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NIH funding notice PAR-17-190

Maximizing Investigators' Research Award for Early Stage Investigators (R35)

Closed on October 3, 2019.

Posted
March 3, 2017
Close date
October 3, 2019
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

461 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $172,708,735 in first-year total cost, median $380,189.

Most frequent study sections

  1. Special Emphasis Panel[ZGM1 TRN-5 (MR)]57
  2. Special Emphasis Panel[ZGM1 TRN-4 (MR)]51
  3. Special Emphasis Panel[ZGM1 TRN-7 (MR)]48
  4. Special Emphasis Panel[ZGM1 TRN-9 (MR)]41
  5. Special Emphasis Panel[ZRG1 CB-N (55)]37

Most frequent institutions

  1. UNIVERSITY OF MICHIGAN AT ANN ARBOR17
  2. UNIV OF NORTH CAROLINA CHAPEL HILL13
  3. UNIVERSITY OF CALIFORNIA, SAN DIEGO13
  4. UNIVERSITY OF PENNSYLVANIA10
  5. YALE UNIVERSITY10
Competing awards under PAR-17-190 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2020Elucidating structures and molecular mechanisms of Pannexin channels1R35GM138321-01LU, WEIVAN ANDEL RESEARCH INSTITUTE, MI$475,000ZRG1
2020Interpretable Deep Learning Algorithms for Pathology Image Analysis1R35GM138216-01MAHMOOD, FAISALBRIGHAM AND WOMEN'S HOSPITAL, MA$447,500ZRG1
2020Molecular interactions in the gut microbiota during early life colonization and perturbation1R35GM138369-01ZACKULAR, JOSEPH PAULCHILDREN'S HOSP OF PHILADELPHIA, PA$440,000ZRG1
2020Examining how the spatial partitioning of metabolism underlies cell state1R35GM138085-01BAILIS, WILL H.CHILDREN'S HOSP OF PHILADELPHIA, PA$440,000ZRG1
2020Investigating histone glycation as a new dynamic epigenetic mark1R35GM138386-01DAVID-SHTERNBERG, YAEL ESLOAN-KETTERING INST CAN RESEARCH, NY$439,201ZRG1
2020Molecular and cellular mechanisms regulating mitochondrial subpopulation dynamics and function in vivo1R35GM137921-01LEWIS, TOMMY LOKLAHOMA MEDICAL RESEARCH FOUNDATION, OK$437,000ZRG1
2020Roles of heat shock transcriptional factor 1 in cell proliferation independent of the heat shock response1R35GM138364-01LI, JIANOKLAHOMA MEDICAL RESEARCH FOUNDATION, OK$437,000ZRG1
2020Computational tools for estimating cell-type-specific effects in bulk RNA-seq and spatial transcriptomics data, using reference single-cell RNA-seq datasets1R35GM138293-01GEELEHER, PAULST. JUDE CHILDREN'S RESEARCH HOSPITAL, TN$436,749ZRG1
2020Mechanisms of vascular dysfunction in acute systemic inflammation1R35GM138191-01STARK, RYAN JVANDERBILT UNIVERSITY MEDICAL CENTER, TN$432,500ZRG1
2020Integrative Approaches for Identifying Causal Gene-Cell Type Pairs of Complex Disease1R35GM138113-01HUANG, KUAN-LINICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$423,069ZRG1
2020Improving metagenomic analysis with novel algorithms and technologies1R35GM138152-01HAJIRASOULIHA, IMANWEILL MEDICAL COLL OF CORNELL UNIV, NY$421,783ZRG1
2020Autophagy degradation of nuclear and chromatin constituents1R35GM137889-01DOU, ZHIXUNMASSACHUSETTS GENERAL HOSPITAL, MA$420,000ZRG1
2020Understanding redox-regulated mechanisms of environmental adaptation in gastrointestinal symbionts1R35GM137952-01HATZIOS, STAVROULAYALE UNIVERSITY, CT$418,750ZRG1
2020Spatial Organization of Membrane Signaling1R35GM138299-01SU, XIAOLEIYALE UNIVERSITY, CT$418,750ZRG1
2020Elucidating physiology of dormant bacteria to combat antibiotic persistence1R35GM137895-01BASAN, MARKUS THOMASHARVARD MEDICAL SCHOOL, MA$416,173ZRG1
2020Traits on trees: Population genomics for understanding complex phenotypes1R35GM137758-01EDGE, MICHAEL DONALDUNIVERSITY OF SOUTHERN CALIFORNIA, CA$412,500ZRG1
2020Synthetic development: dissection of morphogenetic programs via reconstructive and perturbative approaches1R35GM138256-01MORSUT, LEONARDOUNIVERSITY OF SOUTHERN CALIFORNIA, CA$412,500ZRG1
2020Physics and Systems Biology of Cellular Domains1R35GM138341-01MACHTA, BENJAMIN BROOKSYALE UNIVERSITY, CT$409,505ZRG1
2020Spatial Organization of the Mitochondrial Inner Membrane1R35GM137894-01FRIEDMAN, JONATHAN R.UT SOUTHWESTERN MEDICAL CENTER, TX$408,750ZRG1
2020Harnessing Fasting Metabolism to Improve Survival in Bacterial Sepsis1R35GM137984-01HUEN, SARAHUT SOUTHWESTERN MEDICAL CENTER, TX$408,750ZRG1
