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NIH funding notice PAR-15-358

Capturing Complexity in the Molecular and Cellular Mechanisms Involved in the Etiology of Alzheimer's Disease (R01)

Closed on January 7, 2019.

Posted
September 25, 2015
Close date
January 7, 2019
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

63 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $119,776,069 in first-year total cost, median $834,068.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 MDCN-E (56)]25
  2. Special Emphasis Panel[ZRG1 MDCN-T (56)]19
  3. Special Emphasis Panel[ZRG1-MDCN-E(56)R]10
  4. Special Emphasis Panel[ZRG1 MDCN-A (56)]2
  5. Macromolecular Structure and Function C Study Section[MSFC]1

Most frequent institutions

  1. ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI5
  2. UNIVERSITY OF CALIFORNIA-IRVINE5
  3. JACKSON LABORATORY3
  4. UNIVERSITY OF PENNSYLVANIA3
  5. UNIVERSITY OF SOUTH FLORIDA3
Competing awards under PAR-15-358 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2019Systems Genetic Analysis of Cognitive Resilience Using Multi-Parent Crosses1RF1AG063755-01KACZOROWSKI, CATHERINE COOKJACKSON LABORATORY, ME$5,201,511ZRG1
2019Proteomic and Genetic Approaches Defining Apolipoprotein E4 Neuropathologic Mechanisms1RF1AG059751-01A1KROGAN, NEVAN JMAHLEY, ROBERT W.J. DAVID GLADSTONE INSTITUTES, CA$4,669,193ZRG1
2019Integrated understanding of complex viral network biology in Alzheimer's Disease1RF1AG058469-01A1EHRLICH, MICHELLE EGANDY, SAMUEL E.ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$4,111,077ZRG1
2019Systems-level functional proteomics analysis assemblies in Alzheimer's disease and mouse models of tauopathy1RF1AG061706-01EMILI, ANDREWWOLOZIN, BENJAMIN LBOSTON UNIVERSITY MEDICAL CAMPUS, MA$3,945,190ZRG1
2019Connexin 43 and hemorrhagic complication in cerebral amyloid angiopathy1RF1AG064957-01ANDJELKOVIC-ZOCHOWSKA, ANUSKA V.UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$2,251,499ZRG1
2019Mechanisms of APOE-Induced Preclinical Alzheimer's Pathophysiology in Human Olfactory System1R01AG063881-01MISIAK, MAGDALENA MARIANWULIA, EVARISTUS AOBISESAN, THOMAS OHOWARD UNIVERSITY, DC$770,120ZRG1
2019Complexity and Heterogeneity of Alzheimer disease1R56AG061196-01HYMAN, BRADLEY T.MASSACHUSETTS GENERAL HOSPITAL, MA$653,558ZRG1
2019Uncovering the molecular and cellular mechanisms underlying AD using CRISPR/Cas9-edited isogenic neural cells1R56AG061171-01SHI, YANHONGBECKMAN RESEARCH INSTITUTE/CITY OF HOPE, CA$628,647ZRG1
2019Vacuolar Tauopathy1R56AG063344-01LEE, EDWARD BYUNG-HAUNIVERSITY OF PENNSYLVANIA, PA$624,837ZRG1
2019Modulation of Alzheimers disease by Herpes simplex virus infection1R01AG062514-01DARVAS, MARTIN CFUNK, CORYJOHNSTON, CHRISTINE MICHELLEUNIVERSITY OF WASHINGTON, WA$618,734ZRG1
2019Conformational and functional analysis of Apolipoprotein E1R01AG062837-01SORANNO, ANDREAWASHINGTON UNIVERSITY, MO$452,416MSFC
2019Epigenetic roles of DNA adenine methylation in Alzheimer's Disease1R01AG062577-01YAO, BINGEMORY UNIVERSITY, GA$395,513ZRG1
