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67 results for “vestibular schwannoma”
Identification of immune-related candidate biomarkers in plasma of patients with sporadic vestibular schwannoma
<p>Vestibular schwannoma (VS) is an intracranial tumor arising from neoplastic Schwann cells, and typically presenting with hearing loss. The traditional belief that hearing deficit is caused by physical expansion of the VS, compressing the auditory nerve, does not explain the common clinical finding that patients with small tumors can have profound hearing loss, suggesting that tumor-secreted factors could influence hearing ability in VS patients. We conducted profiling of patients' plasma for 66 immune-related factors in patients with sporadic VS (N>170) and identified and validated candidate biomarkers associated with tumor size (S100B) and hearing (MCP-3). We further identified a 9-biomarker panel (TNR-R2, MIF, CD30, MCP-3, IL-2R, BLC, TWEAK, eotaxin, S100B) with outstanding discriminatory ability for VS. These findings revealed possible therapeutic targets for VS, providing a unique diagnostic tool that may predict hearing change and tumor growth in VS patients, and may inform the timing of tumor resection to preserve hearing.</p>
Bevacizumab for Symptomatic Vestibular Schwannoma in Neurofibromatosis Type 2 (NF2)
ClinicalTrials.gov study NCT01207687. IPD Sharing: NO. Countries: 1. Publications: 1.
Vestibular Rehabilitation Protocol in Unilateral Vestibular Schwannoma
ClinicalTrials.gov study NCT07364955. IPD Sharing: YES. Countries: 1. Publications: 4.
Exploratory Evaluation of AR-42 Histone Deacetylase Inhibitor in the Treatment of Vestibular Schwannoma and Meningioma
ClinicalTrials.gov study NCT02282917. IPD Sharing: NO. Countries: 1. Publications: 2.
Microscopic Fluorescence-guided Vestibular Schwannoma Resection Using Fluorescein Sodium and YELLOW 560
ClinicalTrials.gov study NCT04351373. IPD Sharing: NO. Countries: 1. Publications: 1.
Identification of immune-related candidate biomarkers in plasma of patients with sporadic vestibular schwannoma
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Data from: High-dimensional imaging of vestibular schwannoma reveals distinctive immunological networks across histomorphic niches in NF2-related schwannomatosis
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Seurat objects for "Single-cell multi-omic analysis of the vestibular schwannoma ecosystem uncovers a nerve injury-like state" (https://doi.org/10.1038/s41467-023-42762-w)
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Evaluating Pre-Treatment Vestibular Physical Therapy Rehab for Patients with Vestibular Schwannomas
ClinicalTrials.gov study NCT05702749. IPD Sharing: NO. Countries: 1. Publications: 3.
Gamma Knife Radiosurgery vs Initial Conservative Treatment for Vestibular Schwannoma Patients With Preserved Hearing, a Prospective Randomized Study
ClinicalTrials.gov study NCT01938677. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Use of Virtual Reality in Rehabilitation in Patients After Vestibular Schwannoma Surgery.
ClinicalTrials.gov study NCT05578560. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Vestibular Evaluation After Vestibular Schwannoma Treatment
ClinicalTrials.gov study NCT03670589. IPD Sharing: NO. Countries: 1. Publications: 4.
Mapping of Vestibular Centers Activation Using fMRI in Patients With Vestibular Schwannoma
ClinicalTrials.gov study NCT07130851. IPD Sharing: YES. Countries: 1. Publications: 2.
Simultaneous Cochlear Implantation During Translabyrinthine Resection of Vestibular Schwannoma
ClinicalTrials.gov study NCT03958006. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma
ClinicalTrials.gov study NCT01199978. IPD Sharing: Not stated. Countries: 1. Publications: 1.
RGD PET/MRI in Sporadic Vestibular Schwannoma
ClinicalTrials.gov study NCT03393689. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of RAD001 for Treatment of NF2-related Vestibular Schwannoma
ClinicalTrials.gov study NCT01345136. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Role of Psychiatric Profile in Prehabituated Patients After Vestibular Schwannoma Surgery
ClinicalTrials.gov study NCT03638310. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Use of DTT to Define Facial Nerve Position in Vestibular Schwannomas
ClinicalTrials.gov study NCT04057976. IPD Sharing: NO. Countries: 1. Publications: 9.
Efficacy and Safety Study of RAD001 in the Growth of the Vestibular Schwannoma(s) in Neurofibromatosis 2 (NF2) Patients
ClinicalTrials.gov study NCT01490476. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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