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NIH funding notice PAR-16-106

Rapid Assessment of Zika Virus (ZIKV) Complications (R21)

Closed on January 17, 2017.

Posted
February 19, 2016
Close date
January 17, 2017
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov ยท NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

89 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $21,880,770 in first-year total cost, median $229,500.

Most frequent study sections

  1. Special Emphasis Panel[ZAI1 EC-M (J1)]9
  2. Special Emphasis Panel[ZAI1 KP-M (J1)]8
  3. Special Emphasis Panel[ZAI1 BLF-M (S1)]7
  4. Special Emphasis Panel[ZAI1 UKS-M (S1)]6
  5. Special Emphasis Panel[ZAI1 ALW-M (S1)]5

Most frequent institutions

  1. UNIVERSITY OF CALIFORNIA AT DAVIS7
  2. COLORADO STATE UNIVERSITY4
  3. ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI4
  4. UNIVERSITY OF TEXAS MED BR GALVESTON4
  5. UNIVERSITY OF WISCONSIN-MADISON4
Competing awards under PAR-16-106 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2018A Novel Conformation of the ZIKV Protease Provides a Unique 3D Scaffold for Discovering Allosteric Protease Inhibitors as Direct Anti-virals, via HT and Virtual Screening, and Protein Engineering1R21AI134581-01LIDDINGTON, ROBERT COLINSANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, CA$292,500ZAI1
2018Rescuing Neurodevelopment in Zika-exposed Children1R21HD093551-01FERNANDES, MICHELLELANDON, BARBARAWAECHTER, RANDALLWINDWARD ISLANDS RESEARCH & ED FDN, NY$137,500ZHD1
2017Development of a nonhuman primate model of fetal Zika virus infection and disease1R21AI129479-01VAN ROMPAY, KOEN KUNIVERSITY OF CALIFORNIA AT DAVIS, CA$1,786,954ZAI1
2017A Novel Vaccine Platform for Preventing Zika Virus Infection1R21AI134495-01MARKHAM, RICHARD B.JOHNS HOPKINS UNIVERSITY, MD$286,125ZAI1
2017Prevention of Zika transmission with novel Aedes personal protective measures1R21AI130521-01CARLIER, PAUL RGRIECO, JOHN PAULSCHETZ, JOHN AUNIVERSITY OF NORTH TEXAS HLTH SCI CTR, TX$276,530ZAI1
2017Deep mutational scanning of the Zika envelope protein1R21AI133649-01EVANS, MATTHEW JICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$274,277ZAI1
2017Evaluating the Presence of Zika Virus in Neotropical Primates1R21AI129505-01DI FIORE, ANTHONY FRANCISDUDLEY, JAQUELIN PAGEMEYERS, LAUREN ANCELPAYNE, SHELLEY M.UNIVERSITY OF TEXAS AT AUSTIN, TX$273,875ZAI1
2017Mapping the RNA modification N6-methyladenosine during Zika virus infection1R21AI129851-01HORNER, STACY MICHELLEMASON, CHRISTOPHER EDWARDWEILL MEDICAL COLL OF CORNELL UNIV, NY$263,750ZAI1
2017Placental Defenses against Zika Virus Infection1R21AI134576-01KUOHUNG, WENDYBOSTON UNIVERSITY MEDICAL CAMPUS, MA$258,196ZAI1
2017Interferon signaling inhibition by the Zika virus NS5 protein1R21AI129486-01GARCIA-SASTRE, ADOLFOICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$254,250ZAI1
2017ZIKA VIRUS RESISTANCE; HOST DETERMINANTS1R21AI129827-01BOGUNOVIC, DUSANICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$254,250ZAI1
2017Determining West Nile virus antibody-dependent enhancement of Zika virus1R21AI130299-01LIM, JEAN KYOUICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$252,993ZAI1
