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NIH funding notice PA-18-358

NINDS Exploratory Neuroscience Research Grant (R21 Clinical Trial Optional)

Closed on May 7, 2021.

Posted
November 15, 2017
Close date
May 7, 2021
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

682 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $256,787,052 in first-year total cost, median $425,319.

Most frequent study sections

  1. Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]49
  2. Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]37
  3. Acute Neural Injury and Epilepsy Study Section[ANIE]36
  4. Cellular and Molecular Biology of Glia Study Section[CMBG]36
  5. Neural Oxidative Metabolism and Death Study Section[NOMD]32

Most frequent institutions

  1. EMORY UNIVERSITY27
  2. JOHNS HOPKINS UNIVERSITY22
  3. UNIVERSITY OF MICHIGAN AT ANN ARBOR21
  4. UNIVERSITY OF PITTSBURGH AT PITTSBURGH21
  5. MASSACHUSETTS GENERAL HOSPITAL17
Competing awards under PA-18-358 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2022Reverse transcriptase inhibition as a novel therapeutic approach for ADAR-1-related Aicardi Goutières Syndrome1R21NS123477-01VANDERVER, ADELINE LUCIECHILDREN'S HOSP OF PHILADELPHIA, PA$499,550ZRG1
2022Chemical Fingerprints of Cognitive Impairment-related alpha-Synuclein Strains using 3D Small Molecule Microarray and Related Therapeutic Application1R21NS125559-01MAO, XIAOBOJOHNS HOPKINS UNIVERSITY, MD$450,313DDNS
2022Targeting cellular senescence to prevent epileptogenesis1R21NS125552-01FORCELLI, PATRICK ALEXANDERGEORGETOWN UNIVERSITY, DC$429,000CNNT
2022Perlecan Domain V as a therapeutic VCID strategy for the clearance of amyloid beta from the brain in cerebral amyloid angiopathy1R21NS122219-01A1BIX, GREGORY JAYECARARE, ROXANA OCTAVIATULANE UNIVERSITY OF LOUISIANA, LA$382,600BINP
2022Using real-time fMRI neurofeedback and motor imagery to enhance motor timing and precision in cerebellar ataxia1R21NS125546-01LACONTE, STEPHEN MMARVEL, CHERIE LJOHNS HOPKINS UNIVERSITY, MD$275,666CNN
2022Understanding and overcoming Immunotherapy resistance in Pediatric High-Grade Glioma1R21NS125600-01HAMBARDZUMYAN, DOLORESICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$270,938CII
2022Delayed white matter loss in concussive head injuries and its treatment1R21NS125201-01HYDER, DEWAN SYED FAHMEEDKANNURPATTI, SRIDHAR SLEVISON, STEVEN WRBHS-NEW JERSEY MEDICAL SCHOOL, NJ$255,271BINP
2022Metabolic origin of oxidative stress injury in brain ischemia/reperfusion1R21NS125466-01GALKIN, ALEXANDERGROSS, STEVEN SWEILL MEDICAL COLL OF CORNELL UNIV, NY$254,250NOMD
2022Tracing hypoxic state and hypoxia memory in glioblastoma progression1R21NS125700-01FRIEDEL, ROLAND HORSTZOU, HONGYAN JENNYICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$253,563TPM
2022Modern approach to electrical conductivity mapping of spinal cord tissues1R21NS120166-01A1CHARDON, MATTHIEU KEVINNORTHWESTERN UNIVERSITY AT CHICAGO, IL$250,037BNVT
2022Bioenergetics and Neuronal Network Remodeling in a Rodent Model of Temporal Lobe Epilepsy1R21NS121706-01A1WU, YIJEN LINUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$244,211CNNT
2022Developing an image-guided therapeutic strategy to effectively target metabolic reprogramming in glioblastoma1R21NS123606-01OLMEZ, INANPENNSYLVANIA STATE UNIV HERSHEY MED CTR, PA$243,540DT
2022Investigating Divergent Disease Severity in Human Neuronal Models of KCNQ2-Related Developmental and Epilepsy Disorders1R21NS125503-01SIMKIN, DINANORTHWESTERN UNIVERSITY AT CHICAGO, IL$240,000NTRC
2022Improving Human Cerebrovascular Function Using Acute Intermittent Hypoxia1R21NS121742-01A1BRIGHT, MOLLY GNORTHWESTERN UNIVERSITY AT CHICAGO, IL$240,000ANIE
2022Aberrant P-bodies accumulation and clearance in yeast and human cells.1R21NS125790-01SEGEV, NAVAUNIVERSITY OF ILLINOIS AT CHICAGO, IL$239,850ZRG1
2022The role of acetylcholine signaling in the axonal wiring of cortical interneurons1R21NS121436-01A1TANIGUCHI, HIROKIOHIO STATE UNIVERSITY, OH$236,250NDPR
2022Impact of actin binding protein Coronin 1C in the pathogenesis of Parkinson's disease1R21NS125812-01SCHUELE, BIRGITTSTANFORD UNIVERSITY, CA$236,100CMND
2022Single Nucleus Transcriptional Profiling of Intractable Focal Epilepsy1R21NS118349-01A1CANOLL, PETERSCHEVON, CATHERINE AWINAWER, MELODIE ROSECOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$235,250CNNT
