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NIH funding notice PA-21-219

Joint NINDS/NIMH Exploratory Neuroscience Research Grant (R21 Clinical Trial Optional)

Closed on January 7, 2025.

Posted
May 10, 2021
Close date
January 7, 2025
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

654 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $221,979,295 in first-year total cost, median $401,112.

Most frequent study sections

  1. Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]39
  2. Molecular Neurogenetics Study Section[MNG]33
  3. Brain Injury and Neurovascular Pathologies Study Section[BINP]32
  4. Acute Neural Injury and Epilepsy Study Section[ANIE]31
  5. Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]29

Most frequent institutions

  1. JOHNS HOPKINS UNIVERSITY23
  2. EMORY UNIVERSITY18
  3. YALE UNIVERSITY15
  4. UNIVERSITY OF CALIFORNIA, SAN DIEGO13
  5. UNIVERSITY OF PITTSBURGH AT PITTSBURGH13
Competing awards under PA-21-219 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025Development of GPR139 antagonists for the treatment of pain1R21NS140745-01DECKER, ANN MJIN, CHUNYANGRESEARCH TRIANGLE INSTITUTE, NC$603,406DMPB
2025Optimization and Characterization of Small Molecule GPR17 Antagonists for Multiple Sclerosis1R21NS138593-01A1NARAYANAN, SANJURESEARCH TRIANGLE INSTITUTE, NC$547,846DMPB
2025Investigating Cerebellar Development in Ferrets: Implications for Modelling Human Cerebellar Development and Disease1R21NS142543-01HALDIPUR, PARTHIVSEATTLE CHILDREN'S HOSPITAL, WA$516,175NCF
2025Mechanisms of ATAD3A in Regulating the Mitochondrial Genome1R21NS142779-01GROTJAHN, DANIELLE ANNSCRIPPS RESEARCH INSTITUTE, THE, CA$506,000MSFC
2025Identifying the multi-modal factors that determine individual response to tDCS1R21MH140296-01KIM, JUNG-HOONSTOODLEY, CATHERINE J.CHILDREN'S RESEARCH INSTITUTE, DC$498,429HCMF
2025Role of SPARC in Wound Healing After Spinal Cord Injury1R21NS130280-01A1HOLLIS, EDMUND RWINIFRED MASTERSON BURKE MED RES INST, NY$492,250CNNT
2025Mechano-Electrical Regulation of Neurogenesis1R21NS145550-01JUNQUEIRA ALVES, CHRYSTIANZOU, HONGYAN JENNYICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$491,163NCF
2025Discovery of Stimulus-Responsive Microproteins in Human Microglia1R21NS144610-01KALISH, BRIANBOSTON CHILDREN'S HOSPITAL, MA$489,500ZRG1
2025Prion Clearance and Treatment of Recalcitrant Prion Strains Through Deep PrP Suppression1R21NS144519-01MINIKEL, ERIC VALLABHBROAD INSTITUTE, INC., MA$481,250CMND
2025The pathophysiology of morning migraine1R21NS145050-01MELO CARRILLO, AGUSTINBETH ISRAEL DEACONESS MEDICAL CENTER, MA$475,475NPI
2025Identifying Cellular Intraspinal Electrophysiological Features of "Spinal Shock"1R21NS144777-01HE, ZHIGANGRAO, SIYUANSTATE UNIVERSITY OF NY,BINGHAMTON, NY$470,293CNNT
2025Preclinical Evaluation of Anti-Fibrin Immunotherapy for Cerebral ALD: Leveraging a Novel Mouse Model to Guide Clinical Trial Design1R21NS145134-01VAN HAREN, KEITHSTANFORD UNIVERSITY, CA$469,622ZRG1
2025Close-Loop Deep Brain Optoacoustic Stimulation at Sub-millimeter Precision1R21NS145121-01YANG, CHENBOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$465,500ZRG1
2025Filamin A in TSC and FCDII1R21NS142517-01BORDEY, ANGELIQUECALDERWOOD, DAVID AYALE UNIVERSITY, CT$461,250DBD
2025Lysosomal Regulation and Functions for TBK1 in Neurodegenerative Diseases1R21NS143251-01FERGUSON, SHAWNYALE UNIVERSITY, CT$461,197ZRG1
2025Investigating the impact of glioma-associated germline risk alleles on neurodevelopmental trajectories1R21NS142585-01HUSE, JASONWU-HUBER, JIAQIANUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$460,940ZRG1
2025Investigating the Roles of the Deubiquitylation Pathway in TDP-43 Pathology in ALS/FTD1R21NS143648-01GAO, FEN-BIAOUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$460,625CMND
2025Investigating the role of TDP-43 citrullination in ALS pathogenesis1R21NS143203-01A1MASSI, FRANCESCAXU, ZUOSHANGUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$460,625MSFC
2025Towards an iNPC-proSAAS therapy for Parkinson's disease1R21NS140879-01A1LAPERLE, ALEXANDERMAIDMENT, NIGEL TUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$460,563CDIN
2025Effect of intranasal HB-EGF treatment on brain glucose metabolism and inflammation after TBI in the developing brain1R21NS131048-01A1SCAFIDI, JOSEPHSCAFIDI, SUSANNAHUGO W. MOSER RES INST KENNEDY KRIEGER, MD$453,970DBD
