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Dataset results
264 results for “virology”
Raw data accompanying the manuscript "Cost-effective high-speed, three-dimensional live-cell imaging of HIV-1 transfer at the T cell virological synapse"
<p>These are the raw datasets used to generate the figures for the manuscript entitled "Cost-effective high-speed, three-dimensional live-cell imaging of HIV-1 transfer at the T cell virological synapse". The data files are 3D image stacks of a custom-built wide field deconvolution fluorescence microscope (.tif) and super-resolution structured illumination microscopy data (.dv) of Jurkat T cells transferring HIV-1 virus particles to previously uninfected primary T cells.</p>
Forensic examination of Wuhan Institute of Virology COVID-19 patient specimens from December 2019 reveals gross contamination of the laboratory, including undisclosed research on a lethal BSL-4 pathogen
<p>A Zenodo pre-print entitled, “CONTAMINATION OR VACCINE RESEARCH? RNA Sequencing data of early COVID-19 patient samples show abnormal presence of vectorized H7N9 hemagglutinin segment” has been published. In the paper, a forensic examination of the sequencing data from five COVID-19 bronchial lavage patient specimens reveals that the laboratory at the Wuhan Institute of Virology (WIV) was contaminated with a wide range of viruses, including the Nipah virus, a BSL-4 pathogen with a lethality of 50% to 92%. A video summary of the paper can be found here.</p> <p>The highlights of the paper are:</p> <ul> <li>Five patient specimens were sequenced by the WIV in December 2019 and were part of an early report on SARS-CoV-2 published by Dr. Zhengli Shi and colleagues (Nature 579, 270–273 (2020). This paper has been viewed over one million times, making it one of the most highly read paper on the pandemic virus.</li> <li>The most abundant contaminant is an undisclosed H7N9 influenza vaccine, which in one specimen is over six-times as abundant as SARS-CoV-2.</li> <li>The Nipah virus gene sequences were found in infectious cloning vectors of the type used for genetic manipulation.</li> <li>Nineteen other contaminants, including Japanese Encephalitis virus, HIV, human T-cell leukemia virus, and hepatitis delta virus were found.</li> </ul> <p>It is important to investigate why the Wuhan Institute of Virology was extensively contaminated in December 2019 as well as learn more about the undisclosed Influenza Vaccine research and Nipah virus cloning experiments. </p> <p>The Zenodo pre-print can be found here: https://zenodo.org/record/5067706#.YPtyyI4zbOg</p>
COVID-19 Study Assessing the Virologic Efficacy of REGN10933+REGN10987 Across Different Dose Regimens in Adult Outpatients With SARS-CoV-2 Infection
ClinicalTrials.gov study NCT04666441. IPD Sharing: YES. Countries: 1. Publications: 3.
Switch Study to Evaluate F/TAF in HIV-1 Infected Adults Who Are Virologically Suppressed on Regimens Containing ABC/3TC
ClinicalTrials.gov study NCT02469246. IPD Sharing: YES. Countries: 12. Publications: 2.
A Study of JNJ-73763989, JNJ-56136379, Nucleos(t)Ide Analogs, and Pegylated Interferon Alpha-2a in Virologically Suppressed Participants With Chronic Hepatitis B Virus Infection
ClinicalTrials.gov study NCT04667104. IPD Sharing: YES. Countries: 4. Publications: 1.
Switch Study to Evaluate the Safety and Efficacy of Emtricitabine/Rilpivirine/Tenofovir Alafenamide (FTC/RPV/TAF) Fixed Dose Combination (FDC) in HIV-1 Positive Adults Who Are Virologically Suppressed
ClinicalTrials.gov study NCT02345252. IPD Sharing: YES. Countries: 12. Publications: 2.
A Phase IIb Study to Evaluate a Long-Acting Intramuscular Regimen for Maintenance of Virologic Suppression (Following Induction With an Oral Regimen of GSK1265744 and Abacavir/Lamivudine) in Human Imm
ClinicalTrials.gov study NCT02120352. IPD Sharing: YES. Countries: 5. Publications: 6.
Safety and Efficacy of Switching From Dolutegravir and ABC/3TC or ABC/DTG/3TC to B/F/TAF in HIV-1 Infected Adults Who Are Virologically Suppressed
ClinicalTrials.gov study NCT02603120. IPD Sharing: YES. Countries: 10. Publications: 5.
Phase 1, Open-label, Single Dose Study to Examine Safety, Tolerability, Pharmacokinetics and Virologic Impact of VRC01LS or VRC07-523LS in HIV-infected Viremic Adults
ClinicalTrials.gov study NCT02840474. IPD Sharing: NO. Countries: 2. Publications: 4.
Regimen Switch to Dolutegravir/Lamivudine Fixed Dose Combination From Current Antiretroviral Regimen in HIV-1 Infected and Virologically Suppressed Adults (SALSA)
ClinicalTrials.gov study NCT04021290. IPD Sharing: YES. Countries: 17. Publications: 5.
Study to Evaluate the Safety and Efficacy of Teropavimab and Zinlirvimab in Combination With Lenacapavir in Virologically Suppressed Adults With HIV-1 Infection
ClinicalTrials.gov study NCT04811040. IPD Sharing: NO. Countries: 1. Publications: 3.
A Study of Teropavimab and Zinlirvimab in Combination With Capsid Inhibitor Lenacapavir in Virologically Suppressed Adults With HIV-1 Infection
ClinicalTrials.gov study NCT05729568. IPD Sharing: NO. Countries: 4. Publications: 0.
Study to Evaluate Switching From a TDF-Containing Combination Regimen to a TAF-Containing Fixed Dose Combination (FDC) in Virologically-Suppressed, HIV-1 Positive Participants
ClinicalTrials.gov study NCT01815736. IPD Sharing: YES. Countries: 20. Publications: 6.
Switch Study to Evaluate Dolutegravir Plus Lamivudine in Virologically Suppressed Human Immunodeficiency Virus Type 1 Positive Adults (TANGO)
ClinicalTrials.gov study NCT03446573. IPD Sharing: YES. Countries: 10. Publications: 10.
A Registry for Participants With Cirrhosis Who Achieve a Sustained Virologic Response Following Treatment With a Sofosbuvir-Based Regimen Without Interferon for Chronic Hepatitis C Infection
ClinicalTrials.gov study NCT02292706. IPD Sharing: YES. Countries: 10. Publications: 2.
Regimen Switch to Dolutegravir + Rilpivirine From Current Antiretroviral Regimen in Human Immunodeficiency Virus Type 1 Infected and Virologically Suppressed Adults (SWORD-2)
ClinicalTrials.gov study NCT02422797. IPD Sharing: YES. Countries: 11. Publications: 3.
A Trial of 2 Options for Second Line Combination Antiretroviral Therapy Following Virological Failure of a Standard Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI)+2N(t)RTI First Line Regimen
ClinicalTrials.gov study NCT00931463. IPD Sharing: Not stated. Countries: 17. Publications: 4.
A Switch to Doravirine/Islatravir (DOR/ISL) in Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Who Are Virologically Suppressed on Antiretroviral Therapy (ART) (MK-8591A-051)
ClinicalTrials.gov study NCT05631093. IPD Sharing: YES. Countries: 8. Publications: 1.
DRIVESHAFT: Darunavir/Ritonavir In HIV-infected Virologically-suppressed Experienced Subjects
ClinicalTrials.gov study NCT01423812. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Switch to Doravirine/Islatravir (DOR/ISL) in Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Who Are Virologically Suppressed on Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FT
ClinicalTrials.gov study NCT05630755. IPD Sharing: YES. Countries: 6. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.