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121 results for “uric acid”
Associations of serum uric acid with cardiovascular disease risk factors: a retrospective cohort study in Southeastern China
<p class="MsoNormal"><span>Objective: To evaluate the associations between serum uric acid (SUA) levels and cardiovascular disease (CVDs) risk factors, focusing on potential sex-specific differences.</span></p> <p class="MsoNormal"><span>Design: A retrospective cohort study.</span></p> <p class="MsoNormal"><span>Setting: A large community-based survey was conducted every two years from 2010 to 2018 in Hangzhou, Zhejiang Province, Southeastern China.</span></p> <p class="MsoNormal"><span>Participants: 6119 participants aged 40 years and above who underwent at least three times of physical examinations were enrolled. </span></p> <p class="MsoNormal"><span>Methods: Participants were categorized into four groups (Q1-Q4) based on baseline SUA quartiles within the normal range, with hyperuricemia (HUA) as the fifth group. The Q1 was the reference. By stratifying participants by gender, the relationships between SUA levels and systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), and total cholesterol (TC) were investigated using linear regression models in the generalized estimating equation (GEE). Additionally, the associations of elevated SUA levels and HUA with hypertension, hyperglycemia, and dyslipidemia were correspondingly examined using multivariate logistic regression models.</span></p> <p class="MsoNormal"><span>Results: After adjusting for confounding variables, we found positive associations between SUA levels and SBP, DBP, FBG, and TC in women, and with TC in men (P < 0.01). Likewise, Elevated SUA quartiles and HUA were linked to increased dyslipidemia risk in both sexes, and increased hyperglycemia risk only in women, with HRs (95%CI) of 1.64 (1.05-2.55) and 2.37 (1.47-3.81) in the Q4 and HUA group, respectively. Women with HUA had higher hypertension risk (HR=1.45, 95% CI 1.21-1.73), while no such association was observed in men. Stratified analyses revealed significant associations between elevated SUA levels and CVDs risk factors in postmenopausal and non-obese women.</span></p> <p class="MsoNormal"><span>Conclusions: Elevated SUA levels increase the risk of dyslipidemia in both sexes. SUA levels within normal-range and HUA are positively associated with hyperglycemia and hypertension in postmenopausal women, but not in men.</span></p>
A Controlled Study of Uric Acid on the Progression of IgA Nephropathy
ClinicalTrials.gov study NCT00793585. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Uric Acid and Hypertension in African Americans
ClinicalTrials.gov study NCT00241839. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Lowering Serum Uric Acid to Prevent Acute Kidney Injury
ClinicalTrials.gov study NCT00756964. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Tolerance, Pharmacokinetics / Pharmacodynamics (PK / PD) and Immunogenicity of Pegylated Uric Acid Oxidase for Injection in Healthy Adults and Hyperuricemia Volunteers
ClinicalTrials.gov study NCT05226013. IPD Sharing: NO. Countries: 1. Publications: 2.
Using Allopurinol to Relieve Symptoms in Patients With Heart Failure and High Uric Acid Levels
ClinicalTrials.gov study NCT00987415. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Multi-Dose Safety/Pharmacodynamic Study of SEL-212/SEL-037 in Subjects With Symptomatic Gout & Elevated Blood Uric Acid
ClinicalTrials.gov study NCT02959918. IPD Sharing: NO. Countries: 1. Publications: 1.
Losartan and Uric Acid Metabolism in Children With Proteinuric Nephropathies
ClinicalTrials.gov study NCT05402397. IPD Sharing: YES. Countries: 1. Publications: 9.
Uric Acid and the Endothelium in CKD
ClinicalTrials.gov study NCT01228903. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study to Assess the Effect of Intensive Uric Acid (UA) Lowering Therapy With RDEA3170, Febuxostat, Dapagliflozin on Urinary Excretion of UA
ClinicalTrials.gov study NCT03316131. IPD Sharing: NO. Countries: 1. Publications: 1.
Intensive Uric Acid Lowering With Verinurad and Febuxostat in Patients With Albuminuria
ClinicalTrials.gov study NCT03118739. IPD Sharing: NO. Countries: 1. Publications: 2.
To Evaluate the Influence of (LUA Probiotics) on Uric Acid
ClinicalTrials.gov study NCT06969469. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 Diabetes
ClinicalTrials.gov study NCT02502071. IPD Sharing: Not stated. Countries: 1. Publications: 12.
Associations of serum uric acid with cardiovascular disease risk factors: a retrospective cohort study in Southeastern China
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Does Disease Activity Influence the Levels of Uric Acid in Psoriatic Arthritis?
<p>Background: Hyperuricemia is not only associated with the development of gout but also with renal and vascular dysfunction. The prevalence of this condition has already been studied in psoriasis, but there are a few studies that have been carried out in psoriatic arthritis (PsA). Some studies have shown an association with metabolic syndrome, while others with the extent of cutaneous involvement, but there are no studies that have evaluated the disease activity with compound indexes.<br> Objective: The aim of the study was to determine if disease activity, measured by different composite scores, influences the levels of uric acid.<br> Method: This was a cross-sectional, observational study, which included 52 PsA patients. Clinical assessments included dactylitis, tender and swollen joint counts, Psoriasis Area and Severity Index, Leeds Enthesis Index, Minimal Disease Activity and Disease Activity for Psoriatic Arthritis. Hyperuricemia was defined as serum uric acid levels ≥ 6mg/dL in females and ≥ 7mg/dL in males.<br> Results: Among the 52 included patients, 55.76% were female. The mean age was 54.9 ± 11.6 years. Hyperuricemia occurred in 26.92%. Demographic data, diet, comorbidities and medication were similar between patients with and without hyperuricemia. Patients with hyperuricemia had higher waist circumference (p <0.0046). There was no difference in disease activity between groups, either in the isolated items or in the composite indexes. There was a significant difference in uric acid levels according to the classification of chronic kidney disease by estimated glomerular filtration rate (p=0.0016). Individuals using leflunomide had significantly lower levels of uric acid than those who were not using (p=0.0071).<br> Conclusion: This study supports the notion that, in PsA, hyperuricemia is more related to metabolic factors than to disease activity.</p>
Investigation of the Atherogenic Effects of Uric Acid-modified in Endothelial Dysfunction and the the Preventional Mechanism by Anthocyanidines
ClinicalTrials.gov study NCT02797028. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Evaluate the Efficacy and Safety of Arhalofenate for Preventing Flares and Reducing Serum Uric Acid in Gout Patients
ClinicalTrials.gov study NCT02063997. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Correlation Between Serum Uric Acid, Serum Homocysteine Level and Interleukin- 17 in Lupus Nephritis Patients
ClinicalTrials.gov study NCT07017868. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Influence of Hesperidin and Vitamin C on Uric Acid Concentration
ClinicalTrials.gov study NCT04316390. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of Association Between Maternal Uric Acid , Maternal and Fetal Outcome in Pregnant Women With Hypertension
ClinicalTrials.gov study NCT01523327. IPD Sharing: Not stated. Countries: 1. Publications: 2.
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