The notices it replaced
- Reissues: PAR-19-328 Single-Site Investigator-Initiated Clinical Trials (R61/R33 Clinical Trial Required)
- 2 steps back: PAR-18-406 Single-Site Investigator-Initiated Clinical Trials (R61/R33 Clinical Trial Required)
- 3 steps back: PAR-16-405 Single-Site Investigator-Initiated Clinical Trials (R61/R33)
Replaced by PAR-25-028.
Who won it before
60 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $50,008,046 in first-year total cost, median $772,867.
Most frequent study sections
- NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT (JA)]19
- NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT (MA)]13
- Special Emphasis Panel[ZHL1 CSR-G (M1)]10
- NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT (OA)]9
- Special Emphasis Panel[ZHL1 CSR-G (F1)]3
Most frequent institutions
- VANDERBILT UNIVERSITY MEDICAL CENTER4
- STANFORD UNIVERSITY3
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO3
- UNIVERSITY OF COLORADO DENVER3
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH3
| FY | Project | PIs | Institution | First-year cost | Study section |
|---|---|---|---|---|---|
| 2025 | The effect of SPecialty cAre on Recovery from Cardiac arrest (the SPARC trial)1R61HL175113-01A1 | CALLAWAY, CLIFTON W.ELMER, JONATHANGUYETTE, FRANCIS X.PATTERSON (MOORE), CHARITY G | UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA | $2,394,542 | SSPT |
| 2025 | Personalized oxygen therapy for critically ill adults: a randomized trial1R61HL180352-01 | SEMLER, MATTHEW WALLWRIGHT, ADAM T | VANDERBILT UNIVERSITY MEDICAL CENTER, TN | $874,997 | SSPT |
| 2025 | Optimal tuberculosis screening and tuberculosis preventive therapy delivery strategies to improve maternal and birth outcomes among pregnant women with HIV in Uganda: a randomized trial1R61HL178398-01A1 | NAKIMULI, ANNETTEE OLIVIAPHILLIPS, PATRICK PJYOON, CHRISTINA | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA | $853,975 | SSPT |
| 2025 | Effects of operational naps on blood pressure and performance among night shift workers1R61HL172984-01A1 | BUYSSE, DANIEL J.PATTERSON, PAUL D | UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA | $790,584 | SSPT |
| 2025 | Pragmatic trial of midodrine as a vasopressor-sparing agent in septic shock1R61HL177037-01A1 | GAJIC, OGNJEN | MAYO CLINIC ROCHESTER, MN | $783,661 | SSPT |
| 2025 | Multi-component Lifestyle Intervention to Improve Outcomes in Black Adults with Chronic Kidney Disease1R61HL178691-01 | TYSON, CRYSTAL C | DUKE UNIVERSITY, NC | $772,621 | SSPT |
| 2025 | A Sequential Multiple Assignment Randomized Trial of Diet Treatments for Hepatic Steatosis and Cardiometabolic Risk in Adolescents1R61HL174736-01A1 | BAI, SHASHAVOS, MIRIAM B. | MICHIGAN STATE UNIVERSITY, MI | $644,415 | SSPT |
| 2024 | Home-Based, Digital Intervention to Increase Physical Activity in Patients with the Fontan Circulation1R61HL171110-01A1 | GOLDMUNTZ, ELIZABETHMITCHELL, JONATHAN ANDREW | CHILDREN'S HOSP OF PHILADELPHIA, PA | $985,424 | SSPT |