2020Measuring Lipid Flux By Ultra High Resolution Mass Spectrometry1R35GM137991-01MITSCHE, MATTHEW ALVINUT SOUTHWESTERN MEDICAL CENTER, TX$408,750ZRG1
2020Exploiting Pathogen-Encoded Immune Evasion Proteins to Uncover Evolutionarily Conserved Antiviral Host Machinery1R35GM137978-01GAMMON, DON BRADUT SOUTHWESTERN MEDICAL CENTER, TX$408,646ZRG1
2020Mechanisms of Regulation of the m6A mRNA Methylation Machinery1R35GM138185-01ALARCON, CLAUDIO RYALE UNIVERSITY, CT$408,625ZRG1
2020Chemically Precise Framework Materials as a Modular Platform Technology for Electroanalysis1R35GM138318-01MIRICA, KATHERINE ANDREADARTMOUTH COLLEGE, NH$407,020ZRG1
2020Mechanisms of Primary Cilium Assembly and Disassembly1R35GM137956-01BRESLOW, DAVID KINGYALE UNIVERSITY, CT$405,250ZRG1
2020Regulation of rRNA transcription in mammalian tissues1R35GM138035-01PARALKAR, VIKRAM R.UNIVERSITY OF PENNSYLVANIA, PA$405,025ZRG1
2020Deciphering Functional Consequences of Specific and Combinatorial Mutations in Protein Interaction Networks1R35GM137836-01SAHNI, NIDHIUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$405,000ZRG1
2020Computational approaches for protein functional analysis using CRISPR screens1R35GM137927-01XU, HANUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$405,000ZRG1
2020Statistical Methods to Study the Genetic Basis and Mechanisms of Trans Gene Regulation1R35GM138084-01LIU, XUANYAOUNIVERSITY OF CHICAGO, IL$405,000ZRG1
2020Role of DNA Methylation in Liquid-liquid Phase Separation-mediated Heterochromatin Formation1R35GM138097-01BAH, ALAJIUPSTATE MEDICAL UNIVERSITY, NY$405,000ZRG1
2020Regulation and Function of Histone H3K36 Methylation in Mammalian Chromatin1R35GM138181-01LU, CHAOCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$405,000ZRG1
2020Genetic dissection of motivational drive to eat1R35GM138060-01LIU, QILIUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$403,750ZRG1
2020Intracellular cargo transport in Toxoplasma gondii1R35GM138316-01HEASLIP, AOIFEUNIVERSITY OF CONNECTICUT STORRS, CT$402,500ZRG1
2020Chromosome structural variants in meiosis1R35GM137834-01CROWN, KIMBERLY NICOLECASE WESTERN RESERVE UNIVERSITY, OH$402,384ZRG1
2020Peptide regulation of blood-feeding and mating physiology in mosquitoes1R35GM137888-01DUVALL, LAURACOLUMBIA UNIV NEW YORK MORNINGSIDE, NY$402,369ZRG1
2020Uncovering the dynamics of human pathogens using high throughput multiplexed serological tools1R35GM138361-01RODRÍGUEZ-BARRAQUER, ISABELUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$402,101ZRG1
2020Cellular and Molecular Mechanisms of Germline Regeneration1R35GM138008-01OZPOLAT, BUSRA DUYGUMARINE BIOLOGICAL LABORATORY, MA$401,794ZRG1
2020Myeloid lineage targeting to improve recovery from injury and surgery: Cellular and molecular mechanisms1R35GM137906-01TAWFIK, VIVIANNE LSTANFORD UNIVERSITY, CA$401,338ZRG1
2020Utilizing Immune Phenotypes to Prevent Chronic Critical Illness1R35GM138020-01NOMELLINI, VANESSAUNIVERSITY OF CINCINNATI, OH$401,250ZRG1
2020Proteostasis at cellular membranes1R35GM137452-01KUCHAY, SHAFI M.UNIVERSITY OF ILLINOIS AT CHICAGO, IL$399,750ZRG1
2020Mapping the DNA damage response in human cells with high-resolution functional genomics1R35GM138167-01ADAMSON, BRITTANY S.PRINCETON UNIVERSITY, NJ$399,697ZRG1
2020Epigenesis of Cell Fate Potential1R35GM138150-01KOH, ANDREW SUNIVERSITY OF CHICAGO, IL$399,048ZRG1
2020RNA Modifications and Turnover during Viral-induced Decay1R35GM138043-01MULLER, MANDYUNIVERSITY OF MASSACHUSETTS AMHERST, MA$398,750ZRG1
2020Elucidation of the regulation and function of innate lymphoid cells1R35GM138805-01HUANG, YUEFENGCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$397,515ZRG1
2020Novel Bayesian statistical tools for integrating multi-omics data to help elucidate the genomic etiology of complex phenotypes1R35GM138313-01YANG, JINGJINGEMORY UNIVERSITY, GA$397,045ZRG1
2020A general test of the genetic basis of parasite resistance across genetic and environmental contexts1R35GM137975-01GIBSON, AMANDA KUNIVERSITY OF VIRGINIA, VA$397,039ZRG1
2020Investigation of the physiological significance of protein acetylation in Bacillus subtilis1R35GM138303-01CARABETTA, VALERIE JEANROWAN UNIVERSITY, NJ$396,314ZRG1
