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1,540 results for “vaginal”
Cysteine dependence of Lactobacillus iners is a potential therapeutic target for vaginal microbiota modulation
<p>Compressed directories containing code and data files sufficient to reproduce analysis from Bloom et al paper on <em>Lactobacillus iners</em> (<em>Nature Microbiology</em>). An earlier, non-peer-reviewed manuscript version containing largely the same analysis was posted as a pre-print in <em>bioRxiv</em> at (https://doi.org/10.1101/2021.06.12.448098). Three compressed directory for analyses of:</p> <ol> <li>Vaginal <em>Lactobacillus </em>genome catalog characterization and gene content analysis.</li> <li>Analysis of relationship between cervicovaginal microbiota composition and cysteine concentrations in vaginal fluid from a South African cohort</li> <li>Analysis of results of <em>in vitro </em>mixed culture competition assays including: <ol> <li>Pairwise competition between <em>L. iners</em> and <em>Lactobacillus crispatus</em> in <em>Lactobacillus</em> MRS broth containing L-cysteine +/- S-methyl-L-cysteine (SMC)</li> <li>Defined bacterial-vaginosis (BV)-like communities including <em>L. iners</em>, <em>L. crispatus</em>, and BV-associated species <em>Gardnerella vaginalis</em>, <em>Prevotella bivia</em>, and <em>Atopobium (Fannyhessea) vaginae</em> cultured in S-broth with or without SMC and/or metronidazole.</li> </ol> </li> </ol>
Human papillomavirus (HPV) detection in vaginal self-samples: evaluation of eNat® as an alternative suspension medium to ThinPrep®PreservCyt® for vaginal swabs
<p>Dataset 1: HPV positivity on cervical and vaginal self-samples with different HPV real-time PCR assays</p> <p>Dataset 2: hrHPV viral load in cervical and vaginal self-samples</p> <p>Datakey 1: HPV positivity on cervical and vaginal self-samples with different HPV real-time PCR assays</p> <p>Datakey 2: hrHPV viral load in cervical and vaginal self-samples</p>
РИС. 2. Дистальные отделы половой системы особей иЗ смеШанной колонии Monacha claustralis (A–D) и M. cartusiana (E–F). D, F. Вскрытый атриум у двух видов. Условные сокраЩениЯ: at – атриум; atpl – складка внутри атриума; ep – Эпифаллус; fl – бич; mg – слиЗистые желеЗы; pe – пенис; pp – папилла пениса; va – вагина; vap1 – баЗальнаЯ часть вагинального придатка; vap2 – апикальнаЯ часть вагинального придатка; vlb – латеральное выпЯчивание вагины. МасШтаб 1 мм. FIG. 2. Distal parts of the reproductive system of specimens from a mixed colony of Monacha claustralis (A–D) and M. cartusiana (E–F). D, F. Dissected atrium in two species. Abbreviations: at – atrium; atpl – pleat inside the atrium; ep – epiphallus; fl – flagellum; mg – mucus glands; pe – penis; pp – penial papilla; va – vagina; vap1 – basal part of vaginal appendage; vap2 – apical part of vaginal appendage; vlb – lateral bulge of the vagina. Scale bars 1 mm. in Monacha claustralis и M. cartusiana (Gastropoda, Hygromiidae) - два криптических вида антропохорных наЗемных моллюсков на Западе Украины
РИС. 2. Дистальные отделы половой системы особей иЗ смеШанной колонии Monacha claustralis (A–D) и M. cartusiana (E–F). D, F. Вскрытый атриум у двух видов. Условные сокраЩениЯ: at – атриум; atpl – складка внутри атриума; ep – Эпифаллус; fl – бич; mg – слиЗистые желеЗы; pe – пенис; pp – папилла пениса; va – вагина; vap1 – баЗальнаЯ часть вагинального придатка; vap2 – апикальнаЯ часть вагинального придатка; vlb – латеральное выпЯчивание вагины. МасШтаб 1 мм. FIG. 2. Distal parts of the reproductive system of specimens from a mixed colony of Monacha claustralis (A–D) and M. cartusiana (E–F). D, F. Dissected atrium in two species. Abbreviations: at – atrium; atpl – pleat inside the atrium; ep – epiphallus; fl – flagellum; mg – mucus glands; pe – penis; pp – penial papilla; va – vagina; vap1 – basal part of vaginal appendage; vap2 – apical part of vaginal appendage; vlb – lateral bulge of the vagina. Scale bars 1 mm.