| 2024 | Rehabbing with Peloton: Commercially Available Fitness mHealth for Cardiac Rehabilitation among Individuals Recovering from Transcatheter Aortic Valve Replacement1R61HL169336-01A1 | KNOEPKE, CHRISTOPHERPORTZ, JENNIFER | UNIVERSITY OF COLORADO DENVER, CO | $792,235 | SSPT |
| 2024 | A Selective Serotonin Reuptake Inhibitor for Asthma Patients with Frequent Exacerbations1R61HL167909-01A1 | BROWN, E SHERWOODKHAN, DAVID A | UT SOUTHWESTERN MEDICAL CENTER, TX | $790,698 | SSPT |
| 2024 | A randomized double-blind, placebo-controlled phase 2 clinical trial of intravenous citrulline for vaso-occlusive crisis in sickle cell disease1R61HL167806-01A1 | CHAPMAN, KIMBERLY ANNMAJUMDAR, SUVANKAR | CHILDREN'S RESEARCH INSTITUTE, DC | $776,011 | SSPT |
| 2024 | FAMily-centered WEight Loss for Black Adults (FAM WEL B-ing): Optimization and Evaluation using Multiphase Optimization Strategy (MOST) and Social Network Analysis (SNA)1R61HL169357-01A1 | SAMUEL-HODGE, CARMEN D | UNIV OF NORTH CAROLINA CHAPEL HILL, NC | $774,005 | SSPT |
| 2023 | Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent Rheumatic Heart Disease: A non-inferiority randomized trial. (GOALIE)1R61HL166441-01 · under PAR-19-328 | BEATON, ANDREA ZAWACKIOKELLO, EMMY | CINCINNATI CHILDRENS HOSP MED CTR, OH | $1,913,148 | SSPT |
| 2023 | Testing Technology-Based Implementation Strategies for a Family-Based Pediatric Health Behavior Intervention in Community-Based Primary Care: A Cluster Randomized Factorial Trial1R61HL166976-01A1 | BERKEL, CADYSMITH, JUSTIN D | ARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ | $1,592,173 | SSPT |
| 2023 | REVAMP-PH: REpurposing Valsartan May Protect against Pulmonary Hypertension1R61HL167848-01 · under PAR-19-328 | LEARY, PETER J | UNIVERSITY OF WASHINGTON, WA | $761,805 | SSPT |
| 2023 | VENOUS ETHANOL ABLATION IN ISCHEMIC VENTRICULAR TACHYCARDIA- VELVET TRIAL1R61HL164873-01A1 · under PAR-19-328 | VALDERRABANO, MIGUEL | METHODIST HOSPITAL RESEARCH INSTITUTE, TX | $738,259 | SSPT |
| 2023 | Wellness Achieved Through Changing Habits (WATCH): An Acceptance-Based Healthy Lifestyle Intervention for Diverse Adolescents1R61HL158514-01A1 | MANASSE, STEPHANIE | DREXEL UNIVERSITY, PA | $714,670 | SSPT |
| 2023 | Long term efficacy and safety of orlistat for type 1 hyperlipoproteinemia: a randomized, double-blind, placebo-controlled trial1R61HL166373-01 · under PAR-19-328 | GARG, ABHIMANYU | UT SOUTHWESTERN MEDICAL CENTER, TX | $550,629 | ZHL1 |
| 2022 | A novel psychological-behavioral intervention to promote physical activity after acute coronary syndrome1R61HL158529-01A1 · under PAR-19-328 | HUFFMAN, JEFF C | MASSACHUSETTS GENERAL HOSPITAL, MA | $820,552 | SSPT |
| 2022 | The Inorganic Nitrate and eXercise performance in Heart Failure (iNIX-HF): - a phase II clinical trial1R61HL155858-01A1 · under PAR-19-328 | COGGAN, ANDREW RPETERSON, LINDA RUTHSCHECHTMAN, KENNETH B. | WASHINGTON UNIVERSITY, MO | $803,813 | SSPT |
| 2022 | Hospital Airway Resuscitation Trial1R61HL162980-01 · under PAR-19-328 | MOSKOWITZ, ARI | ALBERT EINSTEIN COLLEGE OF MEDICINE, NY | $788,728 | SSPT |
| 2022 | The MObile Health InterVEntion in Pulmonary Arterial Hypertension (MOVE PAH) Study1R61HL158941-01A1 · under PAR-19-328 | BRITTAIN, EVAN L | VANDERBILT UNIVERSITY MEDICAL CENTER, TN | $773,113 | SSPT |