2025Microglial-Mediated Glycosaminoglycan Catabolism in MPS VII Neuropathology.1R21NS144683-01YELLAJOSHYULA, DHANANJAYCASE WESTERN RESERVE UNIVERSITY, OH$453,033CMBG
2025The role of nuclear mechano-transduction in regulating gene expression and shaping the spatial landscape in glioblastoma1R21NS136647-01A1AL DALAHMAH, OSAMACOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$452,375GRIC
2025In Vivo Neuronal Reprogramming of Fibroblasts After Spinal Cord Injury1R21NS136893-01A1ZHANG, CHUN-LIUT SOUTHWESTERN MEDICAL CENTER, TX$451,000CNNT
2025A novel diagnostic assay for parkinsonian tauopathies1R21NS137072-01A1BITAN, GALUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$446,991CNTN
2025Generating NTRK3-FlpO Mice for Genetically Intersecting A-beta Nociceptors1R21NS142656-01LUO, WENQINUNIVERSITY OF PENNSYLVANIA, PA$446,875NPI
2025Methotrexate effects on synaptic plasticity: a path to female resiliency to chemotherapy-induced cognitive deficits1R21NS143130-01REYES, TERESA MUNIVERSITY OF CINCINNATI, OH$445,500ZRG1
2025Role of perinatal testosterone in programming behavioral and astrocyte responses to early life chemotherapy1R21NS145425-01REYES, TERESA MUNIVERSITY OF CINCINNATI, OH$445,500ZRG1
2025Progesterone receptors and migraine chronification1R21NS140790-01A1JOSHI, SUCHITRAUNIVERSITY OF VIRGINIA, VA$444,125NPI
2025Soluble epoxide hydrolase in perinatal brain injury1R21NS143088-01MAEZAWA, IZUMIUNIVERSITY OF CALIFORNIA AT DAVIS, CA$442,750ZRG1
2025Induce and Image extrachromosomal DNA in human glioblastoma avatar1R21NS144792-01XIE, LIANGQICLEVELAND CLINIC LERNER COM-CWRU, OH$442,750CMT
2025Proteostasis maintenance of neuroreceptors by an ER-phagy receptor1R21NS145426-01MU, TINGWEICASE WESTERN RESERVE UNIVERSITY, OH$442,750ZRG1
2025Systematic discovery of Olig2 upstream regulators for central nervous system myelination1R21NS135360-01A1PARK, YUNGKISTATE UNIVERSITY OF NEW YORK AT BUFFALO, NY$440,275ZRG1
2025A novel intrinsic pro-survival mechanism against ischemic brain injury in clinically relevant animal models1R21NS140910-01A1HALPAIN, SHELLEY LUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$438,625BINP
2025Establishing iPSC-based models to investigate the mechanistic interaction between neurotrauma and ALS/FTD1R21NS142733-01KISKINIS, EVANGELOSNORTHWESTERN UNIVERSITY, IL$438,606CMND
2025Creation of a mouse model system for JC virus ORF4 protein1R21NS140693-01A1SAFAK, MAHMUTTEMPLE UNIV OF THE COMMONWEALTH, PA$435,875CNBT
2025Ramping time scale synaptic plasticity in the in vivo cerebellum1R21NS140563-01A1HANSEL, CHRISTIAN ROBERTUNIVERSITY OF CHICAGO, IL$433,592LMDN
2025SERBP1 as a dual modulator of epigenetic regulation in glioblastoma1R21NS137252-01A1PENALVA, LUIZ OTAVIOUNIVERSITY OF TEXAS HLTH SCIENCE CENTER, TX$433,125GRIC
2025Transcriptional regulations underlying cell type specific terminal differentiation of cortical interneurons1R21NS145063-01TANIGUCHI, HIROKIOHIO STATE UNIVERSITY, OH$433,125NCF
2025Function of calcium-activated small conductance potassium channel in astrocytes1R21NS140788-01A1ZHOU, MINOHIO STATE UNIVERSITY, OH$433,125NC
2025Cross validation of gene expression changes in C9orf72 FTD using Drosophila and human model systems1R21NS141011-01SATTLER, RITAZARNESCU, DANIELA CPENNSYLVANIA STATE UNIV HERSHEY MED CTR, PA$432,802CMND
2025Explore the role of a new chemokine to alleviate postoperative pain1R21NS142685-01LAUMET, GEOFFROY OMICHIGAN STATE UNIVERSITY, MI$431,750NPI
2025CYP2C11 Overexpression targeting peri-lesion astrocytes to improve cognitive function in mice with multi-infarct dementia1R21NS142762-01LIU, ZHONGWUHENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES, MI$431,750CDBA
2025Whole brain, PET-based molecular neuroimaging of fos expression – a new tool for imaging neurocircuitry involved in complex behavior1R21NS142826-01ROBISON, ALFRED JSHAPIRO, ERIKHENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES, MI$431,750ZRG1
2025Molecular mechanisms of sex-specific deficits in neurodevelopmental disease1R21MH140028-01MANZINI, M. CHIARARUTGERS BIOMEDICAL AND HEALTH SCIENCES, NJ$431,750DBD
2025Membrane trafficking impairments in fragile x syndrome1R21NS143271-01A1BASSELL, GARY JEMORY UNIVERSITY, GA$430,375NDPR
