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NIH funding notice PAR-19-158

Bioengineering Research Grants (BRG) (R01 Clinical Trial Not Allowed)

Closed on May 7, 2022.

Posted
January 8, 2019
Close date
May 7, 2022
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov ยท NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

194 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $105,187,658 in first-year total cost, median $534,265.

Most frequent study sections

  1. Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]18
  2. Imaging Technology Development Study Section[ITD]18
  3. Emerging Imaging Technologies and Applications Study Section[EITA]12
  4. Imaging Guided Interventions and Surgery Study Section[IGIS]12
  5. Bioengineering, Technology and Surgical Sciences Study Section[BTSS]9

Most frequent institutions

  1. UNIVERSITY OF PENNSYLVANIA11
  2. STANFORD UNIVERSITY8
  3. UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN8
  4. JOHNS HOPKINS UNIVERSITY7
  5. CASE WESTERN RESERVE UNIVERSITY5
Competing awards under PAR-19-158 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2023Image-based cerebrovascular network snythesis(iCNS) to model Alzheimer's Disease1R01AG079894-01LINNINGER, ANDREAS AUNIVERSITY OF ILLINOIS AT CHICAGO, IL$751,339MABS
2023Molecular Tool Development to Identify, Isolate, and Interrogate the Rod Microglia Phenotype in Neurological Disease and Injury1R01AG077768-01A1LIFSHITZ, JONATHANSTABENFELDT, SARAH EARIZONA VETERANS RESEARCH AND EDUCATION FOUNDATION, AZ$746,161CNNT
2023High Performance, Quantitative Breast PET Scanner Integrated With Tomosynthesis2R01CA196528-06A1MAIDMENT, ANDREW DOUGLAS ARNOLDSURTI, SULEMANUNIVERSITY OF PENNSYLVANIA, PA$691,319ITD
2023Engineered probiotic for the treatment of autoimmune diseases1R01AI173318-01BEETON, CHRISTINEBRITTON, ROBERT AHYSER, JOSEPH M.BAYLOR COLLEGE OF MEDICINE, TX$682,280ZRG1
2023Magnetic Resonance Fingerprinting of Tumor Vascular Perfusion and Acidosis1R01CA269354-01A1FLASK, CHRISTOPHER APAGEL, MARK DAVIDCASE WESTERN RESERVE UNIVERSITY, OH$673,812EITA
2023Engineering 3D Osteosarcoma Models to Elucidate Biology and Inform Drug Discovery1R01CA276872-01SWEET-CORDERO, ERIC ALEJANDROYANG, FANSTANFORD UNIVERSITY, CA$666,209ZRG1
2023AI enhanced lifetime-based mesoscopic in vivo imaging of tissue molecular heterogeneity1R01CA271371-01A1BARROSO, MARGARIDAINTES, XAVIERRENSSELAER POLYTECHNIC INSTITUTE, NY$660,757ITD
2023Multicolor PET to interrogate cancer biology1R01EB033000-01A1GRIMM, JANHERRAIZ, JOAQUIN LOPEZPONOMAREV, VLADIMIRUDIAS MOINELO, JOSE MANUELSLOAN-KETTERING INST CAN RESEARCH, NY$659,909IPCA
2023Development of an innovative in vivo voltammetric technique for measurements of tonic serotonin concentrations in the mammalian brain.1R01NS129549-01LEE, KENDALL H.OH, YOONBAESHIN, HOJINMAYO CLINIC ROCHESTER, MN$591,362BNVT
2023Development of an INSPIRE System for the Treatment of Inoperable Liver Tumors1R01CA276232-01SANO, MICHAEL BENJAMINNORTH CAROLINA STATE UNIVERSITY RALEIGH, NC$589,104IGIS
2023Novel Computational Framework for Free-Breathing & Ungated Dynamic MRI2R01EB019961-05A1JACOB, MATHEWSUNIVERSITY OF IOWA, IA$550,567EITA
2023Advancing visible light optical coherence tomography in glaucoma detection1R01EY034607-01YI, JIJOHNS HOPKINS UNIVERSITY, MD$539,899ZRG1
2023A clinical platform for ultrasound-augmented laparoscopy1R01EB030093-01A1SHEKHAR, RAJCHILDREN'S RESEARCH INSTITUTE, DC$535,340IGIS
20233D micro-physiological systems for identification of therapeutic myokines1R01AR080169-01A1JANG, YOUNG CHARLESPARK, SUNG JINEMORY UNIVERSITY, GA$534,091CMT
2023Preclinical microphysiological tumor models for nuclear medicine1R01CA268514-01A1PRATX, GUILLEMSUNWOO, JOHN BYANG, YUNZHISTANFORD UNIVERSITY, CA$529,906ITD
2023Semiconductor Biomaterials to Speed Bone Healing: A Bioengineering-Driven Approach1R01DE031872-01A1VARANASI, VENU GOPALUNIVERSITY OF TEXAS ARLINGTON, TX$479,516MTE
2023Maternal mHealth blood hemoglobin analysis with informed deep learning1R01EB033788-01KIM, YOUNG LWERE, MARTIN CHIENGPURDUE UNIVERSITY, IN$478,600CIDH
2023Optimized Electrical Block of Peripheral Nerves1R01NS126376-01A1GRILL, WARREN M.DUKE UNIVERSITY, NC$457,076BNVT
2023Intra-Articular Drug Delivery Modulating Immune Cells in Inflammatory Joint Disease1R01AR081887-01SHAH, NISARG J.UNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$449,661ZRG1