2020Quantifying Physiologic and Pathologic Viscoelastic Phases of Biomolecular Condensates by Correlative Force and Fluorescence Microscopy1R35GM138186-01BANERJEE, PRIYA R.STATE UNIVERSITY OF NEW YORK AT BUFFALO, NY$396,171ZRG1
2020Characterizing functional translation in putative 'noncoding' regions of a genome1R35GM138192-01JI, ZHENORTHWESTERN UNIVERSITY AT CHICAGO, IL$395,000ZRG1
2020Innate Inflammatory Control of Cachexia1R35GM138381-01EWALD, SARAH E.UNIVERSITY OF VIRGINIA, VA$394,512ZRG1
2020Development of functional synthetic biomolecular condensates.1R35GM138378-01OBERMEYER, ALLIE CCOLUMBIA UNIV NEW YORK MORNINGSIDE, NY$394,480ZRG1
2020Chemistry and Biology of ADP-Ribosylation-Dependent Signaling1R35GM137901-01ZHANG, YONGUNIVERSITY OF SOUTHERN CALIFORNIA, CA$394,433ZRG1
2020Harnessing the human monocyte system to improve surgical recovery1R35GM137936-01GAUDILLIERE, BRICESTANFORD UNIVERSITY, CA$394,250ZRG1
2020Imaging Molecular Level Details of Collagen Fibers by VSFG Microscopy1R35GM138092-01XIONG, WEIUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$393,958ZRG1
2020Lipid Modulation of Ligand-Gated Ion Channels1R35GM137957-01CHENG, WAYLAND WING-LUNWASHINGTON UNIVERSITY, MO$393,750ZRG1
2020Comparative systems biology defines regulatory mechanisms in whole-body regeneration1R35GM138061-01WANG, BOSTANFORD UNIVERSITY, CA$393,296ZRG1
2020Probing tyrosine phosphatase structure and function1R35GM138014-01SHAH, NEEL HCOLUMBIA UNIV NEW YORK MORNINGSIDE, NY$392,979ZRG1
2020Understanding the mechanisms that regulate cytoplasmic capping and defining its contributions to post-transcriptional gene regulation1R35GM137819-01KISS, DANIEL LOUISMETHODIST HOSPITAL RESEARCH INSTITUTE, TX$392,373ZRG1
2020Uncovering the modes and genetics of gut bacterial transmission1R35GM138284-01MOELLER, ANDREWCORNELL UNIVERSITY, NY$392,076ZRG1
2020Determinants of genome-wide activity and specificity of SWI/SNF family chromatin remodeling1R35GM137996-01HODGES, HAMILTON COURTNEYBAYLOR COLLEGE OF MEDICINE, TX$391,600ZRG1
2020Development of the next generation antibody technologies and their applications1R35GM137905-01SHI, YIUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$391,250ZRG1
2020Dissecting natural variation in transcription factor - DNA interactions1R35GM138143-01HUANG, SHAO-SHAN CAROLNEW YORK UNIVERSITY, NY$390,795ZRG1
2020Mechanosensitive mechanisms regulating cellular coordination during tissue morphogenesis and patterning1R35GM137976-01STRATMAN, AMBER NICOLEWASHINGTON UNIVERSITY, MO$390,300ZRG1
2020Achieving enhanced cytosolic delivery and greater efficacy of therapeutic nucleic acids using DNA-surfactant conjugates1R35GM138226-01ROUGE, JESSICA LUNIVERSITY OF CONNECTICUT STORRS, CT$390,300ZRG1
2020Cytokine-mediated reprogramming of mitochondrial function1R35GM138003-01DIVAKARUNI, AJITUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$390,000ZRG1
2020Chemical approaches for generating blood-brain barrier-permeable antibody conjugates1R35GM138264-01TSUCHIKAMA, KYOJIUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$390,000ZRG1
2020In Situ Architecture of Specialized Bacterial Secretion Systems1R35GM138301-01HU, BOUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$390,000ZRG1
2020Mechanisms of gene regulation mediated by human-specific SVA transposons1R35GM138344-01TRIZZINO, MARCOTHOMAS JEFFERSON UNIVERSITY, PA$390,000ZRG1
2020Elucidating the Mechanism in the Regulation of RNA-binding Protein Phase Separation1R35GM138109-01GUO, LINTHOMAS JEFFERSON UNIVERSITY, PA$390,000ZRG1
2020New tools to probe iron and manganese homeostasis in bacterial and eukaryotic cells1R35GM138308-01COTRUVO, JOSEPH ALFREDPENNSYLVANIA STATE UNIVERSITY, THE, PA$389,846ZRG1
2020Elucidation of the first interspecies chemical signaling mechanisms in Capsaspora owczarzaki--the predator of a human pathogen and a model for the evolution of animal multicellularity1R35GM138376-01GERDT, JOSEPH P.TRUSTEES OF INDIANA UNIVERSITY, IN$389,270ZRG1
2020Mechanisms coordinating cell behaviors within tissues during development1R35GM138380-01KASZA, KARENCOLUMBIA UNIV NEW YORK MORNINGSIDE, NY$389,218ZRG1
