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1,647 results for “veins”
Leaf Vein Network CNN Results
<p>Results for leaf vein networks extracted using the LeafVeinCNN software package. The original image data set is available from Blonder et al. (2019) <a href="https://doi.org/10.1002/ecy.2844">https://doi.org/10.1002/ecy.2844</a>. The LeafVeinCNN software used in the analysis is available at <a href="https://doi.org/10.5281/zenodo.4007731"> </a><a href="https://doi.org/10.5281/zenodo.4007730">https://doi.org/10.5281/zenodo.4007730</a></p> <ul> <li>The Results_xxx.zip files contain all the Excel results spreadsheets separated by the code for each field site.</li> <li>results.xls provides a summary of all the network metrics for each file that was analysable</li> <li>Results_figures.pdf provides a summary image of the processing steps and results for each leaf segment</li> <li>Network_images.pdf contains a colour-coded image of each network superimposed on the leaf segment</li> <li>HLD_plots shows the binary tree following Hierarchical Network Decomposition</li> <li>PR_results.zip contains the Excel spreadsheets for evaluation of different enhancement methods for each leaf segment.</li> <li>PR_summary.xls provides a summary of the performance of each enhancement method.</li> <li>PR_F1_images.pdf and PR_FBeta2_images.pdf show the pixel classification for each enhancement and segmentation method compared to the manual ground-truth using two different optimum criteria (F1 and FBeta2).</li> <li>PR_fullwidth_plots show the full Precision-Recall plots for the full-width binary image compared to the manual ground-truth using the FBeta2 metric.</li> <li>PR_skeleton_plots show the full Precision-Recall plots for the skeletonised binary image compared to the manual ground-truth using the FBeta2 metric.</li> <li>PR_threshold_plots.pdf show how a set of network metrics vary with the segmentation threshold for each enhancement method.</li> </ul>
Hydrogen sulfide release via the ACE inhibitor Zofenopril prevents intimal hyperplasia in human vein segments and in a mouse model of carotid artery stenosis
<p>The current strategies to reduce intimal hyperplasia (IH) principally rely on local drug delivery, in endovascular approach. The oral angiotensin converting enzyme inhibitor (ACEi) Zofenopril has additional effects compared to other non-sulfyhydrated ACEi to prevent intimal hyperplasia and restenosis. Given the number of patients treated with ACEi worldwide, these findings call for further prospective clinical trials to test the benefits of sulfhydrated ACEi over classic ACEi for the prevention of restenosis in hypertensive patients.</p> <p>Abstract</p> <p>Objectives</p> <p>Hypertension is a major risk factor for intimal hyperplasia (IH) and restenosis following vascular and endovascular interventions. Pre-clinical studies suggest that hydrogen sulfide (H2S), an endogenous gasotransmitter, limits restenosis. While there is no clinically available pure H2S releasing compound, the sulfhydryl-containing angiotensin-converting enzyme inhibitor Zofenopril is a source of H2S. Here, we hypothesized that Zofenopril, due to H2S release, would be superior to other non-sulfhydryl containing angiotensin converting enzyme inhibitor (ACEi), in reducing intimal hyperplasia in the context of hypertension.</p> <p>Materials</p> <p>Spontaneously hypertensive male Cx40 deleted mice (Cx40-/-) or WT littermates were randomly treated with Enalapril 20 mg (Mepha Pharma) or Zofenopril 30 mg (Mylan SA). Discarded human vein segments and primary human smooth muscle cells (SMC) were treated with the active compound Enalaprilat or Zofenoprilat.