2025Mechanisms of altered RNA transport dynamics by Kif1C mutations in heterospastic paraplegia1R21NS145545-01BASSELL, GARY JJANUSZ-KAMINSKA, ALEKSANDRA MARIAEMORY UNIVERSITY, GA$430,375MNG
2025Myelin Acquisition and Maintenance in Adult Spinal Cord and Brain: Dependence on Activity and TSC Signaling1R21NS145553-01WOOD, TERESA LRUTGERS BIOMEDICAL AND HEALTH SCIENCES, NJ$429,514ZRG1
2025Somatic instability of CAG repeats in spinal and bulbar muscular atrophy1R21NS142744-01MERRY, DIANE ETHOMAS JEFFERSON UNIVERSITY, PA$429,000CMND
2025Post-ischemic protection of white matter following an ischemic attack1R21NS138711-01A1BALTAN, SELVAOREGON HEALTH & SCIENCE UNIVERSITY, OR$429,000BINP
2025Mechanism of Notch inhibition resistance in glioblastoma stem cells1R21NS141081-01A1FAN, XINGUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$429,000MCTC
2025Developing a toolbox to study proteome plasticity in brain endothelial cells1R21NS142439-01LONGDEN, THOMAS AUNIVERSITY OF MARYLAND BALTIMORE, MD$427,625BINP
2025Profiling cell type-specific ubiquitome in UBE3A mutant mice1R21NS142497-01GAO, YUUNIVERSITY OF WISCONSIN-MADISON, WI$427,625MNG
2025Does Electrical Stimulation Enhance the Capacity of Neural Stem Cell Transplants to Improve Recovery from Chronic Spinal Cord Injury1R21NS138955-01A1PERLMUTTER, STEVE IUNIVERSITY OF WASHINGTON, WA$427,625BTEN
2025Protective roles of the lithium-inducible SLC6 transporter in lithium's adverse effects: Insights from Drosophila genetics1R21NS145387-01A1KITAMOTO, TOSHIHIROUNIVERSITY OF IOWA, IA$427,625MNG
2025Control of tongue movements by the cerebellum1R21NS145008-01SHADMEHR, REZAJOHNS HOPKINS UNIVERSITY, MD$426,875SMN
2025Hybrid Differentiation Strategies for Region-Specific SOX10 Lineages1R21NS138850-01A1IYER, NISHATUFTS UNIVERSITY MEDFORD, MA$426,650BTEN
2025Investigating surface signaling effectors of neurofilamenthyperphosphorylation: implications for neurodegenerative disease.1R21NS140178-01A1SOCKANATHAN, SHANTHINIJOHNS HOPKINS UNIVERSITY, MD$426,313CMND
2025Circuit Interactions of Adult-Born Neurons1R21NS141447-01A1OVERSTREET-WADICHE, LINDAUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$424,470MCNP
2025In vivo tracking of innate immune activation and therapeutic response in MS mouse models using [18F]OP-8011R21NS135513-01A1JAMES, MICHELLE LOUISESTANFORD UNIVERSITY, CA$424,234CNBT
2025Defining Mechanisms of Cognitive Dysfunction in Central Nervous System Autoimmunity1R21NS144835-01HAN, MAY HTWESTANFORD UNIVERSITY, CA$423,500CNBT
2025DNAJC12 in dopamine biology, physiology and related-behavior1R21NS136890-01A1FARRER, MATTHEW JUNIVERSITY OF FLORIDA, FL$422,125CDIN
2025Sex-dependent functions of spinal dopamine 1 receptors in neuropathic pain1R21NS145148-01STONE, LAURA SVULCHANOVA, LYUDMILA HWILCOX, GEORGE LATIMERUNIVERSITY OF MINNESOTA, MN$421,437NPI
2025Profiling of adenosine to inosine editing in single neurons1R21NS140812-01A1NECHIPORUK, ALEXOREGON HEALTH & SCIENCE UNIVERSITY, OR$420,744MNG
2025Infections and the Risk of Parkinson's Disease1R21NS142801-01FLORES TORRES, MARIO HHARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH, MA$418,000PRID
2025Non-invasive Imaging for Therapeutic Efficacy (NITE) in Ndufs4 Mouse Model of Leigh Syndrome1R21NS142555-01WU, YIJEN LINUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$416,544CNNT
2025Predicting Migraine Attack Onset with Real-Time Individualized Autonomic Patterns1R21NS145442-01DASILVA, ALEXANDREPICARD, ROSALIND WUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$415,249ZRG1
2025Single cell transcriptomics identifies a dentate granule cell type switch in epilepsy1R21NS139176-01A1ROOPRA, AVTAR SUNIVERSITY OF WISCONSIN-MADISON, WI$414,305CNNT
2025Tactile modulation of the neonatal hypothalamus1R21NS137110-01A1HAMMOCK, ELIZABETH A.D.FLORIDA STATE UNIVERSITY, FL$413,694BNRS
2025Defining the Substrates and Interactome of Focal Adhesion Kinase that Regulate Exocytic Vesicle Fusion1R21NS144608-01GUPTON, STEPHANIEUNIV OF NORTH CAROLINA CHAPEL HILL, NC$413,480NC
2025Neurofilament regulation of sensory neuron axon caliber1R21NS139112-01A1SAGASTI, ALVAROUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$407,739NDPR
2025New Kv7 modulators to stop sensitized overexcitation of neurons1R21NS139257-01A1HOSHI, NAOTOUNIVERSITY OF CALIFORNIA-IRVINE, CA$407,113NPI
2025ASO Therapy for ADNP1R21NS141039-01A1SEGAL, DAVID JUNIVERSITY OF CALIFORNIA AT DAVIS, CA$395,009TAG