| 2022 | LIMA: Lipid anti-Inflammatory Mediators in Asthma to reduce airway hyperresponsiveness in obese asthmatics1R61HL157069-01A1 · under PAR-19-328 | GELHAUS, STACY LYNNHOLGUIN, FERNANDO | UNIVERSITY OF COLORADO DENVER, CO | $741,557 | SSPT |
| 2022 | Efficacy of Precision Text Messaging to Increase Physical Activity in Insufficiently-Active Young Adults1R61HL164868-01 · under PAR-19-328 | CONROY, DAVID E.LAGOA, CONSTANTINO MANUEL | PENNSYLVANIA STATE UNIVERSITY, THE, PA | $724,531 | SSPT |
| 2022 | A hybrid effectiveness-implementation trial evaluating behavioral treatments for insomnia for socioeconomic disadvantaged adults in primary care1R61HL164688-01 · under PAR-19-328 | BERTISCH, SUZANNE | BRIGHAM AND WOMEN'S HOSPITAL, MA | $562,951 | SSPT |
| 2022 | Pre-transplant health coaching to improve patient-reported outcomes in lung transplant candidates1R61HL158811-01A1 · under PAR-19-328 | KENNEDY, CASSIE COLLEEN | MAYO CLINIC ROCHESTER, MN | $484,151 | SSPT |
| 2022 | Understanding the role of bilevel positive airway pressure (BPAP) in pediatric acute asthma exacerbations: A prospective, randomized, double blind, controlled trial.1R61HL158814-01A1 · under PAR-19-328 | WILSON, PATRICK THOMAS | UNIVERSITY OF COLORADO DENVER, CO | $478,224 | SSPT |
| 2022 | Home sleep apnea testing compared to in-lab polysomnography for the evaluation of obstructive sleep apnea in children1R61HL162839-01 · under PAR-19-328 | CIELO, CHRISTOPHER MICHAELTAPIA, IGNACIO ESTEBAN | CHILDREN'S HOSP OF PHILADELPHIA, PA | $360,115 | SSPT |
| 2021 | A Randomized Trial of Protocolized Diuretic Therapy Compared to Standard Care in Emergency Department Patients with Acute Heart Failure1R61HL155810-01 · under PAR-19-328 | COLLINS, SEAN PATRICK | VANDERBILT UNIVERSITY MEDICAL CENTER, TN | $881,233 | ZHL1 |
| 2021 | The ALOHA trial: Addressing Quality of Life, Clinical Outcomes, and Mechanisms in Uncontrolled Asthma Following the DASH Dietary Pattern1R61HL155160-01A1 · under PAR-19-328 | MA, JUN | UNIVERSITY OF ILLINOIS AT CHICAGO, IL | $826,083 | SSPT |
| 2021 | The Efficacy of CAMP Air, a Web-based Asthma Intervention, Among Urban Adolescents with Uncontrolled Asthma1R61HL151958-01A1 · under PAR-19-328 | BRUZZESE, JEAN-MARIE | COLUMBIA UNIVERSITY HEALTH SCIENCES, NY | $819,279 | SSPT |
| 2021 | Reducing Childhood Obesity Using Ecological Momentary Intervention (EMI) and Video Feedback atFamily Meals1R61HL151978-01A1 · under PAR-19-328 | BERGE, JERICA M | UNIVERSITY OF MINNESOTA, MN | $783,541 | SSPT |
| 2021 | Using Smart Displays to Implement an Evidence-Based eHealth System for Older Adults with Multiple Chronic Conditions1R61HL151870-01A1 · under PAR-19-328 | GUSTAFSON, DAVID HMARES, MARIE-LOUISE | UNIVERSITY OF WISCONSIN-MADISON, WI | $777,464 | SSPT |
| 2021 | A Just-In-Time Adaptive Mobile Application Intervention To Reduce Sodium Intake And Blood Pressure In Hypertensive Patients1R61HL155498-01A1 · under PAR-19-328 | DORSCH, MICHAELNALLAMOTHU, BRAHMAJEE K | UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI | $776,114 | SSPT |
