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NIH funding notice PAR-17-046

Exploratory Research for Technology Development (R21)

Closed on April 12, 2019.

Posted
November 1, 2016
Close date
April 12, 2019
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov ยท NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

99 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $20,890,981 in first-year total cost, median $216,300.

Most frequent study sections

  1. Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]18
  2. Cellular and Molecular Technologies Study Section[CMT]10
  3. Synthetic and Biological Chemistry B Study Section[SBCB]10
  4. Instrumentation and Systems Development Study Section[ISD]9
  5. Biomaterials and Biointerfaces Study Section[BMBI]5

Most frequent institutions

  1. UNIVERSITY OF WISCONSIN-MADISON4
  2. MASSACHUSETTS INSTITUTE OF TECHNOLOGY3
  3. PURDUE UNIVERSITY3
  4. STANFORD UNIVERSITY3
  5. UNIVERSITY OF CALIFORNIA, SAN DIEGO3
Competing awards under PAR-17-046 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2020Technology to prepare thin, large-area samples for cryo-EM1R21GM135666-01GLAESER, ROBERT MUNIVERSITY OF CALIF-LAWRENC BERKELEY LAB, CA$279,315CMT
2020Development of selective chemical tools to investigate sialyltransferases and sialoside products1R21GM135734-01NYCHOLAT, CORWIN MICHAELSCRIPPS RESEARCH INSTITUTE, THE, CA$272,375SBCA
2020Off-resonant transient absorption microscopy1R21GM135772-01BARTELS, RANDY A.WILSON, JESSE WILLIAMCOLORADO STATE UNIVERSITY, CO$221,234CMT
2020Antibody Fragments as Biochemical Tools to Interrogate CD9 Function in Inflammatory Diseases1R21GM135853-01NGUYEN, JULIANEWOHLFERT, ELIZABETHUNIV OF NORTH CAROLINA CHAPEL HILL, NC$204,020SAT
2020Affinity-Mediated Covalent Conjugation: A Method for Direct Modification of Specific Receptors on Cell Membranes1R21GM135668-01CHA, JENNIFER NGOODWIN, ANDREW PLIU, XUEDONGUNIVERSITY OF COLORADO, CO$175,853EBIT
2019Chemoselective assembly of multiply-labeled proteins for single molecule applications1R21GM132787-01DAWSON, PHILIP ESCRIPPS RESEARCH INSTITUTE, THE, CA$290,250SBCB
2019A Cell-Based Screen For The Discovery of Novel Proteolysis Targeting Chimeras (PROTACs)1R21GM131420-01KODADEK, THOMAS J.SCRIPPS FLORIDA, FL$285,000CMT
2019Single-molecule and super-resolution imaging methods with maximum photon efficiency, increased spatiotemporal resolution and high detection sensitivity in densely crowded environments1R21GM134342-01PERTSINIDIS, ALEXANDROSSLOAN-KETTERING INST CAN RESEARCH, NY$269,400MSFC
2019Targeted recombination to pinpoint responsible regions within large susceptibility loci in mice1R21GM135494-01PETUKHOVA, GALINAHENRY M. JACKSON FDN FOR THE ADV MIL/MED, MD$266,869MGA
2019Unnatural Amino Acid Chemistry for Lysine Methyltransferase Substrate Discovery1R21GM134285-01GOZANI, OR P.TRIEVEL, RAYMOND CUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$258,787SBCB
2019Development of novel markers to contextualize X-ray fluorescence microscopy1R21GM129592-01A1RALLE, MARTINAOREGON HEALTH & SCIENCE UNIVERSITY, OR$254,898MSFA
2019New Tools for Experimental Phasing of Twinned Diffraction Data1R21GM129649-01A1ZWART, PETRUS HUNIVERSITY OF CALIF-LAWRENC BERKELEY LAB, CA$254,483MSFD
2019Deep Supercooling of Liver Cells and 2D and 3D Tissue Constructs: Effect of Attachment1R21GM136002-01USTA, OSMAN BERKMASSACHUSETTS GENERAL HOSPITAL, MA$252,000CMT
