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236 results for “vitamin A deficiency”
Dataset related to the manuscript entitled "Inhalation with Vitamin D3 Metabolites - A Novel Strategy to Restore Vitamin D3 Deficiencies in Lung Tissue"
<p><strong>The dataset contains the results presented in the manuscript entitled "Inhalation with Vitamin D3 Metabolites - A Novel Strategy to Restore Vitamin D3 Deficiencies in Lung Tissue" Appl. Sci. 2023, 13, 10672. </strong></p><p> </p><p>The presented dataset contains the results of the implementation of the following research project: </p><p><i>Project title</i><strong>:</strong> "Assessment of the possibility of using vitamin D3 in the prevention and treatment of pulmonary fibrosis in the course of hypersensitivity pneumonitis - <i>in vivo</i> studies"</p><p><i>Founder</i><strong>: </strong>National Scientific Center, Poland</p><p><i>Project number</i><strong>:</strong> UMO-2020/38/E/NZ7/00366</p><p><i>Principal Investigator</i>: Marta Kinga Lemieszek</p><p><i>Main investigators:</i><strong> </strong>Michał Chojnacki, Jakub Anisiewicz, Ilona Leśniowska</p><p><i>Place of project implementation</i><strong>:</strong> Department of Medical Biology, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland</p>
Vitamin D deficiency and SARS‑CoV‑2 infection: D-COVID study
<p>D-COVID is a proyect to study the association between COVID-19 infection and vitamin D deficiency in patients of a terciary university hospital. To investigate the clinical evolution and prognosis of patients with COVID-19 and vitamin D deficiency, several queries qere launched into a Database containing plain text apparitions of certain terms in medical reports, as well as structured data. These apparitions were detected using NLP technology, and then saved individually in a database. The presented dataset is a bounded version of such database, containing only relevant data to the one extracted for the associated study. As for the strcture of the dataset, each row represents an apparition of a term in plain text, and the columns contain additional information.</p> <p><strong>- reportdate</strong>: date of the report where the term appears up.</p> <p><strong>- admission_days:</strong> strctured data days in hospitalization, if any.</p> <p><strong>- patient_id</strong>: anonymized patient identifier</p> <p><strong>- sex</strong>: patient sex (1=male, 2=female)</p> <p><strong>-birthdate</strong>: patient birthdate</p> <p><strong>- service</strong>: Service where the report was generated</p> <p><strong>- report_type:</strong> Type of report generated (either a discharge report, note, etc)</p> <p><strong>- record</strong>: unique identifier for the report itself</p> <p><strong>- term</strong>: term (that was read (NLP takes synonims and acronyms into account)</p> <p><strong>- exitus</strong>: medical exitus, if available in structured data, it could also be found in plan text in the previous column.</p>
Vitamin B12 deficiency anaemia and gestational diabetes mellitus: a two-sample Mendelian randomization study
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Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency
<p>Vitamin B12 is critical for hematopoiesis and myelination. Deficiency can cause neurologic deficits including loss of coordination and cognitive decline. However, diagnosis relies on vitamin B12 measurement in the blood which may not accurately reflect levels in the brain. Using programmable phage display, we identified an autoantibody targeting the transcobalamin receptor (CD320) in a patient with progressive tremor, ataxia, and scanning speech. Anti-CD320 impaired cellular uptake of cobalamin (B12) <em>in vitro</em>. Despite normal serum levels, B12 was nearly undetectable in her cerebrospinal fluid (CSF). Immunosuppressive treatment and high-dose systemic B12 supplementation were associated with increased CSF B12 levels and clinical improvement. Optofluidic screening enabled rapid isolation of a patient-derived monoclonal antibody that impaired B12 transport across an <em>in vitro</em> model of the blood-brain barrier. Autoantibodies targeting the same epitope of CD320 were identified in 7 other patients with neurologic deficits of unknown etiology, in 6% of healthy controls, and in 21.4% of a neuropsychiatric lupus cohort. In 132 paired serum and CSF samples, detection of anti-CD320 in the blood predicted B12 deficiency in the brain. However, these individuals did not display any hematologic signs of B12 deficiency despite systemic CD320 impairment. Using a genome-wide CRISPR screen, we discovered that the LDL receptor serves as an alternative B12 uptake pathway in hematopoietic cells. These findings dissect the tissue-specificity of B12 transport and elucidate an autoimmune neurologic condition that may be amenable to immunomodulatory treatment and nutritional supplementation.</p>
Vitamin D to Improve Outcomes by Leveraging Early Treatment: Long-term Brain Outcomes in Vitamin D Deficient Patients
ClinicalTrials.gov study NCT03733418. IPD Sharing: YES. Countries: 1. Publications: 1.
Efficacy of Calcifediol Supplementation in Asthma Control in Asthmatic Patients With Vitamin D Deficiency (ACViD)
ClinicalTrials.gov study NCT02805907. IPD Sharing: NO. Countries: 1. Publications: 2.
Treatment of Vitamin D Deficiency in Intestinal Rehabilitation Clinic Patients With a Portable Ultraviolet B Lamp
ClinicalTrials.gov study NCT01930539. IPD Sharing: NO. Countries: 1. Publications: 9.