2020Microbial multi-stress responses: from intracellular networks to communities1R35GM138210-01JENSEN, PAUL ANTHONYUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$388,921ZRG1
2020Role of Nucleolus and Ribosome Biogenesis in Coordinating Organism-wide Growth1R35GM138340-01SARINAY CENIK, ELIFUNIVERSITY OF TEXAS AT AUSTIN, TX$388,204ZRG1
2020Elucidating Molecular-Level Roles of Essential Metals in Gut Bacteria with New Fluorescent Protein-Based Metal Ion Sensors1R35GM138223-01ZASTROW, MELISSA LYNNUNIVERSITY OF HOUSTON, TX$387,083ZRG1
2020The coevolutionary dynamics of pleiotropic genetic architecture1R35GM138007-01TATE, ANN THOMASVANDERBILT UNIVERSITY, TN$386,636ZRG1
2020Discovery of Novel Mechanisms of Action of Ubiquitin-Like Proteins in Cellular Stress Pathways1R35GM137961-01RADOSHEVICH, LILLIANAUNIVERSITY OF IOWA, IA$385,828ZRG1
2020Mechanisms and Evolution of Host Tolerance to Transposable Elements1R35GM138112-01KELLEHER, ERIN SUNIVERSITY OF HOUSTON, TX$385,263ZRG1
2020Regulation of lipid homeostasis by proliferative signaling pathways1R35GM137985-01DOWEN, ROBERT HOUSTONUNIV OF NORTH CAROLINA CHAPEL HILL, NC$385,143ZRG1
2020Acid-Sensing Ion Channel gating: Conformations and Consequences1R35GM137951-01MACLEAN, DAVID MALCOMUNIVERSITY OF ROCHESTER, NY$385,000ZRG1
2020Endosomes as a multifunctional hub to control GPCR function1R35GM137835-01LOBINGIER, BRADENOREGON HEALTH & SCIENCE UNIVERSITY, OR$384,997ZRG1
2020Sphingolipid-dependent host-microbe interactions1R35GM138281-01JOHNSON, ELIZABETH LCORNELL UNIVERSITY, NY$384,800ZRG1
2020Using directed evolution to study the origins of multicellular development.1R35GM138030-01RATCLIFF, WILLIAM CROFTGEORGIA INSTITUTE OF TECHNOLOGY, GA$384,498ZRG1
2020Non-Covalent Molecular Recognition for Drug Targeting in the Body1R35GM137987-01WEBBER, MATTHEWUNIVERSITY OF NOTRE DAME, IN$383,425ZRG1
2020Advancing evolutionary genetic inference in humans and other taxa1R35GM138286-01SCHRIDER, DANIEL RUNIV OF NORTH CAROLINA CHAPEL HILL, NC$382,894ZRG1
2020Machine Learning for Integrative Modeling of the Immune System in Clinical Settings1R35GM138353-01AGHAEEPOUR, NIMASTANFORD UNIVERSITY, CA$382,710ZRG1
2020Biophysics of Regulatory RNAs and RNPs1R35GM138279-01KEANE, SARAH COURTNEYUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$382,588ZRG1
2020Molecular and Genetic Analysis of Fin Regeneration in Zebrafish1R35GM137878-01KANG, JUNSUUNIVERSITY OF WISCONSIN-MADISON, WI$382,550ZRG1
2020Decoding the non-binary signaling logic that controls cell fate1R35GM138346-01HEEMSKERK, IDSE JOANNESUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$382,533ZRG1
2020Dynamics of Acid-sensing ion channels1R35GM137912-01BANKSTON, JOHNUNIVERSITY OF COLORADO DENVER, CO$382,493ZRG1
2020Merging Computation and Experiment to Understand and Develop Asymmetric Open-Shell Radical Cross-Couplings1R35GM137797-01GUTIERREZ, OSVALDOUNIV OF MARYLAND, COLLEGE PARK, MD$382,297ZRG1
2020Imaging macromolecular machines in gene regulation1R35GM138348-01TAYLOR, DAVID WUNIVERSITY OF TEXAS AT AUSTIN, TX$382,210ZRG1
2020Delivery Strategies for Microbe Therapeutics1R35GM137898-01ANSELMO, AARON CUNIV OF NORTH CAROLINA CHAPEL HILL, NC$382,018ZRG1
2020Dissecting host-pathogen interactions through the lens of genomics1R35GM138283-01KAZEMIAN, MAJIDPURDUE UNIVERSITY, IN$381,824ZRG1
2020Chronic postoperative pain: Genetic and Neural Circuit Mechanisms1R35GM138168-01TAYLOR, NORMANUNIVERSITY OF UTAH, UT$381,250ZRG1
2020Taming Fluorine: Metal-Organic Frameworks for the Heterogeneous Delivery of Fluorinated Building Blocks1R35GM138165-01MILNER, PHILLIP JOHNCORNELL UNIVERSITY, NY$380,718ZRG1
2020Deciphering the chromatin-based DNA damage response pathway1R35GM137798-01LEUNG, JUSTIN WAI CHUNGUNIV OF ARKANSAS FOR MED SCIS, AR$380,000ZRG1
2020Tuning multivalency for optimized ligand presentation1R35GM138296-01GORMLEY, ADAM JOSEPHRUTGERS, THE STATE UNIV OF N.J., NJ$379,476ZRG1
2020Epigenetic Regulation of Lineage Specification1R35GM138289-01TSANGARATOU, AGELIKIUNIV OF NORTH CAROLINA CHAPEL HILL, NC$378,288ZRG1
