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NIH funding notice PAR-22-126

Technology Development Research for Establishing Feasibility and Proof of Concept (R21 - Clinical Trial Not Allowed)

Closed on November 22, 2024.

Posted
March 21, 2022
Close date
November 22, 2024
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

52 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $14,575,165 in first-year total cost, median $237,216.

Most frequent study sections

  1. Genomics, Computational Biology and Technology Study Section[GCAT]5
  2. Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]4
  3. Macromolecular Structure and Function B Study Section[MSFB]4
  4. Special Emphasis Panel[ZRG1 BBBT-M (82)]4
  5. Biochemistry and Biophysics of Membranes Study Section[BBM]3

Most frequent institutions

  1. JOHNS HOPKINS UNIVERSITY2
  2. STANFORD UNIVERSITY2
  3. UNIVERSITY OF CALIFORNIA, SAN DIEGO2
  4. WAKE FOREST UNIVERSITY HEALTH SCIENCES2
  5. ARIZONA STATE UNIVERSITY-TEMPE CAMPUS1
Competing awards under PAR-22-126 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025A knowledge-guided analysis approach to recovering rare signals from single-cell transcriptomic data1R21GM159319-01YIP, YUK-LAP KEVINSANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, CA$536,250ZRG1
2025Development of a model for determining fluid bilayer structure from cryo-EM images of biomembranes.1R21GM160845-01HEBERLE, FREDERICK AWAXHAM, M. NEALUNIVERSITY OF TENNESSEE KNOXVILLE, TN$436,547BBM
2025Efficient and accessible platform for spatial transcriptomics1R21GM159205-01BROUZES, ERICSTATE UNIVERSITY NEW YORK STONY BROOK, NY$436,001ZRG1
2025Develop a technology for whole-genome sequencing of RNA-DNA triplexes1R21GM160927-01LIU, YUUNIVERSITY OF HOUSTON, TX$435,412GCAT
2025Centrifugal microfluidic system for functional cellular analysis1R21GM157641-01ROPER, MICHAEL GABRIELFLORIDA STATE UNIVERSITY, FL$432,800ISD
2025DNA Transistors for Cellular Programming1R21GM159202-01NAKAUCHI, HIROMITSUSTANFORD UNIVERSITY, CA$427,079CMT
2025Enabling Focused Ultrasound-Activated Gene Editing with Thermo-Controlled CRISPR-Cas91R21GM159300-01GAGNON, KEITH THOMASWAKE FOREST UNIVERSITY HEALTH SCIENCES, NC$421,811DBTD
2025Single Molecule Glycosaminoglycan Sequencing using Lysosomal Enzymes1R21GM160865-01WANG, XUARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$413,036EBIT
2025Development of tools for directed evolution of high-specificity, high-efficiency recombinases1R21GM160921-01FOSTER, MARK P.MAGLIERY, THOMAS JOHIO STATE UNIVERSITY, OH$408,633CBP
2025Codon-specific isotope labeling for NMR resonance assignment1R21CA304761-01HARTMAN, MATTHEW CZIAREK, JOSHUA JAMESVIRGINIA COMMONWEALTH UNIVERSITY, VA$403,586MSFB
2025Optimizing RNA import for microinjection-free genetic manipulation in C. elegans1R21GM159351-01SAN MIGUEL, ADRIANANORTH CAROLINA STATE UNIVERSITY RALEIGH, NC$398,774ZRG1
2025Bioorthogonal Chemical Probe for Live Cell Imaging of Lactylation1R21GM160866-01AGATEMOR, CHRISTIANBUCKNELL UNIVERSITY, PA$378,672EBIT
2025Nanoscale biosensor arrays for biomolecule analysis1R21GM160870-01VARADARAJALU, GANESHKUMARMOLARITI INC, MA$316,250ZRG1
2025High-speed, real-time feedback-driven single particle tracking with concurrent smFRET1R21GM157695-01ANDERSSON, SEAN B.BOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$216,675ISD
