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NIH funding notice PAR-18-877

Early Stage Clinical Trials for the Spectrum of Alzheimers Disease and Age-related Cognitive Decline (R01 Clinical Trial Optional)

Closed on January 7, 2022.

Posted
July 26, 2018
Close date
January 7, 2022
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

68 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $107,253,601 in first-year total cost, median $823,295.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 BBBP-B (55)]25
  2. Special Emphasis Panel[ZRG1 BBBP-H (55)]22
  3. Special Emphasis Panel[ZRG1 BBBP-Z (55)]7
  4. Special Emphasis Panel[ZRG1 BBBP-B (52)]6
  5. Special Emphasis Panel[ZRG1 BBBP-J (90)]4

Most frequent institutions

  1. JOHNS HOPKINS UNIVERSITY6
  2. UNIVERSITY OF CALIFORNIA, SAN DIEGO6
  3. UNIVERSITY OF ARIZONA3
  4. WAKE FOREST UNIVERSITY HEALTH SCIENCES3
  5. UNIVERSITY OF CALIFORNIA, SAN FRANCISCO2
Competing awards under PAR-18-877 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2022ACTIVE MIND: An adaptive clinical trial of cognitive training to improve function and delay dementia1R01AG075014-01A1EDWARDS, JERRIUNIVERSITY OF SOUTH FLORIDA, FL$5,508,175ZRG1
2022Safety/Tolerability/Immunogenicity of first-in-human Aβ DNA vaccine, AV-1959D Phase 1 trials in early-stage AD subjects: based on IND18953 cleared by FDA.1R01AG074983-01AGADJANYAN, MICHAEL GSCHNEIDER, LON SSULTZER, DAVIDINSTITUTE FOR MOLECULAR MEDICINE, CA$2,680,709ZRG1
2022Impact of Intensive Treatment of Systolic Blood Pressure on Brain Perfusion, Amyloid and Tau in Older Adults (IPAT-study)1R01AG076660-01VONGPATANASIN, WANPENZHANG, RONGZHU, DAVID CUT SOUTHWESTERN MEDICAL CENTER, TX$2,369,453ZRG1
2022Arterial Stiffness, Cognition, and Equol (ACE)1R01AG074971-01SEKIKAWA, AKIRAUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$2,257,337ZRG1
2022Communication Bridge: A person-centered Internet-based intervention for individuals with primary progressive aphasia2R56AG055425-06ROBERTS, ANGELA CHRISTINEROGALSKI, EMILY JNORTHWESTERN UNIVERSITY AT CHICAGO, IL$2,184,811LCOM
2022PhytoSERM Efficacy to Prevent Menopause Associated Decline in Brain Metabolism and Cognition: A Double-Blind, Randomized, Placebo-Controlled Phase 2 Clinical Trial1R01AG075122-01BRINTON, ROBERTA EILEENHERNANDEZ, GERSON DAVIDMOSCONI, LISAUNIVERSITY OF ARIZONA, AZ$2,121,223ZRG1
2022First in Human Study of a Tau Self-Association Small Molecule Inhibitor in Healthy Volunteers1R01AG076565-01ERHARDT, WILLIAM A.OLIGOMERIX, INC, NY$1,917,889ZRG1
2022Phase II clinical trial of transcranial direct current stimulation in the treatment of primary progressive aphasia1R01AG075111-01A1HAMILTON, ROY HTSAPKINI, KYRANAUNIVERSITY OF PENNSYLVANIA, PA$1,500,901LCOM
2022Optimizing a closed-loop digital meditation intervention for remediating cognitive decline and reducing stress in older adults1R01AG076668-01GAZZALEY, ADAM HZIEGLER, DAVID AUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$1,362,781ZRG1
2022Early Age-Related Hearing Loss Investigation (EARHLI): A Randomized Controlled Trial to Assess Mechanisms Linking Early Age-Related Hearing Loss and Alzheimer's Disease and Related Dementias1R01AG075083-01A1GOLUB, JUSTIN SCOTTCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$1,076,743ZRG1
2022Determinants of Individual Differences in the Efficacy of Aerobic Exercise to Improve Brain Health and Reduce Alzheimer Disease Risk in Older African Americans1R01AG078211-01GLUCK, MARK ARUTGERS THE STATE UNIV OF NJ NEWARK, NJ$953,835ZRG1
2022Targeting language-specific and executive-control networks with transcranial direct current stimulation in aphasic AD1R01AG075404-01A1TSAPKINI, KYRANAJOHNS HOPKINS UNIVERSITY, MD$828,275CNN