2022Multi-modal Tracking of In Vivo Skeletal Structures and Implants1R01AR078924-01A1CRISCO, JOSEPH JRHODE ISLAND HOSPITAL, RI$838,819MRS
2022Artificial Intelligence Driven Platform for PET/MR Imaging1R56EB033332-01MAO, HUIYANG, XIAOFENGEMORY UNIVERSITY, GA$763,919CTIS
2022Deep learning microscope for slide-free and digital histology1R01DE032051-01GILLENWATER, ANN MRICHARDS-KORTUM, REBECCA R.VEERARAGHAVAN, ASHOKRICE UNIVERSITY, TX$687,059ITD
2022Metamaterials Implants for Magnetic Resonance Imaging1R01NS128962-01ARONSON, JOSHUA PAULAY, ILKNURBONMASSAR, GIORGIOMASSACHUSETTS GENERAL HOSPITAL, MA$682,875ZRG1
2022Genetically-engineered stem cells for self-regulating arthritis therapy1R01AR080902-01GUILAK, FARSHIDPHAM, CHRISTINE T.WASHINGTON UNIVERSITY, MO$676,370MTE
2022Autonomous Grippers in the Gastrointestinal Tract2R01EB017742-09GRACIAS, DAVID HSELARU, FLORINJOHNS HOPKINS UNIVERSITY, MD$675,898BMBI
2022A Rational Engineering Design Approach to Minimizing the Off-Target Effects of Baroreceptor Activation Therapy1R01EB033403-01LUDWIG, KIP AUNIVERSITY OF WISCONSIN-MADISON, WI$663,655BNVT
2022Genome-wide mutational integration for ultra-sensitive plasma tumor burden monitoring in immunotherapy1R01CA266619-01LANDAU, DANROBINE, NICOLASWEILL MEDICAL COLL OF CORNELL UNIV, NY$658,506CBSS
2022AI-driven low-cost ultrasound for automated quantification of hypertension, preeclampsia, and IUGR1R01HD110480-01CLIFFORD, GARI DAVIDEMORY UNIVERSITY, GA$655,280CIDH
2022Complementary ex vivo multimodal optical imaging and in vivo Raman spectroscopy to understand tissue dynamics1R01EB033385-01MAHADEVAN-JANSEN, ANITAREESE, JOHN JEFFREYVANDERBILT UNIVERSITY, TN$647,822ITD
2022Optimizing Optogenetics for Cell-type-specific Control in Freely-moving Primates1R01NS123054-01A1PLATT, MICHAEL LUNIVERSITY OF PENNSYLVANIA, PA$647,050BNVT
2022Guiding epilepsy surgery using network models and Stereo EEG1R01NS125137-01BASSETT, DANIELLE SMITHLITT, BRIANUNIVERSITY OF PENNSYLVANIA, PA$644,799ZRG1
2022New Technologies for Real-Time MRI-Guided Robotic-Assisted Abdominal Interventions1R01EB031934-01A1LU, DAVID S.K.TSAO, TSU-CHIN TCWU, HOLDEN HUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$639,203IGIS
2022Dynamic Functional Image-based Deep Learning for Therapy Assessment in Autism2R01NS035193-23A1DUNCAN, JAMES SSTAIB, LAWRENCE H.SUKHODOLSKY, DENIS GVENTOLA, PAMELAYALE UNIVERSITY, CT$637,183EITN
2022Electrodes for selective stimulation of the lateral spinal cord to restore sensation after lower-limb amputation1R01NS121028-01A1FISHER, LEE ELEMPKA, SCOTT FUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$634,330BNVT
2022Angiogenic and anti-microbial supports for pulp regeneration1R01DE031812-01KUMAR, VIVEKNEW JERSEY INSTITUTE OF TECHNOLOGY, NJ$629,992ODCS
2022Fully Automated High-Throughput Quantitative MRI of the Liver1R01EB031886-01A1HERNANDO, DIEGOREEDER, SCOTT B.UNIVERSITY OF WISCONSIN-MADISON, WI$627,116EITA
2022Saving patients from invasive colectomies via trans-endoscopic steerable instrument sheaths1R01EB032385-01A1RUCKER, DANIEL CALEBUNIVERSITY OF TENNESSEE KNOXVILLE, TN$625,441BTSS
2022Transrectal Histotripsy for Focal Ablation of Prostate Cancer1R01CA258581-01A1SCHADE, GEORGE RUNIVERSITY OF WASHINGTON, WA$623,220ZRG1
2022Bioinspired Mechanically Stiff Hydrogels for Osteochondral Tissue Regeneration2R01AR069060-04A1BRYANT, STEPHANIE JUNIVERSITY OF COLORADO, CO$618,349MTE
2022Quantitative Multimodal Imaging Biomarkers for Combined Locoregional and Immunotherapy of Liver Cancer2R01CA206180-06A1DUNCAN, JAMES SMADOFF, DAVID CYALE UNIVERSITY, CT$616,121EITA
2022mRNA Expression Profiling from Extracellular Vesicles (EVs): Generating a Rapid Diagnostic for Stroke1R01EB031579-01A1BAIRD, ALISON ESOPER, STEVEN ALLANUNIVERSITY OF KANSAS LAWRENCE, KS$615,409EBIT
2022Advanced Imaging and Simulation Tools for Personalized Corneal Disease Assessment and Surgery1R01EY032633-01A1DUPPS, WILLIAM JOSEPHGRYTZ, RAFAELROLLINS, ANDREW MARTINCLEVELAND CLINIC LERNER COM-CWRU, OH$612,661PED2
2022Development of Software to Rapidly Assess Placenta Images at Birth1R01EB030130-01A1GERNAND, ALISON DGOLDSTEIN, JEFFERY AWANG, JAMES ZPENNSYLVANIA STATE UNIVERSITY, THE, PA$607,242CIDH
2022Expansion Microscopy2R01EB024261-05BOYDEN, EDWARD S.MASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$605,329CMT
2022Development of a closed-loop control system for plasma medicine1R01EB029705-01A1BERTHIAUME, FRANCOISKREBS, FRED C.MILLER, VANDANASTAPELMANN, KATHARINANORTH CAROLINA STATE UNIVERSITY RALEIGH, NC$593,801ISD
