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NIH funding notice PAR-21-133

First in Human and Early Stage Clinical Trials of Novel Investigational Drugs or Devices for Psychiatric Disorders (U01 Clinical Trial Required)

Closed on October 15, 2024.

Posted
March 2, 2021
Close date
October 15, 2024
Activity codes
U01
Institutes taking part
NIMH

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PAR-18-427 First in Human and Early Stage Clinical Trials of Novel Investigational Drugs or Devices for Psychiatric Disorders (U01-Clinical Trial Required)
  2. 2 steps back: PAR-17-327 First in Human and Early Stage Clinical Trials of Novel Investigational Drugs or Devices for Psychiatric Disorders (U01)
  3. 3 steps back: PAR-14-107 First in Human and Early Stage Clinical Trials of Novel Investigational Drugs for Psychiatric Disorders (U01)
  4. 4 steps back: PAR-12-007 Innovative Pilot Studies of Novel Mechanism of Action Compounds for Treating Psychiatric Disorders (U01)
  5. 5 steps back: PAR-11-316 Innovative Pilot Studies of Novel Mechanism of Action Compounds for Treating Psychiatric Disorders (U01)

Replaced by PAR-25-180.

Who won it before

6 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $4,440,701 in first-year total cost, median $729,032.

Most frequent study sections

  1. Special Emphasis Panel[ZMH1 ERB-B (01)]2
  2. Special Emphasis Panel[ZMH1 ERB-L (05)]2
  3. Special Emphasis Panel[ZMH1 ERB-D (04)]1
  4. Special Emphasis Panel[ZMH1 ERB-S (03)]1

Most frequent institutions

  1. COLUMBIA UNIVERSITY HEALTH SCIENCES1
  2. JOHNS HOPKINS UNIVERSITY1
  3. OCEAN STATE RESEARCH INSTITUTE, INC.1
  4. OHIO STATE UNIVERSITY1
  5. UNIVERSITY OF NEBRASKA MEDICAL CENTER1
Competing awards under PAR-21-133 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2024Use of alpha-frequency deep transcranial interference stimulation (tIS) to understand and modify temporal dynamics of face emotion recognition and social/affective function.1U01MH135436-01JAVITT, DANIEL C.JUCHEM, CHRISTOPHSEHATPOUR, PEJMANCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$1,045,140ZMH1
2023Deep Brain Stimulation for Chronic Auditory Hallucinations in Treatment-Resistant Schizophrenia: an early-stage clinical trial1U01MH130625-01A1CASCELLA, NICOLA GJOHNS HOPKINS UNIVERSITY, MD$794,858ZMH1
2022Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) Trial1U01MH128483-01 · under PAR-18-427LENZE, ERIC JPALANCA, BEN JULIANWASHINGTON UNIVERSITY, MO$703,237ZMH1
2022Magnetic Resonance-guided Focused Ultrasound Ablation of the Anterior Thalamus as a Novel Treatment Paradigm for Anxiety1U01MH128677-01 · under PAR-18-427LUCAS, TIMOTHY HPHAN, K. LUANOHIO STATE UNIVERSITY, OH$532,134ZMH1
2021Low intensity focused ultrasound: a new paradigm for depression and anxiety1U01MH123427-01A1 · under PAR-18-427PHILIP, NOAH STEPHENOCEAN STATE RESEARCH INSTITUTE, INC., RI$610,506ZMH1
2020Dose-Response Relationship and Pharmacokinetics of Intranasal Oxytocin on Neural Impact in Youths with High Levels of Irritability1U01MH120155-01A1 · under PAR-18-427HWANG, SOONJOSHAFFER, CHRISTOPHER LEEUNIVERSITY OF NEBRASKA MEDICAL CENTER, NE$754,826ZMH1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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