</p> <p>Methods</p> <p>IH was evaluated in mice 28 days after focal carotid artery stenosis surgery and in human vein segments cultured for 7 days ex vivo. Human primary smooth muscle cell (SMC) proliferation and migration were studied in vitro.</p> <p>Results</p> <p>Compared to control animals (intima/media thickness=2.3±0.33), Enalapril reduced IH in Cx40-/- hypertensive mice by 30% (1.7±0.35; p=0.037), while Zofenopril abrogated IH (0.4±0.16; p<.0015 vs. Ctrl and p>0.99 vs. sham-operated Cx40-/-mice). In WT normotensive mice, enalapril had no effect (0.9665±0.2 in control vs 1.140±0.27; p>.99), while Zofenopril also abrogated IH (0.1623±0.07, p<.008 vs. Ctrl and p>0.99 vs. sham-operated WT mice). Zofenoprilat, but not Enalaprilat, also prevented intimal hyperplasia in human veins segments ex vivo. The effect of Zofenopril on carotid and SMC correlated with reduced SMC proliferation and migration. Zofenoprilat inhibited the MAPK and mTOR pathways in SMC and human vein segments.</p> <p>Conclusion</p> <p>Zofenopril provides extra beneficial effects compared to non-sulfhydryl ACEi to reduce SMC proliferation and restenosis, even in normotensive animals. These findings may hold broad clinical implications for patients suffering from vascular occlusive diseases and hypertension.</p>
Genome-wide association summary statistics for varicose veins of lower extremities
<p>The dataset contains summary statistics for the discovery and the replication stages of the large-scale genome-wide associations study for varicose veins of lower extremities. The discovery stage was based on genetic association data provided by the Neale Lab (<a href="https://vk.com/away.php?to=http%3A%2F%2Fwww.nealelab.is%2F&cc_key=">http://www.nealelab.is/</a>) for 337,199 UK biobank individuals. Phenotype “varicose veins of lower extremities” was defined based on International Classification of Disease (ICD-10) billing code “I83” present in the electronic patient record. Data were adjusted for two potential confounders – body mass index and deep venous thrombosis. A replication cohort (N=71,256) was generated by means of reverse meta-analysis of two overlapping datasets: genetic association data for 408,455 UK Biobank participants provided by the Gene ATLAS database (<a href="https://vk.com/away.php?to=http%3A%2F%2Fgeneatlas.roslin.ed.ac.uk%2F&cc_key=">http://geneatlas.roslin.ed.ac.uk/</a>), and the above mentioned data provided by the Neale Lab.</p> <p>Please, note, that in Shadrina et al (PLOS Genetics 2019) we only used "discovery" dataset, while in biorxiv preprint (https://doi.org/10.1101/368365) both discovery and replication datasets were used. </p> <p>The data are provided on an "AS-IS" basis, without warranty of any type, expressed or implied, including but not limited to any warranty as to their performance, merchantability, or fitness for any particular purpose. If investigators use these data, any and all consequences are entirely their responsibility. By downloading and using these data, you agree that you will cite the appropriate publication in any communications or publications arising directly or indirectly from these data; for utilisation of data available prior to publication, you agree to respect the requested responsibilities of resource users under 2003 Fort Lauderdale principles; you agree that you will never attempt to identify any participant. </p> <p><strong>When using downloaded data, please cite corresponding paper and this repository:</strong></p> <ol> <li> <p>Shadrina, A. S., Sharapov, S. Z., Shashkova, T. I. & Tsepilov, Y. A. Varicose veins of lower extremities: Insights from the first large-scale genetic study. <em>PLOS Genet.</em> <strong>15,</strong> e1008110 (2019).