Data from: Ovarian cycling and reproductive state shape the vaginal microbiota in wild baboons
Background: The vaginal microbiome is an important site of bacterial-mammalian symbiosis. This symbiosis is currently best characterized for humans, where lactobacilli dominate the microbial community and may help defend women against infectious disease. However, lactobacilli do not dominate the vaginal microbiota of any other mammal studied to date, raising key questions about the forces that shape the vaginal microbiome in non-human mammals. Results: We used Illumina sequencing of the bacterial 16S rRNA gene to investigate variation in the taxonomic composition of the vaginal microbiota in 48 baboons (Papio cynocephalus), members of a well-studied wild population in Kenya. Similar to prior studies, we found that the baboon vaginal microbiota was not dominated by lactobacilli. Despite this difference, and similar to humans, reproductive state was the dominant predictor of baboon vaginal microbiota, with pregnancy, postpartum amenorrhea, and ovarian cycling explaining 18% of the variance in community composition. Furthermore, among cycling females, a striking 39% of variance in community composition was explained by ovarian cycle phase, with an especially distinctive microbial community around ovulation. Peri-ovulatory females exhibited the highest relative abundance of lactic acid-producing bacteria compared to any other phase, with a mean relative abundance of 44%. To a lesser extent, sexual behavior, especially a history of shared sexual partners, also predicted vaginal microbial similarity between baboons. Conclusions: Despite striking differences in their dominant microbes, both human and baboon vaginal microbiota exhibit profound changes in composition in response to reproductive state, ovarian cycle phase, and sexual behavior. We found major shifts in composition during ovulation, which may have implications for disease risk and conception success. These findings highlight the need for future studies to account for fine-scale differences in reproductive state, particularly differences between the various phases of the ovarian cycle. Overall, our work contributes to an emerging understanding of the forces that explain intra- and inter-individual variation in the mammalian vaginal microbiome, with particular emphasis on its role in host health and disease risk.
VMGC - Human Vaginal Microbiome Genome Collection
<p>The VMGC is a large-scale reference genome resource of the human vaginal microbiome, including over 33,000 genomes derived from 786 prokaryotes, 11 fungi, and 4,263 viruses associated with the human vagina. In terms of representation, the VMGC demonstrates high efficiency in capturing microbial sequences, with a median mapping rate of 91.7% across 4,472 vaginal metagenomic samples obtained from 14 countries.</p>
human-vaginal-v1-0 reference for LocalHGT
<p>Please download the file <strong>human-vaginal-v1-0.fasta.gz</strong> and unzip it by "<strong>gzip -d human-vaginal-v1-0.fasta.gz</strong>". After that, pass the full path of the file "<strong>human-vaginal-v1-0.fasta</strong>" to LocalHGT by "<strong>localhgt bkp -r /path-to/human-vaginal-v1-0.fasta</strong>" or "<strong>localhgt event -r /path-to/human-vaginal-v1-0.fasta</strong>". "<strong>human-vaginal-v1-0.fasta</strong><strong>.fai</strong>" is the index file, you can download it or not. If you download it, you should put it in the same folder as <strong>human-vaginal-v1-0.fasta</strong>. If you don't download it, LocalHGT will generate it automatically.<strong> </strong>The file <strong>genomes-all_metadata.tsv</strong> records the taxonomy information of each genome.<strong> </strong>If you want to analyze HGTs in human oral microbiome, you can use this reference.<strong> </strong>Detailed instructions can be seen at <a href="https://github.com/deepomicslab/LocalHGT">LocalHGT</a>.</p>
The canine vaginal microbiome in heat does not influence fertility in healthy breeding bitches
<p>A healthy and balanced vaginal microbiome is often thought to be an important prerequisite for successful breeding and healthy litters. Previous studies investigating the influence of canine vaginal bacteria on fertility mostly relied on aerobic culturing. In recent years, culture-independent methods, such as next-generation sequencing (NGS), have become popular. With the ability to analyze the microbiome as a whole, research in this field has made notable advances. This is the first study to correlate NGS data of the canine vaginal microbiome in heat with fertility data. Healthy breeding bitches (n=80) presented for routine pre-breeding examination were sampled during early heat and mated after ovulation. A vaginal sample was taken for NGS analysis and microbiological culture. Additionally, a blood sample was collected. Fertility data (mating, pregnancy, delivery, litter size) were assessed. NGS revealed a diverse microbiome in all the samples. Bioinformatics and statistical analysis did not provide evidence of larger differences in the microbiome of those bitches that became pregnant and those that did not. </p> <p> </p>
Insight into the ecology of vaginal bacteria through integrative analyses of metagenomic and metatranscriptomic data
<p>Datasets and code used to analyze and and to prepare figures for: "Insight into the ecology of vaginal bacteria through integrative analyses of metagenomic and metatranscriptomic data", France et al 2022.</p>
Comparison of different suture techniques for laparoscopic vaginal cuff closure
<p>Laparoscopic hysterectomy is a commonly performed procedure. However, one high-risk complication is vaginal cuff dehiscence. Currently, there is no standardization regarding thread material or suturing technique for vaginal cuff closure. Therefore, this study aimed to compare extracorporeal and intracorporeal suturing techniques for vaginal cuff closure using a pelvic trainer model. Eighteen experts in laparoscopic surgery performed vaginal cuff closures with interrupted sutures using intracorporeal knotting, extracorporeal knotting and continuous, unidirectional barbed sutures. While using an artificial tissue suturing pad in a pelvic trainer, experts performed vaginal cuff closure using each technique according to block randomization. Task completion time, tension resistance, and the number of errors were recorded. After completing the exercises, participants answered a questionnaire concerning the suturing techniques and their performance. Experts completed suturing more quickly (p < 0.001, p < 0.001, respectively) and with improved tension resistance (p < 0.001, p < 0.001) when using barbed suturing compared to intracorporeal and extracorporeal knotting. Furthermore, the intracorporeal knotting technique was performed faster (p = 0.04) and achieved greater tension resistance (p = 0.023) compared to extracorporeal knotting. The number of laparoscopic surgeries performed per year was positively correlated with vaginal cuff closure duration (p = 0.007). Barbed suturing was a time-saving technique with improved tension resistance for vaginal cuff closure.</p>
Dynamic Crosstalk Between Female Gonadal Hormones and Vaginal Microbiota Across Various Reproductive Phases
<p>Vaginal samples for 16S rRNA sequencing are collected from 150 healthy women across five reproductive phases: follicular phase, luteal phase, early pregnancy, lactation, and menopause, with 30 samples per group.</p>
Data from: Vaginal lactobacilli produce anti-inflammatory beta-carboline (BC) compounds. RNAseq dataset of BC-treated human monocytes.
