Skip to main content
NIH funding notice PAR-21-135

Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33 Clinical Trial Required)

Closed on October 15, 2024.

Posted
March 2, 2021
Close date
October 15, 2024
Activity codes
R61, R33
Institutes taking part
NIMH

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: RFA-MH-18-704 Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33- Clinical Trial Required)
  2. 2 steps back: RFA-MH-17-604 Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33)
  3. 3 steps back: RFA-MH-16-406 Exploratory Clinical Trials of Novel Interventions for Mental Disorders (R61/R33)
  4. 4 steps back: RFA-MH-15-300 Exploratory Clinical Trials of Novel Interventions for Mental Disorders (R21/R33)

Replaced by PAR-25-182.

Who won it before

82 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $58,509,278 in first-year total cost, median $703,334.

Most frequent study sections

  1. Special Emphasis Panel[ZMH1 ERB-D (01)]16
  2. Special Emphasis Panel[ZMH1 ERB-D (03)]10
  3. Special Emphasis Panel[ZMH1 ERB-D (02)]6
  4. Special Emphasis Panel[ZMH1 ERB-D (05)]6
  5. Special Emphasis Panel[ZMH1 ERB-D (09)]6

Most frequent institutions

  1. UNIVERSITY OF CALIFORNIA, SAN DIEGO7
  2. DUKE UNIVERSITY4
  3. UNIVERSITY OF CALIFORNIA LOS ANGELES4
  4. VANDERBILT UNIVERSITY4
  5. YALE UNIVERSITY4
Competing awards under PAR-21-135 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025Developing pregnancy-specific dialectical behavior therapy skills to promote multigenerational mental health1R61MH138444-01CONRADT, LIZ DCROWELL, SHEILA E.DUKE UNIVERSITY, NC$1,440,659ZMH1
2025A Virtual Reality Mindfulness Application for Aggression in Schizophrenia1R61MH133785-01A1KHAN, ANZALEENATHAN S. KLINE INSTITUTE FOR PSYCH RES, NY$656,078ZMH1
2024Mindfulness-based Neurofeedback to augment DBT psychotherapy for adults with Borderline Personality Disorder (MIND-BPD)1R61MH135009-01A1FINEBERG, SARAH KWHITFIELD-GABRIELI, SUSANYALE UNIVERSITY, CT$1,096,439ZMH1
2024Using Exercise to Enhance Consolidation of Exposure-Based Therapeutic Learning in PTSD1R61MH132722-01A1ADAMS, THOMAS GBADOUR, CHRISTAL L.CISLER, JOSHUA MUNIVERSITY OF KENTUCKY, KY$1,081,024ZMH1
2024Targeting Minority Stressors to Improve Eating Disorder Symptoms in Sexual Minority Individuals with Eating Disorders1R61MH133710-01A1BLASHILL, AARON JBROWN, TIFFANY ASHTONAUBURN UNIVERSITY AT AUBURN, AL$978,986ZMH1
2024Engaging Higher-Order Mechanisms of Psychopathology: A Parsimonious Approach to Precision Medicine1R61MH133665-01A1SAUER-ZAVALA, SHANNON ESOUTHWARD, MATTHEW WAYNEUNIVERSITY OF KENTUCKY, KY$870,793ZMH1
2024Optimizing Cognitive Behavioral Social Skills Training with Executive Function Training for Older Adults with Schizophrenia1R61MH132859-01A1GRANHOLM, ERIC LRAJJI, TAREK KHALILUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$773,920ZMH1
2024Evaluation of a brief, scalable module to mitigate suicidal ideation among youth1R61MH137300-01BUITRON, VICTORPETTIT, JEREMY WFLORIDA INTERNATIONAL UNIVERSITY, FL$463,038ZMH1
2023Real time neurofeedback, its neurotransmitter underpinnings, and therapeutic effects, in clinical high risk individuals1R61MH129479-01A1LIN, ALEXANDER PETERNIZNIKIEWICZ, MARGARET AWHITFIELD-GABRIELI, SUSANBOSTON VA RESEARCH INSTITUTE, INC., MA$1,214,504ZMH1
2023Cognitive and neural mechanisms of cognitive-behavioral therapy for avoidant/restrictive food intake disorder1R61MH129331-01A1EDDY, KAMRYN TLAWSON, ELIZABETH AUSTENTHOMAS, JENNIFER JOANNEMASSACHUSETTS GENERAL HOSPITAL, MA$1,082,983ZMH1
