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ShareScore release 0.9.0
Dataset results
9 results for “variability and polymorphism”
Data from: Emergence of long-term balanced polymorphism under cyclic selection of spatially variable magnitude
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Genetic variability among and within domestic Old and New World Camels at the α-lactalbumin gene (LALBA) reveals new alleles and polymorphisms responsible for differential expression
<p><strong>Supplementary Figure 1</strong>. Schematic representation of the <em>LALBA</em> gene in camelids. Boxes indicate the exons (black for the un-translated, white for the signal peptide and grey for the translated). The line shows introns, 5’- and 3’-flanking regions.</p> <p><strong>Supplementary Figure 2</strong><strong>. </strong>Alignment of the α-LA calcium-binding site (red rectangle) of 23 terrestrial species available in the UniProt database (<a href="http://www.uniprot.org/uniprot/">http://www.uniprot.org/uniprot/</a>). The calcium-binding site in the <em>Camelus dromedarius</em> is indicated by a yellow rectangle.</p>
FIGURE. DnaSP DNA polymorphism analysis - Nucleotide variability (Pi) comparison between Strobilanthes lupulina and S. glandulata. The window length and step size were set to 600bp and 200bp respectively. The most varying regions and the commonly used barcoding regions are listed against the base-pair differences found. in Strobilanthes glandulata (Acanthaceae), a new species from Sri Lanka based on the morphological and molecular evidences
FIGURE. DnaSP DNA polymorphism analysis - Nucleotide variability (Pi) comparison between Strobilanthes lupulina and S. glandulata. The window length and step size were set to 600bp and 200bp respectively. The most varying regions and the commonly used barcoding regions are listed against the base-pair differences found.
Genetic Polymorphism Associated With Coronary Heart Disease Susceptibility and Variability of Clopidogrel Response
ClinicalTrials.gov study NCT03373552. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Fluorescent protein-mediated colour polymorphism in reef corals: multi-copy genes extend the adaptation/acclimatization potential to variable light environments
The genomic framework that enables corals to adjust to unfavourable conditions is crucial for coral reef survival in a rapidly changing climate. We have explored the striking intraspecific variability in the expression of coral pigments from the green fluorescent protein (GFP) family to elucidate the genomic basis for the plasticity of stress responses among reef corals. We show that multi-copy genes can greatly increase the dynamic range over which corals can modulate transcript levels in response to the light environment. Using the red fluorescent protein amilFP597 in the coral Acropora millepora as a model, we demonstrate that its expression increases with light intensity, but both the minimal and maximal gene transcript levels vary markedly among colour morphs. The pigment concentration in the tissue of different morphs is strongly correlated with the number of gene copies with a particular promoter type. These findings indicate that colour polymorphism in reef corals can be caused by the environmentally regulated expression of multi-copy genes. High-level expression of amilFP597 is correlated with reduced photodamage of zooxanthellae under acute light stress, supporting a photoprotective function of this pigment. The cluster of light-regulated pigment genes can enable corals to invest either in expensive high-level pigmentation, offering benefits under light stress, or to rely on low tissue pigment concentrations and use the conserved resources for other purposes, which is preferable in less light-exposed environments. The genomic framework described here allows corals to pursue different strategies to succeed in habitats with highly variable light stress levels. In summary, our results suggest that the intraspecific plasticity of reef corals' stress responses is larger than previously thought.
Data from: Fluorescent protein-mediated colour polymorphism in reef corals: multi-copy genes extend the adaptation/acclimatization potential to variable light environments
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A human sleep homeostasis phenotype in mice expressing a primate-specific PER3 variable-number tandem-repeat coding-region polymorphism
GEO Series GSE55255. Mus musculus. 78 samples. Type: Expression profiling by array.
The Cognitive Effects of Lorazepam in Healthy Older Individuals With TOMM40 Variable-length Polymorphisms
ClinicalTrials.gov study NCT01780519. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The polymorphic PolyQ tail protein of the Mediator Complex, Med15, regulates variable response to stress
GEO Series GSE129898. Saccharomyces cerevisiae. 48 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.