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NIH funding notice PAR-16-365

Pilot Clinical Trials for the Spectrum of Alzheimers Disease and Age-related Cognitive Decline (R01)

Closed on January 24, 2018.

Posted
October 6, 2015
Close date
January 24, 2018
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

45 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $52,297,732 in first-year total cost, median $775,183.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 BBBP-Z (55)]26
  2. Special Emphasis Panel[ZRG1 BBBP-V (55)]16
  3. Special Emphasis Panel[ZRG1 BBBP-B (55)]3

Most frequent institutions

  1. COGNITION THERAPEUTICS, INC.4
  2. COLUMBIA UNIVERSITY HEALTH SCIENCES3
  3. INDIANA UNIVERSITY INDIANAPOLIS2
  4. UNIVERSITY OF MINNESOTA2
  5. UNIVERSITY OF PITTSBURGH AT PITTSBURGH2
Competing awards under PAR-16-365 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2018A Randomized, Double-blind, Placebo-Controlled, Parallel-Group, Phase II Study to Evaluate the Safety and Efficacy of CT1812 in Subjects with Mild to Moderate Alzheimer's Disease1R01AG058660-01CATALANO, SUSAN MCOGNITION THERAPEUTICS, INC., PA$5,059,534ZRG1
2018The LUCINDA Trial1R01AG057681-01A1ATWOOD, CRAIG SBUTLER, TRACY A.GALVIN, JAMES ENEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$1,603,736ZRG1
2018Novel Cognitive and Functional Measure for Alzheimer's Disease Prevention Trials1R01AG051346-01A1GOLDBERG, TERRYHARVEY, PHILIP D.SCHNEIDER, LON SNEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC, NY$1,595,795ZRG1
2018Neuron regenerative therapeutic, NNI-362, for first-in-human safety and PK for AD1R01AG056561-01A1KELLEHER-ANDERSSON, JUDITH ANEURONASCENT, INC., MD$1,575,691ZRG1
2018Effects of Alzheimer's disease clinical trial study partners1RF1AG059407-01GILLEN, DANIEL LGRILL, JOSHUAUNIVERSITY OF CALIFORNIA-IRVINE, CA$1,276,222ZRG1
2018Novel automated performance-based ADL outcomes for early AD clinical trials1R01AG053184-01A1MARSHALL, GAD ASHERBRIGHAM AND WOMEN'S HOSPITAL, MA$883,247ZRG1
2018Treating mild cognitive impairment with transcranial direct current stimulation1R01AG058724-01HAMPSTEAD, BENJAMIN MICHAELUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$870,064ZRG1
2018Dietary Modulation of Neuroinflammation in Age-Related Memory Disorders1R01AG058417-01A1SLOAN, RICHARD PSMALL, SCOTT ACOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$825,082ZRG1
2018Enhanced Mediterranean Diet for Alzheimer's Disease Prevention1R01AG060157-01BURNS, JEFFREY MURRAYSULLIVAN, DEBRA KUNIVERSITY OF KANSAS MEDICAL CENTER, KS$758,906ZRG1
2018The effect of physical activity on cognition relative to APOE genotype (PAAD-II)1R01AG058919-01ETNIER, JENNIFER LUNIVERSITY OF NORTH CAROLINA GREENSBORO, NC$730,680ZRG1
2018Optimizing Cognitive Assessment in DIAN with Smartphone-based burst testing1R01AG057840-01A1HASSENSTAB, JASON JWASHINGTON UNIVERSITY, MO$730,239ZRG1
2018Rhythm Experience and Africana Culture Trial (REACT)1R01AG060741-01ERICKSON, KIRK IUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$699,436ZRG1
2018Assessment of lenalidomide to treat Alzheimer's disease1R01AG059008-01DECOURT, BORISSABBAGH, MARWAN NOELCLEVELAND CLINIC LERNER COM-CWRU, OH$496,020ZRG1
