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27
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ShareScore release 0.9.0
Dataset results
27 results for “zinc-finger”
USP5 zinc-finger ubiquitin binding domain with L-cysteine(residue195)-glutathione disulfide structure solution
<p>USP5 zinc-finger ubiquitin binding domain with L-cysteine(residue195)-glutathione disulfide structure solution to 1.6 Å resolution</p>
Data for: A zinc-finger fusion protein refines Gal4-defined neural circuits
<p>This is microscopy image data and related information for</p> <p><strong>A zinc-finger fusion protein refines Gal4-defined neural circuits</strong></p> <p>The analysis of behavior requires that the underlying neuronal circuits are identified and genetically isolated. In several major model species—most notably Drosophila, neurogeneticists identify and isolate neural circuits with a binary, heterologous, expression control system: Gal4-UASG. One limitation of Gal4-UASG is that expression patterns are often too broad to map circuits precisely. To help refine the expression of Gal4 lines, we developed an intersectional genetic AND operator. Interoperable with Gal4, the new system’s key component is a fusion protein in which the DNA-binding domain of Gal4 has been replaced with a zinc finger domain with a different DNA-binding specificity. In combination with its cognate binding site (UASZ) the zinc-finger-replaced Gal4 (‘Zal1’) was functional as a standalone transcription factor. Zal1 transgenes also refined Gal4 expression ranges when combined with UASGZ, a hybrid upstream activation sequence. In this way, combining Gal4 and Zal1 drivers captured restricted cell sets compared with single drivers and improved genetic fidelity. This intersectional genetic AND operation presumably derives from the action of a heterodimeric transcription factor: Gal4-Zal1. Configurations of Zal1-UASZ and Zal1-Gal4-UASGZ are versatile tools for defining, refining, and manipulating targeted neural expression patterns with precision.</p>
Apo USP5 zinc-finger ubiquitin binding domain structure solution 2018/03/30
<p>USP5 zinc-finger ubiquitin binding domain structure solution to 1.55 Å resolution</p>
Heterogeneous expression of zinc-finger E-box-binding homeobox 1 plays a pivotal role in metastasis via regulation of miR-200c in epithelial-mesenchymal transition
GEO Series GSE75117. Homo sapiens. 40 samples. Type: Expression profiling by array.
Conversion of Human Fibroblasts to Stably Self-Renewing Neural Stem Cells with a Single Zinc-Finger Transcription Factor
GEO Series GSE64882. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Molecular mechanisms of transcriptional regulation by the nuclear zinc-finger protein Zfat in T cells
GEO Series GSE83380. Mus musculus. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Identification of potential target genes of KRAB zinc-finger proteins in cancer cells
GEO Series GSE141802. Homo sapiens. 33 samples. Type: Expression profiling by high throughput sequencing.
Zinc-finger protein ZFP488 regulates the timing of oligodendrocyte myelination and remyelination (RNA-Seq)
GEO Series GSE252853. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Sequence specificity is obtained from the majority of modular C2H2 zinc-finger arrays
GEO Series GSE25723. synthetic construct. 80 samples. Type: Other.
Ectopic recruitment of the CTCF N-terminal domain with two proximal zinc-finger domains as a tool for 3D genome engineering
GEO Series GSE300308. Homo sapiens. 51 samples. Type: Other; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Mutant KRAS regulates transposable element RNA and innate immunity via KRAB zinc-finger genes
GEO Series GSE120566. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Zinc-finger protein ZFP488 regulates the timing of oligodendrocyte myelination and remyelination (CUT&Tag)
GEO Series GSE252854. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ZINC-FINGER interactions mediate transcriptional regulation of hypocotyl growth in Arabidopsis
GEO Series GSE112889. Arabidopsis thaliana. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Ectopic recruitment of the CTCF N-terminal domain with two proximal zinc-finger domains as a tool for 3D genome engineering [RNA-seq]
GEO Series GSE300306. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Zinc-finger protein ZFP488 regulates the timing of oligodendrocyte myelination and remyelination
GEO Series GSE252855. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
The zinc-finger protein OEF-1 stabilizes patterns of activating and silencing modifications in the C. elegans germ line
GEO Series GSE147401. Caenorhabditis elegans. 30 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Structure of a zinc-finger antiviral protein in complex with RNA reveals mechanism for selective targeting of CG-rich viral sequences
GEO Series GSE139667. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing; Other.
Molecular mechanisms of transcriptional regulation by the nuclear zinc-finger protein ZFAT in HEK293 cells
GEO Series GSE134612. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Ectopic recruitment of the CTCF N-terminal domain with two proximal zinc-finger domains as a tool for 3D genome engineering [CHIP-seq]
GEO Series GSE300307. Homo sapiens. 27 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Single base-pair resolution analysis of DNA binding motif with MoMotif reveals an oncogenic function of CTCF zinc-finger 1 mutation.
GEO Series GSE190118. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.