</p> </li> <li>Alexandra S. Shadrina, Sodbo Zh. Sharapov, Tatiana I. Shashkova, & Yakov A. Tsepilov. (2018). Genome-wide association summary statistics for varicose veins of lower extremities (Version 1) [Data set]. Zenodo. http://doi.org/10.5281/zenodo.1323484</li> </ol> <p><strong>Funding:</strong></p> <p>The work of ASS was supported by the Russian Science Foundation [Project No 17-75-20223]. <br> The work of YAT was supported by the Russian Ministry of Science and Education under the 5-100 Excellence Programme. <br> The work of SZS was supported by the Institute of Cytology and Genetics [Project No 0324-2018-0017].</p> <p><strong>Column headers - discovery</strong></p> <ol> <li>SNP: SNP rsID</li> <li>b: effect size of effect allele</li> <li>se: standard error of effect size</li> <li>chi2: T^2 value of effect allele</li> <li>Pval: P-value of association (without GC correction)</li> <li>N: sample size</li> <li>Chr: chromosome</li> <li>Pos: position (GRCh37 build)</li> <li>A1: effect allele (coded as "1")</li> <li>A2: reference allele (coded as "0")</li> </ol> <p><strong>Column headers - replication</strong></p> <ol> <li>SNP: SNP rsID</li> <li>A1: effect allele (coded as "1")</li> <li>A2: reference allele (coded as "0")</li> <li>N: Total sample size</li> <li>Z: Z-value of effect allele</li> <li>P: P-value of association (without GC correction)</li> </ol>
Fig. 1. Psilotreta daidalos Malicky 2000. A. Head, anterior view. B. Head, dorsal view. C. Maxillary palp. D. Wing veins. E. Male genitalia, left lateral view. F. Male genitalia, dorsal view. G. Male genitalia, ventral view. H. Phallus, left lateral view. I. Segment X, left lateral view. J. Parameres, ventral view. K in The Psilotreta Banks, 1899 of the Dabie Mountains, east central China, with descriptions of two new species (Insecta: Trichoptera: Odontoceridae)
Fig. 1. Psilotreta daidalos Malicky 2000. A. Head, anterior view. B. Head, dorsal view. C. Maxillary palp. D. Wing veins. E. Male genitalia, left lateral view. F. Male genitalia, dorsal view. G. Male genitalia, ventral view. H. Phallus, left lateral view. I. Segment X, left lateral view. J. Parameres, ventral view. K. Aedeagus, ventral view. Scale bars: A–C = 200 µm; D = 1 mm; E–K = 250 µm.
Text-fig. 8. Ulmaceae a–e, Rosaceae f–l. a: Cedrelospermum, leaflet missing base but showing simple teeth, UAPC-ALTA S 25748. b: Ulmus with prominent teeth, asymmetric base, BBM-PAL-P000015. c: Ulmus leaf with prominent teeth, UAPC-ALTA S 59506. d: Ulmus fruit, UAPC-ALTA S 6590. e: Basal half of Ulmus leaf showing the obtuse teeth with subbasal entry of veins to the teeth, UAPC-ALTA S 59517. f: cf. Rubus, UAPC-ALTA S 67691. g. Prunus leaf, UAPC-ALTA S 25746. h: cf. Hesperomeles UAPC-ALTA S 67692. i: Photinia pagae, UAPC-ALTA S 67693. j: cf. Prunus, detail from g. k: Rosaceous leaf, UAPC-ALTA S 59501. l: Rosaceae, possibly Kerriae. BBM-PAL-P000047. Scale bars: a, f, i, k, l = 2 cm; b–e, g, h, j = 1 cm. in The Early Eocene Flora Of Horsefly, British Columbia, Canada And Its Phytogeographic Significance
Text-fig. 8. Ulmaceae a–e, Rosaceae f–l. a: Cedrelospermum, leaflet missing base but showing simple teeth, UAPC-ALTA S 25748. b: Ulmus with prominent teeth, asymmetric base, BBM-PAL-P000015. c: Ulmus leaf with prominent teeth, UAPC-ALTA S 59506. d: Ulmus fruit, UAPC-ALTA S 6590. e: Basal half of Ulmus leaf showing the obtuse teeth with subbasal entry of veins to the teeth, UAPC-ALTA S 59517. f: cf. Rubus, UAPC-ALTA S 67691. g. Prunus leaf, UAPC-ALTA S 25746. h: cf. Hesperomeles UAPC-ALTA S 67692. i: Photinia pagae, UAPC-ALTA S 67693. j: cf. Prunus, detail from g. k: Rosaceous leaf, UAPC-ALTA S 59501. l: Rosaceae, possibly Kerriae. BBM-PAL-P000047. Scale bars: a, f, i, k, l = 2 cm; b–e, g, h, j = 1 cm.