2022MET kinase fusions in pediatric glioblastoma1R21NS116639-01A1READ, RENEE DEMORY UNIVERSITY, GA$234,750DT
2022Chronic effects of different THC:CBD ratios on executive function and emotional processing in people with multiple sclerosis1R21NS121141-01A1RUDROFF, THORSTENUNIVERSITY OF IOWA, IA$231,750HCMF
2022Exploring the role of the protocadherin CELSR3 in Tourette syndrome1R21NS125519-01BORTOLATO, MARCOUNIVERSITY OF UTAH, UT$228,750DBD
2022The role of CD11c+ microglia in post-ischemic stroke recovery1R21NS125056-01WAN, EDWIN CHI KEUNGWEST VIRGINIA UNIVERSITY, WV$228,000BINP
2022Development and characterization of an AAV-based tool to functionally ablate astrocytic mitochondria in specific brain regions in vivo1R21NS121959-01A1RIMER, MENDELLSRINIVASAN, RAHULTEXAS A&M UNIVERSITY HEALTH SCIENCE CTR, TX$227,250NOMD
2022Developing an inducible mouse model for gene replacement therapy in Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD)1R21NS121858-01A1ROTENBERG, ALEXANDERBOSTON CHILDREN'S HOSPITAL, MA$221,250CNNT
2022Investigating Pathophysiology of Glioma Stem Cells in 3D Bioprinted Vascularized Glioblastoma Model1R21NS121945-01A1SINGH, IRTISHATEXAS A&M UNIVERSITY HEALTH SCIENCE CTR, TX$218,462BNVT
2022Layer 6b, a novel inhibitory gain controller in the neocortex1R21MH128765-01KAMIYA, ATSUSHIJOHNS HOPKINS UNIVERSITY, MD$204,688PMDA
2022Secreted Factors for Zebrafish Spinal Cord Regeneration1R21NS124635-01POSS, KENNETH DDUKE UNIVERSITY, NC$201,250DEV2
2022Imaging tools to assess circuit connectivity and function in zebrafish1R21NS125187-01MCLEAN, DAVIDNORTHWESTERN UNIVERSITY, IL$200,000NDPR
2022Using LIS1 missense mutations to probe dynein regulatory mechanisms1R21NS125481-01SMITH, DEANNA SUNIVERSITY OF SOUTH CAROLINA AT COLUMBIA, SC$182,003SYN
2022Discovery of sensorimotor connectivity mechanisms in a continuous topographic map1R21NS124191-01A1MOENS, CECILIA BFRED HUTCHINSON CANCER RESEARCH CENTER, WA$28,276SMN
2021MiR-218 regulatory networks in adult mice and its relationship to ALS1R21NS121846-01PFAFF, SAMUEL L.SALK INSTITUTE FOR BIOLOGICAL STUDIES, CA$529,100CDIN
2021Role of T cells in alpha-synuclein pathology1R21NS122376-01MOORE, DARREN JOHNVAN ANDEL RESEARCH INSTITUTE, MI$525,081CNBT
2021Contrasting pathomechanisms of membrane versus cytosol alpha-synuclein excess1R21NS121826-01DETTMER, ULFBRIGHAM AND WOMEN'S HOSPITAL, MA$504,625CMND
2021Dopamine signal transduction in striatal neurons in Parkinson’s disease1R21NS125502-01PAPA, STELLA MEMORY UNIVERSITY, GA$500,500CDIN
2021Do allergens contribute to neurodegeneration?1R21NS121754-01CONTI, BRUNOSCRIPPS RESEARCH INSTITUTE, THE, CA$488,125NOMD
2021Functional analysis of the immune landscape in IDH mutant gliomas1R21NS121812-01TABAR, VIVIANESLOAN-KETTERING INST CAN RESEARCH, NY$486,750TTT
2021Astrocytic Glutamate Transporter 1 (GLT-1) enhancement for the treatment of seizures in Dravet Syndrome1R21NS123459-01ROTENBERG, ALEXANDERBOSTON CHILDREN'S HOSPITAL, MA$486,750CNNT
2021In Vivo Imaging of Cortical Glial Activation Using Advanced Diffusion Magnetic Resonance Imaging1R21NS123419-01MAINERO, CATERINAMASSACHUSETTS GENERAL HOSPITAL, MA$479,639CNN
2021Cell-type-specific contributions to cortical dysfunction in frontotemporal dementia1R21NS124209-01COWELL, RITA MARIESOUTHERN RESEARCH INSTITUTE, AL$476,795CMND
2021MicroRNA site-blocking oligonucleotides as a novel therapy for neurodevelopmental disorders1R21NS118280-01A1PROSSER, BENJAMIN LEARSUNIVERSITY OF PENNSYLVANIA, PA$474,874TAG
2021Investigating molecular mechanisms and treatments for CTNNB1 Syndrome using mouse and human models1R21NS119958-01A1JACOB, MICHELE H.TUFTS UNIVERSITY BOSTON, MA$470,715ZRG1
2021Humanized MAPT knockin mouse models for frontotemporal dementia1R21NS119990-01A1KANG, JONGKYUNBRIGHAM AND WOMEN'S HOSPITAL, MA$468,992CDIN
2021Imaging neurovascular physiology in persistent fatigue after COVID-191R21NS123412-01LEWIS, LAURA DIANEBOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$468,750ANIE
2021Molecular Mechanisms of Purkinje Cell Degeneration in Ataxia-Telangiectasia1R21NS121438-01HATTEN, MARY ELIZABETHROCKEFELLER UNIVERSITY, NY$466,125NCF
2021Modulation of intermediate metabolism, a new therapeutic approach for mitochondrial encephalomyopathies1R21NS118233-01A1CHEN, QIUYINGD'AURELIO, MARILENAWEILL MEDICAL COLL OF CORNELL UNIV, NY$466,125IPOD
