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NIH funding notice PAR-20-292

NCI Clinical and Translational Exploratory/Developmental Studies (R21 Clinical Trial Optional)

Closed on July 20, 2022.

Posted
August 24, 2020
Close date
July 20, 2022
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov ยท NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

285 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $62,905,605 in first-year total cost, median $218,089.

Most frequent study sections

  1. Special Emphasis Panel[ZCA1 SRB-P (O1)]21
  2. Special Emphasis Panel[ZCA1 SRB-A (M1)]16
  3. Special Emphasis Panel[ZCA1 SRB-A (J1)]13
  4. Special Emphasis Panel[ZCA1 SRB-F (O2)]12
  5. Special Emphasis Panel[ZCA1 SRB-K (J2)]11

Most frequent institutions

  1. UNIVERSITY OF TX MD ANDERSON CAN CTR14
  2. DUKE UNIVERSITY9
  3. H. LEE MOFFITT CANCER CTR & RES INST9
  4. UNIVERSITY OF PITTSBURGH AT PITTSBURGH7
  5. BECKMAN RESEARCH INSTITUTE/CITY OF HOPE6
Competing awards under PAR-20-292 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2023Novel circulating biomarker digital scores for assessing treatment response in liver cancer1R21CA280444-01YANG, JU DONGZHU, YAZHENCEDARS-SINAI MEDICAL CENTER, CA$436,472ZCA1
2023Targeting tumor cell macrophage lipid interactions to overcome resistance to androgen receptor targeted therapy1R21CA270913-01A1ELKENAWI, ASMAAINDIANA UNIVERSITY INDIANAPOLIS, IN$423,130ZCA1
2023A lung cancer vaccine based on exosomes of induced pluripotent stem cells1R21CA280453-01LI, CHIYADDANAPUDI, KAVITHAUNIVERSITY OF LOUISVILLE, KY$402,401ZCA1
2023The paradox of myeloid leukemia of Down syndrome1R21CA270718-01A1GE, YUBINTAUB, JEFFREY WARRENWAYNE STATE UNIVERSITY, MI$395,973ZCA1
2023Understanding how the interaction between Lag3 deficiency and hypercholesterolemia impact anti-tumor immunity and cardiovascular disease in a melanoma model1R21CA279098-01ADLER, ADAM JRODRIGUEZ, ANNABELLEUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT$271,004ZCA1
2023Alternatively spliced cell surface proteins as drivers of leukemogenesis and targets for immunotherapy1R21CA280367-01PERNA, FABIANAH. LEE MOFFITT CANCER CTR & RES INST, FL$270,783ZCA1
2023Translation initiation as a therapeutic target in neuroblastoma1R21CA267521-01A1GEORGE, RANI E.DANA-FARBER CANCER INST, MA$258,761ZCA1
2023A new highly sensitive targeted imaging method for early tumor detection1R21CA274007-01A1RADU, AURELIANICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$258,238ZCA1
2023Rapid Acute Leukemia Genomic Profiling with CRISPR enrichment and Real-time long-read sequencing1R21CA280520-01YEUNG, CECILIA CFRED HUTCHINSON CANCER CENTER, WA$255,809ZCA1
2023Interaction of cannabidiol (CBD) with targeted inhibitors of essential cancer signaling pathways1R21CA280446-01GOLEMIS, ERICA A.WARD, SARA JRESEARCH INST OF FOX CHASE CAN CTR, PA$255,105ZCA1
2023Tumor-targeted disruption of mismatch repair in microsatellite stable colorectal cancer1R21CA277460-01LIEBERMAN, JUDYBOSTON CHILDREN'S HOSPITAL, MA$248,243ZCA1
2023Molecular biomarkers of future aggressive behavior in pituitary tumors1R21CA280469-01LIN, ANDREWSLOAN-KETTERING INST CAN RESEARCH, NY$248,243ZCA1
2023A Prostate Cancer Dependency Map to Identify Tumor Subtype-Specific Vulnerabilities1R21CA277368-01NELSON, PETER SFRED HUTCHINSON CANCER CENTER, WA$246,840ZCA1
2023Differentiation of tumor progression from radiation necrosis using MR cell size imaging1R21CA270731-01A1XU, JUNZHONGVANDERBILT UNIVERSITY MEDICAL CENTER, TN$245,438ZCA1
2023Targeting Autocrine Hepatocyte Growth Factor (HGF) Production as a Therapeutic Modality in Acute Myeloid Leukemia (AML)1R21CA263337-01A1BLASER, BRADLEY WAYNEWANG, VICTORIAUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$238,101ZCA1
2023TERT epigenetic and genomic variants in stage II melanoma as biomarkers of outcome1R21CA277480-01POLSKY, DAVIDNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$237,724ZCA1
2023Targeting FL3 and SRC kinases for AML therapy1R21CA252366-01A1REDDY, E PREMKUMARICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$237,023ZCA1
2023Disease-homing light delivery by engineering bioluminescent immune cells for whole body precision photomedicine1R21CA263452-01A1SPRING, BRYAN QUILTYNORTHEASTERN UNIVERSITY, MA$236,444ZCA1
2023Developing GRB2-PROTACs for Treatment of Lung Cancer1R21CA267283-01A1JI, HAITAO MARKH. LEE MOFFITT CANCER CTR & RES INST, FL$236,321ZCA1