2025The Role of Proton-Mediated Signaling at the Neuromuscular Junction in ALS Models1R21NS142775-01RENDEN, ROBERT BUNIVERSITY OF NEVADA RENO, NV$387,525SMEP
2025Investigating the role of RHOBTB2 in DEE to develop novel therapies1R21NS142525-01MEFFORD, HEATHER C.ST. JUDE CHILDREN'S RESEARCH HOSPITAL, TN$277,500TAG
2025Role of CNNM2 in Neuronal Mg2+ Homeostasis, Function and Development1R21NS140895-01MILLONIG, JAMES H.RUNNELS, LOREN WRUTGERS BIOMEDICAL AND HEALTH SCIENCES, NJ$274,750DBD
2025A Comprehensive Cell-Type-Specific Developmental Genetic Toolkit for the Drosophila Visual System1R21NS140885-01DESPLAN, CLAUDEOZEL, MEHMET NESETNEW YORK UNIVERSITY, NY$257,750MNG
2025Determining face representations within and transformations between temporal and prefrontal cortex1R21MH138848-01FREIWALD, WINRICHROCKEFELLER UNIVERSITY, NY$254,250NBVP
2025Effects of Noninvasive Brain Stimulation on the Developing Brain1R21NS136909-01A1IKONOMIDOU, HRISSANTHIUNIVERSITY OF WISCONSIN-MADISON, WI$253,756ANIE
2025Prospective Identification of Hypoxic Ischemic Brain Injury Using Portable Magnetic Resonance Imaging1R21NS145048-01BEEKMAN, RACHELGILMORE, EMILYSHETH, KEVIN NAVINYALE UNIVERSITY, CT$251,313BIND
2025Investigating Dysfunction of Neuroimmune-Related Processes in Models of ALS/FTD TDP-431R21NS139100-01A1BOSCO, DARYL ANGELAUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$251,250ZRG1
2025Molecular mechanism of the synapse organizer C1QL31R21NS142751-01HAO, BINGUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT$249,750NC
2025Developing and characterizing sleep-based network homeostasis in a diurnal rodent model for Familial Natural Short Sleep1R21NS139668-01A1WATSON, BRENDON OUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$248,708BNRS
2025Targeting the Mesocortical Glutamatergic Pathway for Chronic Pain Treatment1R21NS137066-01A1YANG, GUANGCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$246,750NPI
2025Neuronal Ensemble Mechanisms of Behavior and Plasticity in a Cnidarian1R21NS135654-01A1YUSTE, RAFAELCOLUMBIA UNIV NEW YORK MORNINGSIDE, NY$246,750NMB
2025Role of LRRC8 Anion Channels in Brain Taurine Signaling and Body Fluid Homeostasis1R21NS140782-01MONGIN, ALEXANDER AALBANY MEDICAL COLLEGE, NY$245,938CMBG
2025Projective Methods for PET/SPECT Image Analysis1R21NS138720-01A1TAGARE, HEMANT DYALE UNIVERSITY, CT$244,500ITN
2025Red Blood Cell BPGM Deficiency Contributes to Cognitive Impairment Following Ischemic Stroke1R21NS140800-01DENG, WENJUNMASSACHUSETTS GENERAL HOSPITAL, MA$240,350ANIE
2025Effects of on-demand and early neuromodulation interventions on bladder function after spinal cord injury1R21NS140942-01GAUNT, ROBERT AUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$238,500BNVT
2025Treating Alzheimer's Disease with PMO RNA Therapeutics1R21NS140937-01DOWDY, STEVEN FUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$238,500DMPB
2025Defining Epstein-Barr virus reservoirs and EBV-regulated gene expression in multiple sclerosis1R21NS138981-01A1GREGORY, SIMON GLUFTIG, MICAH ALANDUKE UNIVERSITY, NC$237,476CNBT
2025Metabotropic glutamate receptor 7 as a potential genetic modifier of cognitive deficits in neurofibromatosis1R21NS143120-01NISWENDER, COLLEEN MVANDERBILT UNIVERSITY, TN$237,399LMDN
2025Dystrophin as a novel regulator of the circadian clock in skeletal muscle and the brain1R21NS140497-01ALEXANDER, MATTHEW SCOTTUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$236,566SMEP
2025Alternative Splicing Directed Epigenetic Regulation in Brain Development1R21NS140948-01NAZIM, MOHAMMADUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$236,250MNG
2025Cell-resolution imaging of synapses and circuits in post-mortem specimens1R21NS142509-01LAUGHLIN, SCOTT T.STATE UNIVERSITY NEW YORK STONY BROOK, NY$235,887EBIT
2025Unveiling CTL1 as the Key Choline Transporter in Oligodendrocytes: Implication for Myelin Formation and Maintenance1R21NS140995-01KIM, HAESUN ARUTGERS THE STATE UNIV OF NJ NEWARK, NJ$235,500ZRG1
2025Mechanisms that support Raphespinal tract plasticity and regeneration after spinal cord injury1R21NS139481-01A1CAFFERTY, WILLIAM B.YALE UNIVERSITY, CT$234,949NDPR
2025Altered arterial smooth muscle in cerebrovascular dysfunction during aging: remodeling of adhesion molecules1R21NS137267-01A1HILL, MICHAEL ASUN, ZHEUNIVERSITY OF MISSOURI-COLUMBIA, MO$234,750IVPP