2022Fully Quantitative Low-Dose, Motion-Resolved Dynamic Contrast-Enhanced MRI in Pancreatic Adenocarcinoma1R01EB032801-01CHRISTODOULOU, ANTHONY GLI, DEBIAOCEDARS-SINAI MEDICAL CENTER, CA$586,150EITA
2022Data Driven Background Estimation in PET Using Event Energy Information1R56EB033585-01SURTI, SULEMANUNIVERSITY OF PENNSYLVANIA, PA$578,570ITD
2022Digital Multiplexed Analysis of Circulating Nucleic Acids in Small-Volume Blood Specimens1R01EB032725-01A1KOHLI, MANISHSMITH, ANDREW MICHAELUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$547,060EBIT
2022A tissue viability imaging biomarker for use in non-invasive breast cancer therapy1R01CA259686-01A1JOSHI, SARANGPAYNE, ALLISONUNIVERSITY OF UTAH, UT$544,684IGIS
2022Time-of-Flight PET for Improved Whole-Body Imaging2R01CA113941-15A1KARP, JOEL SSURTI, SULEMANUNIVERSITY OF PENNSYLVANIA, PA$534,438ITD
2022A novel microfluidic system for studying brain chemistry and application to study of enkephalin-degrading enzymes in pain perception1R01NS128408-01WEBER, STEPHEN G.UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$532,048ISD
2022Optimizing Patient-Specific Deep Brain Stimulation Models Using Electrophysiology1R01NS125143-01MIOCINOVIC, SVJETLANAEMORY UNIVERSITY, GA$524,645BNVT
2022A dual-layer flat panel x-ray detector based on an engineered amorphous chalcogenide alloy for quantifying coronary artery calcium1R01EB033466-01ABBASZADEH, SHIVAWANG, ADAM SUNIVERSITY OF CALIFORNIA SANTA CRUZ, CA$517,942ITD
2022Personalized Strategies for Periodontal Tissue Regeneration - A Converged Biofabrication Approach1R01DE031476-01BOTTINO, MARCO CUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$515,127ZRG1
2022Intraoperative integration of artificial intelligence during cystoscopic surgery1R01CA260426-01A1LIAO, JOSEPH CXING, LEISTANFORD UNIVERSITY, CA$514,044CTIS
2022Biomechanics of Morphogenesis2R37HD044750-14A1DAVIDSON, LANCE A.UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$508,417DEV2
2022Non-Human Primate Model for Developing Closed-Loop Anesthesia Delivery Systems1R01NS123120-01A1BROWN, EMERY NMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$495,216BTSS
2022Automated microscope platform with improved imaging and accurate neuron reconstruction capabilities for high-throughput studies of neuroregeneration1R56NS128413-01CHUNG, SAMUEL HUE-KAYNORTHEASTERN UNIVERSITY, MA$494,526ZRG1
2022Achieve Fairness in AI-Assisted Mobile Healthcare Apps through Unsupervised Federated Learning1R01EB033387-01HU, JINGTONGUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$479,764CIDH
2022Nanoparticles to Track T Cell Immunotherapy Using Magnetic Particle Imaging1R01EB031224-01A1RINALDI-RAMOS, CARLOS MUNIVERSITY OF FLORIDA, FL$472,110IPCA
2022Precision breast radiotherapy with the soft robot and supine CT1R01EB031577-01A1JIN, LIHUASHENG, KEUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$466,487IGIS
2022VINE Catheter: Soft, Tip-extending, Robotic Catheters with Shape Control for Endovascular Surgery1R01EB032417-01A1MORIMOTO, TANIA KIYOYEUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$457,423BTSS
2022Dose analysis for translating animal based vibrational force study for accelerating orthodontic tooth movement to clinic1R01DE030413-01A1CHEN, JIEINDIANA UNIVERSITY INDIANAPOLIS, IN$451,437ODCS
2022Self-Powered Load Sensors for Total Knee Replacement Health Monitoring1R01AR080798-01TOWFIGHIAN, SHAHRZADSTATE UNIVERSITY OF NY,BINGHAMTON, NY$451,309MRS
2022Non-Invasive Imaging of Neurological Glycogen Storage Disease1R01NS127280-01YADAV, NIRBHAY NARAYANHUGO W. MOSER RES INST KENNEDY KRIEGER, MD$415,273EITA
2022Deep learning enabled, deep ultraviolet scanning microscopy for intraoperative assessment of margin status during breast cancer surgery1R01EB033806-01YE, DONG HYEYU, BINGMARQUETTE UNIVERSITY, WI$414,402ITD
2022Geospatial modeling for stroke care1R01NS127114-01BROWN, GRANT DMOHR, NICHOLAS M.ORTEGA-GUTIERREZ, SANTIAGOUNIVERSITY OF IOWA, IA$414,186CDMA
2022Wide-field corneal microlayer tomography for keratoconus1R01EY033429-01ABOU SHOUSHA, MOHAMED FADELRUGGERI, MARCOUNIVERSITY OF MIAMI SCHOOL OF MEDICINE, FL$403,700ZRG1
2022Multiparametric transrectal ultrasound and photoacoustic imaging of human prostate1R56EB033356-01KOTHAPALLI, SRI RAJASEKHARPENNSYLVANIA STATE UNIVERSITY, THE, PA$386,860IGIS