| 2021 | Clinical Trial of the Fit Families Multicomponent Obesity Intervetnion for African American Adolescents and Their Caregivers: Next Step from the ORBIT Initiative1R61HL155793-01 · under PAR-19-328 | CUNNINGHAM, PHILLIPPE BELTONGHOSH, SAMIRANNAAR, SYLVIE | MEDICAL UNIVERSITY OF SOUTH CAROLINA, SC | $765,613 | SSPT |
| 2021 | EFFICACY TRIAL OF A PROGRAM FOR WEIGHT LOSS FOR HISPANIC FATHERS AND INCREASED PHYSICAL ACTIVITY FOR THEIR CHILDREN: HEALTHY DADS, HEALTHY KIDS1R61HL155015-01A1 · under PAR-19-328 | O'CONNOR, TERESIA MARGARETA | BAYLOR COLLEGE OF MEDICINE, TX | $736,610 | SSPT |
| 2021 | Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia1R61HL151952-01A1 · under PAR-19-328 | O'BRIEN, LOUISE M.ZOPF, DAVID ADAM | UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI | $569,532 | SSPT |
| 2021 | Insertable Cardiac Monitor-Guided Early Intervention to Reduce Atrial Fibrillation Burden Following Catheter Ablation (ICM-REDUCE-AF Trial)1R61HL153001-01A1 · under PAR-19-328 | GOLDENBERG, ILAN | UNIVERSITY OF ROCHESTER, NY | $541,118 | SSPT |
| 2020 | Physical Activity to Improve CV Health in Older Women: A Pragmatic Trial1R61HL151885-01 · under PAR-18-406 | KOOPERBERG, CHARLES LLACROIX, ANDREA Z.STEFANICK, MARCIA L. | FRED HUTCHINSON CANCER RESEARCH CENTER, WA | $2,463,010 | SSPT |
| 2020 | The LIMIting AAA with meTformin (LIMIT) Trial1R61HL146835-01A1 · under PAR-19-328 | DALMAN, RONALD LLU, YINGMAHAFFEY, KENNETH W. | STANFORD UNIVERSITY, CA | $1,532,491 | SSPT |
| 2020 | Evaluation of the Asthma Management Program to Promote Activity for Students in Schools (Asthma-PASS)1R61HL147908-01A1 · under PAR-18-406 | REZNIK, MARINA | ALBERT EINSTEIN COLLEGE OF MEDICINE, NY | $867,721 | SSPT |
| 2020 | Maximizing Efficacy of Goal-Directed Sedation to Reduce Neurological Dysfunction in Mechanically Ventilated Infants and Children Study (mini-MENDS)1R61HL151951-01 · under PAR-18-406 | PANDHARIPANDE, PRATIKSMITH, HEIDI A B | VANDERBILT UNIVERSITY MEDICAL CENTER, TN | $855,283 | SSPT |
| 2020 | RE-ENERGIZE FONTAN - RandomizEd Exercise INtERvention desiGned to MaximIZE Fitness in Pediatric FONTAN patients1R61HL146775-01A1 · under PAR-18-406 | BERNSTEIN, DANIELPALANIAPPAN, LATHA PSELAMET TIERNEY, ELIF SEDA | STANFORD UNIVERSITY, CA | $752,734 | SSPT |
| 2019 | Point-of-care C-reactive protein-based tuberculosis screening in people living with HIV: a randomized trial1R61HL146365-01A1 · under PAR-18-406 | DOWDY, DAVID WESLEYPHILLIPS, PATRICK PJYOON, CHRISTINA | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA | $963,941 | ZHL1 |
| 2019 | Guys/Girls Opt for Activities for Life (GOAL) Trial1R61HL144896-01A1 · under PAR-18-406 | ROBBINS, LORRAINE BRENDA | MICHIGAN STATE UNIVERSITY, MI | $788,377 | ZHL1 |
| 2019 | A Mobile Relational Agent to Enhance Atrial Fibrillation Self-care1R61HL144669-01 · under PAR-18-406 | MAGNANI, JARED W. | UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA | $766,398 | ZHL1 |
| 2019 | Randomized Explanatory Trial of a Mediterranean Dietary Pattern Weight Loss Intervention for Primary Care Practices1R61HL142680-01A1 · under PAR-18-406 | KEYSERLING, THOMAS CSAMUEL-HODGE, CARMEN D | UNIV OF NORTH CAROLINA CHAPEL HILL, NC | $759,424 | ZHL1 |