2017Clinical Outcomes of Zika Virus in Sickle Cell Disease1R21HL137439-01KELLY, SHANNONVITALANT, AZ$252,694ZHL1
2017Dental and Craniofacial Effects of Intrauterine Zika Virus Infection1R21DE027235-01CAMPOS-RIVERA, MARIBELUNIVERSITY OF PUERTO RICO MED SCIENCES, PR$251,882ZDE1
2017Innate antiviral defense against Vaginal transmission of ZIKA virus1R21AI131284-01IWASAKI, AKIKOYALE UNIVERSITY, CT$251,250ZAI1
2017Zika Virus Vaccines based on Nanoscale Constructs Presenting the Envelope Protein1R21AI129477-01KANE, RAVI S.GEORGIA INSTITUTE OF TECHNOLOGY, GA$250,187ZAI1
2017Role of autophagy for Zika virus lifecycle1R21AI129496-01JUNG, JAE UUNIVERSITY OF SOUTHERN CALIFORNIA, CA$247,500ZAI1
2017Effects of pre-existing dengue virus immunity on Zika virus infection1R21AI129881-01COLPITTS, TONYA MICHELLEBOSTON UNIVERSITY MEDICAL CAMPUS, MA$246,750ZAI1
2017Construction of a ZIKV-host protein-protein interaction network1R21AI131706-01ZHU, HENGJOHNS HOPKINS UNIVERSITY, MD$245,282ZAI1
2017Innate Immune Inhibition of the Mevalonate Pathway Impairs Neurodevelopment during ZIKV Infection1R21NS102628-01WANG, DONGHAIDUKE UNIVERSITY, NC$238,500ZNS1
2017In vivo efficacy studies of existing drugs re-purposed for flaviviruses in mouse models1R21AI133219-01LI, HONGMINWADSWORTH CENTER, NY$238,240ZAI1
2017Antiviral immunity in the Zika virus mosquito vector1R21AI129863-01ANDINO, RAULUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$237,750ZAI1
2017Role of Persistent Zika Virus Infection of Endothelial Cells in Pathogenesis1R21AI131729-01MACKOW, ERICH RSTATE UNIVERSITY NEW YORK STONY BROOK, NY$235,543ZAI1
2017Microbial interplay between ZIKA virus and the native microbiome in mosquitoes1R21AI129507-01HUGHES, GRANT LESLIEUNIVERSITY OF TEXAS MED BR GALVESTON, TX$235,500ZAI1
2017New Use of Old Drugs for Zika Virus1R21AI134568-01LI, HONGMINWADSWORTH CENTER, NY$235,470ZAI1
2017Pregnant rabbits as a model to evaluate the causative role of ZIKV infection in the etiology of congenital malformations1R21AI129852-01STAATS, HERMAN FDUKE UNIVERSITY, NC$235,406ZAI1
2017Discovering host factors impacting ZIKV infection via forward genetic screens1R21AI129531-01BATES, PAULUNIVERSITY OF PENNSYLVANIA, PA$235,388ZAI1
2017Repurposing drugs to prevent and inhibit Zika virus inflections1R21AI129607-01SCHINAZI, RAYMOND FELIXEMORY UNIVERSITY, GA$234,000ZAI1
2017Identification and evaluation of novel therapeutic strategies for Zika virus-induced CNS disease1R21NS103186-01TYLER, KENNETH L.UNIVERSITY OF COLORADO DENVER, CO$233,250ZNS1
2017Structure based design of recombinant Zika virus antigens for serodiagnosis1R21AI134073-01DESILVA, ARAVINDA M.LAKSHMANANE, PREMKUMARUNIV OF NORTH CAROLINA CHAPEL HILL, NC$233,250ZAI1
2017Targeting Zika Virus Infection with Chloroquine and Related Drugs1R21AI130281-01FINK, SUSAN LEILANIUNIVERSITY OF WASHINGTON, WA$232,625ZAI1
2017Zika Virus Pathogenesis and Selective Autophagy Induction to Inhibit Virus Production1R21AI129846-01SPECTOR, DEBORAH HYEUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$232,500ZAI1
