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NIH funding notice PAR-17-438

Assay development and screening for discovery of chemical probes or therapeutic agents (R01)

Closed on July 20, 2020.

Posted
July 27, 2017
Close date
July 20, 2020
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

43 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $23,106,243 in first-year total cost, median $528,041.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 BST-F (55)]39
  2. Special Emphasis Panel[ZRG1-BST-F(55)R]4

Most frequent institutions

  1. BOSTON CHILDREN'S HOSPITAL2
  2. DUKE UNIVERSITY2
  3. ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI2
  4. JOHNS HOPKINS UNIVERSITY2
  5. KANSAS STATE UNIVERSITY2
Competing awards under PAR-17-438 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2021High-throughput assays and small-molecule discovery of antiviral candidates targeting influenza hemagglutinin1R01AI150885-01A1WILSON, IAN ASCRIPPS RESEARCH INSTITUTE, THE, CA$678,526ZRG1
2021A high-throughput platform to identify selective allosteric inhibitors of the PLC-y isozymes1R01CA258993-01PEARCE, KENNETH HUGHSONDEK, JOHN EZHANG, QISHENGUNIV OF NORTH CAROLINA CHAPEL HILL, NC$569,708ZRG1
2021Discovery of small molecules targeting the histone acetylation reader ENL1R01CA255506-01WEN, HONGVAN ANDEL RESEARCH INSTITUTE, MI$454,068ZRG1
2021Identification of novel anthelmintics through a target-based screen of a parasite ion channel1R01AI155405-01MARCHANT, JONATHAN SSCAMPAVIA, LOUIS DANIELMEDICAL COLLEGE OF WISCONSIN, WI$373,743ZRG1
2021Development of a multiplexed assay in kinetoplastid parasites to identify probes for glycolysis1R01AI156382-01CHRISTENSEN, KENNETH AGOLDEN, JENNIFER E.MORRIS, JAMES CULVINWERBOVETZ, KARL ACLEMSON UNIVERSITY, SC$223,077ZRG1
2020HTS Targeting HIV-1 Protease Autoprocessing for First in Class Drug Discovery1R01AI150223-01CHEN, CHAOPINGCHUNG, THOMAS D YSHERMAN, DAVID HCOLORADO STATE UNIVERSITY, CO$803,950ZRG1
2020Validating Inhibitors of the Immunomodulatory Sphingosine 1-Phosphate Transporter SPNS21R01AI148178-01SCHWAB, SUSAN RUTHNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$672,866ZRG1
2020High Throughput Screen for Inhibitors of Shigella Flexneri Dissemination1R01AI153455-01AGAISSE, HERVE FENGEL, DANIEL AUNIVERSITY OF VIRGINIA, VA$627,361ZRG1
2020Developing Bacterial Glycosyltransferase Inhibitors as Anti-Virulence Drugs1R56AI153202-01HARDWIDGE, PHILIP ROSSKANSAS STATE UNIVERSITY, KS$614,542ZRG1
2020Automated high throughput compound screening for broadly active anti-parasitic nematode drugs1R01AI150866-01AROIAN, RAFFI VUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$602,642ZRG1
2020Discovery of Small Molecule Ligands for PHD1 Reader Domain of Histone Demethylase KDM5A1R01CA250459-01A1ARKIN, MICHELLEFUJIMORI, DANICA GALONICUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$584,086ZRG1
2020Targeting epigenetic reader GAS411R01CA240514-01A1CIERPICKI, TOMASZUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$528,041ZRG1
2020Identification of small molecule modulators of mitochondrial creatine kinase 11R01CA251910-01HITOSUGI, TAROSERGIENKO, EDUARD A.SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, CA$520,361ZRG1
2020Inhibiting sequential biosynthetic steps of a fungal-specific organelle1R01AI148235-01A1KOEHLER, JULIA RPOLLASTRI, MICHAEL PBOSTON CHILDREN'S HOSPITAL, MA$510,459ZRG1
2020Targeting the Sam68-stimulated PARP1 activation for cancer treatment1R01CA244350-01A1WAN, FENGYIJOHNS HOPKINS UNIVERSITY, MD$451,191ZRG1
2020Discovery of Chemical Probes of SAMHD1 for Modulation of Cancer Therapy and the Immune System1R01CA233567-01A1STIVERS, JAMES T.JOHNS HOPKINS UNIVERSITY, MD$374,578ZRG1
2019Development of validated probes for the bacterial type III secretion system1R01AI141511-01A1STONE, VICTORIA AUERBUCHUNIVERSITY OF CALIFORNIA SANTA CRUZ, CA$762,541ZRG1
2019High throughput screening of the Prp8 intein splicing inhibitors for pathogenic fungi1R01AI140726-01A1LI, HONGMINWADSWORTH CENTER, NY$664,586ZRG1
2019Identification of CYP5122A1 inhibitors as chemical probes for Leishmania biology1R01AI139198-01A1WANG, ZHUO MICHAELUNIVERSITY OF KANSAS LAWRENCE, KS$648,204ZRG1