| 2019 | A Pharmacist Intervention for Monitoring and Treating Hypertension Using Bidirectional Texting1R61HL144880-01A1 · under PAR-18-406 | CARTER, BARRY LPOLGREEN, LINNEA ANN | UNIVERSITY OF IOWA, IA | $693,432 | ZHL1 |
| 2019 | Extending CPAP Therapy in Stable Preterm Infants to Increase Lung Growth and Function: A Randomized Controlled Trial1R61HL147906-01 · under PAR-18-406 | MCEVOY, CYNTHIA TTEPPER, ROBERT S. | OREGON HEALTH & SCIENCE UNIVERSITY, OR | $657,183 | ZHL1 |
| 2019 | PCSK9 Inhibition after Heart Transplantation1R61HL139929-01A1 · under PAR-16-405 | FEARON, WILLIAM F | STANFORD UNIVERSITY, CA | $435,534 | ZHL1 |
| 2018 | A double-blind randomized controlled trial to assess the efficacy and safety of a quadruple ultra-low-dose treatment for hypertension (QUARTET USA)1R61HL139852-01 · under PAR-16-405 | CIOLINO, JODY D.HUFFMAN, MARK D | NORTHWESTERN UNIVERSITY AT CHICAGO, IL | $1,228,452 | ZHL1 |
| 2018 | Advanced REperfusion STrategies- The ARREST Trial1R61HL142696-01 · under PAR-16-405 | AUFDERHEIDE, TOM PAULYANNOPOULOS, DEMETRIS | UNIVERSITY OF MINNESOTA, MN | $750,258 | ZHL1 |
| 2018 | Effect of PCSK9 Inhibition on Cardiovascular Risk in Treated HIV Infection (EPIC-HIV Study)1R61HL141047-01 · under PAR-16-405 | HOFFMANN, UDOHSUE, PRISCILLA Y.TAWAKOL, AHMED A | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA | $729,903 | ZHL1 |
| 2018 | REHAB-PH Trial: Repurposing a Histamine Antagonist to Benefit Patients with Pulmonary Hypertension1R61HL142539-01 · under PAR-16-405 | LEARY, PETER J | UNIVERSITY OF WASHINGTON, WA | $685,472 | ZHL1 |
| 2018 | Randomized Trial of Endotracheal Tubes to Prevent Ventilator-Associated Pneumonia - Prevent 2 Study1R61HL138650-01A1 · under PAR-16-405 | AZIZ, MICHAELTREGGIARI, MIRIAM | OREGON HEALTH & SCIENCE UNIVERSITY, OR | $657,073 | ZHL1 |
| 2018 | Comparative effectiveness of social physical play and traditional exercise programming1R61HL142679-01 · under PAR-16-405 | SCIAMANNA, CHRISTOPHER N. | PENNSYLVANIA STATE UNIV HERSHEY MED CTR, PA | $643,916 | ZHL1 |
| 2018 | The Effects of Interleukin-1 Blockade On Exercise Capacity In Patients With Recently Decompensated Systolic Heart Failure1R61HL139943-01 · under PAR-16-405 | ABBATE, ANTONIOVAN TASSELL, BENJAMIN W | VIRGINIA COMMONWEALTH UNIVERSITY, VA | $532,674 | ZHL1 |
| 2018 | Targeting of UnControlled Hypertension in Emergency Department (TOUCHED)1R61HL139454-01A1 · under PAR-16-405 | PRENDERGAST, HEATHER MARIE | UNIVERSITY OF ILLINOIS AT CHICAGO, IL | $505,284 | ZHL1 |
| 2018 | Behavioral Economic Approaches to Increase Physical Activity among Patients with Elevated Risk for Cardiovascular Disease1R61HL141440-01 · under PAR-16-405 | PATEL, MITESH S.VOLPP, KEVIN G | UNIVERSITY OF PENNSYLVANIA, PA | $446,212 | ZHL1 |
| 2017 | Granulocyte-Macrophage Colony Stimulated Factor (GM-CSF) in Peripheral Arterial Disease1R61HL138657-01 · under PAR-16-405 | QUYYUMI, ARSHED A | EMORY UNIVERSITY, GA | $775,100 | ZHL1 |
Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.