2019Differential vulnerability to tauopathy in Alzheimer's disease and Frontotemporal Lobe Dementia1RF1AG063521-01DUFF, KARENCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$390,972ZRG1
2019Peripheral Immune mechanisms involved in the etiology of Alzheimer's disease1R56AG064709-01AGRAWAL, ANSHUUNIVERSITY OF CALIFORNIA-IRVINE, CA$384,800ZRG1
2018Functional Networks in Microglia and Astrocytes Regulating Neuropathology of Alzheimer's Disease1RF1AG059770-01MILOSEVIC, ANAROCKEFELLER UNIVERSITY, NY$4,144,506ZRG1
2018Systems Genetics Approach to Determine Interactors of Apolipoprotein E in Alzheimer’s Disease1RF1AG055104-01A1CARTER, GREGORY WHOWELL, GARETH RSASNER, MICHAELJACKSON LABORATORY, ME$4,075,379ZRG1
2018Capturing the molecular complexity of Alzheimer's disease through the lens of RNA binding proteins1RF1AG056318-01A1LI, HUWOLOZIN, BENJAMIN LBOSTON UNIVERSITY MEDICAL CAMPUS, MA$3,944,412ZRG1
2018Gene x Environment Interactions in Hypothalamic Dysfunction in Alzheimer's Disease1RF1AG059778-01KACZOROWSKI, CATHERINE COOKO'CONNELL, KRISTEN MJACKSON LABORATORY, ME$3,833,547ZRG1
2018Epigenetic suppression of histone methylation reverses age and AD-related cognitive decline1RF1AG057558-01A1WOOD, MARCELO ANDRESUNIVERSITY OF CALIFORNIA-IRVINE, CA$3,774,324ZRG1
2018Conformational polymorphisms of amyloid in AD and immunological biomarkers and therapeutics1RF1AG056507-01A1GLABE, CHARLES G.UNIVERSITY OF CALIFORNIA-IRVINE, CA$3,245,609ZRG1
2018The Enhancer Code of AD-A Genetic Approach1R01AG056511-01A1GLASS, CHRISTOPHER KROSENFELD, MICHAEL GUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$1,073,248ZRG1
2018Computational Prediction and Functional Validation of Novel Risk Loci of Alzheimer's Disease1R56AG060757-01JIN, PENGQIN, ZHAOHUIWINGO, THOMAS SPURGEONEMORY UNIVERSITY, GA$788,200ZRG1
2018The surprising impact of APOE alleles on gut microbiome: does altering the microbiome reduce AD risk?1R56AG057589-01A1ESTUS, STEVENUNIVERSITY OF KENTUCKY, KY$610,216ZRG1
2018Probing Heterogeneity of Alzheimer's disease using iPSCs1R01AG055909-01A1YOUNG-PEARSE, TRACY LBRIGHAM AND WOMEN'S HOSPITAL, MA$416,553ZRG1
2018Cellular and synaptic signaling mechanisms driving early AD pathology1R56AG055497-01A1STUTZMANN, GRACE E.ROSALIND FRANKLIN UNIV OF MEDICINE & SCI, IL$390,000ZRG1
2018The Role of NgR Mediated Inhibition of New Synapse Assembly in Amyloid Beta Peptide Dependent Learning Deficits1R56AG058593-01WILLS, ZACHARY PUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$382,770ZRG1
2018CSVD and AD: the drivers of late life dementia1R01AG057665-01A1MCLAURIN, JOANNESTEFANOVIC, BOJANASUNNYBROOK RESEARCH INSTITUTE, ON$250,059ZRG1
2017Molecular pathobiology of soluble TREM2 in Alzheimer's disease.1RF1AG056130-01BU, GUOJUNHUANG, TIMOTHY YIKAISANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, CA$4,147,115ZRG1
2017Tauopathy in AD and FTD - Molecular Determinants of Phenotypic Diversity1RF1AG056151-01A1CARLSON, GEORGE A.DUFF, KARENFINKBEINER, STEVEN MCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$4,102,378ZRG1