2022Microfluidic platform for solid tumor mechanics and invasion2R01CA221346-05A1WU, MINGMINGCORNELL UNIVERSITY, NY$384,793ISD
2022A 2D Stationary X-ray Source System for Improved Breast Tomosynthesis Imaging2R01CA214515-05A1SCHWOEBEL, PAUL RSRI INTERNATIONAL, CA$88,728ITD
2021Continuous Monitoring and Management of Vaginal Health via Multifunctional OCT/OCTA Endoscopy1R01EB030558-01A1CHEN, ZHONGPINGLANE, FELICIA LUCIAUNIVERSITY OF CALIFORNIA-IRVINE, CA$1,946,945IGIS
2021Cardiac photon counting CT and its application in studying interactions between Alzheimer's and heart disease1RF1AG070149-01BADEA, CRISTIAN TDUKE UNIVERSITY, NC$1,873,076EITA
2021Sample-to-Answer, Rapid, Multiplexed and PCR-Free Diagnostics of Arboviral Diseases in Resource Limited Settings1R01AI155959-01YANIK, AHMET ALIUNIVERSITY OF CALIFORNIA SANTA CRUZ, CA$771,450ZRG1
2021Measurements and modeling of the hemodynamic response function in human cerebral cortex2R56NS095933-05A1RESS, DAVID BBAYLOR COLLEGE OF MEDICINE, TX$759,261EITN
2021Ultra-Long-Acting Polymeric Injectable Multi-Purpose Prevention Technology for Contraception and HIV Prevention1R01AI162246-01BENHABBOUR, SOUMYA RAHIMAUNIV OF NORTH CAROLINA CHAPEL HILL, NC$727,053ZRG1
2021Bi-directional neural interface for probing parallel visual pathways1R01EY032900-01CHICHILNISKY, EDUARDOCOGAN, STUART FHORWITZ, GREGORY DMELOSH, NICHOLAS AMURMANN, BORISSILVA, RUWANSTANFORD UNIVERSITY, CA$708,554BNVT
2021Augmenting Implanted Neuroprosthetics with Targeted Health Monitoring for Spinal Cord Injury - the LIFELINE1R01EB031911-01KILGORE, KEVIN L.CASE WESTERN RESERVE UNIVERSITY, OH$698,247BNVT
2021Physician Assistance Technology in Image-guided Robotic Intervention of Prostate1R01EB030539-01FISCHER, GREGORY SHATA, NOBUHIKOBRIGHAM AND WOMEN'S HOSPITAL, MA$682,653IGIS
2021Real-time in vivo proton range verification in proton therapy with thallium bromide detectors1R01EB029533-01A1ARIร‘O ESTRADA, GERARDUNIVERSITY OF CALIFORNIA AT DAVIS, CA$663,295ITD
2021Low Cost Tethered Capsule Endoscope with High-Resolution Digital Chromoscopy for Barrett's Screening1R01CA252245-01A1ANANDASABAPATHY, SHARMILARICHARDS-KORTUM, REBECCA R.RICE UNIVERSITY, TX$658,492ITD
2021Virtual Biopsy with Tissue-level Accuracy in Glioma1R01CA260705-01MALDJIAN, JOSEPH AUT SOUTHWESTERN MEDICAL CENTER, TX$655,597EITA
2021Integrating TPM and PAM to examine the metabolic underpinning of neurovascular repair after stroke1R01NS120481-01A1HU, SONGLEE, JIN-MOOYANG, LANWASHINGTON UNIVERSITY, MO$649,683ZRG1
2021Models and methods for automatically measuring disease body-wide and staging disease via FDG-PET/CT in Lymphoma1R01CA255748-01A1SCHUSTER, STEPHEN JTORIGIAN, DREWUDUPA, JAYARAM KUNIVERSITY OF PENNSYLVANIA, PA$647,411EITA
2021Prism-PET: A TOF-DOI-Compton PET detector technology for total-body PET imaging1R01EB030413-01A1GOLDAN, AMIRHOSSEINZHAO, WEISTATE UNIVERSITY NEW YORK STONY BROOK, NY$647,165ZRG1
2021OpenSim Enhancements to Enable Computational Design of Personalized Treatments for Movement Impairments1R01EB030520-01A1FREGLY, BENJAMIN JPATTEN, CAROLYNNRICE UNIVERSITY, TX$625,131MRS
2021Functional and Structural Optical Coherence Tomography for Glaucoma2R01EY023285-09HUANG, DAVIDOREGON HEALTH & SCIENCE UNIVERSITY, OR$624,917ZRG1
2021Predicting Relapse at the Time of Diagnosis in Acute Lymphoblastic Leukemia1R01CA251858-01A1DAVIS, KARA LYNNSTANFORD UNIVERSITY, CA$615,576CBSS
2021Focused ultrasound pre-conditioning for augmented nanoparticle penetration in infiltrative gliomas1R01EB030409-01A1HANES, JUSTIN S.PRICE, RICHARD J.UNIVERSITY OF VIRGINIA, VA$606,239IGIS
2021Genome Editing the Blood-Brain Barrier with Sonoselective Focused Ultrasound1R01EB030744-01PRICE, RICHARD J.UNIVERSITY OF VIRGINIA, VA$593,452IGIS
2021Ultra-Fast Knee MRI with Deep Learning1R01AR078762-01PEDOIA, VALENTINAUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$574,344CTIS
2021Rehabilitation from Spinal Cord Injury Using Targeted, Activity-Dependent Intraspinal Stimulation2R01NS099872-05PERLMUTTER, STEVE IUNIVERSITY OF WASHINGTON, WA$572,914BNVT
2021Dual-slope method for enhanced depth sensitivity in frequency-domain near-infrared spectroscopy1R01EB029414-01A1FANTINI, SERGIOTUFTS UNIVERSITY MEDFORD, MA$571,606ITD
2021Characterization of the Properties and Mechanisms of Photobiomodulation-Induced Axonal Block and Evaluation as a Treatment for Neuropathic Pain1R01NS121372-01ANDERS, JUANITA JJENKINS, MICHAEL W.MOFFITT, MICHAELCASE WESTERN RESERVE UNIVERSITY, OH$569,126BNVT