2021Identifying the Long-Term Neurological Effects of COVID-19 Using 7 Tesla Multi-Modal MRI1R21NS122389-01BALCHANDANI, PRITIICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$465,438CNN
2021Characterization and validation of cerebrovascular reactivity (CVR) as a biomarker of vascular dementia in mouse models1R21NS119960-01A1WEI, ZHILIANGJOHNS HOPKINS UNIVERSITY, MD$465,301EITN
2021The role of Nf1 in sleep-dependent regulation of metabolic function1R21NS124198-01KEENE, ALEX CTOMCHIK, SETH MTEXAS A&M UNIVERSITY, TX$465,220NDPR
2021The development of cortico-cerebellar circuits in a genetic form of intellectual disability1R21NS124928-01DE RUBEIS, SILVIAICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$465,058NCF
2021DYT1 Genotype- and Phenotype-Specific Brain Circuits in Dystonia1R21NS120186-01A1KIMBERLEY, TERESA JACOBSONLIU, HESHENGMGH INSTITUTE OF HEALTH PROFESSIONS, MA$464,999SMN
2021Novel Targets that Modulate Multiple Adult Models of ALS in Drosophila1R21NS123207-01ARTAVANIS-TSAKONAS, SPYRIDONVAN VACTOR, DAVID L.HARVARD MEDICAL SCHOOL, MA$464,750CMND
2021Systematic and functional analysis of alternative mRNA splicing in an in vivo model of learning1R21NS121825-01A1ZHANG, YUNHARVARD UNIVERSITY, MA$464,750NDPR
2021Exploring the Pathogenicity of CYLD Variants in FTD1R21NS125845-01YAO, WEI-DONGUPSTATE MEDICAL UNIVERSITY, NY$463,750ZRG1
2021A whole body model of Pol III-related leukodystrophy1R21NS123730-01MOIR, ROBYNWILLIS, IAN MALBERT EINSTEIN COLLEGE OF MEDICINE, NY$462,000MNG
2021Dissecting the Role of Translation Mechanisms Downstream of mTORC1 in TSC Neuropathogenesis1R21NS118616-01A1THOREEN, CARSON CORNELLYALE UNIVERSITY, CT$460,628ZRG1
2021Pericyte angiopoietin2 and neonatal intracranial hemorrhage1R21NS123469-01GREIF, DANIELYALE UNIVERSITY, CT$460,625ZRG1
2021Multimodal imaging of depression in Parkinson's disease1R21NS120116-01A1HOLMES, SOPHIEYALE UNIVERSITY, CT$460,625ZRG1
2021Assessing the potential of reprogrammable microglia as a source of neurons in Alzheimer related dementias1R21NS121449-01HEBERT, JEAN MALBERT EINSTEIN COLLEGE OF MEDICINE, NY$457,610NCF
2021Correction of Mutations Underlying Alternating Hemiplegia of Childhood by Site-Directed RNA Editing1R21NS125495-01ROSENTHAL, JOSHUA J.C.MARINE BIOLOGICAL LABORATORY, MA$456,500MNG
2021Endogenous neurosteroids constrain network activity and limit seizure susceptibility1R21NS120868-01MAGUIRE, JAMIE LYNNTUFTS UNIVERSITY BOSTON, MA$453,750ZRG1
2021Secreted astrocyte proteins regulating rhythmic behavior1R21NS121083-01JACKSON, F ROBTUFTS UNIVERSITY BOSTON, MA$453,750CMBG
2021Translocon-regulated ER proteostasis in glioblastoma1R21NS119959-01A1BADR, CHRISTIAN ELIASISHMAEL, JANE EMASSACHUSETTS GENERAL HOSPITAL, MA$452,925MCT1
2021Brain endothelium and innate immune responses after stroke1R21NS120002-01A1KIMBERLY, WILLIAM TAYLORMASSACHUSETTS GENERAL HOSPITAL, MA$451,377ZRG1
2021Systematic search for novel treatments of infantile spasms among sigma-1 receptor ligands1R21NS118337-01A1VELISEK, LIBORNEW YORK MEDICAL COLLEGE, NY$451,000DBD
2021Multiple climbing fiber innervation of Purkinje cells in the adult cerebellum1R21NS124217-01HANSEL, CHRISTIAN ROBERTUNIVERSITY OF CHICAGO, IL$451,000ZRG1
2021The Contribution of Central Nervous System Demyelination to Bladder Dysfuntion1R21NS125332-01CROCKER, STEPHEN JIMITOLA, JAIMEUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT$451,000CMBG
2021Contribution of GABA-A receptor subunit deletions to Angelman syndrome pathophysiology1R21NS125850-01LEVINE, ERIC SUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT$451,000ZRG1
2021The Role of RanBP2 in the pathogenesis of acute necrotizing encephalopathy1R21NS121462-01VENKATESAN, ARUNJOHNS HOPKINS UNIVERSITY, MD$450,313CNBT
2021Comparison of HD and HDL2 mouse models to reveal common mechanisms of pathogenesis1R21NS124936-01MARGOLIS, RUSSELL LJOHNS HOPKINS UNIVERSITY, MD$450,313CMND
2021Transcriptomic characterization of preoptic area in homeostatic sleep controls using single-nucleus RNA-sequencing1R21NS122370-01A1GUO, XIAOFENGPACK, ALLAN IUNIVERSITY OF PENNSYLVANIA, PA$446,875BNRS
2021J147 Treatment for Traumatic Brain Injury in Brain Damage and Long-Term Functional Recovery1R21NS122193-01A1JIN, RONGPENNSYLVANIA STATE UNIV HERSHEY MED CTR, PA$445,995DDNS
