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NIH funding notice PAR-16-228

Metabolic Reprogramming to Improve Immunotherapy (R01)

Closed on September 7, 2019.

Posted
May 6, 2016
Close date
September 7, 2019
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

18 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $7,356,323 in first-year total cost, median $392,592.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 OTC-Y (55)]15
  2. Special Emphasis Panel[ZRG1 OTC-A (55)]2
  3. Special Emphasis Panel[ZRG1 OTC-X (55)]1

Most frequent institutions

  1. MEDICAL UNIVERSITY OF SOUTH CAROLINA2
  2. UNIVERSITY OF PENNSYLVANIA2
  3. BOSTON UNIVERSITY MEDICAL CAMPUS1
  4. BRIGHAM AND WOMEN'S HOSPITAL1
  5. INDIANA UNIVERSITY INDIANAPOLIS1
Competing awards under PAR-16-228 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2020Understanding how metabolic heterogeneity in cancer affects the tumor microenvironment and anti-tumor immunity1R01CA240909-01A1KAECH, SUSAN MWAHL, GEOFFREY MYLESSALK INSTITUTE FOR BIOLOGICAL STUDIES, CA$599,268ZRG1
2020Anti-oxidant and Metabolic Phenotype in Regulating Tumor Specific T cell Memory Response1R01CA236379-01A1MEHROTRA, SHIKHARMEDICAL UNIVERSITY OF SOUTH CAROLINA, SC$522,428ZRG1
2020Normalizing arginine metabolism with sepiaptein for immunostimulatory-shift of HER2+ breast cancer1R01CA248304-01FURUTA, SAORIUNIVERSITY OF TOLEDO HEALTH SCI CAMPUS, OH$352,657ZRG1
2020Metabolic Control of Innate and Adaptive Immunity in Breast Cancer1R01CA237149-01A1PENG, GUANGYONGSAINT LOUIS UNIVERSITY, MO$346,556ZRG1
2020Exploitation of ER Stress Induced Immune Dysfunction to Improve Immunotherapy1R01CA248359-01THAXTON, JESSICA EMEDICAL UNIVERSITY OF SOUTH CAROLINA, SC$341,981ZRG1
2019Metabolic Regulation ofPD-L1 in CD11c+ Cells1R01CA225108-01A1DU, HONGYAN, CONGINDIANA UNIVERSITY INDIANAPOLIS, IN$547,418ZRG1
2019Role of tumor microenvironment-derived cholesterol in CD8+ T-cell exhaustion1R01CA239255-01A1YI, QINGMETHODIST HOSPITAL RESEARCH INSTITUTE, TX$425,512ZRG1
2019Metabolic reprograming of fatty acid beta-oxidation to improve cancer immunotherapy1R01CA229812-01A1FANG, XIANJUNWANG, XIANG-YANG SHAWNVIRGINIA COMMONWEALTH UNIVERSITY, VA$412,390ZRG1
2019Targeting Tumor Metabolism as a Means of Enhancing Immunotherapy1R01CA226765-01A1POWELL, JONATHAN DJOHNS HOPKINS UNIVERSITY, MD$374,578ZRG1
2019Regulation of antigen presenting cells in the tumor microenvironment by retinoic acid1R37CA234027-01HALDAR, MALAYUNIVERSITY OF PENNSYLVANIA, PA$368,288ZRG1
2019Metabolic Reprogramming of Tumor Infiltrating Lymphocytes for Adoptive Immunotherapy1R01CA233521-01A1KAMMULA, UDAI SUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$357,994ZRG1
2019Exploiting Cancer Metabolism and Drug Efflux with Bystander-Assisted Immunotherapy1R01CA234115-01MANCINI, ROCKWASHINGTON STATE UNIVERSITY, WA$318,579ZRG1
2018Mechanisms of BET bromodomain metabolic reprogramming in triple negative breast cancer1R01CA222170-01A1DENIS, GERALD VBOSTON UNIVERSITY MEDICAL CAMPUS, MA$559,846ZRG1
2018Metabolic Barriers to T Cell Activation in Clear Cell Renal Cell Carcinoma1R01CA217987-01A1RATHMELL, JEFFREY C.VANDERBILT UNIVERSITY MEDICAL CENTER, TN$459,666ZRG1
2018Directing the metabolic fate of CAR T cells1R01CA226983-01JUNE, CARL H.UNIVERSITY OF PENNSYLVANIA, PA$432,308ZRG1
2018In Situ characterization and manipulation of tumor immune cell metabolomics using implantable microdevices1R01CA223150-01A1JONAS, OLIVERBRIGHAM AND WOMEN'S HOSPITAL, MA$366,134ZRG1
2018Nucleus Accumbens-Associated Protein-1 in Melanoma Immunotherapy1R01CA221867-01A1SONG, JIANXUN JIMYANG, JIN-MINGPENNSYLVANIA STATE UNIV HERSHEY MED CTR, PA$160,114ZRG1
2017Metabolic reprogramming of Tregs in tumor immunity1R01CA221290-01CHI, HONGBOST. JUDE CHILDREN'S RESEARCH HOSPITAL, TN$410,606ZRG1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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