2023Targeting adolescent depression symptoms using network-based real-time fMRI neurofeedback and mindfulness meditation1R61MH132072-01AUERBACH, RANDY PATRICKWHITFIELD-GABRIELI, SUSANNORTHEASTERN UNIVERSITY, MA$1,043,995ZMH1
2023Cognitive control targets for the treatment of obsessive compulsive disorder in young children1R61MH129544-01A1FITZGERALD, KATE DIMONDMARSH, RACHELPAGLIACCIO, DAVIDCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$913,595ZMH1
2023ActiveCBT for depression: Transforming treatment through exercise priming1R61MH129407-01A1MEYER, JACOB DIOWA STATE UNIVERSITY, IA$751,796ZMH1
2023iTEST: Introspective Accuracy as a Novel Target for Functioning in Psychotic Disorders1R61MH129379-01A1DEPP, COLIN A.PINKHAM, AMYUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$738,051ZMH1
2023Reward Responsiveness as a Prevention Target in Youth At Risk for Anhedonia1R61MH131751-01A1BURKHOUSE, KATIE LKUJAWA, AUTUMN JVANDERBILT UNIVERSITY, TN$736,838ZMH1
2023Promoting Social Connection to Prevent Late-Life Suicide1R61MH129476-01A1VAN ORDEN, KIMBERLY ALLISONUNIVERSITY OF ROCHESTER, NY$638,667ZMH1
2023Development of a Novel Virtual Reality Treatment for Emerging Adults with ADHD1R61MH131632-01A1LANGBERG, JOSHUA MORRISSHEPHERD, DAVID CARROLLRUTGERS, THE STATE UNIV OF N.J., NJ$599,189ZMH1
2022FlexED: A Digital, Gamified Early Intervention for Eating Disorders1R61MH127137-01A1MERWIN, RHONDA MDUKE UNIVERSITY, NC$967,928ZMH1
2022A Mobile Intervention for Suicide Prevention For Middle-aged And Older Adults After a Suicide-Related Hospitalization1R61MH128516-01 · under RFA-MH-18-704KIOSSES, DIMITRIS NWEILL MEDICAL COLL OF CORNELL UNIV, NY$839,444ZMH1
2022Reducing neural perseveration through closed loop real time fMRI neurofeedback to alleviate depressive symptoms1R61MH128492-01 · under RFA-MH-18-704SHELINE, YVETTE IUNIVERSITY OF PENNSYLVANIA, PA$822,021ZMH1
2022Context-Aware Mobile Intervention for Social Recovery in Serious Mental Illness1R61MH126094-01A1 · under RFA-MH-18-704DEPP, COLIN A.GRANHOLM, ERIC LUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$788,041ZMH1
2022Neural Mechanisms of Response Inhibition Training for Obsessive-Compulsive Disorder and Related Conditions1R61MH125127-01A1LARSON, CHRISTINE LLEE, HAN JOOUNIVERSITY OF WISCONSIN MILWAUKEE, WI$743,895ZMH1
2022Evaluating the Efficacy of Central Executive Training (CET) For Young Children With ADHD1R61MH127031-01A1KOFLER, MICHAEL JFLORIDA STATE UNIVERSITY, FL$668,370ZMH1
2021Cognitive Reappraisal Training Targeting Emotion Circuits As a Therapeutic Intervention in Borderline Patients1R61MH125130-01A1 · under RFA-MH-18-704KOENIGSBERG, HAROLD WICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$980,782ZMH1
2021Behavioral and Neural Target Engagement for ADHD Executive Working Memory Training1R61MH122444-01A1 · under RFA-MH-18-704STEVENS, MICHAEL CHARTFORD HOSPITAL, CT$738,388ZMH1
2021Retraining and Control Therapy (ReACT): Sense of control and catastrophic symptom expectations as targets of a cognitive behavioral treatment for pediatric psychogenic non-epileptic seizures (PNES)1R61MH127155-01 · under RFA-MH-18-704FOBIAN, AARON DUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$691,710ZMH1
2021Enhancing transdiagnostic mechanisms of cognitive dyscontrol using computer-based training1R61MH127005-01 · under RFA-MH-18-704BOMYEA, JESSICAUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$631,240ZMH1
2021Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk in Adolescents at Clinical High Risk for Psychosis1R61MH123574-01A1 · under RFA-MH-18-704CARRION, RICARDOCORNBLATT, BARBARA A.FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, NY$539,015ZMH1