2025GPR123 Activation by Steroid Ligands1R21NS142860-01HALL, RANDY A.EMORY UNIVERSITY, GA$234,750CSRS
2025Instantaneous digital subtraction angiography for neurovascular applications1R21NS140900-01A1TANG, XIANGYANGEMORY UNIVERSITY, GA$234,750ITD
2025Myopathy in purine metabolic disorders: a model for adenylosuccinate synthase deficiency1R21NS143788-01A1HANNA-ROSE, WENDYPENNSYLVANIA STATE UNIVERSITY, THE, PA$233,494SMEP
2025Imaging remyelination in multiple sclerosis using metabolic and ultra-short echo time MRI1R21NS140935-01GUGLIELMETTI, CAROLINEWASHINGTON UNIVERSITY, MO$233,250EITN
2025Luminescence-based biosensor to non-invasively measure UBE3A activity in the brain1R21NS142886-01ZYLKA, MARK J.UNIV OF NORTH CAROLINA CHAPEL HILL, NC$233,250DBD
2025Friend or Foe? The AMPK Signaling Pathway During Developmental Myelination1R21NS142512-01COLOGNATO, HOLLY ASTATE UNIVERSITY NEW YORK STONY BROOK, NY$232,524CMBG
2025Dissociating Sensory and Integrative Pain Processes in the Human Insula1R21NS140918-01RAMAYYA, ASHWINSTANFORD UNIVERSITY, CA$231,000NPI
2025Targeting Specific ASIC Subunits and Heteromers Using Protein Engineering1R21NS138705-01A1MACLEAN, DAVID MALCOLMUNIVERSITY OF ROCHESTER, NY$231,000BBM
2025Protection of Thalamic Neurons Which Regulate Consciousness by Ethosuximide After Cardiac Arrest - A Randomized Pre-Clinical Trial1R21NS139251-01A1SHOYKHET, MICHAELTON, HOAICHILDREN'S RESEARCH INSTITUTE, DC$227,500BINP
2025Uncovering the Molecular Function of the Tweety Homologue Membrane Protein Family1R21NS142832-01KAWATE, TOSHIMITSUCORNELL UNIVERSITY, NY$227,035BBM
2025Characterizing and treating peripheral nervous system dysfunction in Sanfilippo Syndrome1R21NS135412-01A1WEISS, RYAN JOSEPHZELTNER, NADJAUNIVERSITY OF GEORGIA, GA$226,500TAG
2025Understanding SCA1 pathogenesis in human cerebellar organoids1R21NS145182-01CVETANOVIC, MARIJADUTTON, JAMES R.UNIVERSITY OF MINNESOTA, MN$226,139CMND
2025Contributions of gonadal hormones vs. sex chromosomes in shaping sex differences in epilepsy1R21NS143269-01CHRISTIAN-HINMAN, CATHERINE AUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$225,599BIND
2025PP2A B' subunit regulates synaptic development and cognition - learning fromhuman mutations1R21NS137061-01A1WU, CHUNLAILSU HEALTH SCIENCES CENTER, LA$225,000NDPR
2025Determining the specific hemodynamics related to clot formation and subsequent stroke in subjects with carotid webs1R21NS142808-01ALLEN, JASON WILLIAMOSHINSKI, JOHN NEMORY UNIVERSITY, GA$217,472HTBT
2025Understanding the Neuroanatomical Abnormalities of Repetitive Head Impacts1R21NS140565-01ARCINIEGA, HECTORNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$211,875CNN
2025Development and Function of Medulla Tangential Neurons1R21NS138944-01A1TREISMAN, JESSICA ENEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$211,875NDPR
2025Mechanistic and Functional Genomic Interrogation of Meningioma Radiotherapy Response Genes1R21NS141756-01RALEIGH, DAVID RUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$209,910RTB
2025Neocortical and Hippocampal Circuit Dysfunction in the KCNT1 Model of Epilepsy1R21NS133670-01A1BARRY, JEREMY MICHAELUNIVERSITY OF VERMONT & ST AGRIC COLLEGE, VT$207,387CNNT
2025A copy number variant discovery pipeline for integrated genome-exome sequencing1R21MH138855-01BRAND, HARRISONMASSACHUSETTS GENERAL HOSPITAL, MA$206,250GHD
2025Intracranial EEG to test how noninvasive stimulation affects hippocampal-dependent memory1R21MH141420-01VOSS, JOEL LUNIVERSITY OF CHICAGO, IL$205,000ZRG1
2025Developing and Assessing Wearable MEG for Children1R21NS140619-01JAS, MAINAKMASSACHUSETTS GENERAL HOSPITAL, MA$203,000ZRG1
2025Probing mechanisms of long QT type 2-associated neuronal dysfunction using gene-edited stem cell-derived neurons1R21NS136833-01A1JONES, DAVID K.UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$195,000CNNT
2025Understanding small molecule modulation of splicing for Huntington's disease therapy1R21NS142950-01ZHAO, RUIUNIVERSITY OF COLORADO DENVER, CO$195,000DMPB
2025An inducible dual up/down gene regulation CRISPR system to study neuronal activity and regeneration1R21NS140949-01QI, LEI STANLEYSTANFORD UNIVERSITY, CA$192,500MNG
2025Defining the contribution from endothelial cell sphingolipid metabolism to outcomes of acute ischemic stroke in mice1R21NS137105-01A1CAMPBELL, ROBERT AHOLLAND, WILLIAM LSYMONS, JOHN DAVIDUTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, UT$192,500BINP
