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NIH funding notice PAR-18-596

Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional)

Closed on April 17, 2018.

Posted
January 29, 2018
Close date
April 17, 2018
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

53 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $58,653,642 in first-year total cost, median $692,345.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 BDCN-N (50)]10
  2. Special Emphasis Panel[ZRG1 BDCN-W (50)]6
  3. Special Emphasis Panel[ZRG1 MDCN-T (53)]5
  4. Special Emphasis Panel[ZRG1 HDM-Y (50)]4
  5. Special Emphasis Panel[ZRG1 MDCN-P (52)]4

Most frequent institutions

  1. MASSACHUSETTS GENERAL HOSPITAL3
  2. UNIVERSITY OF CALIFORNIA, SAN FRANCISCO3
  3. BOSTON UNIVERSITY MEDICAL CAMPUS2
  4. COLUMBIA UNIVERSITY HEALTH SCIENCES2
  5. GEORGIA STATE UNIVERSITY2
Competing awards under PAR-18-596 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2018Glycoproteomics and the Glycosylation Code of the Brain in Asymptomatic and Symptomatic Alzheimer’s Disease1RF1AG062181-01CUMMINGS, RICHARD DSEYFRIED, NICHOLAS THOMASBETH ISRAEL DEACONESS MEDICAL CENTER, MA$4,145,414ZRG1
2018Targeting a lipid-mediated pro-longevity pathway as Alzheimer's therapy1RF1AG062257-01WANG, JINZHENG, HUIBAYLOR COLLEGE OF MEDICINE, TX$3,942,988ZRG1
2018Dissection of endosomal trafficking mechanisms in Alzheimer's Disease1RF1AG062377-01TSAI, LI-HUEIMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$3,613,268ZRG1
2018Optogenetic dissection of cellular and circuit mechanisms of network dysfunction and amyloid deposition in mouse models of Alzheimer's disease in vivo1RF1AG062234-01PALOP, JORGE JJ. DAVID GLADSTONE INSTITUTES, CA$3,540,000ZRG1
2018New mechanistic insights into how the gut metabolite urolithin A extends lifespan and prevents AD1RF1AG062280-01ANDERSEN, JULIE KAYBUCK INSTITUTE FOR RESEARCH ON AGING, CA$3,414,407ZRG1
2018Age-Associated Modulation of Gene Expression in the CNS1RF1AG062220-01URBANSKI, HENRYK FOREGON HEALTH & SCIENCE UNIVERSITY, OR$3,394,232ZRG1
2018SUGAR-seq: A New Technology for Single-Cell Glycan and Gene Expression Profiling in AD1RF1AG062324-01HSIEH-WILSON, LINDA CCALIFORNIA INSTITUTE OF TECHNOLOGY, CA$3,278,468ZRG1
2018Antibodies Against Conformationally Defined Amyloid Oligomers in Alzheimer’s Disease1RF1AG062296-01NOWICK, JAMES SUNIVERSITY OF CALIFORNIA-IRVINE, CA$3,018,693ZRG1
2018Role of O-GlcNAcylation in Regulating Neurodegeneration in Aging and Alzheimer’s Disease1RF1AG062357-01VILLEDA, SAUL AUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$2,011,875ZRG1
2018Elucidating the Molecular Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Disease1R01AG062335-01KELLIS, MANOLISTSAI, LI-HUEIMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$1,308,813ZRG1
2018PET Imaging of SV2A and Other Biomarkers in Alzheimer's Disease1R01AG062276-01VAN DYCK, CHRISTOPHER HYALE UNIVERSITY, CT$1,108,088ZRG1
2018Systems modeling of shared and distinct molecular mechanisms underlying comorbid Major Depressive Disorder and Alzheimer's disease1R01AG062355-01EHRLICH, MICHELLE ESALTON, STEPHEN RZHANG, BINICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$867,487ZRG1
2018The Contribution of Age-Related Tauopathies to Alzheimer's Disease1R01AG062348-01CRARY, JOHN FONDADICKSON, DENNIS WILLIAMMCKEE, ANN C.BOSTON UNIVERSITY MEDICAL CAMPUS, MA$850,423ZRG1
2018Alzheimer's Disease and Related Dementia Care within the Medicare Program1R01AG062282-01HSU, JOHNMASSACHUSETTS GENERAL HOSPITAL, MA$849,724ZRG1