2017Mechanisms of sexual Zika virus transmission and early immunopathogenesis1R21AI129303-01VOJTECH, LUCIA NUNIVERSITY OF WASHINGTON, WA$232,063ZAI1
2017Rapid Phenotyping of the ZIKV Genome1R21AI129369-01ZHAO, RICHARD YUQIUNIVERSITY OF MARYLAND BALTIMORE, MD$231,750ZAI1
2017Under attack: Modulation of the blood-testes barrier by Zika virus1R21AI129465-01VERMA, SAGUNAUNIVERSITY OF HAWAII AT MANOA, HI$231,000ZAI1
2017Determining the role of host lipids in Zika virus infection1R21AI133631-01TAFESSE, FIKADU G.OREGON HEALTH & SCIENCE UNIVERSITY, OR$231,000ZAI1
2017Functional analysis of Zika virus induced birth defects1R21AI131418-01SHEETS, MICHAEL DUNIVERSITY OF WISCONSIN-MADISON, WI$229,500ZAI1
2017Zika virus evolutionary dynamics in host adaptation1R21AI131454-01ALIOTA, MATTHEW TUNIVERSITY OF WISCONSIN-MADISON, WI$229,500ZAI1
2017Understanding pathogenic noncoding RNA production in Zika Virus infection1R21AI129569-01KIEFT, JEFFREY SUNIVERSITY OF COLORADO DENVER, CO$229,125ZAI1
2017A Nanoscale Plasmonic-Gold Platform for Specific Diagnosis of Zika and Differentiation from other Flavivirus Infections1R21AI131689-01ANANTA, JEYARAMAPINSKY, BENJAMINNIRMIDAS BIOTECH, INC., CA$229,113ZAI1
2017PATHOGENESIS OF OCULAR ZIKA VIRUS INFECTION1R21EY027870-01APTE, RAJENDRA SMINER, JONATHAN JWASHINGTON UNIVERSITY, MO$228,750ZAI1
2017A novel system using human fetal brain neural stem cell to model ZIKV infection1R21AI129509-01WU, PINGUNIVERSITY OF TEXAS MED BR GALVESTON, TX$228,650ZAI1
2017Viral and host determinants of Zika virus tissue tropism1R21AI129431-01LAZEAR, HELENUNIV OF NORTH CAROLINA CHAPEL HILL, NC$228,000ZAI1
2017Role of cell tropism for Zika virus transmission and pathogenesis1R21AI129593-01EBEL, GREGORY DAVIDCOLORADO STATE UNIVERSITY, CO$227,250ZAI1
2017Role of Post-transcription RNA Modifications on Zika Virus Gene Expression1R21AI133617-01FABRIS, DANIELEPAGER, CARA THERESIASTATE UNIVERSITY OF NEW YORK AT ALBANY, NY$226,813ZAI1
2017Social-ecological factors influencing receptivity to Zika virus and the efficacy of interventions in communities along the Texas-Mexico border1R21AI128953-01HAMER, GABRIEL LEETEXAS A&M AGRILIFE RESEARCH, TX$222,750ZAI1
2017Design and validation of a rapid assay for Zika virus in biofluids and insect vectors1R21AI129488-01ROVNAK, JOELCOLORADO STATE UNIVERSITY, CO$222,546ZAI1
2017Pathological Implications of Repression of Cellular RNA Decay by Zika Virus1R21AI130497-01WILUSZ, JEFFREYCOLORADO STATE UNIVERSITY, CO$222,436ZAI1
2017The Olive Baboon, a translational model for the study of Zika virus biology and pathogenesis1R21AI129560-01PAPIN, JAMES FUNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR, OK$222,000ZAI1
2017The Olive Baboon model of Zika Virus induced fetal brain injury1R21NS103772-01MYERS, DEANPAPIN, JAMES FUNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR, OK$222,000ZNS1
2017Nonhuman Primate Model to Assess Fetal Zika Virus Infection Complications1R21AI129308-01GOLOS, THADDEUS GUNIVERSITY OF WISCONSIN-MADISON, WI$221,550ZAI1
2017Diagnostic signatures of Zika virus pathogenesis1R21AI130523-01BLISH, CATHERINE ASTANFORD UNIVERSITY, CA$219,762ZAI1