2025Reelin and Fragile X Syndrome1R21NS141304-01NASH, KEVIN RONUNIVERSITY OF SOUTH FLORIDA, FL$187,500PMDA
2025Metabolic miR-137 Effects Contribute to Neuronal Signaling1R21MH139202-01TSUNODA, SUSAN LCOLORADO STATE UNIVERSITY, CO$185,165NC
2025Promoting spinal cord repair using a polymer-based drug delivery system1R21NS139109-01A1TEDESCHI, ANDREAOHIO STATE UNIVERSITY, OH$184,837ZRG1
2025Dual Roles of Amyloid Beta in CNS Neuropathogenesis of HIV: Investigating Neuroprotective and Neurotoxic Mechanisms in HAND Progression1R21NS145862-01SPRENGER, KAYLAUNIVERSITY OF COLORADO, CO$184,506HCCS
2025Cerebellum wide imaging of neural activity in freely behaving animals1R21NS143157-01EBNER, TIMOTHY JKODANDARAMAIAH, SUHASA BSTRENG, MARTHA LUNIVERSITY OF MINNESOTA, MN$183,751ZRG1
2025Portable Microsampling Backpack with Integrated Sensing System1R21NS140877-01STENKEN, JULIE AUNIVERSITY OF ARKANSAS AT FAYETTEVILLE, AR$147,519ISD
2025Mitochondrial Methionyl-tRNA Formyltransferase (MTFMT) Mouse Model to elucidate Mitochondrial Translation initiation Defect and Disease Mechanisms in Leigh Syndrome1R21NS145159-01NARAYANAN, VINODHRANGASAMY, SAMPATHKUMARTRANSLATIONAL GENOMICS RESEARCH INST, AZ$9,026TAG
2024Contribution of astrocytes to Rett syndrome1R21NS139073-01ALLEN, NICOLA JSALK INSTITUTE FOR BIOLOGICAL STUDIES, CA$522,500CMBG
2024LRRC57 modulates neurotrophic growth factor signaling in synaptic function and behavior1R21MH138869-01ZAKHARENKO, STANISLAV SST. JUDE CHILDREN'S RESEARCH HOSPITAL, TN$500,500NDPR
2024Foxp2 genetic control of sex differences in amygdala-driven social behavior1R21MH135324-01A1CORBIN, JOSHUA GCHILDREN'S RESEARCH INSTITUTE, DC$497,652ZRG1
2024Synthetic System for Neuron Subtype- and Context-Specific Subcellular RNA/Protein Manipulation and Bioactive Delivery1R21NS141110-01MACKLIS, JEFFREY DHARVARD UNIVERSITY, MA$481,250MNG
2024In vitro approaches to study human cerebellar development1R21NS138661-01HALDIPUR, PARTHIVSEATTLE CHILDREN'S HOSPITAL, WA$478,732NCF
2024Measuring Brain Health Using Low-Field Portable MRI1R21NS138995-01DE HAVENON, ADAM H.YALE UNIVERSITY, CT$476,993EITN
2024Deciphering TREM1/2 Function in Primary Brain Cancer Using a New Model of Glioblastoma1R21NS139480-01CHAREST, ALAINBETH ISRAEL DEACONESS MEDICAL CENTER, MA$472,124ZRG1
2024Enhanced Genetic Targeting of Specific Neuronal Populations Using a Minipromoter and Splicing Hybrid Approach1R21NS135454-01A1BYGRAVE, ALEXEI MANSFIELDLING, JONATHANTUFTS UNIVERSITY BOSTON, MA$468,126MNG
2024Neural Substrates of the long-duration response1R21NS137136-01A1KANG, UN JUNGNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$466,125CNNT
2024BMAL1 Circadian Clock Complexes from Mammalian Brain1R21NS136974-01A1WEITZ, CHARLES JHARVARD MEDICAL SCHOOL, MA$466,125NDPR
2024Understanding the effect of Hao-Fountain syndrome-causing mutations on neuronal development1R21NS135343-01A1BEZSONOVA, IRINAO'NEIL, ALISON LINSLEYUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT$461,528DBD
2024Cholinergic Mechanisms of Associative Learning in Cortical Circuits1R21MH137452-01RUDY, BERNARDONEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$460,855SMN
2024Development of Mutant Specific Antisense Oligonucleotides for TARDBP and KIF5A as a Therapeutic for ALS/FTD1R21NS139270-01LANDERS, JOHN EUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$460,625MNG
2024Mitochondrial Transfer to Treat SBMA Motor Neurons1R21NS135044-01A1FENG, XIAMASSACHUSETTS GENERAL HOSPITAL, MA$459,250NOMD
2024Electrical Signaling in Dendritic Branches1R21NS138991-01ANTIC, SRDJAN DUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT$457,875NC
2024Molecular Mechanisms and Heterogeneity in the Inferior Olivary Nucleus Development1R21NS139034-01LI, JAMES Y.HUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT$457,875MNG
2024Molecular regulation of Kainate receptors1R21NS139087-01GANGWAR, SHANTI PALCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$452,375NC
2024Deep Behavioral Phenotyping of Novel Zebrafish Epilepsy Models1R21NS138525-01BARABAN, SCOTT CUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$451,000CNNT
2024MAP4K4 inhibition to prevent CIPN1R21NS135481-01A1HOKE, AHMETJOHNS HOPKINS UNIVERSITY, MD$450,313CNNT