2018Optogenetic modulation and pathophysiological analysis of Alzheimer's disease.1R56AG062208-01NI, XINGJIEZHANG, CAN MARTINMASSACHUSETTS GENERAL HOSPITAL, MA$823,571ZRG1
2018Construct large-scale phenomes of disease and drugs and develop data-driven systems approaches to understand genetic links between Alzheimer's disease and Neuropsychiatric symptoms1R56AG062272-01XU, RONGCASE WESTERN RESERVE UNIVERSITY, OH$789,910ZRG1
2018Computational Prediction and Functional Validation of Novel Epigenetic Risk Loci in Alzheimer's Disease1R56AG062256-01JIN, PENGQIN, ZHAOHUIWINGO, THOMAS SPURGEONEMORY UNIVERSITY, GA$788,285ZRG1
2018Shared genetic, epigenetic, and transcriptomic profiles between AD and PTSD: molecular insights into the heterogeneity of neuropsychiatric symptoms in Alzheimers Disease1R56AG062302-01CHIBA-FALEK, ORNITLUO, SHENGLUTZ, MICHAEL WILLIAMWILLIAMSON, DOUGLAS EDUKE UNIVERSITY, NC$788,011ZRG1
2018Innovative Glycomic/Glycoproteomic Investigation on Alzheimer’s Disease1R56AG062258-01LI, LIANYIN, JUNGEORGIA STATE UNIVERSITY, GA$782,675ZRG1
2018Indigenous Cultural Understandings of Alzheimer's Disease and Related Dementias - Research and Engagement (I-CARE)1R56AG062307-01JACKLIN, KRISTENUNIVERSITY OF MINNESOTA, MN$782,089ZRG1
2018Defining the role of keratan sulfate recognition in Alzheimer's Disease progression1R56AG062342-01MOREMEN, KELLEY W.SCHNAAR, RONALD LWOODS, ROBERT JUNIVERSITY OF GEORGIA, GA$776,544ZRG1
2018Endosome Dysfunction in Alzheimer's Disease1R01AG062376-01NIXON, RALPH A.NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$775,998ZRG1
2018The Massachusetts and Yale ADRC Collaborative Proteomic Biofluid Biomarker Discovery Program1R01AG062306-01ARNOLD, STEVEN ECARLYLE, BECKY CATHERINENAIRN, ANGUS C.MASSACHUSETTS GENERAL HOSPITAL, MA$775,203ZRG1
2018Palliative care needs and outcomes for dementia patients1R01AG062239-01PERIYAKOIL, VYJEYANTHI SSTANFORD UNIVERSITY, CA$773,572ZRG1
2018SV2A PET imaging in Alzheimer's Disease1R01AG062285-01BENDLIN, BARBARA BRIGITTACHRISTIAN, BRADLEY TJOHNSON, STERLING CUNIVERSITY OF WISCONSIN-MADISON, WI$758,565ZRG1
2018Cellular senescence, inflammation and neurotransmission in Alzheimer's disease1R01AG061937-01HASCUP, ERIN RSOUTHERN ILLINOIS UNIVERSITY SCH OF MED, IL$708,790ZRG1
2018Molecular Mechanisms Underlying Behavioral and Psychological Symptoms in Alzheimers Disease1R01AG062249-01DONG, HONGXINWILSON, ROBERT SNORTHWESTERN UNIVERSITY AT CHICAGO, IL$692,345ZRG1
2018Meaningful Engagement and Quality of Life among Assisted Living Residents with Dementia1R01AG062310-01KEMP, CANDACE LYNNGEORGIA STATE UNIVERSITY, GA$683,835ZRG1
2018Role of Lipid-derived Oligomer Strains in AD Phenotypes1R56AG062292-01RANGACHARI, VIJAYUNIVERSITY OF SOUTHERN MISSISSIPPI, MS$671,162ZRG1
2018Systematic elucidation of endosomal trafficking as a therapeutic opportunity in AD using CRISPR-based functional genomics1R01AG062359-01KAMPMANN, MARTINUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$663,216ZRG1
2018Comprehensive Characterization of Glycosylation Alterations in Alzheimer’s Disease1R01AG062240-01JIN, LEE-WAYLEBRILLA, CARLITO BZIVKOVIC, ANGELA MUNIVERSITY OF CALIFORNIA AT DAVIS, CA$658,515ZRG1
2018Probing the role of SORL1 and endosomal network genetic variation on Alzheimer's disease phenotypes in human neurons.1R01AG062148-01YOUNG, JESSICA ELAINEUNIVERSITY OF WASHINGTON, WA$645,205ZRG1
2018Ensuring Access to Novel Alzheimer’s and Dementia Treatments: Evaluating Innovative Payment Approaches1R01AG062277-01GOLDMAN, DANA PLAKDAWALLA, DARIUS N.UNIVERSITY OF SOUTHERN CALIFORNIA, CA$626,769ZRG1