2020Systems Biology of Shape and Size Regulation1R35GM137953-01LOBO, DANIELUNIVERSITY OF MARYLAND BALTIMORE COUNTY, MD$378,160ZRG1
2020Regulatory elements of replication timing and 3D genome organization1R35GM137950-01RIVERA-MULIA, JUAN CARLOSUNIVERSITY OF MINNESOTA, MN$378,043ZRG1
2020Synapse-specific effects of synaptically released zinc: implications for auditory processing1R35GM138023-01ANDERSON, CHARLESWEST VIRGINIA UNIVERSITY, WV$377,936ZRG1
2020A novel approach to improve comprehensive profiling of the epigenome and epitranscriptome1R35GM138122-01BROOKS, ANGELA NORIEUNIVERSITY OF CALIFORNIA SANTA CRUZ, CA$377,787ZRG1
2020Establishing Glyoxalase 2 as a Viable Target for the Treatment of Disease1R35GM137910-01GALLIGAN, JAMES JUNIVERSITY OF ARIZONA, AZ$377,363ZRG1
2020Advancing CRISPR-Cas Technologies for the Discovery and Characterization of Novel Fungal Natural Products1R35GM138207-01GAO, XUERICE UNIVERSITY, TX$377,328ZRG1
2020The genetic basis and adaptive significance of divergence in quantitative traits in sympatric Mimulus species1R35GM138224-01FERRIS, KATHLEEN GRAYTULANE UNIVERSITY OF LOUISIANA, LA$376,437ZRG1
2020Incorporating geography into statistical methods for analysis of population genomic DNA1R35GM137919-01BRADBURD, GIDEONMICHIGAN STATE UNIVERSITY, MI$376,311ZRG1
2020Mechanistic Investigation of Proteostasis at the Outer Mitochondrial Membrane1R35GM137904-01WOHLEVER, MATTHEW LEEUNIVERSITY OF TOLEDO, OH$376,250ZRG1
2020Statistical Methods for Bulk-Tissue and Single-Cell Multi-Omics Integration1R35GM138342-01JIANG, YUCHAOUNIV OF NORTH CAROLINA CHAPEL HILL, NC$376,250ZRG1
2020Isocitrate dehydrogenase (IDH) mutations as drivers of organelle stress and dysfunction"1R35GM137773-01SOHL, CHRISTAL DYANESAN DIEGO STATE UNIVERSITY, CA$376,248ZRG1
2020Regulatory Mechanism of Cullin-RING Ubiquitin Ligases1R35GM138016-01LIU, XINGPURDUE UNIVERSITY, IN$376,148ZRG1
2020Harnessing simulations to uncover molecular mechanisms of mechanosensing1R35GM138312-01HOCKY, GLENNEW YORK UNIVERSITY, NY$375,981ZRG1
2020Capturing the dynamic epigenome using single molecule and single cell approaches1R35GM137832-01RAGUNATHAN, KAUSHIKUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$375,741ZRG1
2020Biogenesis of macromolecular machines for post-transcriptional regulation of translation1R35GM138123-01GHALEI, HOMAEMORY UNIVERSITY, GA$375,500ZRG1
2020Expanding the Functionality of Engineered Extracellular Matrices1R35GM138193-01ROSALES, ADRIANNEUNIVERSITY OF TEXAS AT AUSTIN, TX$374,667ZRG1
2020New Photocatalytic Coupling Reactions to Prepare Bioactive Molecules1R35GM138050-01MARTIN, DAVIDUNIVERSITY OF IOWA, IA$374,454ZRG1
2020Elucidating the Role of Microbial Community Dynamics in Wound Repair and Regeneration1R35GM137828-01KALAN, LINDSAY ROBYNUNIVERSITY OF WISCONSIN-MADISON, WI$374,300ZRG1
2020Understanding the Mechanisms of Respiratory Supercomplexes and mitochondrial Complex I1R35GM137929-01LETTS, JAMES ANTHONYUNIVERSITY OF CALIFORNIA AT DAVIS, CA$373,217ZRG1
2020Mathematical modeling of spatiotemporal and mechanical processes in cellular functions1R35GM138370-01CHEN, JINGVIRGINIA POLYTECHNIC INST AND ST UNIV, VA$373,180ZRG1
2020The Cellular Environment as a Regulator of Intrinsically Disordered Proteins1R35GM137926-01SUKENIK, SHAHARUNIVERSITY OF CALIFORNIA, MERCED, CA$373,120ZRG1
2020Methods for quantifying selection in evolving populations1R35GM138233-01BARTON, JOHN PUNIVERSITY OF CALIFORNIA RIVERSIDE, CA$371,826ZRG1
2020Nanoelectrochemistry and Single Cell Metabolomics1R35GM138133-01DICK, JEFFREY EUNIV OF NORTH CAROLINA CHAPEL HILL, NC$371,771ZRG1
2020Mimicking, Exploiting, and Understanding Biology's Heterogeneity in 4D1R35GM138036-01DEFOREST, COLE AUNIVERSITY OF WASHINGTON, WA$371,605ZRG1
2020Structures and Mechanisms of Iron-Sulfur Proteins in Redox Control and Stress Response1R35GM138157-01ZHANG, LIMEIUNIVERSITY OF NEBRASKA LINCOLN, NE$371,250ZRG1
2020Evolutionary genetics of genotype-by-environment interactions for complex traits1R35GM138300-01LASKY, JESSEPENNSYLVANIA STATE UNIVERSITY, THE, PA$371,105ZRG1
2020Spatiotemporal control of concentration gradients with electrochemistry in extracelluar space1R35GM138241-01LIU, CHONGUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$371,084ZRG1