Text-fig. 9. Miscellaneous leaves. a: Leaf of Anacardiaceae, UAPC-ALTA S 59513. b: Sapindaceous leaf, BBM-PAL-P000046. c: Twig with compound leaves of Averrhoites affinis, UAPC-ALTA S 67694. d, e: cf. Morus. Finely serrate leaf with actinodromous venation, prominent agrophic veins and strongly percurrent tertiary veins, UAPC-ALTA S 67695. f: Leaf with strongly apically arched upper pairs of secondary veins and entire margins, UAPC-ALTA S 59504. g: Compound leaf, UAPC-ALTA S 59504A. h: Detail of (g) showing one leaflet. i: Incomplete basal part of a lamina with rounded base and entire margin, UAPC-ALTA S 6565. j: Compound leaf with leaflets sessile on a stout rachis, UAPC-ALTA sn. Scale bars: a, c, d, i = 2 cm, b, e–h, j = 1 cm. in The Early Eocene Flora Of Horsefly, British Columbia, Canada And Its Phytogeographic Significance
Text-fig. 9. Miscellaneous leaves. a: Leaf of Anacardiaceae, UAPC-ALTA S 59513. b: Sapindaceous leaf, BBM-PAL-P000046. c: Twig with compound leaves of Averrhoites affinis, UAPC-ALTA S 67694. d, e: cf. Morus. Finely serrate leaf with actinodromous venation, prominent agrophic veins and strongly percurrent tertiary veins, UAPC-ALTA S 67695. f: Leaf with strongly apically arched upper pairs of secondary veins and entire margins, UAPC-ALTA S 59504. g: Compound leaf, UAPC-ALTA S 59504A. h: Detail of (g) showing one leaflet. i: Incomplete basal part of a lamina with rounded base and entire margin, UAPC-ALTA S 6565. j: Compound leaf with leaflets sessile on a stout rachis, UAPC-ALTA sn. Scale bars: a, c, d, i = 2 cm, b, e–h, j = 1 cm.
Text-fig. 4. Monocots. a, b: Large monocot leaf part and counterpart, UAPC-ALTA S 17955A, B. a: Wide leaf showing entire margin at left. b: Counterpart showing dark wide midrib, and and secondaries parallel to one another, arising at low acute angle. c–e: Monocot leaf with parallel venation. c: Overview of elongate monocot leaf with parallel veins horizontal and linear to oval structures and smaller leaf fragment of same type lacking them (at lower right), UAPC-ALTA S 59491. d: Higher magnification of the smaller fragment with weak cross veins. e: Higher magnification of larger specimen with linear to oval structures between parallel veins. f, g: Monocot leaf with parallel venation. Fig. (f) shows higher magnification and (g) shows overview, BBM-PAL-P000009. Scale bars: a, b = 5 cm, c = 4 cm, d–f = 1 cm, g = 2 cm. in The Early Eocene Flora Of Horsefly, British Columbia, Canada And Its Phytogeographic Significance
Text-fig. 4. Monocots. a, b: Large monocot leaf part and counterpart, UAPC-ALTA S 17955A, B. a: Wide leaf showing entire margin at left. b: Counterpart showing dark wide midrib, and and secondaries parallel to one another, arising at low acute angle. c–e: Monocot leaf with parallel venation. c: Overview of elongate monocot leaf with parallel veins horizontal and linear to oval structures and smaller leaf fragment of same type lacking them (at lower right), UAPC-ALTA S 59491. d: Higher magnification of the smaller fragment with weak cross veins. e: Higher magnification of larger specimen with linear to oval structures between parallel veins. f, g: Monocot leaf with parallel venation. Fig. (f) shows higher magnification and (g) shows overview, BBM-PAL-P000009. Scale bars: a, b = 5 cm, c = 4 cm, d–f = 1 cm, g = 2 cm.