2018Access and use of long-term services and supports for older adults living alone with Alzheimer's disease and related dementias from four racial/ethnic groups1R56AG062165-01PORTACOLONE, ELENAUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$617,406ZRG1
2018Effect of Hospital and Community Care Coordination on Health Care Access, Quality and Equity among Individuals with Risk Factors or Diagnosis of ADRD1R56AG062315-01CHEN, JIEUNIV OF MARYLAND, COLLEGE PARK, MD$617,127ZRG1
2018Regulation of retromer proteins through an Alzheimer's disease-specific transcription factor complex1R56AG062354-01HENGST, ULRICHCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$602,418ZRG1
2018Geroscience approaches to mitigate tauopathy in aged mouse brain1R01AG062217-01GORDON, MARCIA NMICHIGAN STATE UNIVERSITY, MI$599,789ZRG1
2018LOAD risk genes in postsynaptic endosomal trafficking1R56AG063433-01PENZES, PETERNORTHWESTERN UNIVERSITY AT CHICAGO, IL$544,013ZRG1
2018Golgi-mediated Glycosylation Defects in Alzheimer’s Disease1R56AG062225-01WANG, YANZHUANGUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$526,630ZRG1
2018Cognitive heterogeneity in those with high Alzheimer's Disease Risk1R56AG062109-01AU, RHODABOSTON UNIVERSITY MEDICAL CAMPUS, MA$517,295ZRG1
2018Neuroanatomical associations with the factor structure underlying neuropsychiatric symptoms in Alzheimer's disease1R01AG062268-01HUEY, EDWARD DCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$496,686ZRG1
2018A quantitative framework for understanding endosomal trafficking networks in Alzheimer's disease1R01NS110395-01HARPER, JEFFREY WHARVARD MEDICAL SCHOOL, MA$482,307ZRG1
2018Glycosylation of the perineuronal net in Alzheimer's Disease1R56AG062232-01ESKO, JEFFREY DLEE, KUO-FENSALK INSTITUTE FOR BIOLOGICAL STUDIES, CA$459,954ZRG1
2018Delay of Alzheimer's phenotypes by interventions that increase lifespan1R01AG062303-01MOBBS, CHARLES VICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$423,750ZRG1
2018Axonal endo-lysosome transport mechanisms that regulate APP processing1R01AG062210-01FERGUSON, SHAWNYALE UNIVERSITY, CT$418,750ZRG1
2018Alleviating lysosomal lipid defects in ADRD by blocking cholesterol storage1R01AG063544-01CHANG, TA YUANDARTMOUTH COLLEGE, NH$410,000ZRG1
2018Sleep consolidation as a neuroprotective therapy for Alzheimers disease1R56AG062293-01NAIDOO, NIRMALA NIRINJINIUNIVERSITY OF PENNSYLVANIA, PA$402,500ZRG1
2018Acceleration of AD Phenotypes in Asymptomatic Mouse Models1R01AG062251-01LAZAROV, ORLYUNIVERSITY OF ILLINOIS AT CHICAGO, IL$399,750ZRG1
2018Cerebrovascular Endothelial Function in Aging and Alzheimer's Disease1R56AG062169-01BEHRINGER, ERIK J.LOMA LINDA UNIVERSITY, CA$391,230ZRG1
2018Apolipoprotein E glycosylation and its role in Alzheimer's disease pathogenesis1R56AG062305-01FLOWERS, SARAH ANNGEORGETOWN UNIVERSITY, DC$388,750ZRG1
2018Inference of Common Pathways Underlying Neurodegeneration & Other Age-Progressive Diseases1R01AG062254-01AYYADEVARA, SRINIVASSHMOOKLER REIS, ROBERT JOSEPHUNIV OF ARKANSAS FOR MED SCIS, AR$370,165ZRG1
2018Comparative analysis of geroprotective interventions in established and novel mouse models of Alzheimer's disease1R01AG062328-01LAMMING, DUDLEY WILLIAMMERRINS, MATTHEW J.UNIVERSITY OF WISCONSIN-MADISON, WI$364,982ZRG1
2018Network analysis for identifying disease mechanisms and therapeutic targets for dementia1R01AG062176-01POTASHKIN, JUDITH ANNROSALIND FRANKLIN UNIV OF MEDICINE & SCI, IL$312,000ZRG1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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PAR-18-596: Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional) | ScienceDex | ConductScience