2020Probing the dynamics of chromosome organization in single cells1R35GM137916-01BELIVEAU, BRIAN JOSEPHUNIVERSITY OF WASHINGTON, WA$370,959ZRG1
2020Mining Cryptic Biosynthetic Gene Clusters for Novel Bioactive Compounds1R35GM138002-01PARKINSON, ELIZABETH IVYPURDUE UNIVERSITY, IN$370,472ZRG1
2020Evolution of Stress Response Gene Regulatory Network in a Commensal and Opportunistic Yeast Pathogen1R35GM137831-01HE, BIN ZUNIVERSITY OF IOWA, IA$369,726ZRG1
2020Structural biology of chromatin in vitro and in cells1R35GM138382-01DEBELOUCHINA, GALIAUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$369,398ZRG1
2020Allosteric Regulation of Human G Protein-Coupled Receptors by Membrane Lipids1R35GM138291-01EDDY, MATTHEW THOMASUNIVERSITY OF FLORIDA, FL$368,810ZRG1
2020Mechanisms of Contractile Network Assembly1R35GM138183-01BEACH, JORDANLOYOLA UNIVERSITY CHICAGO, IL$368,430ZRG1
2020Uncovering and harnessing connected metabolic pathways essential to virus infection.1R35GM138199-01MOUNCE, BRYAN CLOYOLA UNIVERSITY CHICAGO, IL$368,430ZRG1
2020Designing cell-instructive hydrogels to understand and exploit mechanobiology1R35GM138187-01CALIARI, STEVENUNIVERSITY OF VIRGINIA, VA$368,327ZRG1
2020New Synthetic Methodology Enabled by Base-Promoted Halogen and Electron Transfer Processes1R35GM138350-01BANDAR, JEFFREY SCOLORADO STATE UNIVERSITY, CO$367,844ZRG1
2020The chemical approach towards homogenous glycoprotein preparation and evaluation1R35GM138336-01ZHANG, QIANGSTATE UNIVERSITY OF NEW YORK AT ALBANY, NY$366,864ZRG1
2020Linking metabolic activity with drug sensitivity using metabolic influence networks1R35GM137795-01CHANDRASEKARAN, SRIRAMUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$366,446ZRG1
2020Microtubule bundles in the mitotic spindle: probing how mechanical and functional robustness emerge from molecular architecture1R35GM138083-01ELTING, MARY WILLIARDNORTH CAROLINA STATE UNIVERSITY RALEIGH, NC$366,035ZRG1
2020Determining the Structure and Function of Newly Discovered Immune Systems1R35GM138080-01JACKSON, RYAN NEALUTAH STATE UNIVERSITY, UT$365,000ZRG1
2020Integrating theory, genomics, and comparative approaches to break barriers to the understanding of genome structure and sex chromosome evolution.1R35GM138098-01BLACKMON, HEATHTEXAS A&M UNIVERSITY, TX$364,967ZRG1
2020Beyond Pseudotime: Enhanced Single-cell Genomics Tools for Understanding the Temporal Dynamics of Development and Disease1R35GM137896-01CUSANOVICH, DARREN AUNIVERSITY OF ARIZONA, AZ$364,590ZRG1
2020Label-free single molecule detection for basic science and translational medicine1R35GM137988-01SU, JUDITHUNIVERSITY OF ARIZONA, AZ$364,590ZRG1
2020Evolutionary approaches to identify genetic architecture regulating aggression1R35GM138345-01KOWALKO, JOHANNA E.FLORIDA ATLANTIC UNIVERSITY, FL$364,097ZRG1
2020Primary Amines as Versatile Precursors for the Synthesis of Bioactive Molecules and Macromolecular Drug Carriers1R35GM138079-01MICHAUDEL, QUENTIN NICOLASTEXAS A&M UNIVERSITY, TX$363,288ZRG1
2020Paragons of Conformational Control in Metalloenzyme Reactivity1R35GM138138-01OLSHANSKY, LISAUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$362,660ZRG1
2020New opportunities for the Cope rearrangement: methods, modular synthesis, and applications in drug discovery1R35GM137893-01GRENNING, ALEXANDER JAMESUNIVERSITY OF FLORIDA, FL$362,434ZRG1
2020Data-driven Computational Modeling and Refinement of Protein Structures on Genomic Scales1R35GM138146-01BHATTACHARYA, DEBSWAPNAAUBURN UNIVERSITY AT AUBURN, AL$362,119ZRG1
2020Investigating structural heterogeneities in amyloid aggregates with multiscale infrared spectroscopic imaging1R35GM138162-01GHOSH, AYANJEETUNIVERSITY OF ALABAMA IN TUSCALOOSA, AL$361,936ZRG1
2020Novel Formulation Technology to Enhance Oral Absorption of Water-insoluble Drugs1R35GM138225-01DONG, XIAOWEIUNIVERSITY OF NORTH TEXAS HLTH SCI CTR, TX$361,504ZRG1
2020Determining mechanisms of innate immune modulation by ADP-ribosylation1R35GM138029-01FEHR, ANTHONY RUNIVERSITY OF KANSAS LAWRENCE, KS$361,008ZRG1
