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NIH funding notice PAR-17-029

Dynamic Interactions between Systemic or Non-Neuronal Systems and the Brain in Aging and in Alzheimers Disease (R01)

Closed on November 5, 2019.

Posted
October 21, 2016
Close date
November 5, 2019
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

40 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $61,414,881 in first-year total cost, median $762,510.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 BDCN-B (55)]14
  2. Special Emphasis Panel[ZRG1-BDCN-B(55)R]6
  3. Special Emphasis Panel[ZRG1 BDCN-A (55)]4
  4. Special Emphasis Panel[ZRG1 BDCN-B (56)]3
  5. Special Emphasis Panel[ZRG1-BDCN-A(55)R]3

Most frequent institutions

  1. WAKE FOREST UNIVERSITY HEALTH SCIENCES4
  2. ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI3
  3. RUSH UNIVERSITY MEDICAL CENTER2
  4. STANFORD UNIVERSITY2
  5. UNIVERSITY OF CALIFORNIA-IRVINE2
Competing awards under PAR-17-029 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2020Age-dependent activation of microglia inflammatory state and its epigenetic modulation1RF1AG068558-01SCHAEFER, ANNETARAKHOVSKY, ALEXANDERICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$2,994,272CMBG
2020Role of circulating Abeta seeds and peripheral tissue damage in Alzheimer's disease pathogenesis1RF1AG059321-01A1MORALES, RODRIGOSOTO, CLAUDIOUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$2,933,932ZRG1
2020Understanding the protective and neuroinflammatory role of human brain immune cells in Alzheimer Disease1R01AG065582-01HAROUTUNIAN, VAHRAMROUSSOS, PANAGIOTISSCHADT, ERIC EICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$1,530,945ZRG1
2020Elucidating changes in astrocyte subpopulations associated with resistance to Alzheimers Disease pathology in multi-ethnic cohorts1R01AG066831-01MENON, VILASCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$811,964GHD
2020Physical exercise and Blood-brain communication: exosomes, Klotho and choroid plexus1R01AG066198-01AMBROSIO, FABRISIAKOLDAMOVA, RADOSVETAUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$782,487ZRG1
2020Physical activity predictors of cognitive and brain health in the risk for Alzheimer's disease1R56AG067200-01ALEXANDER, GENE ERAICHLEN, DAVIDUNIVERSITY OF ARIZONA, AZ$767,484CNN
2020Hemodynamic Mechanisms Linking Aortic Arch Stiffness with Brain Insult in Older Adults1R56AG068630-01KING, KEVIN SAMPAHLEVAN, NIEMAST. JOSEPH'S HOSPITAL AND MEDICAL CENTER, AZ$709,624CICS
2020Gut microbiota-based biomarkers of Alzheimer's disease and its modulation by a ketogenic diet1R56AG064075-01A1YADAV, HARIOMWAKE FOREST UNIVERSITY HEALTH SCIENCES, NC$604,248ZRG1
2020Aging and hyperglycemia alter molecular mechanisms and hippocampal oscillations consistent with Alzheimer's disease1R01AG062762-01A1HYMAN, JAMES M.KINNEY, JEFFERSONUNIVERSITY OF NEVADA LAS VEGAS, NV$603,788ZRG1
2020Altered ENS Neuroimmune Interactions Disrupt Gastrointestinal Motility in Alzheimers Disease1R56AG068394-01BECKER, LARENSTANFORD UNIVERSITY, CA$399,242ASG
2019VGF peptide TLQP-21, a novel microglial C3aR1 modulator in Alzheimer's disease1RF1AG062661-01EHRLICH, MICHELLE ESALTON, STEPHEN RICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$4,083,855ZRG1
2019The role of pericytes in the aging brain and pathogenesis and treatment of neurodegeneration, and Alzheimer's A-beta and tau pathology2RF1AG039452-06ICHIDA, JUSTIN KAWIKAUNIVERSITY OF SOUTHERN CALIFORNIA, CA$3,981,640BINP
2019Mechanistic link between Alzheimer's disease and periodontitis1RF1AG062496-01DEDEOGLU, ALPASLANKANTARCI, IBRAHIM ALPDOGANBOSTON UNIVERSITY MEDICAL CAMPUS, MA$3,732,218ZRG1
2019The Contribution of Kidney Disease to Age-Associated Cognitive Decline1RF1AG061296-01A1MAHER, PAMELA ANNESALK INSTITUTE FOR BIOLOGICAL STUDIES, CA$3,189,011ZRG1
2019Understanding the dynamic interactions between tau pathology and microglia-mediated inflammation in Alzheimer's Disease1R56AG064873-01GUPTA, AJAYRAJ, ASHISHWEILL MEDICAL COLL OF CORNELL UNIV, NY$770,628EITN
2019HDAC9, Aging and Alzheimer's Disease1R56AG064895-01LU, XIN-YUNWEINTRAUB, NEAL LAUGUSTA UNIVERSITY, GA$747,485ZRG1
2019Peripheral TREM2 Epigenetics and the Immune Response in Neurodegenerative Disorders1R56AG063870-01BEKRIS, LYNNCLEVELAND CLINIC LERNER COM-CWRU, OH$737,974ZRG1
2019Elucidating the molecular drivers of impaired mobility within and outside the CNS in Alzheimer’s disease and related disorders1R01AG059732-01A1BUCHMAN, ARON SRUSH UNIVERSITY MEDICAL CENTER, IL$711,340ZRG1