2020Study of a PST-Trained Voice-Enabled Artificial Intelligence Counselor (SPEAC) for Adults with Emotional Distress1R61MH119237-01A1 · under RFA-MH-18-704AJILORE, OLUSOLA A.MA, JUNUNIVERSITY OF ILLINOIS AT CHICAGO, IL$2,112,494ZMH1
2020Neurofeedback and Neural Plasticity of Self-Processing and Affect Regulation Circuits in Suicide Attempting Adolescents1R61MH122634-01 · under RFA-MH-18-704MENDOZA QUEVEDO, KARINAUNIVERSITY OF MINNESOTA, MN$1,032,349ZMH1
2020A Novel Use of a Sleep Intervention to Target the Emotion Regulation Brain Network and Treat Depression and Anxiety1R61MH120245-01A1 · under RFA-MH-18-704GOLDSTEIN-PIEKARSKI, ANDREASTANFORD UNIVERSITY, CA$944,204ZMH1
2020Targeting negative affect through mindfulness training in youth at risk for internalizing problems1R61MH119270-01A1 · under RFA-MH-18-704ADAM, EMMA KCHAVIRA, DENISE ACRASKE, MICHELLE GGARBER, JUDYZINBARG, RICHARD EVANDERBILT UNIVERSITY, TN$939,935ZMH1
2020Suicide Prevention for Sexual and Gender Minority Youth1R61MH120236-01A1 · under RFA-MH-18-704BLASHILL, AARON JWELLS, KRISTEN JENNIFERSAN DIEGO STATE UNIVERSITY, CA$714,957ZMH1
2020Cognitive Training for Emotion Regulation in Psychotic Disorders1R61MH121560-01 · under RFA-MH-18-704STRAUSS, GREGORY PUNIVERSITY OF GEORGIA, GA$622,490ZMH1
2020Treatment of Stress-Related Psychopathology: Targeting Maladaptive and Adaptive Event Processing1R61MH118401-01A1 · under RFA-MH-18-704FEENY, NORAH CHAYES, ADELEZOELLNER, LORI ACASE WESTERN RESERVE UNIVERSITY, OH$586,511ZMH1
2020Facial Affect Sensitivity Training for young children with CU traits.1R61MH117192-01A1 · under RFA-MH-18-704WHITE, BRADLEYUNIVERSITY OF ALABAMA IN TUSCALOOSA, AL$380,283ZMH1
2020Threat Interpretation Bias as Cognitive Marker and Treatment Target in Pediatric Anxiety1R61MH121552-01 · under RFA-MH-18-704ROZENMAN, MICHELLE SHERRYUNIVERSITY OF DENVER (COLORADO SEMINARY), CO$223,617ZMH1
2019Virtual Reality to Improve Social Perspective Taking in Youth with Disruptive Behavior Disorders1R61MH119291-01 · under RFA-MH-18-704HUMMER, THOMAS AINDIANA UNIVERSITY INDIANAPOLIS, IN$796,274ZMH1
2019Shifting Perspectives: Enhancing outcomes in adolescent anorexia nervosa with cognitive remediation therapy1R61MH119262-01 · under RFA-MH-18-704TIMKO, C. ALIXCHILDREN'S HOSP OF PHILADELPHIA, PA$739,343ZMH1
2019Social Media-Based Parenting Program for Women with Postpartum Depressive Symptoms1R61MH118405-01A1 · under RFA-MH-18-704BOYD, RHONDA CGUEVARA, JAMES PCHILDREN'S HOSP OF PHILADELPHIA, PA$630,895ZMH1
2019A Novel Neuromonitoring Guided Cognitive Intervention for Targeted Enhancement of Working Memory1R61MH119289-01 · under RFA-MH-18-704HOSSEINI, HADISTANFORD UNIVERSITY, CA$322,260ZMH1
2018Reward Sensitivity as a Mechanism of Positive Affect Treatment for Anhedonia1R61MH115138-01 · under RFA-MH-17-604CRASKE, MICHELLE GMEURET, ALICIA ESPERANZAUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$876,168ZMH1
2018Developing rumination-focused treatment to reduce risk for depression recurrence (RDR) in adolescence1R61MH116080-01 · under RFA-MH-17-604LANGENECKER, SCOTT AWATKINS, EDWARDUNIVERSITY OF ILLINOIS AT CHICAGO, IL$872,656ZMH1
2018Real-time fMRI Neurofeedback as a Tool to Mitigate Auditory Hallucinations in Patients with Schizophrenia1R61MH113751-01A1 · under RFA-MH-17-604NIZNIKIEWICZ, MARGARET AWHITFIELD-GABRIELI, SUSANHARVARD MEDICAL SCHOOL, MA$780,322ZMH1
2018Visual Remediation in Schizophrenia1R61MH115119-01 · under RFA-MH-17-604KAHN, PAMELA BUTLERSILVERSTEIN, STEVEN MRUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS, NJ$777,702ZMH1
2018Brain response associated with parent-based treatment for childhood anxiety disorders1R61MH115113-01A1 · under RFA-MH-17-604GEE, DYLAN GRACELEBOWITZ, ELIYALE UNIVERSITY, CT$758,175ZMH1