Giant Quartz Veins of the Pyrenees Database - Full Dataset (ESRI Shapefile)
<p>The <strong>GIVEPY Database</strong> (GIant quartz VEins of the PYrenees) is an interactive tool that incorporates information of the geometry, distribution, statistics, and host rock types of 741 giant quartz veins that crop out in the fold and thrust belt of the Pyrenees. The GIVEPY Database follows the <strong>FAIR </strong>principles of data management (Findable, Accessible, Interoperable and Reusable) and is available at: <a href="https://givepy.info/">https://givepy.info/</a>.</p> <p>The Full Dataset consists of a ESRI Shapefile where the giant quartz veins of the Pyrenees are mapped following polygon superposition rules. The <em>.shp</em> file can be opened in any Geographic Information System (GIS) environment. We recommend the use of the <strong>QGIS</strong> software since it is open access and continuously updated.</p> <p>The original CRS is:</p> <p>EPSG: 32631 / WGS1984 - UTM Z31N</p> <p>Do not hesitate to contact Eloi González-Esvertit if you have any questions: e.gonzalez-esvertit@ub.edu</p>
Giant Quartz Veins of the Pyrenees Database - Full Dataset (MSExcel Spreadsheet)
<p>The <strong>GIVEPY Database</strong> (GIant quartz VEins of the PYrenees) is an interactive tool that incorporates information of the geometry, distribution, statistics, and host rock types of 741 giant quartz veins that crop out in the fold and thrust belt of the Pyrenees. The GIVEPY Database follows the <strong>FAIR </strong>principles of data management (Findable, Accessible, Interoperable and Reusable) and is available at: <a href="https://givepy.info/">https://givepy.info/</a>.</p> <p>The Full Dataset consists of a ESRI Shapefile where the giant quartz veins of the Pyrenees are mapped following polygon superposition rules. The <em>.shp</em> file can be opened in any Geographic Information System (GIS) environment. We recommend the use of the <strong>QGIS</strong> software since it is open access and continuously updated.</p> <p>The original CRS is:</p> <p>EPSG: 32631 / WGS1984 - UTM Z31N</p> <p>Do not hesitate to contact Eloi González-Esvertit if you have any questions: e.gonzalez-esvertit@ub.edu</p>
Long read proteogenomics to characterize protein isoform diversity in human umbilical vein endothelial cells (HUVECs)
<p>Endothelial cells (ECs) comprise the lumenal lining of all blood vessels and are critical for the functioning of the cardiovascular system and their phenotypes can be modulated by protein isoforms. To characterize the isoform landscape within EC, we applied a long read proteogenomics approach to analyze human umbilical vein endothelial cells (HUVECs). Transcripts delineated from PacBio sequencing serve as the basis for a sample-specific protein database used for downstream MS analysis to infer protein isoform expression. We detected 53,836 transcript isoforms from 10,426 genes, with 22,195 of those transcripts being novel. Furthermore, the predominant isoform in HUVECs does not correspond with the accepted “reference isoform” 25% of the time, with vascular pathway-related genes among this group. We found 2,597 protein isoforms supported through unique peptides, with an additional 2,280 isoforms nominated upon incorporation of long-read transcript evidence. We characterized a novel alternative acceptor for endothelial-related gene <em>CDH5</em>, suggesting potential changes in its associated signaling pathways. Finally, we identified novel protein isoforms arising from a diversity of splicing mechanisms supported by uniquely mapped novel peptides. Our results represent a high resolution atlas of known and novel isoforms of potential relevance to endothelial phenotypes and function.</p>
Increases in vein length compensate for leaf area lost to lobing in grapevine
<p><span></span></p> <p>There is considerable variation in leaf lobing and leaf size, including among grapevines, some of the most well-studied leaves. We examined the relationship between leaf lobing and leaf size across grapevine populations which varied in extent of leaf lobing. We used homologous landmarking techniques to measure 2,632 leaves across two years in 476 unique, genetically distinct grapevines from 5 biparental crosses which vary primarily in the extent of lobing. We determined to what extent leaf area could explain variation in lobing, vein length, and vein to blade ratio. Although lobing was the primary source of variation in shape across the leaves we measured, leaf area varied only slightly as a function of lobing. Rather, leaf area increases as a function of total major vein length, total branching vein length, and decreases as a function of vein to blade ratio. These relationships are stronger for more highly lobed leaves, with the residuals for each model differing as a function of distal lobing. For a given leaf area, more highly lobed leaves have longer veins and higher vein to blade ratios, allowing them to maintain similar leaf areas despite increased lobing. These findings show how more highly lobed leaves may compensate for what would otherwise result in a reduced leaf area, allowing for increased photosynthetic capacity through similar leaf size.</p>
Fig. 18 in Costal vein chaetotaxy, a neglected character source in Fanniidae and Muscidae (Diptera: Calyptratae)
Fig. 18. ♀♀ of Coenosia Meigen, 1826. A. C. intermedia (Fallén, 1825), wing, ventral view. B. Same, detail of wing showing CS1‒3, ventral view. C. Same, detail of wing showing CS1‒3, dorsal view. D. C. emiliae Lukasheva, 1986, detail of wing showing CS1‒3, dorsal view.