2023Integrated fragment-based phenotypic screening and chemoproteomics for identification of novel small cell lung cancer-specific targets1R21CA277288-01MONASTYRSKYI, ANDRIIRIX, UWEH. LEE MOFFITT CANCER CTR & RES INST, FL$236,321ZCA1
2023DNASE1L3 regulation of anti-tumor immune responses following radiation therapy1R21CA277250-01GOUGH, MICHAEL JAMESPROVIDENCE HEALTH & SERVICES - OREGON, WA$234,218ZCA1
2023Patient-Centered Insights from the POWER Trial: Pre-Operative Window of Adjuvant Endocrine Therapy to Inform Radiation Therapy Decisions in Older Women with Early-Stage Breast Cancer1R21CA277311-01SHOWALTER, SHAYNA LEFRAKUNIVERSITY OF VIRGINIA, VA$233,661ZCA1
2023Nominating vulnerabilities in fusion oncoprotein-driven rhabdomyosarcoma1R21CA273282-01A1SKAPEK, STEPHEN XXU, LINUT SOUTHWESTERN MEDICAL CENTER, TX$230,010ZCA1
2023The Role of Myeloid-Derived Suppressor Cells in Resistance to Bipolar Androgen Therapy in Patients with Advanced Prostate Cancer1R21CA273501-01A1DENMEADE, SAMUEL RSANIN PENA, DAVID ESTEBANJOHNS HOPKINS UNIVERSITY, MD$229,659ZCA1
2023Preclinical assessment of efficacy and tumor microenvironment alterations by PPRX-1701 in glioblastoma1R21CA259734-01A1LAWLER, SEAN EDWARDBROWN UNIVERSITY, RI$229,519ZCA1
2023A novel gene therapy approach targeting STING-silenced cold tumors1R21CA267803-01A1YOU, JIANXINUNIVERSITY OF PENNSYLVANIA, PA$227,906ZCA1
2023Identifying Novel Radiation Sensitizers in Cervical Cancer1R21CA277332-01COLBERT, LAUREN ELIZABETHUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$227,205ZCA1
2023Enhancing CAR T Cell Homing Through Glycoengineering1R21CA270491-01A1AL-ATRASH, GHEATHUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$227,205ZCA1
2023First-in-Human Imaging of Innate Immunity Activation with a Redox-Tuned PET Reporter1R21CA277283-01PIWNICA-WORMS, DAVIDUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$227,205ZCA1
2023Investigating the Effect of FLASH-Radiotherapy on Tumor and Normal Tissue1R21CA273845-01A1FRANK, STEVEN JAYUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$227,205ZCA1
2023Combined bromodomain and CDK4/6 inhibition in NUT Carcinoma and other solid tumors1R21CA277316-01CHENG, MICHAEL L.DANA-FARBER CANCER INST, MA$226,502ZCA1
2023Sieve based full likelihood approach for the Cox proportional hazards model with applications to immunotherapies trials1R21CA263950-01A1HALABI, SUSANWU, YUANDUKE UNIVERSITY, NC$225,803ZCA1
2023Initial Testing of a Mobile App Pain Coping Intervention for Outpatient Oncology Settings1R21CA273832-01A1KELLEHER, SARAHDUKE UNIVERSITY, NC$225,803ZCA1
2023Target the Dusp1 in Jak2 dependent myeloproliferative neoplasm (MPN) for curative treatment1R21CA280723-01AZAM, MOHAMMADCINCINNATI CHILDRENS HOSP MED CTR, OH$225,101ZCA1
2023Special Public T Cell Receptor Sequences that Predict Outcomes for Cancer Patients1R21CA277285-01POLLACK, SETH MNORTHWESTERN UNIVERSITY AT CHICAGO, IL$224,400ZCA1
2023Rapid Response Monitoring with Circulating Tumor DNA in Metastatic Breast Cancer1R21CA280472-01MILES, GEORGEBAYLOR COLLEGE OF MEDICINE, TX$224,400ZCA1
2023Genome-wide synthetic lethal screening for vulnerabilities in a cell model of succinate dehydrogenase-loss paraganglioma1R21CA266999-01A1MAHER, LOUIS JAMESMAYO CLINIC ROCHESTER, MN$222,998ZCA1
2023Therapeutic Targeting of The Long Noncoding RNA SCHLAP1 in Aggressive Prostate Cancer1R21CA277305-01HARGROVE, AMANDA ESOMARELLI, JASON ANDREWDUKE UNIVERSITY, NC$222,213ZCA1
2023A synthetic lethal approach for targeting p53 deficient triple negative breast cancer1R21CA273658-01A1MAKI, CARL GRUSH UNIVERSITY MEDICAL CENTER, IL$221,595ZCA1
2023ULK1 Inhibitor in Combination with Immune Checkpoint Blockade in PancreaticCancer1R21CA270588-01A1MACKEIGAN, JEFFREY PAULMICHIGAN STATE UNIVERSITY, MI$219,491ZCA1
2023A Stem Cell Based Exosomal Vaccine for the Prevention of Cancer1R21CA277314-01LI, CHIYADDANAPUDI, KAVITHAUNIVERSITY OF LOUISVILLE, KY$219,491ZCA1
2023Preoperative immunotherapy in Hepatocellular Carcinoma1R21CA270903-01A1AKCE, MEHMETLESINSKI, GREGORY B.EMORY UNIVERSITY, GA$219,491ZCA1
2023Development of a patient-derived tumoroid culture system to explore novel medical treatments for refractory prolactinomas1R21CA264838-01A1HEANEY, ANTHONY PUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$218,790ZCA1
2023STK11 loss of function and anti-PD-1 therapy resistance in KRAS-driven lung adenocarcinoma1R21CA280266-01SEWARD, DAVID JOSEPHUNIVERSITY OF VERMONT & ST AGRIC COLLEGE, VT$218,790ZCA1
2023Targeting cancer stem-like cells and inflammation for colon cancer chemoprevention1R21CA273646-01A1CHEN, GRACE Y.COLACINO, JUSTIN ADAMUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$218,790ZCA1