2017Zika virus urogenital tropism, pathogenesis and sexual transmission1R21AI129464-01FOY, BRIAN DAVIDCOLORADO STATE UNIVERSITY, CO$211,838ZAI1
2017Opthalmic Manifestations of Congenital Zika Virus Infection1R21EY028318-01BRASIL, PATRICIANIELSEN, KARINTSUI, IRENAUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$211,475ZAI1
2017RNAi methods for Zika virus vector control1R21AI131427-01PALLI, SUBBA RUNIVERSITY OF KENTUCKY, KY$210,000ZAI1
2017Zika virus in the human genital tract and implications for transmission1R21AI129532-01BECKER-DREPS, SYLVIA IRENEBUCARDO, FILEMONUNIV OF NORTH CAROLINA CHAPEL HILL, NC$207,868ZAI1
2017Viral kinetics, immunity and transmission of ZIKV: an exploratory analysis in preparation for vaccine development1R21AI129534-01BRASIL, PATRICIANIELSEN, KARINUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$201,907ZAI1
2017Mucosal Single-Cycle Vaccines against Zika Virus1R21AI130298-01BARRY, MICHAEL AMAYO CLINIC ROCHESTER, MN$198,750ZAI1
2017Identification of diagnostic and prognostic host biomarkers of Zika virus infection by transcriptome profiling1R21AI129455-01CHIU, CHARLES YENUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$198,125ZAI1
2017Fetal Zika virus infection: role of the human placenta1R21AI129508-01HARRIS, EVAPEREIRA, LENORE PALMAUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$197,523ZAI1
2017Preclinical development of candidate Zika virus vaccines using mouse models1R21AI129844-01BARRETT, ALAN D.T.UNIVERSITY OF TEXAS MED BR GALVESTON, TX$196,250ZAI1
2017Rapid development of neutralizing antiserum against Zika virus1R21AI132458-01LIU, RUIWUUNIVERSITY OF CALIFORNIA AT DAVIS, CA$196,250ZAI1
2017The role of the host ubiquitin system in Zika virus replication1R21AI132479-01RAJSBAUM, RICARDOUNIVERSITY OF TEXAS MED BR GALVESTON, TX$193,750ZAI1
2017Pre-clinical evaluation of a Zika virus vaccine1R21AI130180-01GAMBOTTO, ANDREAUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$193,332ZAI1
2017Development of plant-derived, resistance-breaking mosquitocides for controlling vectors of Zika virus1R21AI129951-01PIERMARINI, PETER MRAKOTONDRAIBE, LIVA HARINANTENAINAOHIO STATE UNIVERSITY, OH$193,125ZAI1
2017Imaging and Trafficking of Neurotropic Virus in Maternal/Fetal Nonhuman Primates1R21AI133548-01TARANTAL, ALICE FUNIVERSITY OF CALIFORNIA AT DAVIS, CA$193,000ZAI1
2017Congenital Zika Syndrome and Postnatal Outcomes in Nonhuman Primates1R21NS103658-01HARTIGAN-O'CONNOR, DENNIS J.NOCTOR, STEPHEN CHARLESTARANTAL, ALICE FUNIVERSITY OF CALIFORNIA AT DAVIS, CA$193,000ZNS1
2017Identify ZIKV host factors with an improved CRISPR-based genome-wide knockout screen1R21AI129471-01WU, HAOQUANTEXAS TECH UNIVERSITY HEALTH SCIS CENTER, TX$191,250ZAI1
2017Modulation of Zika Virus Infection by Preexisting West Nile Virus Antibodies1R21AI131696-01JOSHI, ANJALITEXAS TECH UNIVERSITY HEALTH SCIS CENTER, TX$191,250ZAI1
2017GORILLA ADENOVIRUS ZIKA VACCINE FOR HUMANS1R21AI131254-01CURIEL, DAVID TERRYWASHINGTON UNIVERSITY, MO$190,625ZAI1
2017A Guinea Pig Model of Zika Virus Disease1R21OD024896-01KUMAR, MUKESHUNIVERSITY OF HAWAII AT MANOA, HI$182,875ZAI1
