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NIH funding notice PAR-18-953

Clinical Trial Readiness for Rare Diseases, Disorders, and Syndromes (R21 Clinical Trial Not Allowed)

Closed on October 25, 2021.

Posted
October 4, 2018
Close date
October 25, 2021
Activity codes
R21
Institutes taking part
NCATS, NICHD

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page names no earlier notice: it is new, or it does not say.

Replaced by PAR-22-101.

Who won it before

33 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $7,842,522 in first-year total cost, median $241,500.

Most frequent study sections

  1. Special Emphasis Panel[ZTR1 RD-3 (01)]16
  2. Special Emphasis Panel[ZTR1 RD-7 (01)]9
  3. Special Emphasis Panel[ZTR1 RD-5 (01)]4
  4. Special Emphasis Panel[ZTR1 RD-2 (01)]3
  5. Special Emphasis Panel[ZTR1 RD-7 (02)]1

Most frequent institutions

  1. CHILDREN'S HOSP OF PHILADELPHIA4
  2. DUKE UNIVERSITY2
  3. JOHNS HOPKINS UNIVERSITY2
  4. UNIVERSITY OF FLORIDA2
  5. UNIVERSITY OF MINNESOTA2
Competing awards under PAR-18-953 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2022Brain MRI to pre-symptomatically predict seizure onset for Sturge-Weber Syndrome1R21TR004265-01COMI, ANNE MOU, YANGMINGPINTO, ANNA LECTICIABOSTON CHILDREN'S HOSPITAL, MA$271,133ZTR1
2022Functional Biomarkers for ALS1R21TR003589-01A1WILKINS, HEATHER M.UNIVERSITY OF KANSAS MEDICAL CENTER, KS$253,794ZTR1
2022Menstrual Cycle-Related Symptom Variability as a Prognostic Indicator in Lymphangioleiomyomatosis1R21TR003858-01A1GUPTA, NISHANTUNIVERSITY OF CINCINNATI, OH$243,000ZTR1
2022Validating absolute lymphocyte count and plasma sphingosine-1-phosphate as disease biomarkers of sphingosine phosphate lyase insufficiency syndrome in anticipation of a pyridoxine clinical trial1R21TR004262-01SABA, JULIE DUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$242,250ZTR1
2022A Novel Therapeutic Approach to Treat Focal Segmental Glomerulosclerosis (FSGS)1R21TR004257-01SPURNEY, ROBERTDUKE UNIVERSITY, NC$241,500ZTR1
2022Disease Severity Stratification in Multiple Sulfatase Deficiency1R21HD106348-01A1AHRENS-NICKLAS, REBECCA CLARECHILDREN'S HOSP OF PHILADELPHIA, PA$232,535ZTR1
2022REFINING METRICS OF FOOD BEHAVIOR IN SMITH-MAGENIS SYNDROME1R21HD106345-01A1ELSEA, SARAH H.SISLEY, STEPHANIE RENEEBAYLOR COLLEGE OF MEDICINE, TX$225,420ZTR1
2022Clinical Trial Readiness - Primary Ciliary Dyskinesia (CTR-PCD)1R21TR004057-01ROSENFELD, MARGARETSEATTLE CHILDREN'S HOSPITAL, WA$212,161ZTR1
2022Cell-free DNA-Based Analysis for Diagnosis, Monitoring and Optimization of Therapy for Patients with Primary Central Nervous System Lymphomas1R21TR004059-01BETTEGOWDA, CHETANHOLDHOFF, MATTHIASJOHNS HOPKINS UNIVERSITY, MD$204,687ZTR1
2021Targeting FOXM1 in chemo-resistant monocytic AML1R21TR003587-01GARTEL, ANDREI LUNIVERSITY OF ILLINOIS AT CHICAGO, IL$263,793ZTR1
2021PAR-18-953 (ASCOT-DMD)1R21TR004007-01A1THANGARAJH, MATHULAVIRGINIA COMMONWEALTH UNIVERSITY, VA$256,214ZTR1
2021MRI Biomarkers of Disease Progression in Inherited Neuropathies1R21TR003312-01A1DORTCH, RICHARDLI, JUNWAYNE STATE UNIVERSITY, MI$246,172ZTR1
2021Dose Optimization of Nervonic Acid - a Potential Therapy to Alleviate Disease Progression in Adrenoleukodystrophy1R21TR003941-01KARTHA, REENA VUNIVERSITY OF MINNESOTA, MN$232,500ZTR1
2021Defining ichthyosis in Sjogren-Larsson syndrome for clinical trial preparedness1R21HD106350-01RIZZO, WILLIAM B.UNIVERSITY OF NEBRASKA MEDICAL CENTER, NE$223,198ZTR1