2023A Novel VpreB1 Anti-body Drug Conjugate for the Treatment of B-Lineage Acute Lymphoblastic Leukemia/Lymphoma1R21CA280433-01GORDON, PETER MWINTER, STUART SHELDONCHILDREN'S HOSPITALS AND CLINICS, MN$218,718ZCA1
2023Selective targeting of ependymoma progenitor cells via BMI1 inhibition1R21CA280148-01VIBHAKAR, RAJEEVUNIVERSITY OF COLORADO DENVER, CO$218,089ZCA1
2023Natural products inhibitors targeting homology-directed DNA repair for cancer therapy1R21CA270300-01A1SPIES, MARIASPIES, MICHAEL ASHLEYUNIVERSITY OF IOWA, IA$218,089ZCA1
2023Redox manipulation of iron to improve glioblastoma therapy: A phase 1 trial1R21CA270742-01A1ALLEN, BRYANBUATTI, JOHN MUNIVERSITY OF IOWA, IA$218,089ZCA1
2023Identification of serum protein biomarkers by profiling N-glycoproteomes of patient-derived xenografts of neuroendocrine prostate cancer1R21CA276896-01BROOKS, JAMES D.PITTERI, SHARONSTANFORD UNIVERSITY, CA$217,991ZCA1
2023Novel inhibitors of oncogenic p53 mutants for lung cancer therapy.1R21CA267971-01A1DEB, SWATI P.WINDLE, BRAD E.VIRGINIA COMMONWEALTH UNIVERSITY, VA$217,738ZCA1
2023Prevention and treatment of paclitaxel-induced peripheral neuropathy1R21CA277447-01LECKENBY, JONATHAN IANNOBLE, MARK DUNIVERSITY OF ROCHESTER, NY$215,985ZCA1
2023Mechanisms of tamoxifen-associated endometrial cancer risk1R21CA270580-01A1GERTZ, JASONUNIVERSITY OF UTAH, UT$215,869ZCA1
2023Pathomics biomarkers for stratification of clear cell kidney cancers1R21CA277381-01KNUDSEN, BEATRICE SUNIVERSITY OF UTAH, UT$215,693ZCA1
2023Multiplexed Paper-Based Blood Test for Early-Stage Colorectal Cancer Screening1R21CA270727-01A1BADU-TAWIAH, ABRAHAMOHIO STATE UNIVERSITY, OH$215,482ZCA1
2023Discovery of PPI inhibitors for the FAK FAT domain1R21CA267285-01A1MARLOWE, TIMOTHY ATHATCHER, GREGORY R. JUNIVERSITY OF ARIZONA, AZ$215,284ZCA1
2023Engineering Siglec15/TGF-beta targeted bispecific antibodies that modulate the tumor microenvironment and enhances T-cell immunotherapy against pancreatic cancer1R21CA273983-01A1LAI, SAMUELUNIV OF NORTH CAROLINA CHAPEL HILL, NC$214,931ZCA1
2023Amino acid transporter SLC38A5 as a drug target for TNBC: Evaluation with genetic and pharmacologic approaches1R21CA277140-01GANAPATHY, VADIVELTEXAS TECH UNIVERSITY HEALTH SCIS CENTER, TX$214,583ZCA1
2023Mechanism Underlying Sleep Disruption by Mammary Tumors1R21CA276027-01A1DEVRIES, ANNE COURTNEYNELSON, RANDY J.WEST VIRGINIA UNIVERSITY, WV$213,180ZCA1
2023Combining BET protein inhibitors with radiation in HPV oropharyngeal cancer1R21CA267518-01A1IYER, GOPALUNIVERSITY OF WISCONSIN-MADISON, WI$211,862ZCA1
2023Developing glycosylated RNAs as novel clinical targets for aggressive prostate cancer.1R21CA280570-01KERSCHER, AURORA ESQUELAEASTERN VIRGINIA MEDICAL SCHOOL, VA$210,375ZCA1
2023Novel modalities for prostate cancer screening: mast cells as predictors of disease, disease aggressiveness and marks of disease disparity1R21CA274021-01A1OSKERITZIAN, CAROLE AUNIVERSITY OF SOUTH CAROLINA AT COLUMBIA, SC$208,973ZCA1
2023Mechanism-based combination therapy for cholangiocarcinoma1R21CA273759-01A1YOON, KARINA JUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$208,271ZCA1
2023Using proteogenomics to assess the functional impact of alternative splicing events in glioblastoma1R21CA267394-01A1COBBS, CHARLES SSEARLE, BRIAN CHIH-SENGSWEDISH MEDICAL CENTER, FIRST HILL, WA$207,023ZCA1
2023In search of synergistic drug interactions in cancer1R21CA280567-01HUGHES, CHRISTOPHER C. W.UNIVERSITY OF CALIFORNIA-IRVINE, CA$205,740ZCA1
2023Crosslinking-based targeted therapy for triple-negative breast cancer1R21CA280458-01CHEN, SHENGXICUI, XIAOJIANGARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$202,921ZCA1
2023Drug combination nanoparticles for advanced treatment of metastatic TNBC1R21CA273739-01A1MU, QINGXINUNIVERSITY OF WASHINGTON, WA$199,842ZCA1
2023Exploring ovarian-derived hormone STC1 as the mediator of the protective effect of breast feeding against breast cancer.1R21CA270702-01A1GERMAIN, DORIS AICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$197,519ZCA1
2023KIR2DL2 Immune Checkpoint as Modulator of T-Cell Effector Function1R21CA280233-01ABATE-DAGA, DANIELH. LEE MOFFITT CANCER CTR & RES INST, FL$196,934ZCA1
2023Structure-Function Studies of a Cell Penetrating Antibody that Inhibits DNA Repair1R21CA278934-01BLEICHERT, FRANZISKAGLAZER, PETER MYALE UNIVERSITY, CT$195,766ZCA1
2023OR2H1 is an effective target for CAR T cells in human epithelial tumors1R21CA276205-01CONEJO-GARCIA, JOSE RDUKE UNIVERSITY, NC$195,472ZCA1