2017Characterization of Rapidly Progressive Alzheimer's Disease1RF1AG058267-01HAINES, JONATHAN LSAFAR, JIRI G.WISNIEWSKI, THOMAS MNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$3,954,153ZRG1
2017MSUT2 modulates pathological tau in AD and model organisms1RF1AG055474-01KRAEMER, BRIAN C.SEATTLE INST FOR BIOMEDICAL/CLINICAL RES, WA$3,173,979ZRG1
2017Integrated target discovery in Alzheimer's disease1RF1AG055477-01BROWN, CHRISTOPHER DAVIDUNIVERSITY OF PENNSYLVANIA, PA$2,945,840ZRG1
2017Generation of Human iPSC-derived Entorhinal Cortex Neurons for Probing Selective Neuronal Vulnerability in Alzheimer's Disease1RF1AG054564-01ROUSSARIE, JEAN-PIERREROCKEFELLER UNIVERSITY, NY$2,853,240ZRG1
2017Innate Immune IL-10/STAT3 Signaling in Alzheimer's Disease1RF1AG053982-01A1CHANG, KAREN TCHEN, JEANNIEUNIVERSITY OF SOUTHERN CALIFORNIA, CA$2,792,837ZRG1
2017Examining the role of adaptive immunity in Alzheimer's Disease pathogenesis1RF1AG055524-01A1BLURTON-JONES, MATHEW MARKUNIVERSITY OF CALIFORNIA-IRVINE, CA$2,708,461ZRG1
2017Structure and Genesis of tau Aggregates1RF1AG054018-01A1KURET, JEFFOHIO STATE UNIVERSITY, OH$2,363,370ZRG1
2017Controlling tau toxicity from inside and outside of neurons1RF1AG055088-01BICKFORD, PAULA CBLAIR, LAURA JUVERSKY, VLADIMIR NUNIVERSITY OF SOUTH FLORIDA, FL$2,315,030ZRG1
2017Investigation of the effect of structural modifications of tau on assembly state and seeding1RF1AG054000-01A1BITAN, GALUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$1,947,083ZRG1
2017Integrated understanding of complex viral network biology in Alzheimer's Disease1R56AG058469-01DUDLEY, JOEL THOMASEHRLICH, MICHELLE EGANDY, SAMUEL E.ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$844,112ZRG1
2017Mechanisms of Resilience to Alzheimer's Disease Neuropathology1R56AG058281-01MICCI, MARIA-ADELAIDETAGLIALATELA, GIULIOUNIVERSITY OF TEXAS MED BR GALVESTON, TX$725,531ZRG1
2017Conformational polymorphisms of amyloid in AD and immunological biomarkers and therapeutics1R56AG056507-01GLABE, CHARLES G.UNIVERSITY OF CALIFORNIA-IRVINE, CA$698,846ZRG1
2017S-Nitrosylation-Induced Posttranslational Modification and Aberrant Cell Signaling in Sporadic Alzheimer's Disease1R01AG056259-01LIPTON, STUART ASCRIPPS RESEARCH INSTITUTE, THE, CA$677,219ZRG1
2017Probing the molecular and cellular complexity of APP trafficking and its relationship to AD.1R56AG054013-01A1GOLDSTEIN, LAWRENCE S.UNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$582,310ZRG1
2017Emerging Roles of Higher-order Polyamines During Tauopathies1R01AG054559-01LEE, DANIEL CARLUNIVERSITY OF SOUTH FLORIDA, FL$540,201ZRG1
2017Role of beta-adrenergic receptors in modulation of cognition and central and peripheral immune systems in Alzheimer's disease1R01AG054533-01A1SHAMLOO, MEHRDADSTANFORD UNIVERSITY, CA$511,011ZRG1
2017Defining roles of genetic and age in extracellular elimination of neurotoxic aggregates1R37AG056510-01DRISCOLL, MONICA A.RUTGERS, THE STATE UNIV OF N.J., NJ$458,880ZRG1