2021Design of fusion inhibitors to block measles host-to-host infection1R56AI159085-01A1POROTTO, MATTEOCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$561,162GDD
2021A novel method for volumetric oxygen mapping in living retina1R01EY032163-01YI, JIJOHNS HOPKINS UNIVERSITY, MD$552,744ZRG1
2021Virtual Resection to Treat Epilepsy2R56NS099348-05A1BASSETT, DANIELLE SMITHLITT, BRIANUNIVERSITY OF PENNSYLVANIA, PA$551,628ZRG1
2021Integrated visualization, control, and analysis of GEF โ€“ GTPase networks in living cells1R01CA252826-01A1DANUSER, GAUDENZHAHN, KLAUS M.UT SOUTHWESTERN MEDICAL CENTER, TX$541,157EBIT
2021Hyperplexed Quantum Dots for Multidimensional Cell Classification in Intact Tissue1R01EB032249-01SMITH, ANDREW MICHAELUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$540,651EBIT
2021Modulated release of anti-senescence drugs to stimulate aged bone repair2R01DE021103-06A1KUHN, LIISA TIINAUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT$530,450ZRG1
2021Reprogramming Exosomes for Biomedical Applications1R01EB031830-01ZHANG, YONGUNIVERSITY OF SOUTHERN CALIFORNIA, CA$527,574NANO
2021Point-of-Care Microfluidic Biochip for Biomarkers Monitoring for Contributing in Early Sepsis Diagnosis1R01AI148385-01A1BASHIR, RASHIDUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$524,610ISD
2021Localized immunotherapy using alum-binding therapeutics1R01EB031082-01A1IRVINE, DARRELL JWITTRUP, KARL DANEMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$522,925GDD
2021Academic-Industrial Partnership for Translation of Acoustic Angiography2R01CA189479-05A1DAYTON, PAUL AUNIV OF NORTH CAROLINA CHAPEL HILL, NC$516,357ITD
2021An MRI-Guided Steerable Needle to Replace Open Brain Surgery for Epilepsy Patients1R01NS120518-01BARTH, ERIC JOHNWEBSTER, ROBERT JAMESVANDERBILT UNIVERSITY, TN$506,454ZRG1
2021Novel nano-vaccine technology for inducing immunity against gliomas1R01NS122536-01CASTRO, MARIA GMOON, JAMES J.UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$501,930NANO
2021Development of Nanosensors to Image Macrophage Polarization1R56EB032211-01SUGGS, LAURA JUNIVERSITY OF TEXAS AT AUSTIN, TX$497,285NANO
2021Biophysical Characterization of Subthalamic Local Field Potentials in Parkinson's Disease1R01NS119520-01MCINTYRE, CAMERONCASE WESTERN RESERVE UNIVERSITY, OH$494,878BNVT
2021Microribbon scaffold-mediated Immunomodulation for Cranial Bone Repair2R01DE024772-06A1YANG, FANSTANFORD UNIVERSITY, CA$490,208MTE
2021Mineralized collagen composite to accelerate craniofacial bone regeneration1R01DE030491-01HARLEY, BRENDAN A.UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$479,938BTSS
2021Image-guided combination therapies for radiotherapy-induced neurocognitive impairment in pediatric brain tumor survivors1R01CA262887-01NGEN, ETHEL JOSOJOHNS HOPKINS UNIVERSITY, MD$479,525CNBT
2021Unified Shim-RF Coil Technology for Improved Whole-Brain Spectroscopic MRI for Neurological Disorders1R01NS121544-01HAN, HUICEDARS-SINAI MEDICAL CENTER, CA$479,251EITN
20213D Encapsulation, Bioprinting and Controlled Delivery of Functionally Engineered EVs (FEEs)1R01DE030495-01COOPER, LYNDON FGAJENDRAREDDY, PRAVEENRAVINDRAN, SRIRAMUNIVERSITY OF ILLINOIS AT CHICAGO, IL$464,702MTE
2021Microfluidic sorting of lung cancer cells from leukapheresis product as an alternative to metastatic tumor biopsy1R01CA260304-01HABER, DANIEL A.MAHESWARAN, SHYAMALATONER, MEHMETMASSACHUSETTS GENERAL HOSPITAL, MA$452,315ZRG1
2021Macrorecombination in isolated cell pairs via natural genetic transformation1R01AI155812-01A1EDDINGTON, DAVIDMORRISON, DONALDUNIVERSITY OF ILLINOIS AT CHICAGO, IL$444,666CMT
2021Validating MXene Electrodes for Next-Generation Electroencephalography1R01NS121219-01MEDAGLIA, JOHNVITALE, FLAVIAUNIVERSITY OF PENNSYLVANIA, PA$438,978ZRG1
2021Label-free Optical Recording of Neuroelectric Activities1R01NS121934-01CUI, BIANXIAOMUELLER, HOLGERSTANFORD UNIVERSITY, CA$434,139ZRG1
2021Tissue Engineered Rostral Migratory Stream for Directed Neuronal Replacement1R01NS117757-01A1CULLEN, DANIEL KACYUNIVERSITY OF PENNSYLVANIA, PA$428,779BNVT
2021Skeletal Muscle Engineering for the Craniofacial Region1R01DE030490-01SHAH, RISHMAUNIV OF NORTH CAROLINA CHAPEL HILL, NC$416,153ZRG1
2021Noninvasive transcranial detection of intracranial hemorrhage using a tri-coil handheld portable eddy current damping imaging device1R01NS119596-01ZADA, GABRIELUNIVERSITY OF SOUTHERN CALIFORNIA, CA$408,993ANIE