2023Defining the phenotype and cancer penetrance of CTNNA1 loss-of-function germline variants1R21CA267949-01A1KATONA, BRYSON WILLIAMUNIVERSITY OF PENNSYLVANIA, PA$195,301ZCA1
2023Modulating the immuno-metabolic interplay in liver cancer with cryoablation1R21CA274152-01A1COMAN, DANIELYALE UNIVERSITY, CT$192,634ZCA1
2023Exercise and Lung Cancer1R21CA275978-01PERRY, RACHEL JAMISONYALE UNIVERSITY, CT$191,941ZCA1
2023Efficient and cost-effective breast cancer risk stratification using whole slide histopathology images1R21CA273665-01A1GURCAN, METIN NAFIWAKE FOREST UNIVERSITY HEALTH SCIENCES, NC$190,880ZCA1
2023Hypoglossal neuropathy in the pathogenesis of radiation associated dysphagia (hRAD)1R21CA273984-01A1HUTCHESON, KATHERINE ARNOLDSANCHEZ TERRONES, BENJAMINUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$190,380ZCA1
2023Liposome-based mRNA cancer immunotherapy targeting ion channels1R21CA277341-01CONFORTI, LAURAUNIVERSITY OF CINCINNATI, OH$189,338ZCA1
2023A combination strategy to target pathophysiology of chronic lymphocytic leukemia1R21CA259749-01A1GANDHI, VARSHAUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$189,338ZCA1
2023Boosting anti-tumor immunity in the omentum for metastasis prevention1R21CA273656-01A1NAORA, HONAMIUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$189,338ZCA1
2023Quantitative Imaging of OXPHOS in Pancreatic Cancer1R21CA280238-01MANNING, HENRY CHARLESUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$189,338ZCA1
2023Targeting of IL-1 Signaling in Myelofibrosis1R21CA274430-01A1MOHI, GOLAMUNIVERSITY OF VIRGINIA, VA$188,753ZCA1
2023Development of pHLIP-phosphoantigen conjugates for lymphoma therapy1R21CA273042-01A1BAHAL, RAMANWIEMER, ANDREW JUNIVERSITY OF CONNECTICUT STORRS, CT$188,169ZCA1
2023Intraoperative Imaging for Lymph Node Metastases1R21CA280814-01YAMADA, TOHRUUNIVERSITY OF ILLINOIS AT CHICAGO, IL$186,883ZCA1
2023A Multi-Omics Study of the Effect and Mechanisms of Acupuncture on Psychoneurological Symptoms Among Breast Cancer Survivors1R21CA277153-01A1LI, HONGJINUNIVERSITY OF ILLINOIS AT CHICAGO, IL$186,883ZCA1
2023Investigating GSTP1 as a novel regulator of the cysteine redoxome in breast cancer and maker of vulnerability to redox-based therapy1R21CA270876-01A1HELD, JASON M.WASHINGTON UNIVERSITY, MO$183,104ZCA1
2023Dissecting pemetrexed resistance in non-small cell lung carcinoma1R21CA277103-01KANG, SUMINEMORY UNIVERSITY, GA$182,909ZCA1
2023Acoustic Droplet Initiated Radiosensitivity of Hepatocellular Carcinoma1R21CA273838-01A1EISENBREY, JOHNTHOMAS JEFFERSON UNIVERSITY, PA$182,325ZCA1
2023Disrupting long noncoding RNA methylation to elicit antimorph behavior in breast cancer1R21CA270573-01A1JOHNSON, AARON M.UNIVERSITY OF COLORADO DENVER, CO$181,741ZCA1
2023A matrix metalloproteinase biosensor-functionalized metastasis-on-a-chip platform for evaluating adrenocortical carcinoma progression1R21CA277083-01DEDHIA, PRIYA HARAKHLEIGHT, JENNIFERSKARDAL, ALEKSANDEROHIO STATE UNIVERSITY, OH$180,933ZCA1
2023Exploration of the immunosuppressive function of RBMS3/PRRX1 axis in TNBC1R21CA273771-01A1GIBSON, HEATHER MARIEWU, GUOJUNWAYNE STATE UNIVERSITY, MI$179,988ZCA1
2023Targeting RHNO1 in Ovarian Cancer1R21CA273399-01A1KARPF, ADAM R.UNIVERSITY OF NEBRASKA MEDICAL CENTER, NE$179,403ZCA1
2023R21 MPI microRNA directed therapy for treating early stage pancreatic cancer1R21CA277263-01SCHMITTGEN, THOMAS D.ZHANG, FANUNIVERSITY OF FLORIDA, FL$178,234ZCA1
2023Targeting breast cancer microenvironment with small molecule agonist of relaxin receptor1R21CA270712-01A1AGOULNIK, ALEXANDER IAGOULNIK, IRINAFLORIDA INTERNATIONAL UNIVERSITY, FL$172,391ZCA1
2023Non-invasive assessment of graft vs host disease using optoacoustic imaging1R21CA271218-01A1HOLTER CHAKRABARTY, JENNIFER LINMCNALLY, LACEY RUNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR, OK$169,469ZCA1
2023Role of miR-195 in Chemo-Resistant Ovarian Cancer1R21CA280507-01DWIVEDI, SHAILENDRA KUMAR DHARUNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR, OK$169,469ZCA1
2023Pro-Oncogenic Role of a Mitochondrial Lipid Kinase in CLL1R21CA280437-01GHOSH, ASISH KUMARUNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR, OK$169,469ZCA1
2023Metabolic tagging of tumor exosomes for developing enhanced exosome vaccines1R21CA270872-01A1WANG, HUAUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$168,894ZCA1
2023Structural and functional analysis of a novel class of androgen receptor antagonists1R21CA280467-01WANG, ZHOUUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$149,651ZCA1