2019Optimizing the immune response by targeting the Sts enzymes1R01AI141592-01CARPINO, NICHOLAS AFRENCH, JARROD BSCAMPAVIA, LOUIS DANIELSTATE UNIVERSITY NEW YORK STONY BROOK, NY$630,428ZRG1
2019Novel Screening Platform for Discovery of DUB Targeting Probes1R01CA233800-01A1BUHRLAGE, SARA JMARTO, JARROD A.DANA-FARBER CANCER INST, MA$629,796ZRG1
2019High Throughput Screening for Non-antibiotic inhibitors of Clostridium difficile Pathophysiology1R01AI144459-01HURDLE, JULIAN GTEXAS A&M UNIVERSITY HEALTH SCIENCE CTR, TX$577,822ZRG1
2019HTS for TGF-beta receptor assembly inhibitors with anti-tumor and anti-fibrosis activities1R01CA233622-01A1HINCK, ANDREW PJOHNSTON, PAUL A.UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$572,036ZRG1
2019Large-scale screen with a novel assay against RNA editing to identify anti-trypanosomal agents1R01AI143593-01SALAVATI, REZA SALAVATIMCGILL UNIVERSITY, QC$556,320ZRG1
2019Development of small molecule cGAS inhibitors for repression of dsDNA-triggered interferon expression1R01AI141507-01A1TUSCHL, THOMASROCKEFELLER UNIVERSITY, NY$538,003ZRG1
2019Assay development and screening for inhibitors targeting Shiga toxin 21R01AI141635-01A1LI, XIAO-PINGRUTGERS, THE STATE UNIV OF N.J., NJ$526,594ZRG1
2019Discovery of Hsp100-selective inhibitors for targeting multiple microbial pathogens1R01AI141586-01A1ROY, ANURADHASCHOENEN, FRANKZOLKIEWSKI, MICHALKANSAS STATE UNIVERSITY, KS$514,035ZRG1
2019Discovery of Gram-negative permeable chemical probes for tRNA methylation1R01AI139202-01A1HOU, YA-MINGTHOMAS JEFFERSON UNIVERSITY, PA$495,998ZRG1
2019Small molecules to block measles spreading in the central nervous system1R56AI146980-01POROTTO, MATTEOCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$492,576ZRG1
2019High Throughput Screening of Inhibitors Targeting the Enterovirus A71 and D68 2A Proteases1R01AI147325-01WANG, JUNUNIVERSITY OF ARIZONA, AZ$481,106ZRG1
2019Cell-based high-throughput chemical genetic screening for GSDMD inhibitors1R01AI141386-01LUO, HONGBO RBOSTON CHILDREN'S HOSPITAL, MA$442,500ZRG1
2019Identification of human cytomegalovirus life cycle stage-specific therapeutics1R01AI139258-01A1TORTORELLA, DOMENICOICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$413,552ZRG1
2019qHTS of Patient Derived HCC Models to Identify Novel Probes/Therapeutic Agents1R01CA229836-01A1JOHNSTON, PAUL A.UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$400,283ZRG1
2019Discovery and validation of broadly effective LpxH inhibitors as novel therapeutics against multi-drug resistant Gram-negative pathogens1R01AI139216-01A1ZHOU, PEIDUKE UNIVERSITY, NC$387,505ZRG1
2019Target-specific antimalarial compound identification using phenotypic assays1R01AI141543-01A1NILES, JACQUIN CMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$377,417ZRG1
2018Discovery of small molecules inhibiting Toll-like receptor-mediated inflammation1R01AI139014-01HAECKER, HANSST. JUDE CHILDREN'S RESEARCH HOSPITAL, TN$812,562ZRG1
2018Discovery and validation of pan-influenza antivirals1R56AI139015-01CHANDA, SUMIT KSHAW, MEGAN LOUISEICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$749,135ZRG1
2018Parallel Multimodal High-throughput screening to identify activators of the orexin receptors1R01MH117499-01KAMENECKA, THEODORE MKENNY, PAUL J.SCAMPAVIA, LOUIS DANIELSCRIPPS FLORIDA, FL$598,887ZRG1
2018Identification of Chemical Probes for the Orphan Nuclear Receptor NR2F61R01CA225890-01A1SCAMPAVIA, LOUIS DANIELSOLT, LAURA ASCRIPPS FLORIDA, FL$577,866ZRG1
2018A HTS Approach to Discover Guanine Nucleotide-Competitive Inhibitors of Oncogenic KRAS1R01CA223495-01A1ROSSMAN, KENTUNIV OF NORTH CAROLINA CHAPEL HILL, NC$454,077ZRG1
2018Development of small molecules to target KDM4B1R01CA229739-01CHEN, TAOSHENGDAVIDOFF, ANDREW MWHITE, STEPHEN WYANG, JUNST. JUDE CHILDREN'S RESEARCH HOSPITAL, TN$410,606ZRG1
2018Development of neutral ceramidase inhibitor tool compounds1R01CA221948-01A1HALEY, JOHN DOUGLASSCAMPAVIA, LOUIS DANIELSTATE UNIVERSITY NEW YORK STONY BROOK, NY$409,190ZRG1
2018Discovery and validation of broadly effective LpxH inhibitors as novel therapeutics against multi-drug resistant Gram-negative pathogens1R56AI139216-01ZHOU, PEIDUKE UNIVERSITY, NC$393,419ZRG1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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