2019Inverting Coupling Selectivity with Cooperative Metal-Ligand Constructs1R21GM134240-01RADOSEVICH, ALEXANDER TMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$239,599SBCB
2019Controlling the Upstream Migration of Neutrophils through the Modulation of Mac-11R21GM133060-01HAMMER, DANIEL AUNIVERSITY OF PENNSYLVANIA, PA$238,092BMBI
2019Speckle-free phase-contrast ultrasound imaging1R21GM134216-01MERTZ, JEROMEBOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$235,800ITD
2019Visualizing chemical bonding in biological macromolecules by microcrystal electron diffraction1R21GM135784-01NANNENGA, BRENTARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$235,500MSFD
2019Development of Activity-Based Chemical Reporters to Differentiate Proteasome Isoforms in Cells1R21GM131206-01A1TRADER, DARCI JPURDUE UNIVERSITY, IN$232,500SBCB
2019Engineering Long ssDNA for Genome Editing Applications1R21GM129559-01GURUMURTHY, CHANNABASAVAIAHWHITEHEAD, TIMOTHY ANDREWUNIVERSITY OF NEBRASKA MEDICAL CENTER, NE$229,500GDD
2019A Microfluidic Device for Temporal Live-Cell Analysis of Intracellular Biomolecules1R21GM132709-01ESPINOSA, HORACIO DANTE DANTENORTHWESTERN UNIVERSITY, IL$228,087ISD
2019Harnessing genetic code expansion to measure in vivo actin dynamics1R21GM134473-01QUINLAN, MARGOT EUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$227,851EBIT
2019Highly multiplexed single-cell proteomics1R21GM132831-01BUGAJ, LUKASZHUGHES, ALEXUNIVERSITY OF PENNSYLVANIA, PA$225,340EBIT
2019A Method to Insert Locked cis- and trans-Proline Analogues in Full-Length Proteins1R21GM132715-01ETZKORN, FELICIA AVIRGINIA POLYTECHNIC INST AND ST UNIV, VA$223,649MSFB
2019The development of an assay to study chromosome fragility in human cells1UH2GM129516-01LOBACHEV, KIRILL SGEORGIA INSTITUTE OF TECHNOLOGY, GA$222,070ZRG1
2019Updating Bifunctional Chelators to Keep Pace with Modern Biomedical Sciences1R21GM127964-01A1WOODS, MARKOREGON HEALTH & SCIENCE UNIVERSITY, OR$220,781EBIT
2019Mapping Functional Heterogeneity in Tissue1R21GM134219-01GAMCSIK, MICHAELMUDDIMAN, DAVID C.NORTH CAROLINA STATE UNIVERSITY RALEIGH, NC$220,542EBIT
2019Proof of principle for a Scalable Multiplex Proteome Quantitation Technology1R21GM129653-01A1MUNGRUE, IMRANLSU HEALTH SCIENCES CENTER, LA$220,500EBIT
2019Deployable 3D-printed Cellular Communities for Characterizing Bacterial Social Cues and Chemical Warfare1R21GM131349-01ANSLYN, ERIC V.SHEAR, JASON BENUNIVERSITY OF TEXAS AT AUSTIN, TX$217,885EBIT
2019Holographic Single Molecule Localization Microscopy with a Large Axial Range1R21GM134462-01KNER, PETER ALEXANDERUNIVERSITY OF GEORGIA, GA$216,300ISD
2019Turning a sequence barcode into a spectral barcode for single-cell analysis.1R21GM129617-01FINKELSTEIN, ILYA JYEH, HSIN-CHIHUNIVERSITY OF TEXAS AT AUSTIN, TX$215,902CMT
2019MIRROR: A Chip-Scale Mid-IR Ring Resonance System for On-the-fly Reporting of Analytes1R21GM132705-01HAN, ARUMTEXAS ENGINEERING EXPERIMENT STATION, TX$215,831ISD
2019A Scalable Platform to Selectively Purify Engineered Extracellular Vesicles via Self-Cleaving Tags1R21GM126543-01A1CHALMERS, JEFFREY JOHNWOOD, DAVID WOHIO STATE UNIVERSITY, OH$215,492GDD
2019Tandem Discovery of Drug Leads and Targets via Paal-Knorr reaction1R21GM131717-01KORNIENKO, ALEXANDERLA CLAIR, JAMES JTEXAS STATE UNIVERSITY, TX$211,875SBCB
2019New strategy to measure forces at the molecular scale in vivo1R21GM132661-01BERRO, JULIENYALE UNIVERSITY, CT$209,375EBIT
2019Measuring Protein-Protein Interactions using SPT-RESOLFT1R21GM132716-01LIDKE, KEITH AUNIVERSITY OF NEW MEXICO, NM$209,069EBIT
