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ShareScore release 0.9.0
Dataset results
27 results for “viral vectors”
Data from: Pliant pathogens: estimating viral spread when confronted with new vector, host, and environmental conditions
<p>1. Pathogen spread rates are determined, in part, by the performance of pathogens under altered environmental conditions and their ability to persist while switching among hosts and vectors.</p> <p>2. To determine the effects of new conditions (host, vector, and nutrient) on pathogen spread rate, we introduced a vector-borne, viral plant pathogen, Barley Yellow Dwarf Virus PAV (BYDV-PAV) into hosts, vectors, and host nutrient supplies that it had not encountered for thousands of viral generations. We quantified pathogen prevalence over the course of two serial inoculations under the new conditions. Using individual level transmission rates from this experiment, we parameterized a dynamical model of disease spread and projected spread across host populations through a growing season. </p> <p>3. A change in nutrient conditions (increased supply of phosphorus) reduced viral transmission whereas shifting to a new vector or host species had no effect on infection prevalence. However, the reduction in the new nutrient environment was only temporary; infection prevalence recovered after the second inoculation.</p> <p><i>4. Synthesis</i>. These results highlight how robust the pathogen, BYDV-PAV, is to changes in its biotic and abiotic environment. Our study also highlights the need to quantify longitudinal infection information beyond snapshot assessments to project disease risk for pathogens in new environments.</p>
Raw data to: "Vectored antibody gene delivery restores host B and T cell control of persistent viral infection"
<p>Raw data underlying the publication by Ertuna et al. entitled "Vectored antibody gene delivery restores host B and T cell control of persistent viral infection"</p>
Data from: Pliant pathogens: Estimating viral spread when confronted with new vector, host, and environmental conditions
Open the record for dataset details and reuse information.
Data from Pliant pathogens: Estimating viral spread when confronted with new vector, host, and environmental conditions
To determine the effects of new conditions (host, vector, and nutrient) on pathogen spread rate, we introduced a vector-borne viral plant pathogen, Barley Yellow Dwarf Virus PAV (BYDV-PAV) into hosts, vectors, and host nutrient supplies that it had not encountered for thousands of viral generations. We quantified pathogen prevalence over the course of two serial inoculations under the new conditions.
Contrasting impacts of a novel specialist vector on multi-host viral pathogen epidemiology in wild and managed bees
<p>Typically pathogens infect multiple host species. Such multi-host pathogens can show considerable variation in their degree of infection and transmission specificity, which has important implications for potential disease emergence. Transmission of multi-host pathogens can be driven by key host species and changes in such transmission networks can lead to disease emergence. We study two viruses that show contrasting patterns of prevalence and specificity in managed honeybees and wild bumblebees, black queen cell virus (BQCV) and slow bee paralysis virus (SBPV), in the context of the novel transmission route provided by the virus-vectoring <i>Varroa destructor</i>. Our key result is that viral communities and RNA virus genetic variation are structured by location, not host species or <i>V. destructor</i> presence. Interspecific transmission is pervasive with the same viral variants circulating between pollinator hosts in each location; yet, we find virus-specific host differences in prevalence and viral load. Importantly, <i>V. destructor </i>presence increases the prevalence in honeybees and, indirectly, in wild bumblebees, but in contrast to its impact on deformed wing virus (DWV), BQCV and SBPV viral loads are not increased by <i>Varroa </i>presence, and do not show genetic evidence of recent emergence. Effective control of <i>Varroa</i> in managed honeybee colonies is necessary to mitigate further disease emergence, and alleviate disease pressure on our vital wild bee populations. More generally, our results highlight the over-riding importance of geographical location to the epidemiological outcome despite the complexity of multi-host-parasite interactions.</p>
Dose-Escalation Study Of A Self Complementary Adeno-Associated Viral Vector For Gene Transfer in Hemophilia B
ClinicalTrials.gov study NCT00979238. IPD Sharing: Not stated. Countries: 2. Publications: 3.
Adjuvanting Viral Vectored Malaria Vaccines With Matrix M
ClinicalTrials.gov study NCT01669512. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety of a Single Administration of AAV2hAQP1, an Adeno-Associated Viral Vector Encoding Human Aquaporin-1 to One Parotid Salivary Gland in People With Irradiation-Induced Parotid Salivary Hypofuncti
ClinicalTrials.gov study NCT02446249. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Efficacy and Safety of Human Lipoprotein Lipase (LPL)[S447X] Expressed by an Adeno-Associated Viral Vector in LPL-deficient Subjects
ClinicalTrials.gov study NCT00891306. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Safety and Efficacy in LPL-Deficient Subjects of AMT-011, an Adeno-Associated Viral Vector Expressing Human Lipoprotein Lipase [S447X]
ClinicalTrials.gov study NCT01109498. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Contrasting impacts of a novel specialist vector on multi-host viral pathogen epidemiology in wild and managed bees
Open the record for dataset details and reuse information.
Inverse design of viral infectivity-enhancing peptide fibrils from continuous protein-vector embeddings
<p>The Tables S3 - S5 are a supplement for the article "Inverse design of viral infectivity-enhancing peptide fibrils from continuous protein-vector embeddings" uploaded as a Preprint in ChemRxiv DOI: 10.26434/chemrxiv-2023-1kqm3</p>
Safety, Efficacy, Immunogenicity Study of GSK Biologicals' HBV Viral Vector and Adjuvanted Proteins Vaccine (GSK3528869A) in Adult Patients With Chronic Hepatitis B Infection
ClinicalTrials.gov study NCT03866187. IPD Sharing: YES. Countries: 9. Publications: 0.
A Study to Investigate the Safety, Tolerability, and Efficacy of SAR446268, an Adeno-associated Viral Vector-mediated Gene Therapy in Participants Aged 10 to 50 Years of Age With Non-congenital Myoton
ClinicalTrials.gov study NCT06844214. IPD Sharing: YES. Countries: 6. Publications: 0.
A Phase 1/2 Study of SHP648, an Adeno-Associated Viral Vector for Gene Transfer in Hemophilia B Subjects
ClinicalTrials.gov study NCT04394286. IPD Sharing: NO. Countries: 2. Publications: 0.
Viral and transgene-free human induced pluripotent stem (iPS) cells using non-integrating Sendai virus (SeV) vectors.
GEO Series GSE24240. Homo sapiens. 19 samples. Type: Expression profiling by array.
Analysis of the global gene expression in the rat hearts transduced with adeno-associated viral vectors coding VEGF-B
GEO Series GSE38455. Rattus norvegicus. 12 samples. Type: Expression profiling by array.
Study of the Safety and Efficacy of an Adeno-Associated Viral Vector Carrying the SMN Gene After a Single Intravenous Administration of Escalating Doses in Children With Spinal Muscular Atrophy (BLUEB
ClinicalTrials.gov study NCT05747261. IPD Sharing: NO. Countries: 2. Publications: 0.
Clinical Study of the Safety and Immunogenicity of a Recombinant Viral Vector AAV5 (Adeno-Associated Virus Type 5 )-RBD (Receptor Binding Domain)-S Vaccine for the Prevention of Coronavirus Infection
ClinicalTrials.gov study NCT05037188. IPD Sharing: NO. Countries: 1. Publications: 0.
Commensal-driven serotonin production modulates in vivo delivery of synthetic and viral vectors
GEO Series GSE315035. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.