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66 results for “vasodilation”
Systemic application of the TRPV4 antagonist GSK2193874 induces tail vasodilation in a mouse model of thermoregulation
<p>In humans, skin is a primary thermoregulatory organ, with vasodilation leading to rapid body cooling, whereas in Rodentia the tail performs an analogous function. Many thermodetection mechanisms are likely to be involved including transient receptor potential vanilloid-type 4 (TRPV4), an ion channel with thermosensitive properties. Previous studies have shown that TRPV4 is a vasodilator by local action in blood vessels, so here we investigated whether constitutive TRPV4 activity effects <em>Mus muscularis</em> tail vascular tone and thermoregulation. We measured tail blood flow by pressure plethysmography in lightly sedated Mus muscularis (CD1 strain) at a range of ambient temperatures, with and without intraperitoneal administration of the blood brain barrier crossing TRPV4 antagonist GSK2193874. We also measured heart rate and blood pressure. As expected for a thermoregulatory organ, we found that tail blood flow increased with temperature. However, unexpectedly we found that GSK2193874 increased tail blood flow at all temperatures, and we observed changes in heart rate variability. Since local TRPV4 activation causes vasodilation that would increase tail blood-flow, these data suggest that increases in tail blood flow resulting from the TRPV4 antagonist may arise from a site other than the blood vessels themselves, perhaps in central cardiovascular control centres.</p>
Parvalbumin interneuron activity drives fast inhibition-induced vasoconstriction followed by slow substance P-mediated vasodilation
<p>Here, we investigated the hemodynamic responses elicited by optogenetic stimulation of parvalbumin (PV) neurons, the largest population of GABAergic interneurons in the neocortex. This dataset corresponds to the following publication: Thanh Tan Vo, Geun Ho Im, Kayoung Han, Minah Suh, Patrick J. Drew, and SG Kim. Parvalbumin interneuron activity drives fast inhibition-induced vasoconstriction followed by slow substance P-mediated vasodilation. Proceedings of the National Academy of Sciences of the United States of America 2023; Accepted.</p>
Assessment of Biomarkers and Cardiorenal Syndrome in Acute Decompensated Heart Failure With Vasodilator Therapy
ClinicalTrials.gov study NCT00842023. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Vasodilator Therapy for Heart Failure and Preserved Ejection Fraction
ClinicalTrials.gov study NCT01516346. IPD Sharing: Not stated. Countries: 1. Publications: 12.
Comparison of Inhaled Nitric Oxide and Oxygen in Participants Reactivity During Acute Pulmonary Vasodilator Testing
ClinicalTrials.gov study NCT00626028. IPD Sharing: NO. Countries: 5. Publications: 1.
Topical Radial Artery Vasodilation
ClinicalTrials.gov study NCT01155167. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Inhaled Selective Pulmonary Vasodilators for Advanced Heart Failure Therapies and Lung Transplantation Outcomes
ClinicalTrials.gov study NCT03081052. IPD Sharing: NO. Countries: 1. Publications: 2.
Systemic application of the TRPV4 antagonist GSK2193874 induces tail vasodilation in a mouse model of thermoregulation
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Vasodilators and Anti-Oxidant Therapy in Early ATN
ClinicalTrials.gov study NCT00286403. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Predictive Value of Vasodilator Challenge for Right Heart Failure After LVAD Implantation
ClinicalTrials.gov study NCT05836233. IPD Sharing: NO. Countries: 1. Publications: 1.
Effects of Different Vasodilators on Coronary No-reflow During primAry percuTaneous Coronary intErvention in Patients With Acute Myocardial Infarction
ClinicalTrials.gov study NCT00712894. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Vasodilator and Exercise Study for DMD (VASO-REx)
ClinicalTrials.gov study NCT06290713. IPD Sharing: Not stated. Countries: 1. Publications: 65.
A Prospective Study to Evaluate the Effect of Chronic Nitrate Therapy on Vasodilation Function in Coronary Heart Disease
ClinicalTrials.gov study NCT01430780. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Lung Hyperinflation and Response to Pulmonary Vasodilator Therapy
ClinicalTrials.gov study NCT06613321. IPD Sharing: NO. Countries: 1. Publications: 1.
Effects of Pulmonary Vasodilation Upon VA Coupling in Fontan Patients
ClinicalTrials.gov study NCT01607983. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
A Study of Sotatercept for Patients With Eisenmenger Syndrome or Unrepaired Shunt-Associated Pulmonary Arterial Hypertension Resistant to Vasodilator Therapy
ClinicalTrials.gov study NCT07356778. IPD Sharing: NO. Countries: 1. Publications: 0.
ADenosine Vasodilator Independent Stenosis Evaluation II - ADVISE II
ClinicalTrials.gov study NCT01740895. IPD Sharing: Not stated. Countries: 8. Publications: 2.
Comparison of Cardiac Computed Tomography and Vasodilator Stress Magnetic Resonance Imaging Perfusion in Patients With Prior Equivocal Stress Test for Detection of Coronary Artery Disease
ClinicalTrials.gov study NCT00929227. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Impact of Ascorbic Acid Treatment on the Development and Treatment of Vasodilation in Cardiac Surgery
ClinicalTrials.gov study NCT03744702. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Polymorphisms in the Adenosine a2a Receptor Gene and AMPD2 Gene on Adenosine-Induced Vasodilation and Reactive Hyperemia
ClinicalTrials.gov study NCT00253929. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Annotated Behaviour and Observability Dataset (ABODe)
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