2019Gas-Phase Cross-Linking with Ion/Ion Chemistry Coupled to Ion Mobility/Mass Spectrometry1R21GM134408-01WEBB, IANINDIANA UNIVERSITY INDIANAPOLIS, IN$206,989EBIT
2019Multicolor two-photon excitation STED microscopy with multichannel compact semiconductor laser1R21GM131163-01A1DELFYETT, PETERHAN, KYU YOUNGVAN STRYLAND, ERIC WUNIVERSITY OF CENTRAL FLORIDA, FL$206,113ISD
2019Development of New Genome Editing Agents Using RNA Modifying Enzymes1R21GM135736-01KOMOR, ALEXIS C.UNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$205,479MSFD
2019Optogenetic Engineering of 3D Chromatin Architecture1R21GM132778-01LI, WENBOUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$203,570GCAT
2019Genetically encoded photoswitchable antibody mimetic proteins for spatiotemporal control of molecular recognition1R21GM132687-01LIN, MICHAEL Z.STANFORD UNIVERSITY, CA$203,450CMT
2019High content glycomics analysis using next generation sequencing technology1R21GM133195-01NEELAMEGHAM, SRIRAMSTATE UNIVERSITY OF NEW YORK AT BUFFALO, NY$198,247ZRG1
2019Synthetic design of an all-optical electrophysiology system1R21GM131662-01CHANDA, BARONSCHOMAKER, JENNIFER MARIEUNIVERSITY OF WISCONSIN-MADISON, WI$197,094CMT
2019Genetically encodable epitopes to overcome size and resolution limits in cryo-EM1R21GM131299-01A1MILLS, JEREMYNANNENGA, BRENTARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$195,582MSFA
20193-D Imaging Flow Cytometry1R21GM135848-01SUNG, YONGJINUNIVERSITY OF WISCONSIN MILWAUKEE, WI$195,110ISD
2019Finding the right niche:quantifying protein folding stability in materials1R21GM131425-01LECKBAND, DEBORAH EUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$192,730BMBI
2019Unagi-based encoded fluorescent protein kinase sensors1R21GM131302-01ZONDLO, NEAL JUNIVERSITY OF DELAWARE, DE$191,321SBCB
2019Chemical probes of protein histidine phosphatase activity1R21GM127970-01A1BARRIOS, AMY MUNIVERSITY OF UTAH, UT$190,625ZRG1
2019Accurate yet fast implicit solvation1R21GM131228-01ONUFRIEV, ALEXEY VLADVIRGINIA POLYTECHNIC INST AND ST UNIV, VA$190,259MSFD
2019Microfluidic nanoarrays for high-throughput analysis of biological nanostructures1R21GM134414-01WITTENBERG, NATHAN J.LEHIGH UNIVERSITY, PA$184,780ISD
2019Chemically engineered bilayers for cryoEM imaging of membrane proteins in continuous membranes1R21GM131231-01JIANG, QIU-XINGUNIVERSITY OF FLORIDA, FL$184,689BBM
2019A spectroscopic tool for direct chemical structure determination in LC-MS1R21GM135720-01GARAND, ETIENNEUNIVERSITY OF WISCONSIN-MADISON, WI$184,650EBIT
2019Repurposing Bacterial Mechanosensitive Channel as a Membrane Tension Biosensor1R21GM134157-01LIU, ALLEN PO-CHIHUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$181,685EBIT
2019Glycan engineering via exoplasmic Golgi shuttle of glycosylation building blocks and modulators1R21GM134315-01GODULA, KAMILUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$180,179ICI
2019Flexible Rigidity in Peptide Drug Design for Protein-Protein Interaction Inhibitors1R21GM132754-01A1ROCHE, STEPHANE PFLORIDA ATLANTIC UNIVERSITY, FL$178,890MSFA
2019Development of an Electronic Microchip for Real-Time Label-Free Quantification of Conjugation1R21GM132793-01KOVAC, JASNAPENNSYLVANIA STATE UNIVERSITY, THE, PA$177,397ISD
2019Development of a novel genome targeting technology using rational design and continuous evolution.1R21GM132779-01OWENS, JESSE BRUCEUNIVERSITY OF HAWAII AT MANOA, HI$176,875TAG