Fig. 17 in Costal vein chaetotaxy, a neglected character source in Fanniidae and Muscidae (Diptera: Calyptratae)
Fig. 17. ♀ of Thaumasiochaeta Stein, 1911. A. Wing, dorsal view. B. Detail of wing showing CS1‒2, dorsal view.
Fig. 15 in Costal vein chaetotaxy, a neglected character source in Fanniidae and Muscidae (Diptera: Calyptratae)
Fig. 15. ♀♀ of Muscidae Latreille, 1802. A. Myospila bimaculata (Macquart, 1834), detail of wing showing CS1–3, dorsal view. B. Mydaea ancilla (Meigen, 1826), detail of wing showing CS1–3, dorsal view. C. M. affinis Meade, 1891, detail of wing showing CS1–3, dorsal view.
Fig. 16 in Costal vein chaetotaxy, a neglected character source in Fanniidae and Muscidae (Diptera: Calyptratae)
Fig. 16. ♀♀ of Muscidae Latreille, 1802. A. Hebecnema umbratica (Meigen, 1826), detail of wing showing CS1–3, dorsal view. B. H. nigricolor (Fallén, 1825), detail of wing showing CS1–3, dorsal view. C. Gymnodia subtilis (Stein, 1909), detail of wing showing CS1–3, ventral view.
Fig. 12 in Costal vein chaetotaxy, a neglected character source in Fanniidae and Muscidae (Diptera: Calyptratae)
Fig. 12. ♀♀ of Muscidae Latreille, 1802. A. Muscina stabulans (Fallén, 1823), detail of wing showing CS1‒3, dorsal view. B. Palpibracus trivittatus (Malloch, 1934), detail of wing showing CS1‒3, dorsal view.
Fig. 14 in Costal vein chaetotaxy, a neglected character source in Fanniidae and Muscidae (Diptera: Calyptratae)
Fig. 14. ♀♀ of Phaonia Robineau-Desvoidy, 1830. A. P. angelicae (Scopoli, 1763), detail of wing showing CS1‒3, dorsal view. B. P. palpata (Stein, 1897), detail of wing showing CS1‒3, dorsal view. C. P. rufiventris (Scopoli, 1763), detail of wing showing CS1‒3, dorsal view. D. P. canescens Stein, 1916, detail of wing showing CS1‒3, dorsal view.
Fig. 11. Atherigona orientalis Schiner, 1868 in Costal vein chaetotaxy, a neglected character source in Fanniidae and Muscidae (Diptera: Calyptratae)
Fig. 11. Atherigona orientalis Schiner, 1868, ♀. A. Wing, ventral view. B. Detail of wing showing CS1‒3, ventral view.
Fig. 10 in Costal vein chaetotaxy, a neglected character source in Fanniidae and Muscidae (Diptera: Calyptratae)
Fig. 10. ♀♀ of Polietes Rondani, 1866. A. P. domitor (Harris, 1780), wing, ventral view. B. Same, detail of wing showing CS1‒2, ventral view. C. P. lardarius (Fabricius, 1781), detail of wing showing CS1‒2, ventral view.
Fig. 8 in Costal vein chaetotaxy, a neglected character source in Fanniidae and Muscidae (Diptera: Calyptratae)
Fig. 8. ♀♀ of Musca Linnaeus, 1758. A. M. domestica Linnaeus, 1758, detail of wing showing CS1‒3, ventral view. B. M. sorbens Wiedemann, 1830, detail of wing showing CS1‒3, ventral view. C. M. vitripennis Meigen, 1826, detail of wing showing CS1‒3, ventral view.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.