2021smartOCT: a low-cost technology to detect and monitor glaucoma in outpatient and primary care centers1R01EY032670-01BOWDEN, AUDREY KYNSELLAVANDERBILT UNIVERSITY, TN$404,033ZRG1
2021Transcutaneous Direct Current Motor Nerve Block for Spasticity1R01NS116009-01A1BHADRA, NILOYVRABEC, TINA LOUISECASE WESTERN RESERVE UNIVERSITY, OH$402,146BNVT
2021Stem Cell-based Platform for Targeted Enzyme/Prodrug Therapy of Recurrent Ovarian Cancer1R01CA251438-01A1HATEFI, ARASHRUTGERS, THE STATE UNIV OF N.J., NJ$389,366DT
2021Focused kV X-ray Modulated Conformal Radiotherapy for Small Targets1R01EB030493-01A1LIU, WUSTANFORD UNIVERSITY, CA$382,974RTB
2021Vascularized tumor explants for drug testing1R01CA247441-01A1DUDA, DAN GABRIELMUNN, LANCE L.MASSACHUSETTS GENERAL HOSPITAL, MA$378,078DMP
2021A Multipoint Injection Technology for Highly Efficient Convection-Enhanced Delivery of Gene-Based Therapeutics1R01NS117756-01A1LUCAS, TIMOTHY HVITALE, FLAVIAUNIVERSITY OF PENNSYLVANIA, PA$371,603BTSS
2021MINE-MS for horizontal bone loss treatment1R01DE029808-01A1LIU, XIAOHUATEXAS A&M UNIVERSITY HEALTH SCIENCE CTR, TX$355,985MTE
2021Development of Analysis Tools to Enhance Magnetomyographic Assessment of Pelvic Floor Muscles1R01EB031589-01ESWARAN, HARIOLIPHANT, SALLIE SHERRODUNIV OF ARKANSAS FOR MED SCIS, AR$342,000ZRG1
2021Biomaterials-based metabolic rescue of dendritic cells for vaccine design1R01AI155907-01ACHARYA, ABHINAVARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$340,828BMBI
2021Local immunometabolism modulating biomaterials for immunosuppressive applications1R01AR078343-01ACHARYA, ABHINAVARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$337,286BMBI
2021Stratified and mechanically-tough biomaterial implant to improve tendon-to-bone enthesis regeneration1R01AR077858-01A1HARLEY, BRENDAN A.UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$261,665BMBI
2021Develop a large-scale library of comprehensive deformable image registration (DIR) benchmark datasets and an integrated framework for quantifying accuracy of patient-specific DIR results1R01EB029431-01A1YANG, DESHANWASHINGTON UNIVERSITY, MO$105,767EITA
2020Inducing Tolerance with 5-Module chimeric Antigen Receptor (5MCAR) T Cells1R56AI148466-01A1KUHNS, MICHAEL SSERWOLD, THOMAS FUNIVERSITY OF ARIZONA, AZ$777,783TTT
2020Probe-based two photon microscopy for functional, label-free early cancer diagnosis1R01EB030061-01BEN-YAKAR, ADELAGEORGAKOUDI, IRENEXU, CHRISTUFTS UNIVERSITY MEDFORD, MA$747,020ITD
2020Models for aging and Alzheimer with image-based cerebrovascular network synthesis (iCNS)1R56AG066634-01LINNINGER, ANDREAS AUNIVERSITY OF ILLINOIS AT CHICAGO, IL$743,548MABS
2020A Fully Integrated Point-of-Care Test for Ebola1R01AI150888-01A1CHILKOTI, ASHUTOSHDUKE UNIVERSITY, NC$717,426ISD
2020Diagnostic validity and safety of high-gamma language mapping with intracranial EEG1R01NS115929-01ARYA, RAVINDRACRONE, NATHAN EFLINKER, ADEENJOHNS HOPKINS UNIVERSITY, MD$696,283BNVT
2020Focused Ultrasound Regimens that Synergize with Melanoma Immunotherapy1R01EB030007-01BULLOCK, TIMOTHY NPRICE, RICHARD J.UNIVERSITY OF VIRGINIA, VA$675,709IGIS
2020High Speed Angiography at 1000 frames per second1R01EB030092-01RUDIN, STEPHENSTATE UNIVERSITY OF NEW YORK AT BUFFALO, NY$668,040ITD
2020Central thalamic deep brain stimulation to regulate arousal and cognition1R01NS111019-01A1BAKER, JONATHAN LPURPURA, KEITH P.WEILL MEDICAL COLL OF CORNELL UNIV, NY$657,118ZRG1
2020Visualizing oxidative stress using hyperpolarized magnetic resonance1R01CA252037-01KESHARI, KAYVAN RSLOAN-KETTERING INST CAN RESEARCH, NY$656,410IPCA
20203D Printed Scaffolds for Primate Spinal Cord Injury Repair1R01NS114043-01KOFFLER, YACOVTUSZYNSKI, MARK H.UNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$656,077BTSS
2020Multi-scale model of microbial phenotype modulation by mucins1R01AI154242-01FORD, ROSEANNEPAPIN, JASONUNIVERSITY OF VIRGINIA, VA$645,815MABS
2020In vivo Macroscopic Fluorescence Lifetime Molecular Optical Imaging1R01CA250636-01BARROSO, MARGARIDAINTES, XAVIERRENSSELAER POLYTECHNIC INSTITUTE, NY$637,634ZRG1
2020Micro-invasive biochemical sampling of brain interstitial fluid for investigating neural pathology1R01EB027717-01A1CIMA, MICHAEL JLANGER, ROBERT SAMUELWHITE, FOREST MMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$628,550ISD
