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NIH funding notice PAR-19-294

Early-Stage Preclinical Validation of Therapeutic Leads for Diseases of Interest to the NIDDK (R01 Clinical Trial Not Allowed)

Closed on November 12, 2021.

Posted
June 6, 2019
Close date
November 12, 2021
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

14 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $6,781,522 in first-year total cost, median $442,618.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 EMNR-F (50)]10
  2. Special Emphasis Panel[ZRG1 EMNR-H (50)]4

Most frequent institutions

  1. GEORGIA STATE UNIVERSITY2
  2. UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR2
  3. BAYLOR COLLEGE OF MEDICINE1
  4. BOSTON MEDICAL CENTER1
  5. CASE WESTERN RESERVE UNIVERSITY1
Competing awards under PAR-19-294 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2022Early-Stage Preclinical Validation of Carbon Monoxide Prodrugs for Acute Kidney Injury1R01DK128823-01A1DE CAESTECKER, MARK P.OTTERBEIN, LEO EWANG, BINGHEGEORGIA STATE UNIVERSITY, GA$750,347ZRG1
2022Targeting POGLUT1 to promote biliary development in Alagille syndrome1R01DK132751-01HUPPERT, STACEY SJAFAR-NEJAD, HAMEDBAYLOR COLLEGE OF MEDICINE, TX$400,001ZRG1
2022Preclinical Validation of Novel Gut-Restricted LRRK2 Inhibitors as Therapeutic Leads for IBD1R01DK130094-01A1DEVITA, ROBERT JPETER, INGAICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$399,978ZRG1
2022Developing proinsulin misfolding inhibitors for beta cell protection and diabetes treatment1R01DK130174-01A1WANG, WEIDONGUNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR, OK$395,452ZRG1
2022Small molecule inhibitor of CD40 signaling for the control of inflammatory bowel disease1R01DK133903-01SUBAUSTE, CARLOS SCASE WESTERN RESERVE UNIVERSITY, OH$354,200ZRG1
2022New Therapeutic Leads for Proteinuric Kidney Diseases1R01DK133940-01LU, WEININGBOSTON MEDICAL CENTER, MA$267,000ZRG1
2021Pre-clinical Validation of A Novel Protein Drug Candidate for ASH and NASH Treatment1R01DK126080-01A1FARRIS, ALTON BLIU, ZHI-RENYANG, JENNY J.GEORGIA STATE UNIVERSITY, GA$614,398ZRG1
2021Small molecule antagonists targeting EphB receptors for the treatment of nonalcoholic steatohepatitis (NASH)1R01DK128819-01BOUDINA, SIHEMMIMCHE, PATRICEUNIVERSITY OF UTAH, UT$599,884ZRG1
2021Preclinical Validation of PPARg Acetylation Inhibitors for Diabetes Prevention and Treatment1R01DK128848-01QIANG, LIWANG, WEIDONGUNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR, OK$476,180ZRG1
2021Optimizing small molecule SWELL1-LRRC8 modulators to treat Type 2 diabetes1R01DK126068-01A1SAH, RAJANWASHINGTON UNIVERSITY, MO$423,936ZRG1
2020Targeting RAGE/DIAPH1: Novel Therapeutic Strategy for Diabetic Complications1R01DK122456-01A1RAMASAMY, RAVICHANDRANSCHMIDT, ANN MARIENEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$672,000ZRG1
2020Development of long-acting glucose-responsive insulin formulations1R01DK121336-01A1CHOU, DANNY HUNG-CHIEHSTANFORD UNIVERSITY, CA$643,846ZRG1
2020Preclinical validation of oral therapeutic lead proteins targeting epithelial GM1 ganglioside for ulcerative colitis therapy1R01DK123712-01A1MATOBA, NOBUYUKIUNIVERSITY OF LOUISVILLE, KY$461,300ZRG1
2020SLC26A3 (DRA) Inhibitors for Treatment of Hyperoxaluria and Nephrolithiasis1R01DK126070-01CIL, ONURUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$323,000ZRG1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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PAR-19-294: Early-Stage Preclinical Validation of Therapeutic Leads for Diseases of Interest to the NIDDK (R01 Clinical Trial Not Allowed) | ScienceDex | ConductScience