Skip to main content
NIH funding notice PAR-19-194

Microbial-based Cancer Therapy -Bugs as Drugs (R21 Clinical Trial Not Allowed)

Closed on February 17, 2022.

Posted
February 22, 2019
Close date
February 17, 2022
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

20 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $4,603,998 in first-year total cost, median $213,241.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 OTC-M (08)]5
  2. Cancer Prevention Study Section[CPSS]4
  3. Special Emphasis Panel[ZRG1 OTC-D (08)]2
  4. Cancer Immunopathology and Immunotherapy Study Section[CII]1
  5. Developmental Therapeutics Study Section[DT]1

Most frequent institutions

  1. BECKMAN RESEARCH INSTITUTE/CITY OF HOPE2
  2. UNIVERSITY OF FLORIDA2
  3. ARIZONA STATE UNIVERSITY-TEMPE CAMPUS1
  4. CLEVELAND CLINIC LERNER COM-CWRU1
  5. DUKE UNIVERSITY1
Competing awards under PAR-19-194 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2023Deciphering microbial contribution to androgen bioavailability in castration resistant prostate cancer patients1R21CA277064-01GHARAIBEH, RAADJOBIN, CHRISTIANUNIVERSITY OF FLORIDA, FL$207,931CPSS
2022Designer EcN for treatment of solid tumors1R21CA249995-01A1LESSER, CAMMIEMASSACHUSETTS GENERAL HOSPITAL, MA$249,442ZRG1
2022Utilizing Hybrid Antigen-Presenting Neutrophils to Prime WT1-Specific Immune Responses as Therapy for Acute Leukemia1R21CA256593-01A1MANUEL, EDWINBECKMAN RESEARCH INSTITUTE/CITY OF HOPE, CA$246,840ZRG1
2022Repurposing Mycobacterium tuberculosis tRNase toxins for cancer chemotherapy1R21CA267852-01WOYCHIK, NANCY ANNRBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL, NJ$236,333DMP
2022Microbiome-derived regulators of therapy-resistant colorectal tumors1R21CA267707-01GRIFFIN, TIMOTHY J.JAGTAP, PRATIK DSUBRAMANIAN, SUBBAYAUNIVERSITY OF MINNESOTA, MN$218,550MCT2
2022Engineering non-proliferating-but-active (NPBA) probiotic for breast-cancer gene therapy1R21CA267427-01HOVEY, RUSSELL CTAN, CHEEMENGUNIVERSITY OF CALIFORNIA AT DAVIS, CA$206,627DT
2022Chemical Remodeling of Cell Surface to Enhance the Accumulation of Therapeutic Bacteria to Tumors1R21CA259800-01A1PIRES, MARCOS M.THEVENIN, DAMIENUNIVERSITY OF VIRGINIA, VA$197,477ZRG1
2022Cancer-specific metabolites as cues to engineer and target anti-tumor therapeutic bacteria1R21CA267711-01A1DWIDAR, MOHAMMEDCLEVELAND CLINIC LERNER COM-CWRU, OH$188,169CPSS
2022Bacteriophage-mediated microbiota modification to prevent colorectal cancer development1R21CA264927-01A1EL HADDAD, LYNNJOBIN, CHRISTIANUNIVERSITY OF FLORIDA, FL$178,234CPSS
2022Validating p53 Ser46 crotonylation as a potential target for possible anti-cancer therapy1R21CA272890-01LU, HUATULANE UNIVERSITY OF LOUISIANA, LA$177,650MONC
2022Mechanisms of anti-tumor activity of group A Streptococcus in pancreatic adenocarcinoma1R21CA267302-01A1BOONE, BRIAN ALUKOMSKI, SLAWOMIRWEST VIRGINIA UNIVERSITY, WV$177,650ZRG1
2021Transplanting Unique Human Microbiomes to Improve Immunotherapy in Glioblastoma1R21CA252634-01A1EGAN, KATHLEEN M.MCFARLAND, BRADEN COXUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$415,031ZRG1
2021African trypanosome parasites: a new tool to unveil potential immunological strategies to target CLL1R21CA259345-01DE TREZ, CARLHU, CHIH-CHI ANDREWMETHODIST HOSPITAL RESEARCH INSTITUTE, TX$360,852IHD
2021Multi-strain, live biotherapeutics as adjuncts to checkpoint inhibitor therapy1R21CA249822-01A1KIM, HYUNGSOORAMER-TAIT, AMANDA ELLENSANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, CA$263,086ZRG1
2021Effects of tumor-microbial interactions on EGFR-targeted therapy resistance in lung cancer1R21CA263751-01RAZ, DAN JBECKMAN RESEARCH INSTITUTE/CITY OF HOPE, CA$246,840MCT1
2021Elucidating the role of intratumoral microbiota on immunotherapy efficacy1R21CA248904-01A1REDMOND, WILLIAM LPROVIDENCE PORTLAND MEDICAL CENTER, OR$234,218CPSS
2021Cancer therapy with a combination of oncolytic bacteria and virus to enhance targeted cell killing and anti-tumor immune responses1R21CA249517-01A1KONG, WEIRAHMAN, MASMUDUR MOHAMMEDARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$220,193ZRG1
2021Remotely controlled listerial bactodrones for cancer immunotherapy1R21CA249814-01A1GIGLEY, JASONGOMELSKY, MARKUNIVERSITY OF WYOMING, WY$186,018ZRG1
2020Novel immunotherapeutic regimen combining the dendritic cell expansion power of Albumin-Flt3L and inflammatory cues of Salmonella1R21DE029910-01HUNG, CHIEN-FUJOHNS HOPKINS UNIVERSITY, MD$204,688CII
2020The impact of genetic diversity among Akkermansia strains on the effectivenes of immune checkpoint inhibitors in cancer immunotherapies1R21CA249243-01HE, YOU-WENVALDIVIA, RAPHAEL HZHANG, TIANDUKE UNIVERSITY, NC$188,169ZRG1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

ScienceDex for faculty

Your academic CV and NIH biosketch

Make your CV in your school's format and your NIH biosketch from it, then download both as Word files.