2018Gaze-contingent music reward therapy for social anxiety1R61MH116089-01 · under RFA-MH-17-604SCHNEIER, FRANKLIN R.NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC, NY$648,489ZMH1
2018Amygdala rtfMRI Neurofeedback for Treatment Resistant Depression1R61MH115927-01 · under RFA-MH-17-604YOUNG, KYMUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$607,337ZMH1
2018Neurofeedback of amygdala activity for PTSD1R61MH115110-01A1 · under RFA-MH-17-604HAMPSON, MICHELLEHARPAZ-ROTEM, ILANYALE UNIVERSITY, CT$577,144ZMH1
2018Treating Phobia with Multivoxel Neuro-reinforcement1R61MH113772-01A1 · under RFA-MH-17-604CRASKE, MICHELLE GLAU, HAKWANUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$465,850ZMH1
2018Social Cognitive Training to Enhance the Efficacy of CBT for Depression in Youth: A Developmental Approach1R61MH115125-01A1 · under RFA-MH-17-604GARBER, JUDYVANDERBILT UNIVERSITY, TN$304,062ZMH1
2017Imaging-guided tDCS therapy in major depression1R61MH110526-01A1 · under RFA-MH-16-406NARR, KATHERINE LWANG, DANNY JJUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$1,083,270ZMH1
2017Developing Neuronal KCNQ Channel Modulators for Mood Disorders1R61MH111932-01 · under RFA-MH-16-406MURROUGH, JAMES WARRENICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$835,810ZMH1
2017Identifying neural mechanisms of PTSD symptom reduction induced by combined estrogen and prolonged exposure therapy1R61MH111907-01 · under RFA-MH-16-406MILAD, MOHAMMED RUNIVERSITY OF ILLINOIS AT CHICAGO, IL$794,098ZMH1
2017Development of A Novel Transdiagnostic Intervention for Anhedonia1R61MH110027-01A1 · under RFA-MH-16-406DICHTER, GABRIEL SSMOSKI, MORIA J.UNIV OF NORTH CAROLINA CHAPEL HILL, NC$751,002ZMH1
2017Brain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART)1R61MH111929-01A1 · under RFA-MH-16-406BLUMBERG, HILARY PATRICIAYALE UNIVERSITY, CT$749,522ZMH1
2017Novel Behavioral Intervention to Target Social Reward Sensitivity and Attachment1R61MH113769-01 · under RFA-MH-16-406TAYLOR, CHARLESUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$748,183ZMH1
2017Effects of THC on Retention of Memory for Fear Extinction Learning in PTSD1R61MH111935-01 · under RFA-MH-16-406RABINAK, CHRISTINE ANNEWAYNE STATE UNIVERSITY, MI$732,733ZMH1
2017Target Engagment of a Novel Dissonance-Based Treatment for DSM-5 Eating Disorders.1R61MH111782-01A1 · under RFA-MH-16-406STICE, ERIC MOREGON RESEARCH INSTITUTE, OR$678,712ZMH1
2017Glutamate reducing interventions in schizophrenia1R61MH112800-01 · under RFA-MH-16-406SMALL, SCOTT ACOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$648,967ZMH1
2017Virtual Reality Attention Management Program for Improving Attention in Children1R61MH110043-01A1 · under RFA-MH-16-406SCHWEITZER, JULIE B.UNIVERSITY OF CALIFORNIA AT DAVIS, CA$564,074ZMH1
2017Levetiracetamin in First Episode Psychosis1R61MH112833-01 · under RFA-MH-16-406GOFF, DONALD C.NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$512,748ZMH1
2017Enhancing Gamma Band Response in Schizophrenia to Improve Working Memory1R61MH112793-01 · under RFA-MH-16-406SINGH, FIZAUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$478,738ZMH1
2017Brain plasticity underlying acquisition of new organizational skills in children1R61MH113663-01 · under RFA-MH-16-406CASTELLANOS, FRANCISCO XAVIERNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$448,590ZMH1
2017The DMPFC as a target in treatment-resistant Bulimia Nervosa and Anorexia Nervosa:investigating target engagement, dosing, reliability and duration of effect using rTMS, fMRI,and a sham controlled arm1R61MH110034-01A1 · under RFA-MH-16-406DOWNAR, JONATHAN ALEXANDER STEWARTWOODSIDE, D BLAKEUNIVERSITY HEALTH NETWORK, ON$435,853ZMH1
