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NIH funding notice PAR-13-007

Early-Stage Pharmacological Validation of Novel Targets and Accompanying Pre-Therapeutic Leads for Diseases of Interest to the NIDDK (R01)

Closed on March 7, 2016.

Posted
October 10, 2012
Close date
March 7, 2016
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

22 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $9,870,348 in first-year total cost, median $476,388.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 EMNR-R (56)]19
  2. Special Emphasis Panel[ZRG1-EMNR-R(56)R]3

Most frequent institutions

  1. RESEARCH TRIANGLE INSTITUTE2
  2. UNIVERSITY OF CALIFORNIA, SAN FRANCISCO2
  3. WASHINGTON UNIVERSITY2
  4. BETH ISRAEL DEACONESS MEDICAL CENTER1
  5. DARTMOUTH COLLEGE1
Competing awards under PAR-13-007 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2017SMALL MOLECULE BACTERIAL LECTIN ANTAGONISTS FOR UTI TREATMENT AND PREVENTION1R01DK108840-01A1HULTGREN, SCOTT J.JANETKA, JAMES WWASHINGTON UNIVERSITY, MO$485,650ZRG1
2017APJ receptor agonism for metabolic syndrome1R01DK103625-01A1MAITRA, RANGANRESEARCH TRIANGLE INSTITUTE, NC$471,450ZRG1
2016A PSGL-1 Glycopeptide Mimetic for Treatment of Metabolic Syndrome1R01DK107405-01CHAIKOF, ELLIOTKAHN, BARBARA B.BETH ISRAEL DEACONESS MEDICAL CENTER, MA$638,976ZRG1
2016Xanthine oxidase inhibition raises intracellular purines to activate AMPK, improve glucose control and decrease fatty liver and atherosclerosis in type 2 diabetes1R01DK108936-01SHOELSON, STEVEN EJOSLIN DIABETES CENTER, MA$413,750ZRG1
2016Pre-clinical studies to explore the therapeutic potential of insulin-degrading enzyme inhibitors1R56DK106200-01A1SAGHATELIAN, ALANSEELIGER, MARKUS ASALK INSTITUTE FOR BIOLOGICAL STUDIES, CA$331,500ZRG1
2016Validation of Aconitase-Isocitrate Pathway as a Target for Anemia Treatment1R01DK101550-01A1GOLDFARB, ADAM N.UNIVERSITY OF VIRGINIA, VA$237,000ZRG1
2016Preclinical Development of Khellin Analogs for Anti-Diabetic Therapy1R56DK108887-01A1WANG, WEIDONGUNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR, OK$222,000ZRG1
2015Preclinical validation of ABHD5 as a target for treatment of obesity.1R01DK105963-01GRANNEMAN, JAMES GWAYNE STATE UNIVERSITY, MI$686,724ZRG1
2015Small Molecule Inhibitors of LMPTP: An Obesity Drug Target1R01DK106233-01BOTTINI, NUNZIOPINKERTON, ANTHONY BRUCELA JOLLA INSTITUTE FOR IMMUNOLOGY, CA$633,892ZRG1
2015Eicosanoid-based Therapy for Diabetes1R01DK103616-01A1IMIG, JOHN DMEDICAL COLLEGE OF WISCONSIN, WI$485,131ZRG1
2015Validation of small molecule 12-lipoxygenase inhibitors in metabolic disease1R01DK105588-01MIRMIRA, RAGHAVENDRA GNADLER, JERRY L.INDIANA UNIVERSITY INDIANAPOLIS, IN$481,326ZRG1
2015Activating cystic fibrosis transmembrance conductance regulator: the therapeutic potential of RNA directed gene activation1R01DK104681-01MORRIS, KEVIN VSCRIPPS RESEARCH INSTITUTE, THE, CA$413,735ZRG1
2015TARGETING THE MITOCHONDRIAL PYRUVATE CARRIER TO TREAT NONALCOHOLIC STEATOHEPATITIS1R01DK104735-01FINCK, BRIAN NWASHINGTON UNIVERSITY, MO$410,065ZRG1
2015Targeting Diabetes With Novel Small Molecule Therapeutics1R56DK100624-01A1LEBECHE, DJAMELICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$169,500ZRG1
2014IKKepsilon/TBK1 Inhibitors for the Treatment of Obesity and Type 2 Diabetes1R01DK100319-01SALTIEL, ALAN R.UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$594,912ZRG1
2014Designed Small Molecule Inhibitors of Ghrelin O-Acyl Transferase1R01DK100627-01A1HARRAN, PATRICK G.TONTONOZ, PETER JUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$554,272ZRG1
2014Pharmacological Validation of IRE1 for Diabetes Mellitus1R01DK100623-01MALY, DUSTIN JPAPA, FEROZ RUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$501,998ZRG1
2014Preclinical Validation of Transglutaminase 2 as a Novel Target for Celiac Disease1R01DK100619-01A1KHOSLA, CHAITANSTANFORD UNIVERSITY, CA$482,228ZRG1
2014Preclinical development of CFTR stabilizers targeting the CAL PDZ domain1R01DK101541-01MADDEN, DEAN RDARTMOUTH COLLEGE, NH$482,128ZRG1
2014Therapeutics Development for Hepatic Fibrosis1R01DK100414-01A1MAITRA, RANGANRESEARCH TRIANGLE INSTITUTE, NC$450,143ZRG1
2014Optimization of novel inhibitors of TRPC5 as anti-proteinuric therapeutics1R01DK103658-01HOPKINS, COREY R.VANDERBILT UNIVERSITY, TN$368,055ZRG1
2014Urea transport inhibitors as a new class of diuretics1R01DK101373-01VERKMAN, ALAN SUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$355,913ZRG1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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PAR-13-007: Early-Stage Pharmacological Validation of Novel Targets and Accompanying Pre-Therapeutic Leads for Diseases of Interest to the NIDDK (R01) | ScienceDex | ConductScience