2021Thalamocortical network dysfunction in a novel genetic model of GRIN2D developmental and epileptic encephalopathy1R21NS121980-01FRANKEL, WAYNE N.MAKINSON, CHRISTOPHER DONALDCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$445,500CNNT
2021Molecular mechanisms of glial-mediated synapse alterations in Fragile X syndrome1R21NS122366-01MASON, CAROL A.SHIRASU-HIZA, MICHELE MCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$445,500NDPR
2021A versatile reporter for visualization of myelin plasticity in the genetically modified rat1R21NS117983-01A1HORNER, PHILIP JMETHODIST HOSPITAL RESEARCH INSTITUTE, TX$444,125CMBG
2021Analysis of stroke-induced changes in connectivity and neural activity1R21NS120193-01A1LIU, JIALINGUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$444,125BINP
2021Elucidating glial diversity in the peripheral nervous system1R21NS124164-01KUCENAS, SARAH CUNIVERSITY OF VIRGINIA, VA$444,125ZRG1
2021Single-cell transcriptomic analysis of sibling progenitors with differential Notch activity1R21NS122053-01A1GUO, SUUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$444,125MNG
2021Exosomes as the mechanism of mesenchymal stem cell brain repair in neonatal stroke1R21NS120285-01A1VEXLER, ZINAIDA SUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$444,125BINP
2021A new human iPSC model of ALS: natural modifiers protecting FUS mutation carriers from the disease1R21NS122169-01GUO, ZIYUANZHU, HAININGCINCINNATI CHILDRENS HOSP MED CTR, OH$443,750CMND
2021Diurnal Experimental Models to Investigate Neural Mechanisms of Sleep Disturbance in Smith-Magenis Syndrome1R21NS125449-01IWASE, SHIGEKIYAN, LILYUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$443,728NDPR
2021Control of Forebrain Neuroblast Migration in Mouse and Human1R21NS120664-01A1CONOVER, JOANNE CUNIVERSITY OF CONNECTICUT STORRS, CT$442,750NCF
2021Characterizing the oxysterol, 20-hydroxycholesterol, as a mediator of remyelination in multiple sclerosis1R21NS117020-01A1BENNER, ERIC JGREGORY, SIMON GDUKE UNIVERSITY, NC$442,750CNBT
2021Modulation of brain iron by local hepcidin in prion disorders1R21NS125228-01SINGH, NEENACASE WESTERN RESERVE UNIVERSITY, OH$442,750CMND
2021Identification of proteins that structurally couple epidermal cells to somatosensory neurons1R21NS125795-01PARRISH, JAY ZROGERS, STEPHENUNIVERSITY OF WASHINGTON, WA$441,500ICI
2021An electro-mechanical mechanism of spike propagation in myelinated axons1R21NS121431-01KRAMER, RICHARD HUNIVERSITY OF CALIFORNIA BERKELEY, CA$440,687NTRC
2021Discovering new therapies to promote myelin repair1R21NS124168-01GAULTIER, ALBAN PSANTOS, WEBSTER LUNIVERSITY OF VIRGINIA, VA$440,030DDNS
2021Laser Interstitial Thermal Therapy for the Treatment of Glioblastoma1R21NS123589-01RAO, GANESHBAYLOR COLLEGE OF MEDICINE, TX$440,000CNBT
2021A zebrafish model to study functional regeneration of motor circuits1R21NS125207-01MCLEAN, DAVIDNORTHWESTERN UNIVERSITY, IL$440,000CNNT
2021Developing new paradigms for mouse forelimb sensorimotor circuit analysis1R21NS125594-01SHEPHERD, GORDON MNORTHWESTERN UNIVERSITY AT CHICAGO, IL$440,000ZRG1
2021The role of poison exons in neurodevelopment1R21NS121572-01A1CARVILL, GEMMA LOUISENORTHWESTERN UNIVERSITY AT CHICAGO, IL$440,000NCF
2021Neurological consequences of COVID-19 during the early recovery period: Imaging Analysis of the Blood Brain Barrier and Neurovascular alterations1R21NS123871-01CHEN, YUFENRAGIN, ANN BNORTHWESTERN UNIVERSITY AT CHICAGO, IL$439,694CNBT
2021Cholinergic modulation of Descending Pain Control Pathways1R21NS120582-01A1MCGEHEE, DANIEL SUNIVERSITY OF CHICAGO, IL$438,712MNPS
2021Role of Pacs2 in central nervous system myelination1R21NS123775-01PARK, YUNGKISTATE UNIVERSITY OF NEW YORK AT BUFFALO, NY$438,625CMBG
2021Regulation of microglia-mediated neuroinflammation by store operated Orai1 channels1R21NS122347-01PRAKRIYA, MURALINORTHWESTERN UNIVERSITY AT CHICAGO, IL$438,473NTRC
2021Identification of conserved ALS-FTD suppressor genes1R21NS116254-01A1HART, ANNE CHURCHBROWN UNIVERSITY, RI$437,532MNG
2021Impact of LZTR1 Mutations on Oligodendrocyte Development and Function1R21NS125347-01WACLAW, RONALD RCINCINNATI CHILDRENS HOSP MED CTR, OH$437,250NCF