2019Catalysts Bearing Traceless Tethers for Single Step Meta and Para C-H Functionalization1R21GM134339-01BREWSTER, TIMOTHYUNIVERSITY OF MEMPHIS, TN$174,489SBCA
2019Explicit ions in implicit solvent: fast and accurate.1R21GM134404-01ONUFRIEV, ALEXEY VLADVIRGINIA POLYTECHNIC INST AND ST UNIV, VA$171,753MSFD
2019Esterase Specificity for Pharmacology and Chemical Biology1R21GM135780-01RAINES, RONALD TMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$150,600SBCB
2019Tools for the Detection of Ethylene1R21GM135824-01MICHEL, BRIANUNIVERSITY OF DENVER (COLORADO SEMINARY), CO$109,130SBCA
2018Development of genetically-encoded reporters for olfactory cilia signaling1R21GM126304-01FEINSTEIN, PAULHUNTER COLLEGE, NY$312,000MIST
2018Radioprotectants for structural biology1R21GM126406-01A1BOREK, DOMINIKA MARTAUT SOUTHWESTERN MEDICAL CENTER, TX$243,000MSFC
2018Development of Affinity Rod Scaffolds for Cryo-EM Sample Preparation1R21GM127958-01A1THOMPSON, DAVID HPURDUE UNIVERSITY, IN$242,152BMBI
2018Stereoselective Assembly of Challenging Glycosidic Linkages with Earth-Abundant Metal Catalysts1R21GM128442-01HUANG, XUEFEIXU, HAOGEORGIA STATE UNIVERSITY, GA$241,875SBCB
2018Rapid screening of gene-edited cells1R21GM129652-01HUANG, BOUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$240,000ZRG1
2018Development of label-free computational flow cytometry for high-throughput micro-organism classification1R21GM128020-01MERTZ, JEROMEBOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$239,527ZRG1
2018Synthetic glycan biomarkers: Novel reporters of cell metabolism1R21GM126537-01NEELAMEGHAM, SRIRAMSTATE UNIVERSITY OF NEW YORK AT BUFFALO, NY$239,250EBIT
2018Development of CRISPR-Cas9 gene drive technology in mice with potential for broad utility and applied genetics1R21GM129448-01A1COOPER, KIMBERLY LYNNUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$235,625GCAT
2018Single-Molecule Analysis of DNA Secondary Structures during DNA Replication1R21GM126600-01CIMPRICH, KARLENE ASTANFORD UNIVERSITY, CA$235,500MGB
2018Mosaic analysis with double markers in the study of neuronal migration disorders1R21MH115347-01A1ZARBALIS, KONSTANTINOSUNIVERSITY OF CALIFORNIA AT DAVIS, CA$235,500NCF
2018Image-Seq: A high-density microfluidic trap array for single cell transcriptome analysis coupled with image based phenotyping1R21GM131279-01YELLEN, BENJAMIN BIRONDUKE UNIVERSITY, NC$233,755CMT
2018Development of Bifunctional Electrochemical Zero-Mode Waveguides for Studies of Single Enzyme Electron Transfer Events1R21GM126246-01BOHN, PAUL WUNIVERSITY OF NOTRE DAME, IN$231,750EBIT
2018A genetically-encoded device that counts cell cycles1R21GM126287-01LIU, CHANG CUNIVERSITY OF CALIFORNIA-IRVINE, CA$231,750MGA
2018Adaptive optics modeling in nonlinear microscopy to improve deep tissue imaging1R21GM128135-01VENUGOPALAN, VASANUNIVERSITY OF CALIFORNIA-IRVINE, CA$231,750BMIT
2018Developing Acoustic Patterning for Neuroengineering1R21GM131281-01DALECKI, DIANEHOCKING, DENISE CUNIVERSITY OF ROCHESTER, NY$231,000BMBI
2018Single cell tagging of localized RNA from whole populations1R21GM126307-01STORMO, GARY DWASHINGTON UNIVERSITY, MO$228,750GCAT
2018A Quantum Dot Probe for Nanosecond-Timescale Imaging of Fast Biological Processes1R21GM127919-01WEISS, EMILY ALLYNNORTHWESTERN UNIVERSITY, IL$228,280ZRG1
2018Multiscale Fabrication and Imaging Platform for Bioscience Applications1R21GM129607-01SOMAN, PRANAVSYRACUSE UNIVERSITY, NY$225,000BMBI