2022Strategies for discerning chemotherapy response and resistance in ovarian cancer1R21CA267599-01A1WEI, WEIINSTITUTE FOR SYSTEMS BIOLOGY, WA$510,364ZCA1
2022Molecular Cloaking Devices for Manipulation of Cysteine Post-Translational Modifications1R21CA273954-01KODADEK, THOMAS J.UNIVERSITY OF FLORIDA, FL$496,766ZCA1
2022A Pilot Study to Evaluate the Benefits of Phytocannabinoids for the Treatment of Chronic Chemotherapy-Induced Peripheral Neuropathy1R21CA260447-01A1LEE, RICHARD TBECKMAN RESEARCH INSTITUTE/CITY OF HOPE, CA$452,540ZCA1
2022Targeting MUC1-C with an antibody drug conjugate for the therapy of advanced prostate cancer1R21CA262991-01A1KUFE, DONALD W.DANA-FARBER CANCER INST, MA$442,214ZCA1
2022Developing ATAC-array as a novel epigenetic biomarker to guide personalized therapy in pancreatic cancer1R21CA263285-01A1LEACH, STEVEN DDARTMOUTH COLLEGE, NH$421,689ZCA1
2022The Association Between CBT-I Dose, Sleep Duration, and Fatigue in Breast Cancer Patients1R21CA270987-01PERLIS, MICHAEL LLOYDUNIVERSITY OF PENNSYLVANIA, PA$417,828ZCA1
2022DNP-MRSI for the Detection of Latent, Treatment-Resistant Cellular Domains in HCC1R21CA263364-01A1GADE, TERENCE PUNIVERSITY OF PENNSYLVANIA, PA$416,075ZCA1
2022Developing Improved Models of Basal Cell Carcinoma to Evaluate Tumor-Drug Response1R21CA267941-01A1WONG, SUNNY YUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$401,117ZCA1
2022Investigating PROTAC-mediated antigen degradation as a novel strategy to enhance cytotoxic T-cell responses against cancer in vivo.1R21CA274064-01SCHLIEHE, CHRISTOPHERERASMUS MEDICAL CENTER$277,686ZCA1
2022Translation and validation of non-invasive measurement of PD-L1 levels with positron emission tomography (PET) in head and neck malignancies and intracranial metastases1R21CA259964-01A1ABOIAN, MARIAMYALE UNIVERSITY, CT$274,072ZCA1
2022Genomic Analysis of Cutaneous CD30+ Lymphoproliferative Disorders1R21CA259932-01A1QUERFELD, CHRISTIANESONG, JOOBECKMAN RESEARCH INSTITUTE/CITY OF HOPE, CA$266,867ZCA1
2022Pursuing molecular biomarkers to guide adjuvant therapy for HPV+ head and neck cancers after transoral robotic surgery1UH2CA267502-01BASU, DEVRAJUNIVERSITY OF PENNSYLVANIA, PA$265,891ZCA1
2022Multi-omic Predictive Markers for Ovarian Cancer Therapy Response and Outcomes1R21CA267050-01MODUGNO, FRANCESMARYMAGEE-WOMEN'S RES INST AND FOUNDATION, PA$261,420ZCA1
2022Diapause-like adaptation of triple-negative breast cancer cells during chemotherapy treatment1R21CA267539-01DHIMOLEA, EUGENMITSIADES, CONSTANTINE S.ALBERT EINSTEIN COLLEGE OF MEDICINE, NY$257,461ZCA1
2022Development of cell-based models for fibrolamellar carcinoma1R21CA274098-01VAKILI, KHASHAYARBOSTON CHILDREN'S HOSPITAL, MA$257,222ZCA1
2022Targeting the Progesterone Receptor as a Novel Means to Increase Efficacy of Immune Checkpoint Inhibitors in Hormone Receptor Positive Breast Cancer1R21CA274044-01HAGAN, CHRISTYHARTMAN, ZACHARY CONRADUNIVERSITY OF KANSAS MEDICAL CENTER, KS$255,588ZCA1
2022Development of Novel ERRalpha Antagonists as Breast Cancer Therapeutics1R21CA263414-01A1MCDONNELL, DONALD PDUKE UNIVERSITY, NC$254,868ZCA1
2022Randomized Feasibility Trial for Mesh in Pre-Pectoral Reconstruction1R21CA263455-01A1DELONG, MICHAEL RAYFESTEKJIAN, JACOUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$254,460ZCA1
2022Modeling and Targeting B/Myeloid Mixed Phenotype Acute Leukemia1R21CA263223-01A1CHEN, WENYONGBECKMAN RESEARCH INSTITUTE/CITY OF HOPE, CA$252,046ZCA1
2022CHEK2 loss promotes prostate cancer resistance to PARP inhibitors1R21CA267496-01A1JIA, LIBRIGHAM AND WOMEN'S HOSPITAL, MA$251,048ZCA1
2022Defining the impact of mutational drivers on the immune microenvironment of CLL1R21CA267527-01WU, CATHERINE JU-YINGYIN, SHANYEDANA-FARBER CANCER INST, MA$249,645ZCA1
2022Investigation of the impact of pegylated Interferon on clonal trajectory and inflammatory cytokine production in MPN patients1R21CA267632-01DUNBAR, ANDREW JEFFREYRAMPAL, RAAJITSLOAN-KETTERING INST CAN RESEARCH, NY$248,243ZCA1
2022Dopamine Metabolism and Nonpharmacologic Insomnia Interventions Among Cancer Survivors1R21CA274059-01MAO, JUN JSLOAN-KETTERING INST CAN RESEARCH, NY$248,243ZCA1
2022Integrated Genotypic, Phenotypic and Immunologic Analysis of Ethnically Diverse Prostate Cancers1R21CA270862-01DORFF, TANYABECKMAN RESEARCH INSTITUTE/CITY OF HOPE, CA$246,840ZCA1
2022Gender-affirming estrogen therapy and breast cancer treatment outcome1R21CA267088-01HENG, YU JING JANWULF, GERBURG MBETH ISRAEL DEACONESS MEDICAL CENTER, MA$245,438ZCA1