2018Blood Biomarkers as Surrogate Endpoints of Treatment Responses to Aerobic Exercise and/or Cognitive Training in Amnestic Mild Cognitive Impairment1R01AG059654-01LI, DANNIUNIVERSITY OF MINNESOTA, MN$490,750ZRG1
2018A Randomized Controlled Trial of Visual Cues, Signage, and Spaced-Retrieval Education within Long Term Care Communities to Assist with Wayfinding1R01AG056384-01A1DAVIS, REBECCAGRAND VALLEY STATE UNIVERSITY, MI$445,552ZRG1
2018Biomarker Predictors of Memantine Sensitivity in patients with Alzheimer's Disease1R01AG059640-01SWERDLOW, NEAL RUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$392,500ZRG1
2017Global Alzheimer's Platform Trial-Ready Cohort for Preclinical/Prodromal Alzheimer's Disease1R01AG053798-01A1AISEN, PAUL S.CUMMINGS, JEFFREY L.SPERLING, REISA A.UNIVERSITY OF SOUTHERN CALIFORNIA, CA$5,001,194ZRG1
2017A Pilot Synaptic Vesicle Glycoprotein 2A (SV2A) PET Study to Evaluate the Effect of CT1812 Treatment on Synaptic Density in Subjects with Mild to Moderate Alzheimer's Disease1RF1AG057553-01CATALANO, SUSAN MCOGNITION THERAPEUTICS, INC., PA$4,130,741ZRG1
2017A Pilot CSF Catheter Study to Evaluate the Effect of CT1812 Treatment on Aβ Oligomer Clearance into CSF in Subjects with Mild to Moderate Alzheimerʼs Disease1RF1AG057780-01CATALANO, SUSAN MCOGNITION THERAPEUTICS, INC., PA$2,527,271ZRG1
2017Multidomain Alzheimers Risk Reduction Study (MARRS) Pilot1R01AG057508-01LARSON, ERIC BYAFFE, KRISTINEUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$1,371,136ZRG1
2017Anti-Viral therapy in Alzheimer's disease1R01AG055422-01A1DEVANAND, DAVANGERE PCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$1,327,757ZRG1
2017Phase II RCT of High-dose Vitamin D Supplements in Older Adults without Dementia1R01AG051618-01A1OLICHNEY, JOHN MUNIVERSITY OF CALIFORNIA AT DAVIS, CA$960,877ZRG1
2017Modified Ketogenic Diet Effects on Alzheimer's Disease Biomarkers and Cognition in Mild Cognitive Impairment1R01AG055122-01CRAFT, SUZANNEWAKE FOREST UNIVERSITY HEALTH SCIENCES, NC$954,203ZRG1
2017Multicultural Healthy Diet to Reduce Cognitive Decline & Alzheimer Disease Risk1R01AG055527-01A1MOSSAVAR-RAHMANI, YASMINALBERT EINSTEIN COLLEGE OF MEDICINE, INC, NY$856,849ZRG1
2017Circadian rhythm disturbance and agitation in Alzheimer's disease1R01AG054771-01ROSENBERG, PAUL BWU, MARK NJOHNS HOPKINS UNIVERSITY, MD$797,636ZRG1
2017COGNITIVE TRAINING AND NEUROPLASTICITY IN MILD COGNITIVE IMPAIRMENT1R01AG052440-01A1DEVANAND, DAVANGERE PCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$781,608ZRG1
2017Efficacy and Mechanisms of Combined Aerobic Exercise and Cognitive Training in MCI (The ACT Trial)1R01AG055469-01A1LIN, FENG VANKEEYU, FANGUNIVERSITY OF MINNESOTA, MN$776,403ZRG1
2017Exercise for Brain Health with Increased Genetic Risk for Alzheimer's Disease1R01AG057552-01SMITH, JEROME CARSONUNIV OF MARYLAND, COLLEGE PARK, MD$775,183ZRG1
2017MIND Food and Speed of Processing Training in Older Adults with Low Education, The MINDSpeed Alzheimer's Disease Prevention Pilot Trial1R01AG052439-01A1CLARK, DANIEL OUNVERZAGT, FREDERICK W.INDIANA UNIVERSITY INDIANAPOLIS, IN$763,405ZRG1