2020Optimization of a Minimally-Invasive Bidirectional Optogenetic Peripheral Nerve Interface with Single Axon Read-in & Read-out Specificity1R01NS118188-01CALDWELL, JOHN HGIBSON, EMILYWEIR, RICHARD FERGUS FFRENCHUNIVERSITY OF COLORADO DENVER, CO$624,492BNVT
2020Prodrugs targeting norepinephrine transporter for dual-selective therapy of refractory neuroblastoma1R01CA251883-01BRODEUR, GARRETT MCHORNY, MICHAELCHILDREN'S HOSP OF PHILADELPHIA, PA$622,966GDD
2020First-in-human clinical translation of a near-infrared, nerve-specific fluorophore to facilitate tissue-specific fluorescence-guided surgery1R01NS116994-01A1GIBBS, SUMMER LYNNEHENDERSON, ERIC RDARTMOUTH-HITCHCOCK CLINIC, NH$620,782IPCA
2020Integrated analysis of HCC CTCs for Liver Transplant Candidate Selection1R01CA246304-01AGOPIAN, VATCHETSENG, HSIAN-RONGYOU, SUNGYONGUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$618,982CBSS
2020Enhancing Epigenetic Analysis Of Rare Cells With Multi-Phase Microfluidics1R01CA247479-01BEEBE, DAVID JLANG, JOSHUA MICHAELUNIVERSITY OF WISCONSIN-MADISON, WI$610,874EBIT
2020Quantitative protein network profiling to improve CAR design and efficacy1R01CA240985-01A1SMITH, STEPHEN EDWARD PAUCHASEATTLE CHILDREN'S HOSPITAL, WA$600,156CII
2020A platform to functionally sort and analyze tumor cells within combinatorial metastatic micorenvironments1R01CA245550-01A1PROVENZANO, PAOLOWOOD, DAVID KEVINUNIVERSITY OF MINNESOTA, MN$598,441TPM
2020In vivo Imaging and Quantification of Cilia Beating Dynamics Using Phase-Resolved Optical Imaging Technology1R01EB030024-01CHEN, ZHONGPINGWONG, BRIANUNIVERSITY OF CALIFORNIA-IRVINE, CA$593,557ITD
2020A soft X-Ray Phase-Based Microscope for Biomedical Applications1R01EB028829-01FERRARA, JOSEPH DAVIDMAKAROVA, OLGA V.OLIVO, ALESSANDROTANG, CHA-MEIYAGI, YUKAKORIGAKU AMERICAS CORPORATION, TX$566,401ISD
2020SERS diagnostics platform for liquid bioapsy analysis of tumor-associated exosomes1R01CA241666-01A1CARNEY, RANDYUNIVERSITY OF CALIFORNIA AT DAVIS, CA$564,554ZRG1
2020Computational and Statistical Framework to Model Tissue Shape and Mechanics2R01EB016701-05A1ANDERSON, ANDREW EDWARDUNIVERSITY OF UTAH, UT$563,658MABS
2020Exosome separation and digital resolution detection of blood-based nucleic acid biomarkers for noninvasive therapeutic diagnostics in cancer1R01EB029805-01CUNNINGHAM, BRIAN T.DEMIRCI, UTKANKOHLI, MANISHUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$556,370CMT
2020Tumor-penetrating nano-theranostics for image-guided interventions in spontaneous feline head and neck cancer1R01DE029237-01LI, YUANPEIUNIVERSITY OF CALIFORNIA AT DAVIS, CA$525,840NANO
2020Engineering bispecific antibodies for non-hormonal contraception1R01HD101562-01LAI, SAMUELUNIV OF NORTH CAROLINA CHAPEL HILL, NC$523,187BMBI
2020TOPAS - nBio, a Monte Carlo tool for radiation biology research2R01CA187003-05A1SCHUEMANN, JAN PATRICK OSCARMASSACHUSETTS GENERAL HOSPITAL, MA$520,921ZRG1
2020Developing whole-body computational phantoms for blood dosimetry to model the impact of radiation on the immune system1R01CA248901-01BOLCH, WESLEY EPAGANETTI, HARALDMASSACHUSETTS GENERAL HOSPITAL, MA$511,615RTB
2020Engineered neuroprotective stem-cell exosomes for in utero spina bifida therapy1R01NS115860-01A1FARMER, DIANA LEEWANG, AIJUNUNIVERSITY OF CALIFORNIA AT DAVIS, CA$499,899BTSS
2020Biomimetic Matrix for Ex Vivo and In Vivo Activation of T Cells1R01EB029341-01A1MAO, HAI-QUANSCHNECK, JONATHAN PJOHNS HOPKINS UNIVERSITY, MD$479,444BMBI
2020Imaging of Retinal Hydroxyapatite as an Early Screen for AMD1R01EY030443-01A1THOMPSON, RICHARD BLAIRUNIVERSITY OF MARYLAND BALTIMORE, MD$475,130ZRG1
2020Mathematical modeling of optimal therapeutic combinations for HIV cure1R01AI150500-01CARDOZO OJEDA, ERWING FABIANFRED HUTCHINSON CANCER RESEARCH CENTER, WA$464,126HCCS
2020A Wireless Multi-function Microscope for Lifetime Imaging of the Brain Tumor Vasculome1R01CA237597-01A1PATHAK, ARVIND PJOHNS HOPKINS UNIVERSITY, MD$453,962ZRG1
2020Smart Dura: A Functional Large-scale, High-Density Optoelectric Dura for Non-Human Primates1R01NS116464-01CHAMANZAR, MAYSAMREZACARNEGIE-MELLON UNIVERSITY, PA$450,652BNVT
2020An experimentally-refined, dynamic gene regulatory network model of T-cell memory1R56AI153442-01BARSKI, ARTEMMIRALDI, EMILYCINCINNATI CHILDRENS HOSP MED CTR, OH$445,620MABS
2020Use of Radiological Clips for Improving Quantitative Ultrasound Imaging1R01CA251939-01OELZE, MICHAEL L.UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$444,902EITA
