: NO. Countries: 1. Publications: 1.
Do patients of different craniofacial patterns have different minimum cross-sectional area and cross-sectional areas of the upper airways? A systematic review with network meta-analysis
<div>Dataset for all analyses. Dataset initially made available to editor and peer-reviewers during the peer review phase. After acceptance, the dataset will be made openly available to all without any restrictions.</div>
Drug-Induced Sleep Endoscopy for Upper Airway Evaluation in Obstructive Sleep Apnea
ClinicalTrials.gov study NCT00695214. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Assessing Upper Airway Patency in Tracheostomy Patients During One Way Speaking Valve Trial
ClinicalTrials.gov study NCT04685902. IPD Sharing: NO. Countries: 1. Publications: 4.
Conditions of Diagnostic Panendoscopy of the Upper Airway Under Propofol Remifentanil General Anesthesia
ClinicalTrials.gov study NCT02093143. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Inspire Home Study: Utilization of Home Monitoring During Therapy Optimization in Patients With an Inspire Upper Airway Stimulation System (Comparison of Home Sleep Testing vs. In-lab Polysomnography
ClinicalTrials.gov study NCT04416542. IPD Sharing: NO. Countries: 1. Publications: 1.
Heliox in Experimental Upper Airway Obstruction
ClinicalTrials.gov study NCT00788788. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Sleep, Upper Airway and Dental Occlusion in Children With Large Overjet
ClinicalTrials.gov study NCT04964830. IPD Sharing: NO. Countries: 1. Publications: 18.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.