2021Clinical validation of at-home methods of sleep assessment in Rett Syndrome1R21TR003942-01PETERS, SARIKA UVANDERBILT UNIVERSITY MEDICAL CENTER, TN$214,422ZTR1
2021Biomarkers for 12-lipoxygenase inhibition as a therapeutic intervention for heparin-induced thrombocytopenia and thrombosis (HIT/T)1R21TR003185-01A1HOLINSTAT, MICHAEL ALLANUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$208,600ZTR1
2021Optimizing Muscular Dystrophy Clinical Trial Designs using Modeling and Simulation1R21TR004006-01KIM, SARAHUNIVERSITY OF FLORIDA, FL$190,625ZTR1
2020Development of a reliable, valid, and sensitive outcome measure in Rett syndrome1R21HD103348-01NEUL, JEFFREY LVANDERBILT UNIVERSITY MEDICAL CENTER, TN$275,091ZTR1
2020Characterization of RASopathy Mutations Underlying Lymphatic Anomalies and Preparation for Clinical Development1R21TR003331-01LI, DONGCHILDREN'S HOSP OF PHILADELPHIA, PA$264,000ZTR1
2020Development and validation of clinical outcome assessments in LGMD2A1R21TR003184-01JOHNSON, NICHOLAS ELWOODSTATLAND, JEFFREYVIRGINIA COMMONWEALTH UNIVERSITY, VA$254,174ZTR1
2020Magnetic resonance and ultrasound imaging as biomarkers for detection and monitoring of Parsonage-Turner Syndrome (PTS)1R21TR003033-01A1SNEAG, DARRYLHOSPITAL FOR SPECIAL SURGERY, NY$251,421ZTR1
2020Methods to Improve Clinical Trials for A-T1R21TR003534-01LEDERMAN, HOWARD M.LEFTON-GREIF, MAUREEN ANATALE, VALERIEJOHNS HOPKINS UNIVERSITY, MD$244,900ZTR1
2020Proof of concept treatment interventions in a rodent model of the rare disease bronchiolitis obliterans1R21TR003037-01A1PALMER, SCOTT MDUKE UNIVERSITY, NC$241,500ZTR1
2020Facilitating personalized medicine of monogenic stone patients by genetic characterization1R21TR003174-01HARRIS, PETER C.LIESKE, JOHN CMAYO CLINIC ROCHESTER, MN$238,500ZTR1
2020Preclinical evaluation of the efficacy and mechanism of action for an alkylated polyamine analogue diethylnorspermine in treating pheochromocytoma/paraganglioma1R21TR003044-01A1GHAYEE, HANS K.UNIVERSITY OF FLORIDA, FL$228,750ZTR1
2020Tumor Immune Profiling to Optimize Clinical Trial Readiness in Basal Cell Nevus Syndrome1R21TR003341-01BICKERS, DAVID RINSEYCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$202,500ZTR1
2020Clinical Trial Readiness for K channel inhibitors in Cantu Syndrome1R21HD103347-01GRANGE, DOROTHY KATHERINENICHOLS, COLIN GWASHINGTON UNIVERSITY, MO$196,875ZTR1
2019Biomarkers to enable ASO prevention trials in genetic prion disease carriers1R21TR003040-01ARNOLD, STEVEN EMASSACHUSETTS GENERAL HOSPITAL, MA$271,761ZTR1
2019Frataxin measurement for clinical trial readiness in Friedreich ataxia1R21TR003035-01LYNCH, DAVID ROBINSONCHILDREN'S HOSP OF PHILADELPHIA, PA$267,601ZTR1
2019Systemic biomarkers of brain injury from hyperammonemia1R21TR003166-01AH MEW, NICHOLASCALDOVIC, LJUBICA MORIZONOCHILDREN'S RESEARCH INSTITUTE, DC$260,407ZTR1
2019Distensibility and Remodeling as markers of Therapeutic Response in Eosinophilic Esophagitis1R21TR003039-01MENARD-KATCHER, CALIES DMUIR, AMANDA BROOKECHILDREN'S HOSP OF PHILADELPHIA, PA$242,750ZTR1
2019Evaluating the psychometric properties of three clinical trial outcome measures for Rett syndrome1R21HD101075-01BYIERS, BREANNE JUNIVERSITY OF MINNESOTA, MN$231,288ZTR1
2019Clinical Trial Readiness for Rare Diseases, Disorders and Syndromes1R21TR003034-01SHY, MICHAEL E.UNIVERSITY OF IOWA, IA$209,000ZTR1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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