2018Tools for Creating a Super-Resolution Interaction Map of Subcellular Dynamics in Living Bacteria Cells1R21GM128022-01BITEEN, JULIEUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$223,768ZRG1
2018A 10-K REBCO 23.5-T magnet towards a tabletop liquid-helium-free 1-GHz magnet for microcoil NMR spectroscopy1R21GM129688-01PARK, DONGKEUNMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$222,071ISD
2018Plasmon-coupled Fluorescence Correlation Spectroscopy in Nanoholes1R21GM129561-01LAKOWICZ, JOSEPH R.UNIVERSITY OF MARYLAND BALTIMORE, MD$220,357ISD
2018Detecting elusive biologically significant structural differences with serial crystallography1R21GM129570-01SOARES, ALEXEI SUAREZBROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB, NY$219,284MSFC
2018Development of a Real Time Cellular Tool to Monitor a Previously Untraceable Lipid1R21GM131352-01STAHELIN, ROBERT VIRGILPURDUE UNIVERSITY, IN$218,750BBM
2018Co-culture of probiotic bacteria for growth factor delivery in minigut organoids1R21GM131189-01MANSELL, THOMAS JIOWA STATE UNIVERSITY, IA$215,161CMT
2018Enabling Robust Single-Molecule Vibrational Spectroscopy Through Microcavity-Enhancement1R21GM127957-01GOLDSMITH, RANDALL HUNIVERSITY OF WISCONSIN-MADISON, WI$214,634EBIT
2018Overcoming Steric Challenges in Glycosylations1R21GM127971-01MCDONALD, FRANK EDWARDEMORY UNIVERSITY, GA$212,380SBCB
2018Optogenetic toolkit for remote control of voltage-gated calcium channels1R21GM126532-01HAN, GANGZHOU, YUBINTEXAS A&M UNIVERSITY HEALTH SCIENCE CTR, TX$208,200MIST
2018Fast energy evaluation for multi-protein systems1R21GM127952-01A1KOZAKOV, DMYTROSTATE UNIVERSITY NEW YORK STONY BROOK, NY$199,507MSFB
2018Developing nanoparticle optical reporters of compressive, tensile, and shear forces for use in living cells and tissues.1R21GM129879-01DIONNE, JENNIFER A.GOODMAN, MIRIAM BSTANFORD UNIVERSITY, CA$196,250NANO
2018Minimizing off-target frequency of CRISPR/Cas9 systems via zwitterionic polymer conjugation/peptide fusion1R21GM128004-01JIANG, SHAOYIUNIVERSITY OF WASHINGTON, WA$194,219ZRG1
2018"Develop an Efficient and General Strategy for the Synthesis of Challenging Glycosides"1R21GM126370-01A1TANG, WEIPINGUNIVERSITY OF WISCONSIN-MADISON, WI$184,890SBCB
2018A Sensor for quantification of hydrogen sulfide1R21GM129590-01FONTENOT, SEAN ALDONUNIVERSITY OF OREGON, OR$182,053EBIT
2018Developing Diffusion-Contrast Super-Resolution Microscopy to Study Protein Interactions at Extreme Concentration Ratios in Live Cells1R21GM127965-01A1PUCHNER, GEORG ELIAS MICHAELUNIVERSITY OF MINNESOTA, MN$141,673CMT
2018Capture and characterize transient catalytic intermediates by X-ray crystallography1R21GM127944-01ROUSSEAU, DENIS L.ALBERT EINSTEIN COLLEGE OF MEDICINE, INC, NY$94,075MSFB
2018Debugging eukaryotic membrane protein expression in E. coli using single-molecule fluorescence microscopy1R21GM126476-01ROBERTSON, JANICE LUNIVERSITY OF IOWA, IA$60,202MSFC
2018New IDEAS for GWAS loci: predict functional mutations, target genes and tissues driving disease association1R21GM127915-01ZHANG, YUPENNSYLVANIA STATE UNIVERSITY, THE, PA$1GCAT
2017Fast single-molecule refractive index binding sensor1R21GM126887-01RIEHN, ROBERTNORTH CAROLINA STATE UNIVERSITY RALEIGH, NC$201,730EBIT
2017Optogenetic control of protein assembly1R21GM126253-01TUCKER, CHANDRA LUNIVERSITY OF COLORADO DENVER, CO$194,375ZRG1
2017Particle-drops for democratization of digital assays1R21GM126414-01DI CARLO, DINOUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$153,227EBIT

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