2022In vivo CRISPR-screening of novel cancer cell-intrinsic targets that sensitize to local ionizing radiation, and possible combination with systemic checkpoint blockade.1R21CA267607-01A1WEICHSELBAUM, RALPH RUNIVERSITY OF CHICAGO, IL$240,831ZCA1
2022Repurposing Bazedoxifene for chemoprevention in pre-invasive pancreatic cancer IPMN1R21CA259715-01A1CHIO, CHRISTINE IOK INCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$238,542ZCA1
2022Defining and targeting the epigenetic programs involved in melanoma development1R21CA267141-01SMALLEY, KEIRANH. LEE MOFFITT CANCER CTR & RES INST, FL$236,321ZCA1
2022Characterization of the oncogenic potential of circRNAs in melanoma1R21CA267291-01KARRETH, FLORIANH. LEE MOFFITT CANCER CTR & RES INST, FL$236,321ZCA1
2022Defining and targeting the immune-suppressive metabolic microenvironment of leptomeningeal melanoma metastases1R21CA274060-01SMALLEY, INNAH. LEE MOFFITT CANCER CTR & RES INST, FL$236,321ZCA1
2022Suppression of Prostate Cancer1R21CA262963-01A1LOGAN, SUSAN K.NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$236,050ZCA1
2022Development of TLR5 agonist based approaches to boost chemo-immunotherapy by modulating immunosuppressive networks1R21CA267274-01BRACKETT, CRAIG M.ROSWELL PARK CANCER INSTITUTE CORP, NY$235,901ZCA1
2022A Novel Treatment Strategy for Metastatic Breast Cancer1R21CA259719-01A1BAKIN, ANDREI V.ROSWELL PARK CANCER INSTITUTE CORP, NY$235,901ZCA1
2022DISSECTING AND TARGETING THE ROLE OF GALNT14 IN HIGH-RISK OSTEOSARCOMA1R21CA267914-01KOHLER, JENNIFER JYUSTEIN, JASONBAYLOR COLLEGE OF MEDICINE, TX$235,869ZCA1
2022Novel Prostate cancer therapy based on m-aconitase inhibition1R21CA245343-01A1MOORE, ANNAMICHIGAN STATE UNIVERSITY, MI$235,035ZCA1
2022Humanizing CXCL13 and CXCR5 in mice1R21CA256380-01A1LOLIS, ELIASYALE UNIVERSITY, CT$234,919ZCA1
2022Anti-CD25 Radioimmunotherapy and Total Marrow Irradiation for Treatment of Relapsed and Refractory Acute Leukemia1R21CA270912-01WONG, JEFFREY YBECKMAN RESEARCH INSTITUTE/CITY OF HOPE, CA$233,179ZCA1
2022Targeting MUC1-C for the Treatment of Small Cell Lung Cancer Progression1R21CA267138-01KUFE, DONALD W.DANA-FARBER CANCER INST, MA$232,259ZCA1
2022Tumor-specific drug activation by pericellular proteases1R21CA256460-01A1O'DONOGHUE, ANTHONY JOHNOWEN, SHAWN CUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$231,823ZCA1
2022Targeting defective spliceosomal pathway in myeloid malignancies1R21CA270590-01VISCONTE, VALERIAYANG, CHAO-YIEUNIVERSITY OF TENNESSEE HEALTH SCI CTR, TN$231,699ZCA1
2022Non-invasive, image-based, in-vivo assessment of tumor hypoxia to guide hypoxia-driven adaptive radiation therapy1R21CA274426-01DONAHUE, MANUS JOSMUNDSON, EVAN CVANDERBILT UNIVERSITY MEDICAL CENTER, TN$231,643ZCA1
2022Microbiome-based biomarkers and models of lung cancer development and treatment1R21CA260382-01A1JOHNSON, WILLIAM EVANSEGRE, DANIELBOSTON UNIVERSITY MEDICAL CAMPUS, MA$231,413ZCA1
2022Neuron-macrophage interactions in models of chemotherapy-induced peripheral neuropathy1R21CA274588-01GRUEBER, WESLEY BSHIN, GRACE JI-EUNCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$230,711ZCA1
2022Therapeutic targeting of MYC interactions with an essential cofactor1R21CA267540-01A1COLE, MICHAEL DAVIDDARTMOUTH COLLEGE, NH$230,010ZCA1
2022Immunomodulatory effects of topical artesunate on cervical intraepithelial neoplasia 2/3.1R21CA263256-01A1TRIMBLE, CORNELIA LJOHNS HOPKINS UNIVERSITY, MD$229,659ZCA1
2022Using Canine Organoids to Advance Therapeutic Drug Development in Bladder Cancer1R21CA267372-01ALLENSPACH, KARINMOCHEL, JONATHAN PAULIOWA STATE UNIVERSITY, IA$229,348ZCA1
2022Overcoming drug resistance using small molecule activators of protein phosphatase 2A1R21CA273979-01BLACK, JENNIFER D.UNIVERSITY OF NEBRASKA MEDICAL CENTER, NE$228,958ZCA1
2022Circadian regulation of cancer therapy-associated neuroinflammation1R21CA267135-01A1VALDEZ, ERIN GSTANFORD UNIVERSITY, CA$228,831ZCA1
2022Proliferating cell nuclear antigen in regulation of androgen receptor signalings in castration-resistant prostate cancer cells1R21CA256009-01A1DONG, ZHONGYUNUNIVERSITY OF CINCINNATI, OH$227,205ZCA1
2022Clonal drivers of resistance to immune checkpoint blockade in liver malignancies1R21CA259799-01A1GENOVESE, GIANNICOLAUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$227,205ZCA1
2022Innovative Treatment of Chemotherapy-Induced Painful Peripheral Neuropathy in Adolescents and Young Adults with Cancer: A two arm pilot study1R21CA256136-01A1ABDI, SALAHADINUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$227,205ZCA1