2019Dietary Effects on Imaging and Fluid-based Biomarkers of the Adipose-Brain Axis in Alzheimers Disease1R01AG064014-01BRINKLEY, TINA EWAKE FOREST UNIVERSITY HEALTH SCIENCES, NC$676,042CNN
2019Endothelial progenitor cells and neurovascular injury in the aging brain1R01AG064228-01NATION, DANIEL AUNIVERSITY OF CALIFORNIA-IRVINE, CA$623,354ANIE
2019Investigating the Contribution of Peripheral versus Central Nervous System Immune Dysfunction to Cognitive Aging1R01AG058772-01A1BETTCHER, BRIANNE MAGOUIRKUNIVERSITY OF COLORADO DENVER, CO$621,033ZRG1
2019Aging and hyperglycemia alter molecular mechanisms and hippocampal oscillations consistent with Alzheimer's disease1R56AG062762-01HYMAN, JAMES M.KINNEY, JEFFERSONUNIVERSITY OF NEVADA LAS VEGAS, NV$601,576ZRG1
2019Mast cell/histamine-mediated inflammation and subsequent decrease of lymphatic amyloid beta clearance accelerate progression of Alzheimer's disease1R56AG061097-01ZAWIEJA, DAVID CARLTEXAS A&M UNIVERSITY HEALTH SCIENCE CTR, TX$574,591ZRG1
2019Effects of Sepsis and Aging on Brain: Roles of Complement and Histones1R56AG061207-01A1WARD, PETER AUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$485,664ZRG1
2019Neurodegeneration and Microvascular Damage in Alzheimer's Disease1R01AG058884-01A1HONGPAISAN, JARINTHOMAS JEFFERSON UNIVERSITY, PA$390,000ZRG1
2018Gut Liver Brain Biochemical Axis in Alzheimer's Disease1RF1AG058942-01KADDURAH-DAOUK, RIMA FVAN DUIJN, CORNELIA MARJADUKE UNIVERSITY, NC$3,407,970ZRG1
2018Effects of Western and Mediterranean Diets on Metabolic and Neuropathologic Risk Factors for Alzheimer's Disease in Nonhuman Primates1RF1AG058829-01CRAFT, SUZANNESHIVELY, CAROL A.WAKE FOREST UNIVERSITY HEALTH SCIENCES, NC$2,771,584ZRG1
2018The gut-brain axis and age-related microglial cell dysfunction1RF1AG059622-01JOHNSON, RODNEY WUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$1,898,865ZRG1
2018Elucidating the Molecular Drivers of Impaired Mobility Within and Outside the CNS in Alzheimer's Disease and Related Disorders1R56AG059732-01BUCHMAN, ARON SRUSH UNIVERSITY MEDICAL CENTER, IL$757,536ZRG1
2018Exercise and Cognitive Function in Alzheimers Disease Progression: Role of the Vascular Endothelium1R56AG057584-01RICHARDSON, RUSSELL S.UNIVERSITY OF UTAH, UT$657,983ZRG1
2018Multi-omic Investigation of Exercise Effects in Mild Cognitive Impairment1R01AG058644-01MAPSTONE, MARKUNIVERSITY OF CALIFORNIA-IRVINE, CA$644,589ZRG1
2018Pathogenic consequences of altered insulin signaling in the diabetic brain.1R56AG052524-01A1GINSBERG, STEPHEN DMATHEWS, PAUL MNATHAN S. KLINE INSTITUTE FOR PSYCH RES, NY$595,009ZRG1
2018Mechanisms underlying sporadic Alzheimer's disease1R01AG060238-01LAZAROV, ORLYUNIVERSITY OF ILLINOIS AT CHICAGO, IL$399,750ZRG1
2018Circulating factors mediating systemic bioenergetic capacity in the pathogenesis and treatment of Alzheimer's Disease1R56AG057864-01MOLINA, ANTHONY JWAKE FOREST UNIVERSITY HEALTH SCIENCES, NC$13,640ZRG1
2017Dynamic Non-Neuronal Interactions between the Gut Microbiota and the Brain in Aging and in Cerebral Amyloid Angiopathy1RF1AG058463-01BRYAN, ROBERT MMCCULLOUGH, LOUISE D.UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$3,731,831ZRG1
2017Dynamic Interactions of the S-Nitrosoproteome in Type 2 Diabetes/Metabolic Syndrome and Alzheimer’s Disease1RF1AG057409-01LIPTON, STUART ASCRIPPS RESEARCH INSTITUTE, THE, CA$3,398,220ZRG1
2017Neuroinflammatory mechanisms of aging-related vascular cognitive impairment (VCI)1RF1AG058273-01ALKAYED, NABIL JOREGON HEALTH & SCIENCE UNIVERSITY, OR$2,495,260ZRG1
2017Claudin Expression Profiles and Blood Brain Barrier in Aging1RF1AG057928-01ANDJELKOVIC-ZOCHOWSKA, ANUSKA V.UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$2,343,371ZRG1
2017Brain cellular senescence as a driver of Alzheimers Disease1RF1AG057964-01GALVAN, VERONICAMAGNUSSON, KATHY ROREGON STATE UNIVERSITY, OR$2,192,011ZRG1
2017Regulation of immune cell metabolism in aging and Alzheimer's disease: role of the kynurenine pathway1RF1AG058047-01ANDREASSON, KATRIN I.STANFORD UNIVERSITY, CA$2,042,865ZRG1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-10-0.1.1. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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PAR-17-029: Dynamic Interactions between Systemic or Non-Neuronal Systems and the Brain in Aging and in Alzheimers Disease (R01) | ScienceDex | ConductScience