2017Interventions to Attenuate Cognitive Decline1R01AG056428-01A1EDWARDS, JERRIUNIVERSITY OF SOUTH FLORIDA, FL$739,503ZRG1
2017Enriching clinical trials requiring amyloid positivity with practice effects1R01AG055428-01A1DUFF, KEVIN MHOFFMAN, JOHN MUNIVERSITY OF UTAH, UT$730,318ZRG1
2017Evaluation of Brain and Cognitive Changes in Older Adults with MCI Taking Lithium to Prevent Alzheimer Type Dementia1R01AG055389-01GILDENGERS, ARIEL GERARDUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$728,145ZRG1
2017The delivery of essential fatty acids to the Brain in Alzheimer's disease1R01AG054434-01A1YASSINE, HUSSEIN NUNIVERSITY OF SOUTHERN CALIFORNIA, CA$708,721ZRG1
2017Decreasing Alzheimer's Disease and Related Dementias after Delirium-Exercise and Cognitive Training (DDD-ECT)1R01AG055391-01KHAN, BABAR AINDIANA UNIVERSITY INDIANAPOLIS, IN$702,719ZRG1
2017Communication Bridge: A person-centered Internet-based intervention for individuals with primary progressive aphasia1R01AG055425-01A1ROGALSKI, EMILY JNORTHWESTERN UNIVERSITY AT CHICAGO, IL$663,165ZRG1
2017In Silico Screening of Medications for Slowing Alzheimer's Disease Progression.1R01AG057684-01KENNEDY, RICHARD ESCHNEIDER, LON SUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$658,103ZRG1
2017Age- Related Mild Cognitive Impairment and novel protective role of Glutathione: implications for Alzheimer's Disease1R01AG054131-01A1SEKHAR, RAJAGOPAL VISWANATHBAYLOR COLLEGE OF MEDICINE, TX$548,688ZRG1
2017Noninvasive Cortical Stimulation to Improve Memory in Mild Cognitive Impairment1R01AG055526-01TAYLOR, JOY LPALO ALTO VETERANS INSTIT FOR RESEARCH, CA$514,753ZRG1
2017Mindfulness Training for Mitigating Age-Related Cognitive Decline in the Elderly1R01AG054427-01PRAKASH, RUCHIKA SHAURYAOHIO STATE UNIVERSITY, OH$365,677ZRG1
2016Phase 1b first-in-patient safety trial for CT1812, a novel Alzheimer’s synaptic protection therapeutic1RF1AG054176-01CATALANO, SUSAN MCOGNITION THERAPEUTICS, INC., PA$2,410,669ZRG1
2016A double-blinded, randomized, controlled phase 2a safety, proof-of-concept and exploratory end point trial of the drug LM11A-31 in patients with mild to moderate Alzheimer's disease.1R01AG051596-01A1WINDISCH, MANFREDPHARMATROPHIX, INC., CA$1,499,874ZRG1
2016Conversational engagement as a means to delay onset AD: Phase II1R01AG051628-01A1DODGE, HIROKO HAYAMAOREGON HEALTH & SCIENCE UNIVERSITY, OR$780,921ZRG1
2016Problem Adaptation Therapy for Mild Cognitive Impairment with Depression1R01AG050514-01A1KIOSSES, DIMITRIS NROSENBERG, PAUL BWEILL MEDICAL COLL OF CORNELL UNIV, NY$772,824ZRG1
2016Hyperbaric oxygen therapy for cognition in diabetic elderly at high dementia risk1R01AG051545-01A1SANO, MARYSCHNAIDER BEERI, MICHALICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$663,782ZRG1
2016INtervention for Cognitive Reserve Enhancement in delaying the onset of Alzheimer’s Symptomatic Expression: The INCREASE study1R01AG054130-01JICHA, GREGORY AMOGA, DANIELA CLAUDIAUNIVERSITY OF KENTUCKY, KY$352,153ZRG1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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