2022Addressing Hearing Loss as a Common Unmet Contributor to Neuropsychiatric Symptoms1R01AG076525-01NIEMAN, CARRIE LOH, ESTHER SEUNGHEEJOHNS HOPKINS UNIVERSITY, MD$818,314ZRG1
2022Establishing the optimal frequency of dance movement for neurocognitive and physical outcomes in people at risk of Alzheimer's disease1R01AG076669-01HUGENSCHMIDT, CHRISTINA ESORIANO, CHRISTINA TWAKE FOREST UNIVERSITY HEALTH SCIENCES, NC$782,691ZRG1
2022Intermittent Hypoxia Training: A Novel Therapy for Mild Cognitive Impairment1R01AG076675-01SHI, XIANGRONGUNIVERSITY OF NORTH TEXAS HLTH SCI CTR, TX$733,970ZRG1
2022Adaptive Neuromodulation of Working Memory Networks in Aging and Dementia1R01AG075417-01A1DAVIS, SIMON WDUKE UNIVERSITY, NC$733,471ZRG1
2022Assessment of Language and Cognition in Older Deaf Signers1R01AG074928-01GOLLAN, TAMARUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$657,027ZRG1
2022Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease1R01AG065171-01A1MUNRO, CYNTHIA ANNJOHNS HOPKINS UNIVERSITY, MD$656,300ZRG1
2022Language Switching with Alzheimer's Disease1R01AG076415-01GOLLAN, TAMARUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$631,730ZRG1
2022Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity (EXEC-study)1R01AG076456-01BRONAS, ULF GUNIVERSITY OF ILLINOIS AT CHICAGO, IL$508,214ZRG1
2021A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 2 Study to Evaluate the Safety and Efficacy of CT1812 in Subjects with Dementia with Lewy Bodies1R01AG071643-01CAGGIANO, ANTHONY OGALVIN, JAMES EHAMBY, MARY ECOGNITION THERAPEUTICS, INC., PA$10,764,669ZRG1
2021A Single Ascending Dose / Multiple Ascending Dose Phase I study of the GSM 776890 in healthy normal subjects1R01AG070353-01GALASKO, DOUGLAS RWAGNER, STEVEN LEEUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$3,156,733ZRG1
2021Food Effect study and drug supply scale-up for PTI-1251R01AG067972-01A1BURNS, LINDSAY HCASSAVA SCIENCES, INC, TX$2,710,220ZRG1
2021Phase 1 Clinical Trial of CMS121, a Novel Therapeutic Candidate for Alzheimer's Disease1R01AG074447-01MAHER, PAMELA ANNERASCHKE, WILLIAM CVIROGENICS, INC., CA$2,503,169ZRG1
2021Mechanisms, response heterogeneity and dosing from MRI-derived electric field models in tDCS augmented cognitive training: a secondary data analysis of the ACT study1RF1AG071469-01FANG, RUOGUWOODS, ADAM J.UNIVERSITY OF FLORIDA, FL$2,180,958ZRG1
2021BEACH: Biomarker and Edema Attenuation in IntraCerebral Hemorrhage Phase 2a Trial1R01AG069930-01HANLEY, DANIEL FVAN ELDIK, LINDA JJOHNS HOPKINS UNIVERSITY, MD$2,078,174ZRG1
2021First-in-Human (Phase 1) Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of IBC-Ab002 in Persons with Early Alzheimer's Disease (AD)1R01AG071810-01YOLES, ETIIMMUNOBRAIN CHECKPOINT INC., NY$1,984,624ZRG1
2021A Phase 1b Multiple Ascending Dose Study of the Safety and Tolerability of BMS-984923 in Alzheimer's Disease1R01AG073177-01MECCA, ADAM PETERYALE UNIVERSITY, CT$1,967,865ZRG1
2021Differential Effects of Exercise Modality on Cognition and Brain in Older Adults1R01AG070036-01SZABO-REED, AMANDA N.VIDONI, ERIC DENNISUNIVERSITY OF KANSAS MEDICAL CENTER, KS$1,375,262ZRG1
2021Phase II trial of GM-CSF/sargramostim in Alzheimer's Disease1R01AG071151-01POTTER, HUNTINGTONPRESSMAN, PETER SCOTTUNIVERSITY OF COLORADO DENVER, CO$1,340,244ZRG1
2021A Clinical Trial of AAV2-BDNF Gene Therapy in Alzheimer's Disease1R01AG071656-01TUSZYNSKI, MARK H.UNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$1,201,473ZRG1
2021Novel food-based approach for prevention of age-associated cognitive decline inolder adults with obesity1R56AG065236-01A1COHEN, RONALD ADAS, SAI KRUPAFRANCESCHINI, MARIA ANGELAROBERTS, SUSAN BTUFTS UNIVERSITY BOSTON, MA$1,189,438ZRG1