2025Ready, set, then go: Rapid posttranslational induction of protein production by drug administration in vivo1R21GM157668-01LIN, MICHAEL Z.STANFORD UNIVERSITY, CA$192,500CMT
2025Tools for probing the physical paralipidome of membrane proteins1R21CA300756-01LEVENTAL, KANDICE ROSEUNIVERSITY OF VIRGINIA, VA$186,250BBM
2024Validation of penta-omic assays in brain tissue and identification of markers of tissue and -omic data quality1R21AG088936-01MACDONALD, JEFFREY M.MIECZKOWSKI, PIOTR ANDRZEJSCOTT, WILLIAM KUNIV OF NORTH CAROLINA CHAPEL HILL, NC$440,079MNG
2024Development of Novel Heterogeneous Range Modulators for FLASH Particle Therapy1R21CA294634-01TEO, BOON-KENG KEVINUNIVERSITY OF PENNSYLVANIA, PA$403,219RTB
2024Engineered orthogonal signaling systems for selective phosphorylation of protein kinase substrates1R21CA293623-01TURK, BENJAMIN EYALE UNIVERSITY, CT$391,531CSRS
2024Novel, Scalable Approach for Isolation of Exomeres for RNA Delivery1R21GM154180-01WALTON, STEPHEN PATRICKMICHIGAN STATE UNIVERSITY, MI$289,946ZRG1
2024Developing graphene grids to overcome air-water-interface issues1R21GM154216-01LANDER, GABRIEL CSCRIPPS RESEARCH INSTITUTE, THE, CA$276,000MSFC
2024Recombinase polymerase amplification to enable same-cell, DNA/RNA multi-omic single cell sequencing1R21GM152950-01HIGGINSON, DANIELSLOAN-KETTERING INST CAN RESEARCH, NY$265,500GCAT
2024Improving the Sensitivity and Selectivity of Laser Desorption Ionization Using N-Heterocyclic Carbene Mass Ionization Tags1R21GM155773-01CAMDEN, JONUNIVERSITY OF NOTRE DAME, IN$247,767EBIT
2024Development of two-dimensional (2D) acoustic force elastography microscopy for the non-contact measurement of elastic property of cell encapsulated scaffolds1R21GM154167-01LIU, HSIAO-CHUANUNIVERSITY OF SOUTHERN CALIFORNIA, CA$246,368ZRG1
2024A Plug-and-Play Platform for Continuous Directed Evolution of Nonribosomal Peptide Synthetases1R21GM154190-01JOHNSTON, CHAD WILLIAMBAYLOR COLLEGE OF MEDICINE, TX$240,000CBP
2024Graphene covalent grids for single-particle cryo-EM1R21GM154202-01HE, MAGGIEUNIVERSITY OF ARKANSAS AT FAYETTEVILLE, AR$238,845ZRG1
2024Genetically Encoded Magnetometer for Intracellular Dynamic Measurement1R21GM154219-01CHEN, YUNJOHNS HOPKINS UNIVERSITY, MD$235,586INN
2024Development of aerosol fluorescence spectrometer for measuring multiple physicochemical properties of respiratory and drug particles in situ1R21GM155887-01OHNO, PAULAUBURN UNIVERSITY AT AUBURN, AL$229,454ZRG1
2024Microscale Enzymatic Remodeling of Molecular Glycosylation1R21GM152878-01HOLLAND, LISA AWEST VIRGINIA UNIVERSITY, WV$228,000ZRG1
2024Shapeshifting Cyclic Peptides as Single Molecule Polypharmacological Drugs1R21GM154148-01STOWELL, MICHAEL H. B.UNIVERSITY OF COLORADO, CO$213,563CSB
2024Developing a redox-mediated single NP detection for bioconjugate analysis.1R21GM155760-01ALPUCHE-AVILES, MARIO ALBERTOUNIVERSITY OF NEVADA RENO, NV$206,028EBIT
2024DEVELOP GENOMEWIDE TECHNOLOGY TO PROFILE DNA ADP-RIBOSYLATION1R21GM154218-01LEUNG, ANTHONY K LJOHNS HOPKINS UNIVERSITY, MD$204,688GCAT
2024Development of a nanobody tool kit to study connexin channels1R21GM155757-01CONTRERAS, JORGE ENRIQUEUNIVERSITY OF CALIFORNIA AT DAVIS, CA$201,250BBM