2021Differential roles of neuronal and astrocytic aromatase in status epilepticus and chronic epilepsy1R21NS124980-01CHRISTIAN-HINMAN, CATHERINE AUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$436,150CNNT
2021Dysregulated Ribosomal Protein Synthesis in Amyloid and Tau Mouse Models1R21NS121786-01KLANN, ERICNEW YORK UNIVERSITY, NY$435,875CMND
2021Nerve transfer for urinary bladder reinnervation: Organ donor and cadaver studies1R21NS123206-01BARBE, MARY FTEMPLE UNIV OF THE COMMONWEALTH, PA$435,875KUFD
2021Dorsal root injury and ischemic spinal cord injury1R21NS124199-01SON, YOUNG-JINTEMPLE UNIV OF THE COMMONWEALTH, PA$435,875CNNT
2021Developing a cell-based high throughput screening for USP15 deubiquitinase inhibitor discovery1R21NS123322-01ZHUANG, ZHIHAOUNIVERSITY OF DELAWARE, DE$434,686DDNS
2021Mechanisms underlying Notch function in hypoxia1R21NS120023-01A1HADDAD, GABRIEL GUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$434,500NOMD
2021Developing an Astroglial Model for Fragile X Syndrome1R21NS122157-01A1DUNAEVSKY, ANNAUNIVERSITY OF NEBRASKA MEDICAL CENTER, NE$434,385ZRG1
2021Functional evaluation of genes adjacent to risk-modulating SNPs in the pathogenesis of PSP1R21NS123211-01BURTON, EDWARD ALANUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$434,125CMND
2021Bioluminescent indicators for noninvasive imaging of acetylcholine release1R21NS122055-01LIN, MICHAEL Z.STANFORD UNIVERSITY, CA$433,663EBIT
2021Gene therapy with modified GlcNAc-1-phosphotransferase for mucolipidosis1R21NS124193-01DICKSON, PATRICIA IKORNFELD, STUART AWASHINGTON UNIVERSITY, MO$433,125TAG
2021Restoring neurofilaments to axons in a mouse model of CMT2E1R21NS125468-01BROWN, ANTHONYOHIO STATE UNIVERSITY, OH$433,125SYN
2021How Does 3' UTR Secondary Structure Program mRNA Transport in Myelination?1R21NS123533-01ZUCHERO, JOHN BSTANFORD UNIVERSITY, CA$432,982MSFB
2021CLC-2 voltage-gated chloride channel structure and ligand recognition1R21NS125767-01MADUKE, MERRITT CSTANFORD UNIVERSITY, CA$432,850BBM
2021Extransynaptic GABAA modulators for benzodiazepine refractory status epilepticus1R21NS121590-01A1DUDEK, F. EDWARDUNIVERSITY OF UTAH, UT$432,826NTRC
2021Role of Transglutaminase 2 in Synucleinopathies1R21NS123770-01MOURADIAN, M. MARALRBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL, NJ$431,750NOMD
2021Regulation of Kv2 potassium channel diversity and function in brain by electrically silent subunits1R21NS123417-01FERNS, MICHAEL JUNIVERSITY OF CALIFORNIA AT DAVIS, CA$431,750NTRC
2021Determining a Role for Protein Kinase A in Dendrite Development using a FRET-based Sensor1R21NS122159-01BOUSTANY, NADAFIRESTEIN, BONNIE LRUTGERS, THE STATE UNIV OF N.J., NJ$431,444ZRG1
2021Examining the Effects of Suppression of Slow Rhythms on Resting State fMRI1R21NS122013-01A1GOPINATH, KAUNDINYA SRINIVASANKEILHOLZ, SHELLA DEMORY UNIVERSITY, GA$430,375EITN
2021Celiac ganglia plasticity after spinal cord injury1R21NS119985-01A1LI, YAQINGEMORY UNIVERSITY, GA$430,299CNNT
2021Developing Biomarkers of Parkinson’s Disease Inflammation Using a Network Proteomics Approach1R21NS123882-01HIGGINBOTHAM, LENORAEMORY UNIVERSITY, GA$430,270CNN
2021Sleep-Wake and Epilepsy Interactions in a Mouse Model of Temporal Lobe Epileps1R21NS122011-01PEDERSEN, NIGEL PAULEMORY UNIVERSITY, GA$429,995CNNT
2021Defining CAMK4 transcript isoforms for axonal plasticity1R21NS120498-01A1PETRUSKA, JEFFREY CUNIVERSITY OF LOUISVILLE, KY$429,458ZRG1
2021Identification and characterization of chromatin regulators of coordinated synaptic gene expression1R21NS125864-01LARSCHAN, ERICA NICOLEO'CONNOR-GILES, KATHALEEN MBROWN UNIVERSITY, RI$429,309SYN
2021The Retrosplenial Gate Hypothesis for Anterior Thalamic Stimulation in Temporal Lobe Epilepsy1R21NS121745-01AHMED, OMAR JAMILUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$429,000CNNT
2021Blockade of colony stimulating factor 1 receptor to reduce inflammatory nerve injury1R21NS121621-01SHEIKH, KAZIM AUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$429,000CNBT
2021Hippocampal Circuit Dysfunction in SCN8A Gain-of-Function Encephalopathy1R21NS121700-01AHMED, OMAR JAMILUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$429,000CNNT
2021The Mechanism of Gray Matter Atrophy in Experimental Autoimmune Encephalomyelitis1R21NS121806-01MACKENZIE-GRAHAM, ALLAN JAMESUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$429,000CNBT