2017Identifying genetic correlatesof Zika virus infection and transmission in US mosquitoes1R21AI131683-01CIOTA, ALEXANDER TIMOTHYWADSWORTH CENTER, NY$181,504ZAI1
2017Single-cycle infectious Zika viruses for the development of a live-attenuated vaccine1R21AI130500-01MARTINEZ-SOBRIDO, LUISUNIVERSITY OF ROCHESTER, NY$180,457ZAI1
2016Development of an Innovative, Effective, RNA-based Vaccine for Zika Virus1R21AI128992-01STINCHCOMB, DAN THOMASVAN HOEVEN, NEAL SCOTTACCESS TO ADVANCED HEALTH INSTITUTE, WA$312,550ZAI1
2016A NHP model for vaginal Zika Virus transmission1R21OD023818-01MILLER, CHRISTOPHER JAMESUNIVERSITY OF CALIFORNIA AT DAVIS, CA$312,234ZAI1
2016Host-pathogen interactions in ZIKV infection leading to microcephaly1R21NS100477-01SHRESTA, SUJANSTRONGIN, ALEX YTERSKIKH, ALEXEY VSANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, CA$307,250ZNS1
2016Novel Testing to Elucidate Reproductive Outcomes of ZIKV Infection - Olympics 20161R21HD090955-01BYINGTON, CARRIE L.UNIVERSITY OF UTAH, UT$302,000ZHD1
2016Development of a model for determining the causal relationship between Zika virus infection during pregnancy and fetal microcephaly.1R21HD091032-01STREBLOW, DANIEL NOREGON HEALTH & SCIENCE UNIVERSITY, OR$262,500ZHD1
2016Structure-based Design of Zika Virus Inhibitors Targeting Envelope Glycoprotein (E)1R21AI129306-01JACOBS, AMY LYNNRIZZO, ROBERT C.STATE UNIVERSITY NEW YORK STONY BROOK, NY$252,708ZAI1
2016Assessment of infection route and vulnerability of neural precursor classes to Zika virus1R21NS101151-01CONNOR, JOHN HHAYDAR, TARIK FBOSTON UNIVERSITY MEDICAL CAMPUS, MA$246,750ZNS1
2016Molecular and Antibody Detection of Zika Virus in Saliva at the Point of Care1R21DE026700-01BAU, HAIM HUNIVERSITY OF PENNSYLVANIA, PA$241,500ZDE1
2016Nonhuman Primate Model to Assess Embryonic Zika Virus Infection1R21HD091163-01GOLOS, THADDEUS GUNIVERSITY OF WISCONSIN-MADISON, WI$229,500ZHD1
2016A Rapid and Specific Diagnostic for Immunoglobulin Response to Zika Virus Exposure Based on De novo Designed Low Cost Hyper-stable Mini-Protein Epitopes1R21AI128950-01BAKER, DAVIDYAGER, PAULUNIVERSITY OF WASHINGTON, WA$221,788ZAI1
2016Is Culex quinquefasciatus a vector of the Zika virus?1R21AI128931-01LEAL, WALTER SUNIVERSITY OF CALIFORNIA AT DAVIS, CA$220,350ZAI1
2016Role of type I interferon signaling in Zika virus infection of the brain1R21NS100182-01WEISS, SUSAN RUNIVERSITY OF PENNSYLVANIA, PA$201,250ZAI1
2016Zika virus infection of neural stem cells to model pathogen-induced microcephaly1R21NS100545-01HORNER, STACY MICHELLESILVER, DEBRADUKE UNIVERSITY, NC$198,750ZNS1
2016Potential for mosquitoes in the United States to transmit Zika virus1R21AI128918-01RASGON, JASON LPENNSYLVANIA STATE UNIVERSITY, THE, PA$196,500ZAI1
2016Leveraging Established Fetal Primate Models to Expedite ZIKV Investigations1R21OD023716-01BARRY, PETER ANOCTOR, STEPHEN CHARLESTARANTAL, ALICE FUNIVERSITY OF CALIFORNIA AT DAVIS, CA$193,000ZHD1
2016Development of a Recombinant Zika Virus Vaccine Based on Subunit Envelope (E) Amtigen Fused to a TLR5 Agonist (Flagellin)1R21AI128960-01LIU, GETUSSEY, LYNDA GVAXINNATE CORPORATION, NJ$118,261ZAI1

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