2020High-resolution volumetric imaging of metabolic activity in tissues and its application to tumor metabolism1R01EB029523-01MIN, WEICOLUMBIA UNIV NEW YORK MORNINGSIDE, NY$420,123CMT
2020Development and application of non-thermal high frequency IRE to treat hepatic tumors1R01CA240476-01A1DAVALOS, RAFAEL VIDALVIRGINIA POLYTECHNIC INST AND ST UNIV, VA$417,538BTSS
2020Ultrasound-controlled remote activation of CAR T cells for localized tumor immunotherapy1R01EB029122-01WANG, YINGXIAOUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$411,946CMT
2020Synchronized brain dynamics and eye movement trajectory for objective evaluation of robot-assisted surgical skills1R01EB029398-01BESHARAT SHAFIEI, SOMAYEHROSWELL PARK CANCER INSTITUTE CORP, NY$393,075BTSS
2020Diffuse Optics for Pediatric Hydrocephalus Management1R01NS113945-01BAKER, WESLEYCHILDREN'S HOSP OF PHILADELPHIA, PA$385,000ZRG1
2020Point-of-care screening test for early cervical cancer detection1R01CA246315-01A1LINNES, JACQUELINEMOHAMMED, SULMA IBRAHIMPURDUE UNIVERSITY, IN$384,085CBSS
2020Stratified and mechanically-tough biomaterial implant to improve tendon-to-bone enthesis regeneration1R56AR077858-01HARLEY, BRENDAN A.UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$382,265BMBI
2020Versatile femtosecond technology for adaptive multi-photon imaging1R01EB028933-01RENNINGER, WILLIAMUNIVERSITY OF ROCHESTER, NY$380,398ISD
2020Accurate 4D Liver Tumor Localization for Radiotherapy using Contrast-Agent-Free X-ray Imaging and Liver Biomechanical Modeling1R01CA240808-01A1ZHANG, YOUUT SOUTHWESTERN MEDICAL CENTER, TX$373,721EITA
2020Automated platform for high-throughput genetic analyses in C. elegans1R01NS115995-01FANG-YEN, CHRISTOPHERUNIVERSITY OF PENNSYLVANIA, PA$371,664ISD
2020T cell roles in regeneration across nerve graft alternatives1R01NS115960-01WOOD, MATTHEW D.WASHINGTON UNIVERSITY, MO$369,832CNNT
2020Long-Term Tracking of Cerebral Microvascular Structural and Functional Alterations between Normal and Alzheimer's Aging1R01AG067228-01LEE, JONGHWANBROWN UNIVERSITY, RI$368,604ZRG1
2020Biodegradable Matrices with Structural and Physical Cues for Interface Engineering1R01EB030060-01NUKAVARAPU, SYAMUNIVERSITY OF CONNECTICUT STORRS, CT$363,678MTE
2020Expanding the Therapeutic Window of Nanoparticle STING Agonists for Cancer Immunotherapy1R01CA245134-01A1WILSON, JOHN TANNERVANDERBILT UNIVERSITY, TN$363,450NANO
2020New protein engineering-based tools and technologies for characterizing cell surface proteolysis in cancer cells for novel neo-epitope biomarkers and drug targets1R01CA248323-01WELLS, JAMES AUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$362,803MSFA
2020MIRDcell Version 31R01CA245139-01HOWELL, ROGER W.RBHS-NEW JERSEY MEDICAL SCHOOL, NJ$356,850RTB
2020Enhancing CAR-T cell activity against solid tumors by vaccine boosting through the chimeric receptor1R01CA247632-01IRVINE, DARRELL JMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$348,609ZRG1
2020Quantitative Fluorescence Imaging-Guided Detection and Targeted Therapy Monitoring Platform for Ovarian Cancer Micrometastases1R01CA243164-01A1SUNAR, ULASWRIGHT STATE UNIVERSITY, OH$340,883ZRG1
2020Treating Primary aldosteronism-induced hypertension via microwave thermal therapy1R01EB028848-01PRAKASH, PUNITKANSAS STATE UNIVERSITY, KS$331,841IGIS
2020Subcellular Wireless Axons for in vivo Localized Neuronal Excitation1R01NS105691-01A1KOZAI, TAKASHI DANIEL YOSHIDAUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$328,196BNVT
2020Developing Multimodal Multiplexed ImmunoPET-Raman Probes to Guide Immunotherapies1R01EB029756-01A1BARDHAN, RIZIAIOWA STATE UNIVERSITY, IA$327,970IPCA
2020New craniofacial bone engineering through miR-23-27-24 cluster mediated osteogenic-angiogenic coupling1R01DE027686-01A1LUAN, XIANGHONGTEXAS A&M UNIVERSITY, TX$325,384MTE
2020Multi-coil multi-nuclear add-on system for clinical field strength NMR-based biomarker detection for Duchenne Muscular Dystrophy1R01EB028533-01A1MCDOUGALL, MARY PRESTONTEXAS ENGINEERING EXPERIMENT STATION, TX$316,096EBIT
2020Novel tools for in vitro electrophysiology and neurotrauma modeling1R01NS113935-01FINAN, JOHN DENDEAVOR HEALTH CLINICAL OPERATIONS, IL$169,615BNVT
2020Optical Mapping of Electromechanics of the Stomach1R01EB029428-01ROGERS, JACK MUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$75,022ITD

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