2021Leveraging behavioral state to enhance specificity of non-invasive brain stimulation on motor circuits1R21NS118055-01A1VESIA, MICHAELUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$429,000MRS
2021Stroke Outcome in Pregnancy and Preeclampsia1R21NS120419-01A1CIPOLLA, MARILYN JUNIVERSITY OF VERMONT & ST AGRIC COLLEGE, VT$429,000BINP
2021Chemo-immunotherapy strategy for pediatric high grade glioma1R21NS123879-01CASTRO, MARIA GSCHWENDEMAN, ANNAUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$429,000DT
2021Protease Activated Bi-Specific Antibody Prodrugs for Efficient Transportation Across Blood-Brain Barrier1R21NS118104-01A1GE, XINURAYAMA, AKIHIKOUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$429,000ZRG1
2021Validation of a New Stroke Simulation Model for Evaluating Stroke Prevention and Treatment Policies in Type 2 Diabetes Patients1R21NS120223-01A1YE, WENUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$429,000ODHS
2021Synergistic Interactions of SARs-CoV2 and environmental toxicants in Experimental Parkinsonism1R21NS122280-01A1SMEYNE, RICHARD JTHOMAS JEFFERSON UNIVERSITY, PA$429,000CNNT
2021Regulatory mechanisms of lysosomal degradation in neurodegenerative disease1R21NS125167-01ZHU, MICHAEL XUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$429,000NOMD
2021Brain Connectivity Signatures of Behavior and Cognition in Duchenne Muscular Dystrophy1R21NS125184-01JOSHI, SHANTANU H.UNIVERSITY OF CALIFORNIA LOS ANGELES, CA$429,000CNN
2021Spatial transcriptomics mapping of basal ganglia to understand critical periods for sensorimotor learning1R21NS123763-01A1WHITE, STEPHANIE ANNWOLLMAN, ROYUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$429,000SMN
2021Insights into Gordon Holmes syndrome by substrate profiling of Triad3A and Chip using Orthogonal Ubiquitin Transfer1R21NS116760-01A1MABB, ANGELA MYIN, JUNGEORGIA STATE UNIVERSITY, GA$428,848SYN
2021Cellular Basis for Genetic Susceptibility to Neurodevelopmental Disorders1R21NS122398-01GIRIRAJAN, SANTHOSHPENNSYLVANIA STATE UNIVERSITY, THE, PA$428,267ZRG1
2021Exploring Apoptosome-Independent Mechanisms for Casp9 activation in Axon Pruning1R21NS123313-01DESHMUKH, MOHANISH PUNIV OF NORTH CAROLINA CHAPEL HILL, NC$427,625NOMD
2021Using Medicare Claims to Advance Our Understanding of Guillain-Barre Syndrome1R21NS119867-01A1TRAUB, REBECCAUNIV OF NORTH CAROLINA CHAPEL HILL, NC$427,625NAME
2021Does Contact Sport Induce Fibrillar Amyloid Deposition in the Brain?1R21NS119948-01A1VASKA, PAULSTATE UNIVERSITY NEW YORK STONY BROOK, NY$427,250ANIE
2021Noradrenergic modulations of fMRI signal1R21NS121838-01A1FUKUDA, MITSUHIROUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$427,153EITN
2021Establishment of immunocompetent spontaneous glioma model to study glioma-associated astrocytes1R21NS118359-01A1KORDULA, TOMASZ KVIRGINIA COMMONWEALTH UNIVERSITY, VA$426,938TME
2021Cell Senescence and Death in Neurodegenerative Diseases1R21NS125171-01MILLIGAN, CAROLORR, MIRANDA ETHELWAKE FOREST UNIVERSITY HEALTH SCIENCES, NC$426,250CDIN
2021Targeting Sur1-Trpm4 in sepsis-induced brain injury1R21NS121504-01ANEJA, RAJESH K.UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$425,028SAT
2021Neuroimaging and Behavioral Studies to Assess For Neuroinflammation in COVID-19 During Convalescence1R21NS121615-01CHANG, LINDAWILSON, ELEANOR M.P.UNIVERSITY OF MARYLAND BALTIMORE, MD$424,875CNBT
2021Role and Function of Peroxisomal Ether Phospholipids in TBI1R21NS117867-01A1JONES, JACE WSARKAR, CHINMOYUNIVERSITY OF MARYLAND BALTIMORE, MD$424,875NOMD
2021Mechanisms of Neuronal Loss Mediated by mTORC1-TFEB Deregulation in Human iPSC Model of GBA1-Associated Parkinsons Disease1R21NS123153-01AWAD, OLA A.UNIVERSITY OF MARYLAND BALTIMORE, MD$424,875NOMD
2021Distinct mechanisms for memory storage and retrieval in hippocampal engram cells1R21NS122356-01WILTGEN, BRIAN JUNIVERSITY OF CALIFORNIA AT DAVIS, CA$423,823BRLE
2021Nanoparticle-Based Drug Delivery Targeting the Respiratory Neural Network1R21NS119862-01A1SEVEN, YASIN BUNIVERSITY OF FLORIDA, FL$423,540RIBT
2021Exercise-dependent mechanisms of protection in polyglutamine degeneration1R21NS121276-01TODI, SOKOLWESSELLS, ROBERT JOHNWAYNE STATE UNIVERSITY, MI$423,500CMND