2024Targeting scaffolding proteins to disrupt radioresistance in glioblastoma1R21NS139236-01VIAPIANO, MARIANO SEBASTIANUPSTATE MEDICAL UNIVERSITY, NY$448,250RTB
2024Modulating Blood-Brain Barrier Permeability by TRPV4 activation1R21NS135529-01A1LIU, CHUNLEIQIN, ZHENPENGUNIVERSITY OF TEXAS DALLAS, TX$447,501DMPB
2024Traumatic Axonal Injury: Tau and Amyloid Pathogenesis in vitro1R21NS135384-01A1SMITH, DOUGLAS HAMILTONUNIVERSITY OF PENNSYLVANIA, PA$446,875BINP
2024Behavioral and circuit manipulations of directional tuning in Subiculum1R21MH135321-01A1NITZ, DOUGLAS ARTHURUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$446,627LMDN
2024Studying astrocyte borders using injectable biomaterials1R21NS136831-01A1O'SHEA, TIMOTHY MARKBOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$446,126BNVT
2024Exploring the Rescue Strategy for Female NEXMIF Haploinsufficiency via X Chromosome Reactivation1R21MH134174-01A1MAN, HENGYEBOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$445,184ZRG1
2024Axonal signaling regulating oligodendrocyte differentiation1R21NS135041-01A1MACKLIN, WENDY BUNIVERSITY OF COLORADO DENVER, CO$444,599CMBG
2024Patterned optogenetic neuromodulation to reprogram glioma stem cells1R21NS127229-01A1HORNER, PHILIP JROSTOMILY, ROBERT CMETHODIST HOSPITAL RESEARCH INSTITUTE, TX$444,125NCF
2024Localized translational dysregulation in an autism spectrum disorder model using in situ cryo-EM1R21NS137060-01A1LOERCH, SARAHUNIVERSITY OF CALIFORNIA SANTA CRUZ, CA$443,121MSFC
2024Developing single nuclei tRNA-seq to profile tRNA diversity at the single cell level1R21NS139431-01SCHAFFER, ASHLEIGH ESWEET, THOMAS JCASE WESTERN RESERVE UNIVERSITY, OH$442,750ZRG1
2024Investigating electromagnetic field-based neuromodulation of slow-wave brain activity and glymphatic system1R21NS137573-01A1CHEN, NAN-KUEIUNIVERSITY OF ARIZONA, AZ$440,640ZRG1
2024A dynamic synaptic sensor controlling hippocampal CA3 circuit function1R21NS138721-01ARMSTRONG, JOHN NORMANCONTRACTOR, ANISNORTHWESTERN UNIVERSITY AT CHICAGO, IL$440,000NC
2024Epileptic Electrophysiological Brain Networks Modeling with Partially Observable Brain Regions1R21NS135482-01A1LIU, FENGTHE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY, NJ$438,836ZRG1
2024Visualizing and Manipulating Neuronal ESCRT Dynamics in vivo1R21NS140785-01RODAL, AVITAL ADAHBRANDEIS UNIVERSITY, MA$438,833NC
2024Recognition and Ubiqutination of neurodevelopmental chromatin regulators1R21NS139210-01FERGUSON, COLE JOHNUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$438,342MSFC
2024Rapid In Vivo Screening of Combination Gene Therapies for Axonal Regeneration after Spinal Cord Injury1R21NS135479-01A1CASTLE, MICHAELLU, PENGZHETUSZYNSKI, MARK H.UNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$437,250CNNT
2024Molecular analysis of the blood-nerve barrier in health and diabetes1R21NS137238-01A1DANEMAN, RICHARDUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$437,250MNG
2024Revealing the complexity of dis-inhibitory circuitries1R21NS140988-01HAJOS, NORBERTTRUSTEES OF INDIANA UNIVERSITY, IN$435,875NC
2024Homeostatic regulation of CaV2 voltage-gated calcium channels at synapses1R21NS139113-01KIM, HONGKYUNROSALIND FRANKLIN UNIV OF MEDICINE & SCI, IL$434,225NDPR
2024Glioblastoma-secreted GABA contributes to the immunosuppressive environment1R21NS131767-01A1KAUFMAN, DANIELUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$432,250CNBT
2024Functional and molecular dissection of dopaminergic signaling in spinal locomotor circuit development1R21NS135780-01A1MASINO, MARK AUNIVERSITY OF MINNESOTA, MN$431,996SMN
2024GLIOMA INTERACTION WITH THE NEUROGENIC NICHE THROUGH EXTRACELLULAR VESICLES1R21NS128212-01A1GUERRERO-CAZARES, HUGOMAYO CLINIC JACKSONVILLE, FL$430,375ZRG1
2024Generation of Parkinson-derived human glial progenitor cells for dopaminergic neuronal conversion1R21NS135306-01A1PETERSON, DANIEL ALANROSALIND FRANKLIN UNIV OF MEDICINE & SCI, IL$429,925CNNT
2024Structural basis of ER-mitochondria membrane contacts and neuronal health1R21NS138590-01SERYSHEVA, IRINA IUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$429,000BBM
2024Converging molecular mechanisms in axon degeneration and astrocyte morphogenesis1R21NS138718-01MONK, KELLY ROREGON HEALTH & SCIENCE UNIVERSITY, OR$429,000CMBG
2024Schwann cell Piezo1 and pain sensation1R21NS138704-01YU, HONGWEIMEDICAL COLLEGE OF WISCONSIN, WI$429,000NPI