<p>Primary human monocytes were isolated from peripheral blood mononuclear cells via CD14+ magnetic selection. Monocytes were then treated with 3 beta-carboline compounds isolated from the supernatant of vaginal <em>Lactobacillus crispatus</em> strain MV-1A-US (HM-637). The beta-carbolines are labled 322/BC1; 325/BC3 and 361/BC6. We find that BC6 suppresses inflammatory signaling genes in untreated and in LPS-treated monocytes. FIles include raw reads, count table and code for DESeq2-generated differentially expressed genes. </p>
Assessing the prevalence of Female Genital Schistosomiasis and comparing the acceptability and performance of health worker-collected and self-collected cervical-vaginal swabs using PCR testing among women in North-Western Tanzania: the ShWAB study
<p>Female genital schistosomiasis (FGS) is a severe neglected disease, caused by infection with <em>Schistosoma haematobium</em>. The WHO has prioritized the improvement of diagnostics for FGS and previous studies have explored the PCR-based detection of <em>Schistosoma</em> DNA on genital specimens, with encouraging results. We aimed to determine the prevalence of FGS among women living in an endemic district in North-western Tanzania, applying and preliminary comparing self-collected and operator-collected cervical-vaginal swabs followed by PCR, and to assess the acceptability of these sampling procedures.</p>
A INTERVENTIONAL CROSS SECTIONAL STUDY BETWEEN INTRA VAGINAL PLATELET RICH PLASMA AND ESTROGEN FOR TREATMENT OF GENITO-URINARY SYNDROME IN POST MENOPAUSAL WOMEN.
<p>Genitourinary syndrome of menopause (GSM) is a new term for a condition more renowned as atrophic vaginitis. It is used to describe a variety of menopausal symptoms and signs that are related to the physical changes of the vulva, vagina and lower urinary tract. The etiology of GSM is secondary to decreased levels of endogenous estrogens and represents a common but underreported condition. Currently Intra-Vaginal application of oestrogen has been considered an effective treatment of atrophic vaginitis.Recently, PRP has becoming popular as a non-operative treatment option for GSM symptoms.Our study focuses on the use platelet rich plasma for the treatment of GSM as it has natural mechanisms of cell regeneration and requires less frequent dosing and have better compliance when compared to estrogen creams. Purpose of the study is to compare the effectiveness of intra vaginal estrogen cream with intravaginal PRP in treatment of GSM.</p>
DMPA & High Dose Oral Progestin (MPA) Tablets in Outpatient Treatment of Acute Excessive Vaginal Bleeding
ClinicalTrials.gov study NCT01148420. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Triapine, Cisplatin, and Radiation Therapy in Treating Patients With Cervical Cancer or Vaginal Cancer
ClinicalTrials.gov study NCT00941070. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Randomized Cross-Over Study of Self-Insertion of Two Placebo Vaginal Film Formulations
ClinicalTrials.gov study NCT04391036. IPD Sharing: NO. Countries: 1. Publications: 3.
Safety and Efficacy Trial of a Dapivirine Vaginal Matrix Ring in Healthy HIV-Negative Women
ClinicalTrials.gov study NCT01539226. IPD Sharing: NO. Countries: 2. Publications: 5.
Vaginal Cleansing at Cesarean Delivery to Reduce Infection: A Randomized, Controlled Trial
ClinicalTrials.gov study NCT00386477. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Vaginal Testosterone Cream vs ESTRING for Vaginal Dryness or Decreased Libido in Early Stage Breast Cancer Patients
ClinicalTrials.gov study NCT00698035. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Quick Start Initiation of the Contraceptive Vaginal Ring in Adolescents
ClinicalTrials.gov study NCT00369967. IPD Sharing: NO. Countries: 1. Publications: 10.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.