Suspected Deficient Activation of Vitamin D in Patients With Secondary Hyperparathyroidism
ClinicalTrials.gov study NCT00754442. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Vitamin D Deficiency, Insulin Resistance and FGF-23
ClinicalTrials.gov study NCT00491322. IPD Sharing: NO. Countries: 1. Publications: 4.
Prevention of Vitamin D Deficiency Following Pediatric CHD Surgery: a Phase II Dose Evaluation Randomized Controlled Trial Comparing Usual Care With a High Dose Pre-operative Supplementation Regimen B
ClinicalTrials.gov study NCT01838447. IPD Sharing: Not stated. Countries: 1. Publications: 63.
Treatment Study of Vitamin D Deficiency in Adolescents
ClinicalTrials.gov study NCT01784029. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Controlled Trial of Prenatal Vitamin D3 Supplementation to Prevent Vitamin D Deficiency in Mothers and Their Infants
ClinicalTrials.gov study NCT00610688. IPD Sharing: Not stated. Countries: 2. Publications: 9.
Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency
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Sphingolipid serum profiling in vitamin D deficient and dyslipidemic obese dimorphic adults
<p>Recent studies on Saudi Arabians indicate a prevalence of dyslipidemia and vitamin D deficiency (25(OH)D) in both normal weight and obese subjects. In the present study the sphingolipid pattern was investigated in 23 normolipidemic normal weight (NW), 46 vitamin D deficient dyslipidemic normal weight (-vitDNW) and 60 vitamin D deficient dyslipidemic obese (-vitDO) men and women by HPTLC-primuline profiling and LC-MS analyses. Results indicate higher levels of total ceramide (Cer) and dihydroceramide (dhCers C18–22) and lower levels of total sphingomyelins (SMs) and dihydrosphingomyelin (dhSM) not only in -vitDO subjects compared to NW, but also in –vitDNW individuals. A dependency on body mass index (BMI) was observed analyzing specific Cer acyl chains levels. Lower levels of C20 and 24 were observed in men and C24.2 in women, respectively. Furthermore, LC-MS analyses display dimorphic changes in NW, -vitDNW and –vitDO subjects. In conclusion, LC-MS data identify the independency of the axis high Cers, dhCers and SMs from obesity <em>per se</em>. Furthermore, it indicates that long chains Cers levels are specific target of weight gain and that circulating Cer and SM levels are linked to sexual dimorphism status and can contribute to predict obese related co-morbidities in men and women.</p>
Vitamin D Deficiency and Pregnancy Outcome: A longitudinal Interventional Study
<p><strong><u><span>ABSTRACT</span></u></strong><span>:</span></p> <p><strong><span>Introduction:</span></strong><span> <span>Vitamin D is a fat-soluble vitamin responsible for increasing the absorption of calcium, magnesium, phosphate, and multiple other biological effects. Deficiency of vitamin D is a common global problem, especially in females. It is naturally produced by the body on exposure to sunlight. Deficiency of vitamin D in pregnancy predisposes to pre-eclampsia, GDM, preterm birth to the mother, hypocalcemic tetany, low birth weight, and congenital rickets in the fetus. In general, 10 (400) units of vitamin D are recommended for all pregnant women per day.</span></span><span> <strong><span>Materials and methods:</span></strong> The study was conducted in the OBGY department of MGM Medical College, Aurangabad, Maharashtra, between August 2022 to August 2023. A complete procedure was explained to all the second-trimester pregnant women willing to participate in this study, and informed written consent was obtained from them. Their detailed history was taken and subjected to an estimation of 25 hydroxyvitamin D and serum calcium. <strong><span>Results:</span></strong> A high prevalence of vitamin D deficiency is found (81%). In teenage pregnancy, the occurrence of vitamin D deficiency is higher. In our study, vitamin D deficiency was more prevalent in rural areas thanurban areas. It was more in the Muslim population. A sedentary life is prone to vitamin D deficiency. The incidence of GDM, pre-eclampsia, and low birth weight was significantly lower in tested and treated patients. Empirical vitamin D supplementation should be given to each pregnant patient.</span></p> <p><strong><em><span> </span></em></strong></p> <p><strong><em><span>Keywords: GDM, Preeclampsia, prevalence, teenage pregnancy, low birth weight.</span></em></strong></p> <p><span> </span></p>
The Prevalence of Vitamin D Deficiency and Effects of Vitamin D Supplementation in HIV-1 Infected Patients
ClinicalTrials.gov study NCT00306410. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Effect of Vitamin d Deficiency in Chronic Rhinosinusitis With Nasal Polyposis
ClinicalTrials.gov study NCT04529668. IPD Sharing: NO. Countries: 1. Publications: 1.
Vitamin Deficiency and Blood Pressure in Hospitalized Jewish General Hospital (JGH) Patients
ClinicalTrials.gov study NCT00921622. IPD Sharing: NO. Countries: 1. Publications: 1.
Determination of Effective Vitamin D Replacement and Monitoring Strategies in Vitamin D Deficiency State
ClinicalTrials.gov study NCT01430793. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Vitamin D Deficiency in Adolescent Girls
ClinicalTrials.gov study NCT01180946. IPD Sharing: Not stated. Countries: 1. Publications: 4.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.