2021Mechanisms of Transglutaminase 2 (TG2)-Mediated Gene Expression in Astrocyte1R21NS119673-01A1JOHNSON, GAIL V. W.UNIVERSITY OF ROCHESTER, NY$423,500CMBG
2021Laser Induced NanoCarbon Multielectrode Arrays for Neurotransmitter Sensing1R21NS123937-01BEDEWY, MOSTAFACUI, XINYAN TRACYUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$423,280BNVT
2021Enhancing Neurogenesis for Brain Tissue Regeneration1R21NS118399-01A1MODO, MICHEL M.UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$422,979BNVT
2021Retrograde Signaling for Homeostatic Control of Synaptic Transmission1R21NS121284-01WANG, TINGTINGGEORGETOWN UNIVERSITY, DC$422,840SYN
2021Regeneration-permissive glia after spinal cord injury1R21NS123492-01LEE, JAE KUNIVERSITY OF MIAMI SCHOOL OF MEDICINE, FL$422,125CMBG
2021Investigating Lung Injury After Cervical Spinal Cord Injury1R21NS121966-01ALILAIN, WARREN JOSEPHUNIVERSITY OF KENTUCKY, KY$420,750CNNT
2021Neural mechanisms of error correction during manual interception of moving targets1R21NS121624-01A1SCHEIDT, ROBERT A.MARQUETTE UNIVERSITY, WI$420,750MFSR
2021Modifiability of Conduction Across Preganglionic Axonal Branch Points1R21NS121850-01HOCHMAN, SHAWNEMORY UNIVERSITY, GA$420,393CNNT
2021Roles of the X-linked Intellectual Disability gene ZDHHC9 in White Matter formation1R21NS125202-01THOMAS, GARETHTEMPLE UNIV OF THE COMMONWEALTH, PA$420,200CMBG
2021Regulation of Adult Hippocampal Neural Stem Cells by Glutamate Transport1R21NS123797-01KIRBY, ELIZABETH DIANAOHIO STATE UNIVERSITY, OH$420,021NCF
2021Effects of Docosahexaenoic Acid on Oxidative Stress White Matter Injury and Brain Inflammation in a Pre-Clinical Model of Pediatric TBI1R21NS121491-01SCHOBER, MICHELLE ELENAUNIVERSITY OF UTAH, UT$419,375NOMD
2021The Norepinephrine transporter as a therapeutic target for treatment of alpha-synuclein pathology in PD1R21NS121976-01URS, NIKHILUNIVERSITY OF FLORIDA, FL$419,375CDIN
2021Balance and Gait in Essential Tremor: Effects of Thalamic DBS1R21NS119849-01A1CHRISTOU, EVANGELOS AOKUN, MICHAEL SUNIVERSITY OF FLORIDA, FL$419,375MRS
2021Development of a novel rodent model of hypothalamic hamartoma and epilepsy1R21NS125211-01WEST, PETER JUNIVERSITY OF UTAH, UT$419,375CNNT
2021ELAVL3 in ALS/FTD1R21NS121805-01RAVITS, JOHNUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$417,259CMND
2021Examining cross-species suppression of neurodegeneration by loss of a conserved RNA binding protein in models of ALS and FTD1R21NS121977-01HART, ANNE CHURCHJAWORSKI, ALEXANDERBROWN UNIVERSITY, RI$416,481CMND
2021LPA6 signaling as a modulator of oligodendrocyte differentiation and CNS myelination1R21NS123317-01FUSS, BABETTEVIRGINIA COMMONWEALTH UNIVERSITY, VA$415,888CMBG
2021Astrocyte regulation of cortical neurodegeneration in C9orf72 FTD/ALS1R21NS125861-01SATTLER, RITAST. JOSEPH'S HOSPITAL AND MEDICAL CENTER, AZ$415,637CMBG
2021Alpha-synuclein driven cellular changes and vocal dysfunction in Parkinson's Disease1R21NS123512-01MILLER, JULIE ELIZABETHUNIVERSITY OF ARIZONA, AZ$415,482CDIN
2021The Role of Motor Cortex Output Circuits in Stroke Recovery1R21NS125571-01SATO, TAKASHIMEDICAL UNIVERSITY OF SOUTH CAROLINA, SC$414,750BINP
2021Quantitative characterization of neuronal trans-SNARE complexes using DNA origami1R21NS123257-01ZHANG, ZHAOUNIVERSITY OF WISCONSIN-MADISON, WI$414,305BBM
2021Transfer RNA Dynamics During Neural Differentiation1R21NS121995-01CLEARY, MICHAELUNIVERSITY OF CALIFORNIA, MERCED, CA$413,429MNG
2021Shank3 and the Par polarity complex in neurodevelopmental disorders1R21NS125782-01ZHANG, HUAYERBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL, NJ$412,962DBD
2021Cellular and Molecular Mechanisms of Behavioral Dysfunction in a Zebrafish Model of CHARGE Syndrome1R21NS120079-01A1MARSDEN, KURT C.NORTH CAROLINA STATE UNIVERSITY RALEIGH, NC$411,240ZRG1
2021Serotonergic modulation of nucleus reuniens in affective and cognitive behaviors1R21NS119847-01A1VERTES, ROBERT PAULFLORIDA ATLANTIC UNIVERSITY, FL$411,125BRLE
2021Cell Specific Identification of IL-1R Actions in Acute and Chronic Pain1R21NS122154-01A1QUAN, NINGTOLL, LAWRENCE RFLORIDA ATLANTIC UNIVERSITY, FL$411,125NPI
2021Gene Therapy Rescue of Angelman Syndrome with Reelin1R21NS124195-01NASH, KEVIN RONUNIVERSITY OF SOUTH FLORIDA, FL$411,125CNNT
2021Exploring a new arm of the integrated stress response and its connection to neurodegeneration1R21NS120123-01A1YANG, XIANG-LEISCRIPPS RESEARCH INSTITUTE, THE, CA$410,563CMND