2022Defining the novel cancer testis antigen HSPA1L as immunotherapeutic target in AML1R21CA259324-01A1KONOPLEVA, MARINA YUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$227,205ZCA1
2022Enhancing CAR T therapy in multiple myeloma1R21CA267275-01KANG, YUBINDUKE UNIVERSITY, NC$225,803ZCA1
2022Twofold Reduction in Gadolinium Dose for Brain MRI Exams using a Novel Unbalanced T1 Relaxation-Enhanced Steady-State (uT1RESS) Technique1R21CA273280-01EDELMAN, ROBERT R.ENDEAVOR HEALTH CLINICAL OPERATIONS, IL$225,803ZCA1
2022Environmental Carcinogens Induce Minority MOMP to Initiate Carcinogenesis in Lung Cancer and Mesothelioma whileMaintaining Apoptotic Resistance via Mcl-11R21CA256466-01A1RIPLEY, ROBERT TAYLORBAYLOR COLLEGE OF MEDICINE, TX$224,400ZCA1
2022Inhibition of fatty acid amide hydrolase as a novel strategy to prevent nephrotoxicity of cisplatin.1R21CA274012-01LI, NINGJUNVIRGINIA COMMONWEALTH UNIVERSITY, VA$223,694ZCA1
2022Targeting poly (ADP ribose) polymerase (PARP) in endometrial cancer1R21CA267098-01WEROHA, SARAVUTMAYO CLINIC ROCHESTER, MN$222,998ZCA1
2022Dual anti-leukemic and cardio protective role for ROCK1R21CA263470-01A1KAPUR, REUBENSHI, JIANJIANINDIANA UNIVERSITY INDIANAPOLIS, IN$222,296ZCA1
2022Super-Resolution Imaging of Higher-Order Heterochromatin Structure for Early Detection of Lung Carcinogenesis1R21CA259787-01A1LIU, YANGUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$222,122ZCA1
2022Bacterial DNA as a Diagnostic Biomarker of Hepatocellular Carcinoma1R21CA259921-01A1ZARRINPAR, AMIRUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$221,595ZCA1
2022Precision Genetic RNAi Medicines to Treat Metastatic Triple-Negative Breast Cancer (TNBC)1R21CA267883-01DOWDY, STEVEN FUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$221,595ZCA1
2022Application of in vivo humanized PDX mouse model and ex vivo organoid model to assess the therapeutic efficacy of combinatorial therapy for pseudomyxoma peritonei1R21CA259243-01A1LEE, YONG JUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$220,953ZCA1
2022pSer784-VCP: a clinically relevant link between autophagy and DNA damage response1R21CA263435-01A1SHAO, JIEYAWASHINGTON UNIVERSITY, MO$220,894ZCA1
2022Metabolic modulation of alkylating agent efficacy in MEK inhibitor resistant thyroid cancers.1R21CA274046-01PAPANDREOU, IOANNAOHIO STATE UNIVERSITY, OH$220,894ZCA1
2022Targeting Tryptophan Dioxygenase Degradation for Suppression of Tumor Immune Evasion1R21CA270879-01ALTMAN, RYAN ALIU, AIMINPURDUE UNIVERSITY, IN$220,632ZCA1
2022Tumor-specific anti-angiogenic anti-CD70-FGF/VEGF-trap fusion antibodies for renal cancer therapy1R21CA263362-01A1MAKHOV, PETR B.RESEARCH INST OF FOX CHASE CAN CTR, PA$219,725ZCA1
2022Modulation of the human pancreatic microenvironment by combined cytokine and immune checkpoint blockade1R21CA266088-01EL-RAYES, BASSELLESINSKI, GREGORY B.EMORY UNIVERSITY, GA$219,491ZCA1
2022Mechanisms underlying radiation-induced dysphagia1R21CA263107-01A1KING, SUZANNE N.UNIVERSITY OF LOUISVILLE, KY$219,491ZCA1
2022Novel strategies to target lung cancer metastasis to bone1R21CA267612-01A1BECK, GEORGE R.EMORY UNIVERSITY, GA$219,491ZCA1
2022Contrast-Enhanced Ultrasound for Diagnosis and Therapy of Cholangiocarcinoma1R21CA259750-01A1ANTON, KEVINEISENBREY, JOHNTHOMAS JEFFERSON UNIVERSITY, PA$218,790ZCA1
2022ER stress pathways regulate T-cell allogeneic and anti-tumor responses1R21CA263140-01A1YU, XUE-ZHONGMEDICAL COLLEGE OF WISCONSIN, WI$218,790ZCA1
2022Lymphatic delivery of immunotherapy to prevent irAEs1R21CA267263-01A1SEVICK, EVA M.UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$218,790ZCA1
2022Development of Novel Combination Strategies to Overcome Resistance to KRASG12C Inhibition in Colorectal Cancers1R21CA267412-01A1LEOPOLD, JUDITH SUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$218,790ZCA1
2022Ex vivo generation of tumor-reactive T cells for adoptive cell transfer using an immune enhanced, patient derived tumor organoid-on-a-chip (iTOC)1R21CA263137-01A1BEANE, JOAL DSKARDAL, ALEKSANDEROHIO STATE UNIVERSITY, OH$218,513ZCA1
2022CD117-Targeted Radioimmunotherapy with Astatine-211 for Acute Myeloid Leukemia and Myelodysplastic Syndrome1R21CA245598-01A1WALTER, ROLAND BRUNOFRED HUTCHINSON CANCER CENTER, WA$218,488ZCA1
2022Novel Sequencing Based Diagnostics for Leukemia in Low Resource Settings1R21CA259926-01A1ALEXANDER, THOMAS BLICKWANG, JEREMY RUNIV OF NORTH CAROLINA CHAPEL HILL, NC$218,089ZCA1
2022Impact of Obesity on Immuno-Oncology Agents in Endometrial Cancer1R21CA267584-01BAE-JUMP, VICTORIA LINZAMBONI, WILLIAM CUNIV OF NORTH CAROLINA CHAPEL HILL, NC$218,089ZCA1
