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Dataset results
258 results for “zinc finger”
USP5 zinc-finger ubiquitin binding domain with L-cysteine(residue195)-glutathione disulfide structure solution
<p>USP5 zinc-finger ubiquitin binding domain with L-cysteine(residue195)-glutathione disulfide structure solution to 1.6 Å resolution</p>
Data for: A zinc-finger fusion protein refines Gal4-defined neural circuits
<p>This is microscopy image data and related information for</p> <p><strong>A zinc-finger fusion protein refines Gal4-defined neural circuits</strong></p> <p>The analysis of behavior requires that the underlying neuronal circuits are identified and genetically isolated. In several major model species—most notably Drosophila, neurogeneticists identify and isolate neural circuits with a binary, heterologous, expression control system: Gal4-UASG. One limitation of Gal4-UASG is that expression patterns are often too broad to map circuits precisely. To help refine the expression of Gal4 lines, we developed an intersectional genetic AND operator. Interoperable with Gal4, the new system’s key component is a fusion protein in which the DNA-binding domain of Gal4 has been replaced with a zinc finger domain with a different DNA-binding specificity. In combination with its cognate binding site (UASZ) the zinc-finger-replaced Gal4 (‘Zal1’) was functional as a standalone transcription factor. Zal1 transgenes also refined Gal4 expression ranges when combined with UASGZ, a hybrid upstream activation sequence. In this way, combining Gal4 and Zal1 drivers captured restricted cell sets compared with single drivers and improved genetic fidelity. This intersectional genetic AND operation presumably derives from the action of a heterodimeric transcription factor: Gal4-Zal1. Configurations of Zal1-UASZ and Zal1-Gal4-UASGZ are versatile tools for defining, refining, and manipulating targeted neural expression patterns with precision.</p>
Apo USP5 zinc-finger ubiquitin binding domain structure solution 2018/03/30
<p>USP5 zinc-finger ubiquitin binding domain structure solution to 1.55 Å resolution</p>
Ascending Dose Study of Genome Editing by the Zinc Finger Nuclease (ZFN) Therapeutic SB-318 in Subjects With MPS I
ClinicalTrials.gov study NCT02702115. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Ascending Dose Study of Genome Editing by Zinc Finger Nuclease Therapeutic SB-FIX in Subjects With Severe Hemophilia B
ClinicalTrials.gov study NCT02695160. IPD Sharing: NO. Countries: 1. Publications: 1.
Ascending Dose Study of Genome Editing by the Zinc Finger Nuclease (ZFN) Therapeutic SB-913 in Subjects With MPS II
ClinicalTrials.gov study NCT03041324. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Natural variation in the zinc-finger-encoding exon of Prdm9 affects hybrid sterility phenotypes in mice
Open the record for dataset details and reuse information.
Lemon zinc finger protein ClSUP induces the accumulation of reactive oxygen species and inhibits citrus yellow vein-clearing virus infection via interactions with ClDOF3.4
Open the record for dataset details and reuse information.
Safety Study of Zinc Finger Nuclease CCR5-modified Hematopoietic Stem/Progenitor Cells in HIV-1 Infected Patients
ClinicalTrials.gov study NCT02500849. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of Molecular-targeted Therapy Using Zinc Finger Nuclease in Cervical Precancerous Lesions
ClinicalTrials.gov study NCT02800369. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
A Phase I Study of T-Cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases SB-728mR in HIV-Infected Patients
ClinicalTrials.gov study NCT02388594. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Autologous T-Cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases SB-728 for HIV
ClinicalTrials.gov study NCT00842634. IPD Sharing: NO. Countries: 1. Publications: 1.
The KRAB zinc finger protein SNERV represses proviral endogenous retroviruses and underlies the Sgp3 and Gv1 loci
GEO Series GSE121640. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Regulation of alternative polyadenylation by the C2H2-zinc finger protein Sp1
GEO Series GSE165772. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
A zinc finger transcription factor enables social behaviors by controlling transposable elements and immune response in prefrontal cortex
GEO Series GSE246064. Mus musculus. 33 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide functional perturbation of human microsatellite repeats using engineered zinc finger transcription factors
GEO Series GSE163886. Homo sapiens. 81 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Multiparameter functional diversity of human C2H2 zinc finger proteins
GEO Series GSE76496. Homo sapiens. 252 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
MIR sequences recruit zinc finger protein ZNF768 to expressed genes
GEO Series GSE111879. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Zinc finger transcription factors displaced SREBP proteins as the major sterol regulators during Saccharomycotina evolution
GEO Series GSE47433. Yarrowia lipolytica. 14 samples. Type: Expression profiling by high throughput sequencing.
Oncogenic zinc finger protein ZNF322A promotes lung cancer stemness through transcriptionally suppressing c-Myc expression [RNA-Seq]
GEO Series GSE94537. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.