2020Learning to learn in structural biology with deep neural networks1R35GM137966-01WHITE, ANDREW DAVIDUNIVERSITY OF ROCHESTER, NY$360,287ZRG1
2020Systematic approaches to reveal novel regulatory functions of tyrosine phosphorylation1R35GM138127-01NAEGLE, KRISTEN MUNIVERSITY OF VIRGINIA, VA$360,148ZRG1
2020Structural variation analysis with and without a reference genome1R35GM138212-01CHONG, ZECHENUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$359,989ZRG1
2020Decoding and Rewiring Enzymatic Redox Signal Transduction Pathways1R35GM138277-01BHAGI, AMBIKAUNIVERSITY OF MINNESOTA, MN$359,096ZRG1
2020Transcriptome reprogramming in the early embryo1R35GM137973-01LEE, MILER T. S.UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$358,763ZRG1
2020Towards an Atomistic Understanding of Mitochondrial Protein Biogenesis1R35GM138206-01HERZIK, MARK ANTHONYUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$356,947ZRG1
2020Generation of DNA memory by bacterial CRISPR-Cas9 systems1R35GM137883-01ZHANG, YANUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$356,944ZRG1
2020Metaproteomics to investigate intestinal microbiota-host and -diet interactions1R35GM138362-01KLEINER, MANUELNORTH CAROLINA STATE UNIVERSITY RALEIGH, NC$356,930ZRG1
2020Physics of Living Matter: From Molecule to Embryo1R35GM138203-01STREICHAN, SEBASTIAN JUNIVERSITY OF CALIFORNIA SANTA BARBARA, CA$356,056ZRG1
2020Radical-Mediated Atom-Transfer Strategies for Chemical Synthesis1R35GM138107-01SCHMIDT, VALERIE ANNEUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$355,443ZRG1
2020Molecular mayhem: Immune modulation and eicosanoid signaling during infection1R35GM137934-01DILLMAN, ADLER RAYUNIVERSITY OF CALIFORNIA RIVERSIDE, CA$354,944ZRG1
2020Function of Chromatin Features in Cellular Programming1R35GM137833-01MURPHY, PATRICK J.UNIVERSITY OF ROCHESTER, NY$354,890ZRG1
2020Advanced algorithms to infer and analyze 3D genome structures1R35GM137974-01WANG, ZHENGUNIVERSITY OF MIAMI CORAL GABLES, FL$354,694ZRG1
2020Phenonium ions as control elements for the synthesis of chiral small molecules1R35GM137920-01RACE, NICHOLAS JAMESUNIVERSITY OF MINNESOTA, MN$352,689ZRG1
2020Understanding the control mechanisms of 3D cell migration from new dimensions1R35GM138179-01SUN, BOOREGON STATE UNIVERSITY, OR$352,506ZRG1
2020Peptides and Small-molecules Targeting Signaling Proteins and Protein-Protein Interfaces1R35GM138217-01VASHISTH, HARISHUNIVERSITY OF NEW HAMPSHIRE, NH$351,965ZRG1
2020Scope and mechanism of coordinated alternative splicing and alternative polyadenylation1R35GM138319-01MIURA, PEDROUNIVERSITY OF NEVADA RENO, NV$351,938ZRG1
2020Metal-Free Electrocatalysis for Fine-Chemical Synthesis1R35GM138114-01POWERS, DAVID CTEXAS A&M UNIVERSITY, TX$349,658ZRG1
2020Structure and assembly of membrane proteins at tight junctions1R35GM138368-01VECCHIO, ALEX J.UNIVERSITY OF NEBRASKA LINCOLN, NE$349,449ZRG1
2020The Development and Experimental Verification of Computational Methods to Design and Predict the Properties of Therapeutic Proteins1R35GM138220-01PANTAZES, ROBERT JAUBURN UNIVERSITY AT AUBURN, AL$349,201ZRG1
2020Development and Application of New Genome Editing Tools for the Functional Investigation of Genetic Variants of Uncertain Significance1R35GM138317-01KOMOR, ALEXIS C.UNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$349,064ZRG1
2020Molecular Mechanisms of Replication Stress Response1R35GM137800-01DUNGRAWALA, HUZEFA MANNANUNIVERSITY OF SOUTH FLORIDA, FL$347,014ZRG1
2020Dissecting the roles of ubiquitin in translation control1R35GM137954-01SILVA, GUSTAVO MDUKE UNIVERSITY, NC$344,503ZRG1
2020Improving Small Molecule Synthesis by Controlling Reactions between Transition Metals and Carbon-Heteroatom Electrophiles1R35GM137971-01NEUFELDT, SHARONMONTANA STATE UNIVERSITY - BOZEMAN, MT$343,279ZRG1
2020Combining chemical and computational tools for predictive models of microbiome communities1R35GM138201-01DE LA FUENTE, CESARUNIVERSITY OF PENNSYLVANIA, PA$342,713ZRG1
2020Stress sensing and processing by bacterial cytoplasmic megacomplexes1R35GM138018-01CABEEN, MATTHEW TOKLAHOMA STATE UNIVERSITY STILLWATER, OK$342,523ZRG1