2024Algorithms and Software for Multidimensional Vibrational Spectroscopy of Coarse-Grained Protein Models1R21AG085412-01KANANENKA, ALEXEIUNIVERSITY OF DELAWARE, DE$200,000MSFB
2024Novel geometric deep learning models for tissue structure-aware spatial expression representations from spatially resolved single-cell transcriptomics data1R21GM155774-01GAO, SHOU-JIANGHUANG, YUFEIUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$198,750MABS
2024New Chemical Tools to Measure Cell Membrane Tension in Vivo1R21GM153048-01JOKERST, JESSE VINCENTUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$197,500ZRG1
2024Safe Continual Learning for Sepsis Early Detection1R21GM154171-01XIE, PENGTAOUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$183,524CDMA
2024Development of a novel model to study the effects of LINE-1 retrotransposons in disease and normal physiology using nanobodies1R21GM155785-01COOK, PAMELADRUMMOND, JAMESMERCER UNIVERSITY MACON, GA$176,238GCAT
2024Novel deep learning frameworks for predicting nucleosome-binding proteins1R21GM152740-01CUI, FENGROCHESTER INSTITUTE OF TECHNOLOGY, NY$148,000MSFC
2023Establishment of a Cell-Based Screening Platform for DNA Encoded Libraries1R21GM149993-01KODADEK, THOMAS J.UNIVERSITY OF FLORIDA, FL$338,100SBCB
2023A universal approach for determining three-dimensional RNA structures1R21GM151508-01SERGANOV, ALEXANDERNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$296,625MSFB
2023Nanoplasmonic Spatiotemporal Imaging of Single-Cell Protein Secretion and Intercellular Communication1R21GM151528-01KURABAYASHI, KATSUONEW YORK UNIVERSITY, NY$251,659ZRG1
2023Expedite Enzymatic Assembly of Glycans via DNA (de)Hybridization-Enabled Catch-and-Release1R21GM150050-01LI, LEIGEORGIA STATE UNIVERSITY, GA$234,000SBCA
2023Rational PROTAC design enabled by integrated in silico molecular modeling and in vitro biomimetic affinity assessment1R21GM151651-01CHENG, QUAN JASONUNIVERSITY OF CALIFORNIA RIVERSIDE, CA$226,733MSFA
2023Photochemical Technologies for Improved Glycosylation Reactions1R21GM149588-01CRICH, DAVIDPOPIK, VLADIMIR VUNIVERSITY OF GEORGIA, GA$217,444SBCA
2023Mapping protein signatures to single allele chromatin topologies at genomic resolution1R21CA282715-01SPILLE, JAN-HENDRIKUNIVERSITY OF ILLINOIS AT CHICAGO, IL$211,378GCAT
2023Toward synthetic chemically defined mRNA for human therapeutics1R21GM150088-01GAGNON, KEITH THOMASWAKE FOREST UNIVERSITY HEALTH SCIENCES, NC$205,541SBCA
2023Cell tracking in low-frame-rate video based on displacement prediction1R21GM150066-01IURICICH, FEDERICOCLEMSON UNIVERSITY, SC$204,149BDMA
2023Affinity purification of cross-ß fibrils using immobilized thioflavin1R21AG081686-01JIANG, WENPURDUE UNIVERSITY, IN$184,326MSFB
2023A Bipolar Electrochemical Single Entity Bioanalyzer1R21GM149994-01ZHANG, BOUNIVERSITY OF WASHINGTON, WA$179,493ZRG1
2023An Integrated Catheter Dressing for Early Detection of Catheter-related Bloodstream Infections1R21GM150104-01CEYLAN KOYDEMIR, HATICETEXAS A&M UNIVERSITY, TX$175,018BTSS
2023Chromatically Orthogonal Photolabile Protecting Groups for the Parallel On-Chip Synthesis of High-Density Glycan Microarrays1R21GM151612-01WINTER, ARTHUR H.IOWA STATE UNIVERSITY, IA$148,587CSB

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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