2017Transcranial laser stimulation of prefrontal metabolism in post-traumatic stress disorder1R61MH113721-01 · under RFA-MH-16-406TIAN, FENGHUAUNIVERSITY OF TEXAS ARLINGTON, TX$228,750ZMH1
2016NMDA receptor modulation for hyperarousal in PTSD1R61MH110540-01 · under RFA-MH-16-406MATHEW, SANJAY JBAYLOR COLLEGE OF MEDICINE, TX$718,188ZMH1
2016A Computerized Intervention Targeting Cognitive Control Network Deficits in Depression1R61MH110509-01 · under RFA-MH-16-406ANGUERA, JOAQUIN AAREAN, PATRICIA A.GUNNING, FAITH MUNIVERSITY OF WASHINGTON, WA$674,022ZMH1
2016Mobile-Assisted Cognitive Behavior Therapy for Negative Symptoms in Schizophrenia1R61MH110019-01 · under RFA-MH-16-406GRANHOLM, ERIC LUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$670,663ZMH1
2016Increasing Motivation in ADHD Via Self-activation of VTA1R61MH106751-01A1 · under RFA-MH-15-300ADCOCK, RACHEL ALISONKOLLINS, SCOTT HDUKE UNIVERSITY, NC$667,315ZMH1
2016Targeting Dopaminergic Mechanisms of Slowing to Improve Late Life Depression1R61MH110029-01 · under RFA-MH-16-406RUTHERFORD, BRET RNEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC, NY$656,706ZMH1
2016A Novel Cognitive Reappraisal Intervention for Suicide Prevention1R61MH110542-01 · under RFA-MH-16-406KIOSSES, DIMITRIS NWEILL MEDICAL COLL OF CORNELL UNIV, NY$630,060ZMH1
2016Using Serious Game Technology to Improve Sensitivity to Eye Gaze in Autism1R61MH110624-01 · under RFA-MH-16-406SCHERF, KATHRYN SUZANNEPENNSYLVANIA STATE UNIVERSITY, THE, PA$549,224ZMH1
2016Preventing Internalizing Psychopathology in Preadolescents Exposed to Chronic Stress1R21MH107631-01 · under RFA-MH-15-300WADSWORTH, MARTHA EPENNSYLVANIA STATE UNIVERSITY, THE, PA$522,538ZMH1
2016Prefrontal Cortical Engagement and Clinical Effects of non-invasive Direct Current Stimulation for Cognitive Control Impairments in Schizophrenia1R61MH110044-01 · under RFA-MH-16-406CHO, RAYMOND YUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$425,430ZMH1
2016Physiology-based virtual reality training for social skills in schizophrenia1R21MH106748-01A1 · under RFA-MH-15-300PARK, SOHEESARKAR, NILANJANVANDERBILT UNIVERSITY, TN$417,200ZMH1
2016Dopamine enhancement of fear extinction learning in PTSD1R21MH108753-01 · under RFA-MH-15-300CISLER, JOSHUA MUNIV OF ARKANSAS FOR MED SCIS, AR$386,320ZMH1
2015EEG/fMRI Controlled TMS Real-time Neural Feedback in Anti-Depressive Treatment1R21MH106775-01 · under RFA-MH-15-300BROWN, TRUMAN RMEDICAL UNIVERSITY OF SOUTH CAROLINA, SC$722,721ZMH1
2015Transcranial Direct Current Stimulation (tDCS) as a Treatment for Acute Fear1R21MH106772-01 · under RFA-MH-15-300KRYSTAL, ANDREW DDUKE UNIVERSITY, NC$465,109ZMH1
2015The effects of ondansetron on neural systems and symptoms associated with sensory phenomena1R21MH107589-01 · under RFA-MH-15-300STERN, EMILY RICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$447,077ZMH1
2015Enhancing Social Cognitive Training with Oxytocin: Linking Target Engagement to Clinical Effects1R21MH107564-01 · under RFA-MH-15-300MARDER, STEPHEN RUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$336,989ZMH1
2015Graduated sensory salience as an intervention for intrusive negative thinking1R21MH106591-01 · under RFA-MH-15-300SIEGLE, GREG JUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$323,760ZMH1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

ScienceDex for faculty

Your academic CV and NIH biosketch

Make your CV in your school's format and your NIH biosketch from it, then download both as Word files.