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163 results for “valproic acid”
Valproic Acid Synergizes With Cisplatin and Cetuximab in vitro and in vivo in Head and Neck Cancer by Targeting the Mechanisms of Resistance - Unpublished data
<p>Antitumor effects of valproic acid (VPA) in combination with Cisplatin/Cetuximab doublet in head and neck squamous cell carcinoma (HNSCC) models. We reported unpublished data of the effects of this combination on cell cycle and 3D cell cultures</p>
Valproic Acid and Carnitine in Patients With Spinal Muscular Atrophy
ClinicalTrials.gov study NCT00227266. IPD Sharing: Not stated. Countries: 2. Publications: 41.
Valproic Acid, Radiation, and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma
ClinicalTrials.gov study NCT00879437. IPD Sharing: YES. Countries: 1. Publications: 1.
A Phase II Trial of Valproic Acid in Patients With Advanced Thyroid Cancers of Follicular Cell Origin
ClinicalTrials.gov study NCT01182285. IPD Sharing: NO. Countries: 1. Publications: 4.
CARNIVAL Type I: Valproic Acid and Carnitine in Infants With Spinal Muscular Atrophy (SMA) Type I
ClinicalTrials.gov study NCT00661453. IPD Sharing: Not stated. Countries: 3. Publications: 39.
Trial of Oral Valproic Acid for Retinitis Pigmentosa
ClinicalTrials.gov study NCT01233609. IPD Sharing: Not stated. Countries: 1. Publications: 20.
Sorafenib, Valproic Acid, and Sildenafil in Treating Patients With Recurrent High-Grade Glioma
ClinicalTrials.gov study NCT01817751. IPD Sharing: NO. Countries: 1. Publications: 1.
Valproic Acid With Temozolomide and Radiation Therapy to Treat Brain Tumors
ClinicalTrials.gov study NCT00302159. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Valproic Acid (Depakote[Registered Trademark]) to Treat Autoimmune Lymphoproliferative Syndrome (ALPS)
ClinicalTrials.gov study NCT00605657. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Valproic Acid for the Prevention of Post-Amputation Pain
ClinicalTrials.gov study NCT01928849. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Data from: Valproic acid is protective in cellular and worm models of oculopharyngeal muscular dystrophy
Objective: To explore valproic acid (VPA) as a potentially beneficial drug in cellular and worm models of oculopharyngeal muscular dystrophy (OPMD). Methods: Using a combination of live cell imaging and biochemical measures, we evaluated the potential protective effect of VPA in a stable C2C12 muscle cell model of OPMD, in lymphoblastoid cell lines derived from patients with OPMD and in a transgenic Caenorhabditis elegans OPMD model expressing human mutant PABPN1. Results: We demonstrated that VPA protects against the toxicity of mutant PABPN1. Of note, we found that VPA confers its long-term protective effects on C2C12 cell survival, proliferation, and differentiation by increasing the acetylated level of histones. Furthermore, VPA enhances the level of histone acetylation in lymphoblastoid cell lines derived from patients with OPMD. Moreover, treatment of nematodes with moderate concentrations of VPA significantly improved the motility of the PABPN-13 Alanines worms. Conclusions: Our results suggest that VPA helps to counteract OPMD-related phenotypes in the cellular and C elegans disease models.
Synergistic antitumor interaction of valproic acid and simvastatin and docetaxel in Prostate cancer cells
<p>Synergistic antitumor interaction of valproic acid, simvastatin and docetaxel in prostate cancer cells on cell migration, cell cycle perturbation, apoptosis, 3D cell culture models and stem marker reduction in<em> in vivo</em> model.</p>
Study of Efficacy and Safety of Valproic Acid in Chronic Lymphocytic Leukemia (CLL)
ClinicalTrials.gov study NCT00810680. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of Valproic Acid to Treat HIV Infected Adults
ClinicalTrials.gov study NCT00312546. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Valproic Acid in Treating Cyanotic Breath Holding Spells
ClinicalTrials.gov study NCT04482764. IPD Sharing: NO. Countries: 1. Publications: 1.
Valproic Acid in Childhood Progressive Brain Tumors
ClinicalTrials.gov study NCT01861990. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Azacitidine and Valproic Acid Plus Carboplatin in Patients With Ovarian Cancer
ClinicalTrials.gov study NCT00529022. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Valproic Acid-associated Hypoalbuminemia in Medically Fragile Patients
ClinicalTrials.gov study NCT00723762. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Valproic Acid and Its Effects on HIV Latent Reservoirs
ClinicalTrials.gov study NCT00289952. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease
ClinicalTrials.gov study NCT01552434. IPD Sharing: Not stated. Countries: 1. Publications: 2.
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International Brain Laboratory public data
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OpenNeuro
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