2024The mechanism and role of androgen receptor Serine 16 phosphorylation in SBMA1R21NS139090-01MERRY, DIANE ETHOMAS JEFFERSON UNIVERSITY, PA$429,000CMND
2024Cell type specific analysis of Src kinase-NMDA receptor complexes in schizophrenia1R21MH135361-01A1HAHN, CHANG-GYUTHOMAS JEFFERSON UNIVERSITY, PA$429,000PMDA
2024The TMS-evoked potential as a measure of cortical excitation and inhibition during cognitive processes1R21NS137987-01WESSEL, JAN RUNIVERSITY OF IOWA, IA$427,625ZRG1
2024Hyperpolarized MRI for Metabolic Imaging of Epileptic Tissue1R21NS139180-01KSENDZOVSKY, ALEXANDERMAYER, DIRKUNIVERSITY OF MARYLAND BALTIMORE, MD$427,625EITN
2024Directly Converted Neurons as a Novel Cellular Model for ALS and FTD1R21NS139222-01MILLER, TIMOTHY M.WASHINGTON UNIVERSITY, MO$427,625CMND
2024GLT-1/EAAT2 signaling as a novel player in myelin repair1R21NS135262-01A1FUSS, BABETTEVIRGINIA COMMONWEALTH UNIVERSITY, VA$426,938CMBG
2024Elucidating the mechanisms of ependymal ciliary signaling1R21NS140934-01ASKWITH, CANDICE CMYKYTYN, KIRK AOHIO STATE UNIVERSITY, OH$424,338CSF1
2024Racial and Ethnic Differences of Non-Motor Symptoms in Parkinson's Disease1R21NS135213-01A1VENUTO, CHARLES STANLEYUNIVERSITY OF ROCHESTER, NY$423,500NMBH
2024Cerebellar Nuclei Dysfunction in Spinocerebellar Ataxia Type 11R21NS136962-01A1CVETANOVIC, MARIJAUNIVERSITY OF MINNESOTA, MN$423,500CDIN
2024CCL2/CCR2 modulates HIV-associated ischemic stroke by regulating blood brain barrier monocyte recruitment1R21NS141704-01TORICES, SILVIAUNIVERSITY OF MIAMI SCHOOL OF MEDICINE, FL$422,125HCCS
2024Pre-clinical testing of a novel gene therapy for pediatric neurodegenerative disease1R21NS137243-01A1RIOS, JONATHANUT SOUTHWESTERN MEDICAL CENTER, TX$419,482TAG
2024Accelerated Rosette Trajectories- Based 5D MR Spectroscopic Imaging AND MR Imaging of Myelin Fraction in Perinatally HIV-Infected Adults1R21NS134488-01A1THOMAS, MICHAEL ALBERTUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$415,876HCCS
2024Investigating the interplay between polymorphic α-syn fibril conformation and cell-dependent pathology1R21NS139178-01LEE, MYUNGWOONPAEK, JUNGWOOKDREXEL UNIVERSITY, PA$414,191MSFB
2024Optical Sensing of the Spread of Alpha-Synuclein Aggregates in Models of Parkinson's Disease and Related Dementias1R21NS135424-01A1WEBB, KEVIN JPURDUE UNIVERSITY, IN$406,260CMND
2024Population voltage imaging of sensory and cognitive signals in somatosensory (S1) cortex1R21NS138989-01FELDMAN, DANIELJI, NAUNIVERSITY OF CALIFORNIA BERKELEY, CA$399,077SMN
2024Electronic nicotine device systems (ENDS)-induced alterations in glutamate homeostasis: Effects on seizure susceptibility1R21NS131301-01A1CAMPBELL, SUSAN LATOYAUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$396,590CNNT
2024Transcriptional profiling of proliferative skeletal muscle mononucleated cells coupled with broadband electrical cytometry towards diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome1R21NS139044-01CHENG, XUANHONGLEHIGH UNIVERSITY, PA$390,178ZRG1
2024Engineered GABA oxidase for GABA sensing in vivo1R21NS139078-01MONBOUQUETTE, HAROLD GEORGEUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$388,158BNVT
2024Epigenetic mechanisms of HAND pathogenesis1R21NS137986-01A1BUKRINSKY, MICHAEL ILYASVIRIDOV, DMITRIGEORGE WASHINGTON UNIVERSITY, DC$382,072HCCS
2024Molecular determinants of high seizure risk times1R21NS135477-01A1BERNARD, CHRISTOPHEROOPRA, AVTAR SUNIVERSITY OF WISCONSIN-MADISON, WI$372,625CNNT
2024Determining the role of astrocyte BMP signaling in cortical astrocyte heterogeneity1R21NS137659-01ALLEN, NICOLA JSALK INSTITUTE FOR BIOLOGICAL STUDIES, CA$285,000CMBG
2024Develop a human-mouse chimeric brain model for studying tau pathology in human neuron in vivo1R21NS140907-01XU, RANJIEPURDUE UNIVERSITY, IN$274,750CMND
2024The role of extracellular vesicles in septic encephalopathy metabolism and immunity1R21NS135088-01KOUTROULIS, IOANNISCHILDREN'S RESEARCH INSTITUTE, DC$273,000NOMD
2024Exploring Feasibility of Gene-Targeted Therapeutics for Epigenetic Neurodevelopmental Disorders1R21NS137088-01GABEL, HARRISON WWASHINGTON UNIVERSITY, MO$272,125MNG
2024Genotype-informed single cell transcriptomic profiling of mosaic brain tissue1R21NS133873-01A1HEINZEN, ERIN LUNIV OF NORTH CAROLINA CHAPEL HILL, NC$268,410ZRG1

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