2021Functionalized Enzyme Treatments for Dual-Targeting of Inflammation in Spinal Cord Injury1R21NS123596-01KESELOWSKY, BENJAMIN GEORGESCHMIDT, CHRISTINE EUNIVERSITY OF FLORIDA, FL$410,030CNNT
2021Molecular mechanisms of abnormal dendritic spine development and function in human neurons with TSC2 disease mutations1R21NS125419-01GOMEZ, TIMOTHY MUNIVERSITY OF WISCONSIN-MADISON, WI$407,645NDPR
2021Beyond ephrins: unbiased discovery of novel signaling pathways regulating topographic map formation and maturation in vivo.1R21NS124542-01POULAIN, FABIENNE EMMANUELLEUNIVERSITY OF SOUTH CAROLINA AT COLUMBIA, SC$407,545BDE
2021Robotically Augmented Mental Practice for Neuromotor Facilitation1R21NS118435-01A1SHINOHARA, MINORUGEORGIA INSTITUTE OF TECHNOLOGY, GA$407,538MFSR
2021Upper-respiratory infection, oligodendrocyte plasticity and behavior1R21NS121741-01A1STEELMAN, ANDREW JONATHANUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$405,672BNRS
2021Decoding neural cell fate diversity1R21NS123803-01EISEN, JUDITH SMILLER, ADAM CUNIVERSITY OF OREGON, OR$405,625NCF
2021Reducing vascular cognitive impairment within and across generations by epigenetic conditioning1R21NS118223-01A1GIDDAY, JEFFREY MLSU HEALTH SCIENCES CENTER, LA$404,250CDIN
2021Enhancing Mask/ANKHD1 activity to protect against Tau-induced neurodegeneration1R21NS123861-01WU, CHUNLAILSU HEALTH SCIENCES CENTER, LA$404,250NOMD
2021Genetic control of neuronal progenitor proliferation in zebrafish1R21NS125217-01GRINBLAT, YEVGENYAUNIVERSITY OF WISCONSIN-MADISON, WI$395,227NCF
2021The Role of the Adaptive Immune System in Epilepsy1R21NS114741-01A1SIMEONE, KRISTINA ASIMEONE, TIMOTHY A.CREIGHTON UNIVERSITY, NE$383,480CNNT
2021Assessing determinants of electrocardiographic alterations and identifying exacerbating factors in pediatric epilepsy1R21NS119929-01A1LAI, YI-CHENBAYLOR COLLEGE OF MEDICINE, TX$369,560ANIE
2021REM sleep control by the sublaterodorsal tegmental nucleus glutamatergic neurons1R21NS123495-01ZHONG, PENGSRI INTERNATIONAL, CA$355,860ZRG1
2021Targeting Complement Component 3 in a Model of Synucleinopathy1R21NS121393-01BENSKEY, MATTHEW JOHNMICHIGAN STATE UNIVERSITY, MI$352,125CNBT
2021Unique ubiquitin processes in misfolded protein diseases of the nervous system1R21NS123147-01TODI, SOKOLWAYNE STATE UNIVERSITY, MI$346,500CMND
2021A 3D-Printed Nerve Cuff for 1-Photon Optogenetic Vagal Stimulation1R21NS124313-01FONTAINE, ARJUN KWEIR, RICHARD FERGUS FFRENCHUNIVERSITY OF COLORADO DENVER, CO$302,897BNVT
2021Brain Vascular Heterogeneity1R21NS114461-01A1PARDO-VILLAMIZAR, CARLOS ASTINS, MONIQUE FJOHNS HOPKINS UNIVERSITY, MD$287,823ANIE
2021High resolution analysis of human cerebellar neurogenesis1R21NS117848-01HALDIPUR, PARTHIVSEATTLE CHILDREN'S HOSPITAL, WA$282,750NCF
2021Role of Microglial Calcium Waves in Ischemic Stroke1R21NS116431-01A1TVRDIK, PETRUNIVERSITY OF VIRGINIA, VA$282,625CMBG
2021Combined Biomaterial and Neuromodulatory Approach to Promote Axonal Outgrowth and Connections After Cervical SCI1R21NS116550-01A1MARTIN, JOHN HCITY COLLEGE OF NEW YORK, NY$266,200CNNT
2021DATA-DRIVEN MODELS TO PREDICT DELAYED CEREBRAL ISCHEMIA AFTER SUBARACHNOID HEMORRHAGE1R21NS123478-01DAVIES, JASONIONITA, CIPRIAN N.STATE UNIVERSITY OF NEW YORK AT BUFFALO, NY$251,625ANIE
2021Enhanced intra-arterial drug delivery to the brain after blood brain barrier opening: comparison between osmotic and MRI-guided focused ultrasound opening techniques1R21NS118232-01PEARL, MONICA SMITHCHILDREN'S RESEARCH INSTITUTE, DC$249,347DT
2021Microbial-mediated blood-brain barrier development at the intersection of the gut-brain axis1R21NS121432-01A1LU, JINGUNIVERSITY OF CHICAGO, IL$246,000ZRG1
2021Regulating transcription of the key neural lineage driver ASCL11R21NS120431-01JOHNSON, JANE EUT SOUTHWESTERN MEDICAL CENTER, TX$245,500NCF
2021Linking the molecular logic of sensory neuron diversity and somatosensory circuitry in mouse spinal cord: development of novel tools for viral tracing and 3D analysis1R21NS120665-01DODD, JANEMASON, CAROL A.COLUMBIA UNIVERSITY HEALTH SCIENCES, NY$243,000MNG
2021Transcribed Ultra Conserved Regions in Glioblastoma1R21NS122136-01ABOUNADER, ROGERUNIVERSITY OF VIRGINIA, VA$242,250CAMP

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