2021RCT Targeting Cognition in Early Alzheimer's Disease by Improving Sleep with Trazodone (Rest)1R01AG071522-01GREENBERG, BARRY DAVIDROSENBERG, PAUL BJOHNS HOPKINS UNIVERSITY, MD$785,568ZRG1
2021A Proof of Concept Trial of a Sirtuin-NAD+ Activator in Alzheimer's Disease1R01AG071074-01A1BHASIN, SHALENDERMARSHALL, GAD ASHERBRIGHAM AND WOMEN'S HOSPITAL, MA$752,126ZRG1
2021Objectively Measured Sedentary Behavior and Physical Activity in PREVENTABLE Study1R01AG074592-01BEDDHU, SRINIVASANUNIVERSITY OF UTAH, UT$740,106ZRG1
2021Repurposing Siponimod for Alzheimer's Disease1R01AG073212-01DECOURT, BORISSABBAGH, MARWAN NOELWILSON, JEFFREY RCLEVELAND CLINIC LERNER COM-CWRU, OH$731,856ZRG1
2021Slow-wave sleep enhancement in those at risk for Alzheimer's disease: Links with memory, excitotoxicity, and plasma A-beta1R01AG068001-01A1WILCKENS, KRISTINE ANNUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$720,431ZRG1
2021PATH-Pain: A Primary Care-Based Psychosocial Intervention To Improve Cognitive and Depression Outcomes in Older Adults with MCI and Early Stage AD1R01AG070055-01A1KIOSSES, DIMITRIS NRAVDIN, LISA DREID, MANNEY CARRINGTONWEILL MEDICAL COLL OF CORNELL UNIV, NY$718,167ZRG1
2021Compensation Training and Lifestyle Modifications to promote healthy aging in persons at risk for Alzheimer's disease: a digital application supported intervention1R01AG066748-01A1SCHMITTER-EDGECOMBE, MAUREENTOMASZEWSKI-FARIAS, SARAH EUNIVERSITY OF CALIFORNIA AT DAVIS, CA$692,048ZRG1
2021Veri-T: A phase 1 Placebo-Controlled Trial of Verdiperstat in Semantic Variant Primary Progressive Aphasia Due to Underlying FTLD-TDP1R01AG073482-01BOXER, ADAM L.LJUBENKOV, PETER ALEXANDERUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$677,137ZRG1
2021Modulation of Hippocampal Circuitry and Memory Function with Focused Ultrasound in Amnestic MCI1R01AG073480-01BOOKHEIMER, SUSAN YUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$621,961ZRG1
2021Clinical trial of vestibular therapy to reduce falls in patients with Alzheimer's disease1R01AG065259-01A1AGRAWAL, YURIJOHNS HOPKINS UNIVERSITY, MD$523,611ZRG1
2021Practice effects of daily functioning across the Alzheimer’s disease spectrum1R01AG073261-01DUFF, KEVIN MUNIVERSITY OF UTAH, UT$478,400ZRG1
2020A randomized, placebo-controlled, double-blind study to evaluate safety and efficacy of NDX-1017 treatment in Alzheimer's dementia patients1R01AG068268-01BERNICK, CHARLESHUA, XUEMOEBIUS, HANS JOERGATHIRA PHARMA, INC., WA$7,811,344ZRG1
2020The POINTER Neurovascular Ancillary Study1R01AG066910-01BRINKLEY, TINA ESHALTOUT, HOSSAMWAKE FOREST UNIVERSITY HEALTH SCIENCES, NC$2,474,352ZRG1
2020Targeted physical and cognitive activity in a VR environment in older adults at risk for Alzheimer's disease1R01AG065356-01PA, JUDYUNIVERSITY OF SOUTHERN CALIFORNIA, CA$1,406,971ZRG1
2020Reducing African Americans' Alzheimer's Disease Risk Through Exercise-MCI Cohort (RAATE-MCI)1R01AG067765-01CARMICHAEL, OWEN T.NEWTON, ROBERT LEELSU PENNINGTON BIOMEDICAL RESEARCH CTR, LA$968,867ZRG1
2020Neurocognitive Impairment Assessment in Symptomatic Carotid  Occlusion Recanalized Endovascularly: NIA SCORE1R01AG065238-01HASAN, DAVID M.UNIVERSITY OF IOWA, IA$886,752ZRG1
2020Transcranial Photobiomodulation for Alzheimer's Disease (TRAP-AD)1R01AG068248-01CASSANO, PAOLOIOSIFESCU, DAN VLADOSORIO, RICARDO SNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$873,715ZRG1
2020Cognitive and Physical Exercise to Improve Outcomes after Surgery in the Elderly1R01AG061161-01A1HUGHES, CHRISTOPHERVANDERBILT UNIVERSITY MEDICAL CENTER, TN$841,781ZRG1