2022Organoid modeling of pre-metastatic niche formation in the liver by primary colorectal tumor secreted factors1R21CA259766-01A1SKARDAL, ALEKSANDERTSUNG, ALLANOHIO STATE UNIVERSITY, OH$218,068ZCA1
2022Mechanisms of immune control of intratumor heterogeneity and clonal competition1R21CA270610-01TALOS, FLAMINIASTATE UNIVERSITY NEW YORK STONY BROOK, NY$217,410ZCA1
2022Effects of exercise during platinum chemotherapy on neuropathy: examining the interoceptive brain system and inflammation1R21CA259422-01A1KLECKNER, IAN ROBERTUNIVERSITY OF MARYLAND BALTIMORE, MD$216,686ZCA1
2022Targeting of eIF4A along with immunotherapy to overcome chemoresistance1R21CA256462-01A1RAMAN, DAYANIDHIUNIVERSITY OF TOLEDO HEALTH SCI CAMPUS, OH$216,686ZCA1
2022Identification of luteolin as a BRAF-degrading molecule for developing new therapeutic agents1R21CA252393-01A1LIU-SMITH, FENGUNIVERSITY OF TENNESSEE HEALTH SCI CTR, TN$215,985ZCA1
2022Re-designing anti-CD20 monoclonal antibody therapy using novel insights into limitations of innate immune cytotoxicity1R21CA267040-01A1ZENT, CLIVE STEVENUNIVERSITY OF ROCHESTER, NY$215,985ZCA1
2022Robust Causal Comparisons of Nonrandomized Oncology Studies1R21CA270585-01TAN, MING TONYGEORGETOWN UNIVERSITY, DC$215,910ZCA1
2022CD147-CAR-NK Cells for Hepatocellular Carcinoma Treatment1R21CA267368-01LIU, DONGFANGRBHS-NEW JERSEY MEDICAL SCHOOL, NJ$215,585ZCA1
2022DNA methylation, Liquid Biopsy, and Pancreatic Cancer1R21CA263132-01A1FUTSCHER, BERNARD WNELSON, MARK ANTHONYSHROFF, RACHNAUNIVERSITY OF ARIZONA, AZ$215,284ZCA1
2022Microbiota-mediated enhancement of the anti-tumor effect of natural killer cells1R21CA263462-01A1JOBIN, CHRISTIANTHOMAS, RYAN M.UNIVERSITY OF FLORIDA, FL$213,881ZCA1
2022Preventing Therapeutic Resistance in RAS-mutated Pediatric Cancers1R21CA267515-01KORTUM, ROBERTHENRY M. JACKSON FDN FOR THE ADV MIL/MED, MD$213,876ZCA1
2022Developing a patient derived model platform to treat BRCA1/2-mutant pancreatic cancers1R21CA263996-01A1BRODY, JONATHANSEARS, ROSALIE COREGON HEALTH & SCIENCE UNIVERSITY, OR$210,688ZCA1
2022Developing corrector small molecules for reactivation of mutant p53 in cancer1R21CA267495-01A1KAISER, PETERRYCHNOVSKY, SCOTT D.UNIVERSITY OF CALIFORNIA-IRVINE, CA$210,003ZCA1
2022Advancing Bladder Cancer Care by Imaging and Intravesical Immune Checkpoint Blockade1R21CA263243-01A1TYAGI, PRADEEPUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$209,468ZCA1
2022Targeted neuroendocrine cancer therapy using Verrucarin A1R21CA256151-01A1JASKULA-SZTUL, RENATALIU, XIAOGUANG MARGARETUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$208,271ZCA1
2022Modeling Dynamic Immune Cell Modulation in a 3-D Tissue Engineered Platform to Enhance Patient-specific Immunotherapy for Lung Cancer1R21CA263365-01A1DESHANE, JESSY SATYADASUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$208,271ZCA1
2022Exosomal Thomsen-Friedenreich glycoantigen as a new biomarker for lung cancer screening and early detection1R21CA267934-01A1DY, GRACERITTENHOUSE-OLSON, KATE WWU, YUNSTATE UNIVERSITY OF NEW YORK AT BUFFALO, NY$207,953ZCA1
2022Targeting the ENL YEATS domain for the development of anti-leukemia agents1R21CA267512-01LIU, WENSHE RAYTEXAS A&M UNIVERSITY, TX$207,486ZCA1
2022Targeting MUC16 transactivation for ovarian cancer treatment1R21CA267570-01WANG, EDWARD WENGEBECKMAN RESEARCH INSTITUTE/CITY OF HOPE, CA$205,700ZCA1
2022The microbiome ecosystem of Barrett's esophagus and progression to cancer1R21CA259687-01A1PAULSON, THOMAS GFRED HUTCHINSON CANCER CENTER, WA$205,700ZCA1
2022Novel biologics platform for targeting tumors driven by intracellular oncoproteins1R21CA267362-01KOIDE, SHOHEINEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$198,103ZCA1
2022Neoadjuvant anti-PD-1 immunotherapy and Stereotactic Radiation in Patients with Recurrent Glioblastoma1R21CA256421-01A1PATIL, CHIRAG GADKARYSHIAO, STEPHEN L.CEDARS-SINAI MEDICAL CENTER, CA$195,181ZCA1
2022R21: A novel antibody-drug conjugate for treatment of squamous cell lung carcinoma1R21CA273645-01GRINSTAFF, MARK W.BOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$192,844ZCA1
2022Off-the-shelf CAR-T Therapy via Tumor-Selective Immuno-engagers1R21CA267087-01SNOOK, ADAMTHEVENIN, DAMIENLEHIGH UNIVERSITY, PA$191,901ZCA1
2022A high-throughput screen for inhibitors of Plk1-interacting checkpoint helicase (PICH)1R21CA259718-01A1AZUMA, YOSHIAKICLARKE, DUNCAN J.UNIVERSITY OF MINNESOTA, MN$191,885ZCA1

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