2020Characterizing the molecular regulators of stem cell populations during homeostasis and regeneration in Hydractinia, an emerging cnidarian research organism1R35GM138156-01SCHNITZLER, CHRISTINEUNIVERSITY OF FLORIDA, FL$342,391ZRG1
2020One, Two, and Three Rieske Routes for Catalyzing Site-Specific Oxygenations1R35GM138271-01BRIDWELL-RABB, JENNIFER DUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$340,435ZRG1
2020Endothelial Glycocalyx Disintegrity: Repairing the Damage caused by Trauma-Hemorrhage1R35GM137958-01RICHTER, JILLIAN ROUSEUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$340,101ZRG1
2020Multi-scale computational investigation of functions and mechanisms of protein-RNA phase separation.1R35GM138243-01POTOYAN, DAVITIOWA STATE UNIVERSITY, IA$339,524ZRG1
2020Functional annotation of new genes aided by deep learning1R35GM138184-01KIM, PORAUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$334,778ZRG1
2020Resolving Methodological Challenges in Genomics Research: Causality, Risk Prediction, and Reproducibility1R35GM138121-01WEN, XIAOQUANUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$331,923ZRG1
2020Late-stage C-H functionalization and C-C/N coupling enabled by new strategies for electrochemically-controlled radical formation1R35GM138373-01SEVOV, CHRISTOOHIO STATE UNIVERSITY, OH$329,346ZRG1
2020New and Improved Sensor Platforms and Quantification of Nitric Oxide for In Vitro and In Vivo Systems1R35GM138245-01IVERSON, NICOLE MARIEUNIVERSITY OF NEBRASKA LINCOLN, NE$329,055ZRG1
2020Genetic determinants of interbacterial competition during host colonization1R35GM137886-01SEPTER, ALECIAUNIV OF NORTH CAROLINA CHAPEL HILL, NC$328,158ZRG1
2020Unsupervised optimization of protein therapeutics using closed-loop in vitro synthesis, nanosensing, and deep-learning1R35GM138265-01REUEL, NIGEL FIOWA STATE UNIVERSITY, IA$327,666ZRG1
2020Cellular organization, division, and differentiation in an ancient, genetically reduced bacterium1R35GM138202-01LIECHTI, GEORGE WARRENHENRY M. JACKSON FDN FOR THE ADV MIL/MED, MD$319,034ZRG1
2020Tubular lysosomes in health and disease1R35GM138116-01JOHNSON, ALYSSALOUISIANA STATE UNIV A&M COL BATON ROUGE, LA$318,967ZRG1
2020Three-dimensional field effect transistor arrays as a platform technology for intracellular electrophysiology recording.1R35GM138250-01XU, SHENGUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$306,144ZRG1
2020Dynamic probes of endogenous protein aggregation and cell signaling1R35GM138211-01BUGAJ, LUKASZUNIVERSITY OF PENNSYLVANIA, PA$306,048ZRG1
2020Tools to Study Electrophilic Stress and Develop Covalent Drugs1R35GM138335-01FRANZINI, RAPHAEL M.UNIVERSITY OF UTAH, UT$305,000ZRG1
2020Development of a Rapid Antibiotic Susceptibility Test Capable of Detecting Heteroresistance1R35GM138354-01YUNKER, PETERGEORGIA INSTITUTE OF TECHNOLOGY, GA$302,422ZRG1
2020New technologies for in situ measurement of exosome release from brain slice cultures1R35GM138173-01BAKER, CHRISTOPHER ANEW MEXICO STATE UNIVERSITY LAS CRUCES, NM$302,277ZRG1
2020High throughput functional characterization of lncRNAs in macrophage biology1R35GM137801-01CARPENTER, SUSANUNIVERSITY OF CALIFORNIA SANTA CRUZ, CA$300,537ZRG1
2020Interrogation and interpretation of protein kinase signaling dynamics at single-cell resolution1R35GM138214-01XUE, MINUNIVERSITY OF CALIFORNIA RIVERSIDE, CA$289,202ZRG1
2020Super-multiplexed fluorescence nanoscopy for imaging-based proteomics1R35GM138039-01HAN, KYU YOUNGUNIVERSITY OF CENTRAL FLORIDA, FL$267,626ZRG1
2020Defining cis-regulatory networks controlling a core stress response1R35GM138120-01SAMMONS, MORGAN ANDREWSTATE UNIVERSITY OF NEW YORK AT ALBANY, NY$262,035ZRG1
2020Deciphering the Mechanisms and Cellular Roles of Monomer-Driven Actin Dynamics1R35GM137959-01VITRIOL, ERIC AUNIVERSITY OF FLORIDA, FL$154,880ZRG1
2020Understanding how structural mutations and individual RNA isoformsare involved in human health and disease1R35GM138636-01EBBERT, MARK T WMAYO CLINIC JACKSONVILLE, FL$3,570ZRG1
2019High-resolution deconvolution of selection effects on the composition of the B cell repertoire1R35GM133682-01BRINEY, BRYANSCRIPPS RESEARCH INSTITUTE, THE, CA$483,750ZGM1

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