2020Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease1R01AG068260-01MASDEU, JOSEPH CSEKHAR, RAJAGOPAL VISWANATHBAYLOR COLLEGE OF MEDICINE, TX$808,231ZRG1
2020Health Beliefs, Glycemic Control, and Preventing Cognitive Decline in African Americans with Diabetes and Mild Cognitive Impairment: A Randomized Clinical Trial1R01AG065467-01ROVNER, BARRY W.THOMAS JEFFERSON UNIVERSITY, PA$779,451ZRG1
2020Enhancement of Hippocampal Plasticity Using Repetitive Transcranial Magnetic Stimulation1R01AG062543-01A1CHOU, YING-HUIUNIVERSITY OF ARIZONA, AZ$735,123ZRG1
2020The Use of Deferiprone to Improve Subarachnoid Hemorrhage Cognitive Outcome: U-DISCO1R01AG068848-01A1HASAN, DAVID M.TORNER, JAMES CTRANEL, DANIEL T.ZANATY, MARIOUNIVERSITY OF IOWA, IA$727,973ZRG1
2020Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease1R01AG063925-01A1MALHOTRA, ATULUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$726,355ZRG1
2020Enhancing gamma band response to improve working memory in individuals with mild cognitive impairment1R01AG065252-01SINGH, FIZAUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$721,636ZRG1
2020Citalopram as a posterior cortical protective therapy in Parkinson disease1R01AG065246-01A1KOTAGAL, VIKASUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$709,919ZRG1
2020Yoga, Aerobic and Stretching Exercise Effects on Neurocognitive Performance: A Randomized Controlled Trial1R01AG066630-01GOTHE, NEHA PRAVINUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$697,729ZRG1
2020Effects of Orally Administered Nicotinamide Riboside on Bioenergetic Metabolism, Oxidative Stress and Cognition in Mild Cognitive Impairment and Mild Alzheimer's Dementia1R01AG066670-01DU, FEIFORESTER, BRENT PETERMCLEAN HOSPITAL, MA$561,552ZRG1
2020Promoting Reengagement in Daily Meaningful Activity Intervention for Adults with Mild Cognitive Impairment and Their Caregivers1R01NR018162-01A1LU, YUEH-FENG YVONNEINDIANA UNIVERSITY INDIANAPOLIS, IN$554,750ZRG1
2020Testing the Efficacy of FFC-AC-EIT in Patients with Alzheimers Disease and Related Dementias1R01AG065338-01BOLTZ, MARIERESNICK, BARBARAUNIVERSITY OF MARYLAND BALTIMORE, MD$505,805ZRG1
2019Allopregnanolone as Regenerative Therapeutic for Alzheimer's: Phase 2 Clinical Trial1R01AG063826-01BRINTON, ROBERTA EILEENRODGERS, KATHLEEN E.SCHNEIDER, LON SUNIVERSITY OF ARIZONA, AZ$8,410,912ZRG1
2019Establishing the science behind Alzheimer's recruitment registries: opportunities for increasing diversity and accelerating enrollment into trials1R01AG063954-01BLEAKLEY, AMYLANGBAUM, JESSICA BROOKEBANNER HEALTH, AZ$1,458,714ZRG1
2019POINTER-zzz: Sleep Ancillary to U.S. Study to Protect Brain Health through Lifestyle Intervention to Reduce Risk of Alzheimer's Disease1R01AG064440-01BAKER, LAURA D.HAYDEN, KATHLEEN MWAKE FOREST UNIVERSITY HEALTH SCIENCES, NC$1,370,747ZRG1
2019Modulation effects of Baduanjin mind-body exercise on subjective cognitive decline1R01AG063975-01KONG, JIANMASSACHUSETTS GENERAL HOSPITAL, MA$813,924ZRG1
2019The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults with Down Syndrome1R01AG063909-01DONNELLY, JOSEPH E.PTOMEY, LAUREN TAYLORUNIVERSITY OF KANSAS MEDICAL CENTER, KS$762,834ZRG1
2019Revitalizing Cognition in Older Adults at Risk for Alzheimer's Disease with Near-Infrared Photobiomodulation1R01AG064587-01ALEXANDER, GENE EBOWERS, DAWNWOODS, ADAM J.UNIVERSITY OF FLORIDA, FL$738,176ZRG1
2019Treating primary progressive aphasia and elucidating neurodegeneration in the language network using transcranial direct current stimulation1R01AG059763-01A1HAMILTON, ROY HUNIVERSITY OF PENNSYLVANIA, PA$727,899ZRG1

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