2017Impact of Amyloid Beta on Hippocampal Neurophysiology and Calcium Activity across the Sleep-Wake Cycle1R01AG054551-01A1GOMPERTS, STEPHEN N.MASSACHUSETTS GENERAL HOSPITAL, MA$416,261ZRG1
2017Immunotherapy in Alzheimer's Disease Animal Models Using Tau Recombinant Antibodies1R56AG055479-01D'ABRAMO, CRISTINAFEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, NY$412,500ZRG1
2017ROLE OF GLIAL CIRCADIAN CLOCK DYSFUNCTION IN THE PATHOGENESIS OF ALZHEIMER'S DISEASE1R01AG054517-01A1MUSIEK, ERIK STEVENWASHINGTON UNIVERSITY, MO$381,250ZRG1
2016Understanding the mechanism of SPl1 dependent Alzheimer disease risk1RF1AG054011-01GOATE, ALISON MICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$4,223,847ZRG1
2016Molecular Characterization and Validation of Gender Differences in Alzheimers Disease Pathogenesis1RF1AG054014-01CAI, DONGMINGZHANG, BINICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$4,211,117ZRG1
2016Cell type specific epigenetic analysis to understand complex mechanisms underlying Alzheimer's disease phenotypes1RF1AG054012-01KELLIS, MANOLISTSAI, LI-HUEIMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$3,861,008ZRG1
2016Structure and Inhibition of Amyloid in Alzheimer's Disease1RF1AG054022-01EISENBERG, DAVIDUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$3,779,925ZRG1
2016Contribution of DNA Repair Deficits to Alzheimer Pathogenesis1RF1AG053981-01MUCKE, LENNARTJ. DAVID GLADSTONE INSTITUTES, CA$3,714,865ZRG1
2016Molecular mechanisms and cellular implications of tau dysfunction1RF1AG053951-01ODDE, DAVID J.RHOADES, ELIZABETHUNIVERSITY OF PENNSYLVANIA, PA$2,739,985ZRG1
2016Cell autonomous and non-cell autonomous roles of the GWAS risk factor BIN1 in Alzheimer's disease neuropathology1RF1AG054223-01THINAKARAN, GOPALUNIVERSITY OF CHICAGO, IL$2,060,594ZRG1
2016Regulation of tau expression in Alzheimer disease and aging1R01AG054008-01CRARY, JOHN FONDAICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$834,068ZRG1
2016Tau-Spliceosome Interactions in Alzheimer's Disease1R01AG053960-01SEYFRIED, NICHOLAS THOMASSHULMAN, JOSHUA MBAYLOR COLLEGE OF MEDICINE, TX$648,994ZRG1
2016A multi-scale data-driven model of the Abeta pore function and Ca2+ toxicity in Alzheimer's disease1R01AG053988-01DEMURO, ANGELOULLAH, GHANIMUNIVERSITY OF SOUTH FLORIDA, FL$465,335ZRG1
2016Multi-level Integrative Proteomics to Alzheimer's Disease Pathways1R01AG053987-01PENG, JUNMINST. JUDE CHILDREN'S RESEARCH HOSPITAL, TN$459,835ZRG1
2016Mechanisms of Apolipoprotein E Isoform Conferred Susceptibility and Resistance to Alzheimer's Disease1R01AG053990-01SADOWSKI, MARTIN JOSEPHNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$435,679ZRG1
2016Formation and Propagation of Tau Oligomeric Strains in Alzheimer's Disease1R01AG054025-01KAYED, RAKEZUNIVERSITY OF TEXAS MED BR GALVESTON, TX$387,500ZRG1
2016Role of Systemic Amylin Dyshomeostasis in Alzheimer's Disease1R01AG053999-01DESPA, FLORINUNIVERSITY OF KENTUCKY, KY$374,820ZRG1

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